| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Morán, E J Mufson, P Gómez-Ramo. Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains. Acta neuropathologica. vol 87. issue 3. 1994-07-20. PMID:8009960. |
acetylcholinesterase and butyrylcholinesterase have been associated with structures undergoing neurofibrillary degeneration, as well as with all types of senile plaques, in non-demented aged and alzheimer's brains. |
1994-07-20 |
2023-08-12 |
Not clear |
| N C Inestrosa, R Alarcón, J Arriagada, A Donoso, J Alvarez, E O Campo. Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes. Journal of the neurological sciences. vol 122. issue 1. 1994-06-24. PMID:8195795. |
blood markers in alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes. |
1994-06-24 |
2023-08-12 |
Not clear |
| A H Mohamme. Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128832. |
research on memory enhancing effects of acetylcholinesterase (ache) inhibitors was stimulated by the finding of diminished cholinergic markers in patients with alzheimer's disease, and the correlation of cognitive impairment to cholinergic deficits in these patients. |
1994-04-14 |
2023-08-12 |
rat |
| A Enz, R Amstutz, H Boddeke, G Gmelin, J Malanowsk. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease. Progress in brain research. vol 98. 1994-01-06. PMID:8248533. |
brain selective inhibition of acetylcholinesterase: a novel approach to therapy for alzheimer's disease. |
1994-01-06 |
2023-08-12 |
human |
| W C Benzing, E J Mufson, D M Armstron. Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques. Brain research. vol 625. issue 1. 1993-12-29. PMID:8242391. |
as part of an ongoing investigation devoted to understanding the pathogenesis of senile plaques, we employed histochemical and immunocytochemical techniques to examine the distribution and cytologic features of acetylcholinesterase (ache), choline acetyltransferase (chat), somatostatin (som), neurotensin (nt) and substance p (sp) containing fibers and neurons within the amygdala of: (1) patients with alzheimer's disease (ad); (2) age-matched non-demented controls (nc); and (3) a group of non-demented cases, who upon postmortem neuropathologic examination exhibited sufficient numbers of senile plaques to be classified as ad. |
1993-12-29 |
2023-08-12 |
human |
| C I Wright, C Geula, M M Mesula. Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239315. |
neurofibrillary tangles and amyloid plaques express acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity in alzheimer's disease. |
1993-12-10 |
2023-08-12 |
Not clear |
| C I Wright, C Geula, M M Mesula. Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363355. |
butyrylcholinesterase (bche) and an altered form of acetylcholinesterase (ache) accumulate in the plaques and tangles of alzheimer's disease (ad). |
1993-09-30 |
2023-08-12 |
Not clear |
| S Michaelson, D H Smal. A protease is recovered with a dimeric form of acetylcholinesterase in fetal bovine serum. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518952. |
a protease activity which co-purified with affinity-purified fetal bovine serum acetylcholinesterase (ache) has been shown to release the amyloid protein precursor (app) of alzheimer's disease from cell membranes. |
1993-07-29 |
2023-08-12 |
cattle |
| Z X Shen, Z Zhan. Anomalous acetylcholinesterase in CSF without clinical diagnosis of Alzheimer's disease. Lancet (London, England). vol 342. issue 8862. 1993-07-27. PMID:8100344. |
anomalous acetylcholinesterase in csf without clinical diagnosis of alzheimer's disease. |
1993-07-27 |
2023-08-12 |
Not clear |
| b' A Bilkei-Gorz\\xc3\\xb. Neurotoxic effect of enteral aluminium. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 31. issue 5. 1993-07-07. PMID:8505021.' |
acetylcholinesterase activity increased and choline-acetyltransferase activity decreased, resulting in a diminished cholinergic activity, which is a characteristic of alzheimer's disease. |
1993-07-07 |
2023-08-12 |
rat |
| T Arendt, M K Brückner, M Lange, V Big. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303164. |
changes in acetylcholinesterase and butyrylcholinesterase in alzheimer's disease resemble embryonic development--a study of molecular forms. |
1993-06-24 |
2023-08-11 |
human |
| T Arendt, M K Brückner, M Lange, V Big. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303164. |
the pattern of molecular forms of acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (bche, ec 3.1.1.8) separated by density gradient centrifugation was investigated in the brain and cerebrospinal fluid in alzheimer's disease (ad), in human embryonic brain and in rat brain after experimental cholinergic deafferentation of the cerebral cortex. |
1993-06-24 |
2023-08-11 |
human |
| C Saldanha, T Quintão, C Garci. [Evaluation of blood esterases in Alzheimer's disease]. Acta medica portuguesa. vol 5. issue 11. 1993-04-08. PMID:1293953. |
there was a significant negative correlation (r = -0.82; p < 0.001) between mean corpuscular hemoglobin concentration (mchg) and erythrocyte acetylcholinesterase activity in alzheimer's patients. |
1993-04-08 |
2023-08-11 |
human |
| K M Schegg, L S Harrington, S Neilsen, R M Zweig, J H Peacoc. Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease. Neurobiology of aging. vol 13. issue 6. 1993-02-26. PMID:1491735. |
soluble and membrane-bound forms of brain acetylcholinesterase in alzheimer's disease. |
1993-02-26 |
2023-08-11 |
Not clear |
| K M Schegg, L S Harrington, S Neilsen, R M Zweig, J H Peacoc. Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease. Neurobiology of aging. vol 13. issue 6. 1993-02-26. PMID:1491735. |
in order to determine the effect of alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase (ache) in the brain, postmortem samples (delay interval less than 12 h) were obtained from parietal cortex (brodmann area 40) and hippocampus as well as the areas containing their respective projection nuclei, i.e., substantia innominata and septal nucleus, in 9 patients with alzheimer's disease (ad) and 4 normal controls. |
1993-02-26 |
2023-08-11 |
Not clear |
| E Holsboer-Trachsler, M Hatzinger, R Stohler, U Hemmeter, J Gray, J Müller, R Kocher, R Spiege. Effects of the novel acetylcholinesterase inhibitor SDZ ENA 713 on sleep in man. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 1. 1993-02-26. PMID:8424849. |
a novel brain-selective acetylcholinesterase inhibitor, sdz ena 713, is under development for the treatment of dementia of the alzheimer type. |
1993-02-26 |
2023-08-12 |
human |
| C I Wright, C Guela, M M Mesula. Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 2. 1993-02-18. PMID:8421706. |
neurofibrillary tangles and amyloid plaques express acetylcholinesterase and butyrylcholinesterase activity in alzheimer disease. |
1993-02-18 |
2023-08-12 |
Not clear |
| A E Coleman, C Geula, B H Price, M M Mesula. Differential laminar distribution of acetylcholinesterase and butyrylcholinesterase containing tangles in the cerebral cortex of Alzheimer's disease. Brain research. vol 596. issue 1-2. 1993-01-28. PMID:1467998. |
differential laminar distribution of acetylcholinesterase and butyrylcholinesterase containing tangles in the cerebral cortex of alzheimer's disease. |
1993-01-28 |
2023-08-11 |
Not clear |
| A E Coleman, C Geula, B H Price, M M Mesula. Differential laminar distribution of acetylcholinesterase and butyrylcholinesterase containing tangles in the cerebral cortex of Alzheimer's disease. Brain research. vol 596. issue 1-2. 1993-01-28. PMID:1467998. |
a sensitive histochemical method for the visualization of acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity was used to determine the laminar distribution of cholinesterase-positive cortical tangles in alzheimer's disease (ad). |
1993-01-28 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the alzheimer type. |
1993-01-26 |
2023-08-11 |
Not clear |