| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) activities of cerebrospinal fluid (csf) collected post mortem from the lateral ventricles, cisterna magna, and lumbar regions of the spinal cord of patients with a histologically confirmed diagnosis of alzheimer's disease were compared with those of normal, age matched control patients, patients with dementia of non-alzheimer aetiology, and patients with non-dementing neurological disorders. |
1993-01-26 |
2023-08-11 |
Not clear |
| R N Kalaria, S N Kroon, I Grahovac, G Perr. Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease. Neuroscience. vol 51. issue 1. 1993-01-15. PMID:1465181. |
acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of alzheimer's disease. |
1993-01-15 |
2023-08-11 |
Not clear |
| R N Kalaria, S N Kroon, I Grahovac, G Perr. Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease. Neuroscience. vol 51. issue 1. 1993-01-15. PMID:1465181. |
previous studies have used a sensitive histochemical technique to demonstrate acetylcholinesterase and butyrylcholinesterase within the pathological lesions of alzheimer's disease. |
1993-01-15 |
2023-08-11 |
Not clear |
| M Emre, C Geula, B J Ransil, M M Mesula. The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain. Neurobiology of aging. vol 13. issue 5. 1993-01-11. PMID:1461343. |
our results also show that beta ap1-40 itself is not the source of the altered acetylcholinesterase enzyme activity that has been described in the plaques and tangles of alzheimer's disease. |
1993-01-11 |
2023-08-11 |
rat |
| J M Kerwin, C M Morris, R H Perry, E K Perr. Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. Neuroscience letters. vol 143. issue 1-2. 1992-12-23. PMID:1436650. |
it is concluded that even at moderately advanced stages of alzheimer's disease with onset in the senium, axonal processes and ngf receptor mechanisms may be structurally intact in areas of cholinergic innervation from the basal forebrain, despite evidence of cholinergic dysfunction (decreased choline acetyltransferase (chat) and acetylcholinesterase), but that in presenile alzheimer's and in demented parkinson's disease cases the receptor declines in conjunction with the loss of subcortical neurones and their processes. |
1992-12-23 |
2023-08-11 |
human |
| S Nakamura, M Takemura, T Suenaga, I Akiguchi, J Kimura, O Yasuhara, T Kimura, N Kitaguch. Occurrence of acetylcholinesterase activity closely associated with amyloid beta/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease. Acta neuropathologica. vol 84. issue 4. 1992-12-18. PMID:1441923. |
occurrence of acetylcholinesterase activity closely associated with amyloid beta/a4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of alzheimer's disease. |
1992-12-18 |
2023-08-11 |
Not clear |
| S Nakamura, M Takemura, T Suenaga, I Akiguchi, J Kimura, O Yasuhara, T Kimura, N Kitaguch. Occurrence of acetylcholinesterase activity closely associated with amyloid beta/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease. Acta neuropathologica. vol 84. issue 4. 1992-12-18. PMID:1441923. |
to investigate the possible relationship between acetylcholinesterase (ache)-containing fiber density and senile plaque density and between ache-positive plaques and beta/a4 protein deposition, ache histochemistry, the modified bielschowsky's method and beta/a4 protein immunohistochemistry were performed on the amygdala of alzheimer's disease (ad) and aged control cases. |
1992-12-18 |
2023-08-11 |
Not clear |
| L Mrzljak, P S Goldman-Raki. Acetylcholinesterase reactivity in the frontal cortex of human and monkey: contribution of AChE-rich pyramidal neurons. The Journal of comparative neurology. vol 324. issue 2. 1992-12-03. PMID:1430332. |
since nonhuman primates possess a system of ache-reactive pyramidal neurons similar to human, they provide a potentially useful animal model for analyzing acetylcholinesterase neuronal systems in the cortex, which are compromised in various neuropathological diseases like alzheimer's disease. |
1992-12-03 |
2023-08-11 |
human |
| N Ogane, E Giacobini, R Strubl. Differential inhibition of acetylcholinesterase molecular forms in normal and Alzheimer disease brain. Brain research. vol 589. issue 2. 1992-11-25. PMID:1393597. |
differential inhibition of acetylcholinesterase molecular forms in normal and alzheimer disease brain. |
1992-11-25 |
2023-08-11 |
Not clear |
| N Ogane, E Giacobini, R Strubl. Differential inhibition of acetylcholinesterase molecular forms in normal and Alzheimer disease brain. Brain research. vol 589. issue 2. 1992-11-25. PMID:1393597. |
molecular forms of acetylcholinesterase were studied in three brain regions from alzheimer disease patients and non-demented, age-matched controls. |
1992-11-25 |
2023-08-11 |
Not clear |
| K P Ebmeier, R Hunter, S M Curran, N J Dougal, C L Murray, D J Wyper, J Patterson, M T Hanson, K Siegfried, G M Goodwi. Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1410128. |
effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in alzheimer's disease. |
1992-11-25 |
2023-08-11 |
Not clear |
| K P Ebmeier, R Hunter, S M Curran, N J Dougal, C L Murray, D J Wyper, J Patterson, M T Hanson, K Siegfried, G M Goodwi. Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1410128. |
the effects of a single oral dose of the acetylcholinesterase inhibitor velnacrine maleate on word and object recognition memory and regional uptake of 99mtc-exametazime were examined in patients with alzheimer's disease. |
1992-11-25 |
2023-08-11 |
Not clear |
| Iu V Burov, T D Baĭmanov, N I Maĭso. [Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on synaptosomal uptake of neuromediators]. Biulleten' eksperimental'noi biologii i meditsiny. vol 113. issue 4. 1992-11-06. PMID:1356507. |
the study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3h-serotonin (3h-5-ht), 3h-adrenaline (3h-ad), 3h-noradrenaline (3h-ha), 2h-dopamine (3h-da), 3h-gamma-aminobutyric acid (3h-gaba), 3h-glutamic acid (3h-glu), 3h-aspartic acid (3h-asp) and 3h-glycine (3h-gli) showed that tacrine and amiridin (5 x 10(-5) m) statistically significantly (p less than 0.05) inhibited the uptake of 3h-da and 3h-5-ht. |
1992-11-06 |
2023-08-11 |
Not clear |
| M Z Wrona, R N Goyal, D J Turk, C L Blank, G Dryhurs. 5,5'-Dihydroxy-4,4'-bitryptamine: a potentially aberrant, neurotoxic metabolite of serotonin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1357095. |
furthermore, an unidentified autoxidation product of this neurotransmitter is an inhibitor of acetylcholinesterase (ache), an enzyme compromised in the alzheimer brain. |
1992-10-26 |
2023-08-11 |
mouse |
| S Heckers, C Geula, M M Mesula. Acetylcholinesterase-rich pyramidal neurons in Alzheimer's disease. Neurobiology of aging. vol 13. issue 4. 1992-09-21. PMID:1508295. |
the distribution of acetylcholinesterase (ache)-rich pyramidal neurons was studied in the cortices of 7 alzheimer's disease (ad) patients and 4 normal-aged subjects. |
1992-09-21 |
2023-08-11 |
human |
| E K Perry, M Johnson, J M Kerwin, M A Piggott, J A Court, P J Shaw, P G Ince, A Brown, R H Perr. Convergent cholinergic activities in aging and Alzheimer's disease. Neurobiology of aging. vol 13. issue 3. 1992-08-12. PMID:1625768. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) activities have been examined postmortem in a series of 66 individuals with no evidence of cns disease, ranging in age from 24 gestational weeks to 95 years and in 33 cases of alzheimer's disease (ad) aged 57-89 years. |
1992-08-12 |
2023-08-11 |
human |
| K Urakami, K Takahashi, H Saito, A Okada, S Nakamura, S Tanaka, N Kitaguchi, Y Tokushima, S Yamamot. Amyloid beta protein precursors with kunitz-type inhibitor domains and acetylcholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. Acta neurologica Scandinavica. vol 85. issue 5. 1992-08-06. PMID:1377855. |
amyloid beta protein precursors with kunitz-type inhibitor domains and acetylcholinesterase in cerebrospinal fluid from patients with dementia of the alzheimer type. |
1992-08-06 |
2023-08-11 |
Not clear |
| K Urakami, K Takahashi, H Saito, A Okada, S Nakamura, S Tanaka, N Kitaguchi, Y Tokushima, S Yamamot. Amyloid beta protein precursors with kunitz-type inhibitor domains and acetylcholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. Acta neurologica Scandinavica. vol 85. issue 5. 1992-08-06. PMID:1377855. |
we used the elisa to measure the concentration of amyloid protein precursor with kunitz type trypsin inhibitor domains (appi) in csf of dementia of the alzheimer type (dat) and examined the correlation of appi with acetylcholinesterase (ache) and somatostatin (srif). |
1992-08-06 |
2023-08-11 |
Not clear |
| J J Buccafusco, W J Jackson, A V Terr. Effects of concomitant cholinergic and adrenergic stimulation on learning and memory performance by primates. Life sciences. vol 51. issue 2. 1992-07-28. PMID:1614276. |
physostigmine and other centrally-acting acetylcholinesterase inhibitors are currently being examined for their potential in the treatment of alzheimer's disease. |
1992-07-28 |
2023-08-11 |
monkey |
| M Mesulam, K Carson, B Price, C Geul. Cholinesterases in the amyloid angiopathy of Alzheimer's disease. Annals of neurology. vol 31. issue 5. 1992-07-02. PMID:1375822. |
vessels affected by amyloid angiopathy in patients with alzheimer's disease also displayed intense acetylcholinesterase and butyrylcholinesterase activity when examined by light and electron microscopy. |
1992-07-02 |
2023-08-11 |
Not clear |