| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E G McGeer, E A Singh, P L McGee. Peripheral-type benzodiazepine binding in Alzheimer disease. Alzheimer disease and associated disorders. vol 2. issue 4. 1989-01-26. PMID:2848549. |
peripheral-type benzodiazepine binding of [3h]ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (chat) and acetylcholinesterase (ache) were measured in 7 cortical areas from postmortem brains of 18 patients with alzheimer disease (ad), 12 age-matched controls, and 15 miscellaneous neurological cases. |
1989-01-26 |
2023-08-11 |
Not clear |
| J A Kaye, C May, J R Atack, E Daly, D L Sweeney, M F Beal, S Kaufman, S Milstien, R P Friedland, S I Rapopor. Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease. Annals of neurology. vol 24. issue 5. 1989-01-24. PMID:2462403. |
monoamine metabolites, biopterin, acetylcholinesterase (ache) activity, and somatostatin-like immunoreactivity (sli) were determined in the lumbar cerebrospinal fluid (csf) of 24 patients with dementia of the alzheimer type (dat) without myoclonus or extrapyramidal signs, in 8 patients with dat and myoclonus, and in 14 age-matched healthy control subjects. |
1989-01-24 |
2023-08-11 |
human |
| E J Mufson, D C Mash, L B Hers. Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease. Annals of neurology. vol 24. issue 5. 1989-01-24. PMID:3202615. |
the cholinergic neurons located within the pedunculopontine nucleus (ch5) of patients with alzheimer's disease (ad; n = 15), parkinson's disease (pd; n = 2), and neurologically normal (n = 6) subjects were visualized immunohistochemically using choline acetyltransferase, pharmacohistochemically using acetylcholinesterase, or by reduced histochemical methods using nicotinamide adenine dinucleotide phosphate diaphorase (nadph-d). |
1989-01-24 |
2023-08-11 |
human |
| H R Brashear, M S Godec, J Carlse. The distribution of neuritic plaques and acetylcholinesterase staining in the amygdala in Alzheimer's disease. Neurology. vol 38. issue 11. 1988-12-06. PMID:3185903. |
the distribution of neuritic plaques and acetylcholinesterase staining in the amygdala in alzheimer's disease. |
1988-12-06 |
2023-08-11 |
Not clear |
| H R Brashear, M S Godec, J Carlse. The distribution of neuritic plaques and acetylcholinesterase staining in the amygdala in Alzheimer's disease. Neurology. vol 38. issue 11. 1988-12-06. PMID:3185903. |
acetylcholinesterase reactivity was reduced in the alzheimer's cases, but the basal nucleus was easily recognized by the characteristic large neurons. |
1988-12-06 |
2023-08-11 |
Not clear |
| A G Rasmussen, R Adolfsson, T Karlsso. New method specific for acetylcholinesterase in cerebrospinal fluid: application to Alzheimer's disease. Lancet (London, England). vol 2. issue 8610. 1988-10-05. PMID:2900955. |
new method specific for acetylcholinesterase in cerebrospinal fluid: application to alzheimer's disease. |
1988-10-05 |
2023-08-11 |
Not clear |
| D L Sparks, S T DeKosky, W R Markesber. Alzheimer's disease. Aminergic-cholinergic alterations in hypothalamus. Archives of neurology. vol 45. issue 9. 1988-09-29. PMID:2901257. |
to better understand the role of the hypothalamus in alzheimer's disease (ad), we have measured dopamine, norepinephrine (ne), and serotonin (5ht) levels, tritiated spiperone and tritiated serotonin blinding, and choline acetyltransferase (chat) and acetylcholinesterase activity in seven subregions of the hypothalamus from 18 normal control subjects and ten patients with ad. |
1988-09-29 |
2023-08-11 |
human |
| V Kumar, E Giacobin. Cerebrospinal fluid choline, and acetylcholinesterase activity in familial vs. non-familial Alzheimer's disease patients. Archives of gerontology and geriatrics. vol 7. issue 2. 1988-09-29. PMID:3415394. |
cerebrospinal fluid choline, and acetylcholinesterase activity in familial vs. non-familial alzheimer's disease patients. |
1988-09-29 |
2023-08-11 |
Not clear |
| V Kumar, E Giacobin. Cerebrospinal fluid choline, and acetylcholinesterase activity in familial vs. non-familial Alzheimer's disease patients. Archives of gerontology and geriatrics. vol 7. issue 2. 1988-09-29. PMID:3415394. |
acetylcholinesterase (ache) and choline (ch) in the cerebrospinal fluid (csf) from familial and non-familial alzheimer disease patients were studied. |
1988-09-29 |
2023-08-11 |
Not clear |
| E G McGeer, E A Singh, P L McGee. gamma-Glutamyltransferase: normal cortical levels in Alzheimer disease. Alzheimer disease and associated disorders. vol 1. issue 1. 1988-09-08. PMID:2899437. |
gamma-gt activities were the same in cortical samples from alzheimer and age-matched control brains, and there was no correlation between gamma-gt and choline acetyltransferase (chat) or acetylcholinesterase (ache) levels, both of which were significantly reduced in the alzheimer samples. |
1988-09-08 |
2023-08-11 |
Not clear |
| J R Atack, C May, J A Kaye, A D Kay, S I Rapopor. Cerebrospinal fluid cholinesterases in aging and in dementia of the Alzheimer type. Annals of neurology. vol 23. issue 2. 1988-07-14. PMID:3377438. |
protein concentration and acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities were assayed in the cerebrospinal fluid (csf) of 26 healthy normal subjects (20-86 years old), 27 patients with dementia of the alzheimer type (dat), and 10 patients with dementia of the alzheimer type with extrapyramidal signs (edat). |
1988-07-14 |
2023-08-11 |
human |
| E Danielsson, S A Eckernäs, A Westlind-Danielsson, O Nordström, T Bartfai, C G Gottfries, A Walli. VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer's disease/senile dementia of the Alzheimer type. Neurobiology of aging. vol 9. issue 2. 1988-06-24. PMID:2897639. |
vip-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by alzheimer's disease/senile dementia of the alzheimer type. |
1988-06-24 |
2023-08-11 |
Not clear |
| P Hammond, S Brimijoi. Acetylcholinesterase in Huntington's and Alzheimer's diseases: simultaneous enzyme assay and immunoassay of multiple brain regions. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2964509. |
acetylcholinesterase in huntington's and alzheimer's diseases: simultaneous enzyme assay and immunoassay of multiple brain regions. |
1988-04-21 |
2023-08-11 |
Not clear |
| P Hammond, S Brimijoi. Acetylcholinesterase in Huntington's and Alzheimer's diseases: simultaneous enzyme assay and immunoassay of multiple brain regions. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2964509. |
a newly developed enzyme-linked immunosorbent assay for acetylcholinesterase (ache) protein was combined with conventional measures of enzyme activity in a study of 15 brain regions from six control cases (non-neurological deaths), six cases of alzheimer's disease, and six cases of huntington's disease. |
1988-04-21 |
2023-08-11 |
Not clear |
| B Drukarch, J E Leysen, J C Stoo. Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease. Life sciences. vol 42. issue 9. 1988-03-29. PMID:2893967. |
in a recent study we have documented the acetylcholinesterase and outward k+-current inhibiting activity of 9-amino-1,2,3,4-tetrahydroacridine (tha), a drug reportedly active in the treatment of alzheimer patients. |
1988-03-29 |
2023-08-11 |
Not clear |
| C J Smith, E K Perry, R H Perry, J M Candy, M Johnson, J R Bonham, D J Dick, A Fairbairn, G Blessed, N J Birdsal. Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders. Journal of neurochemistry. vol 50. issue 3. 1988-03-23. PMID:3339358. |
as previously reported, the levels of both choline acetyltransferase and acetylcholinesterase were markedly reduced in both alzheimer's disease and parkinson's disease--with a greater loss of both enzymes in the demented subgroup of parkinsonian patients. |
1988-03-23 |
2023-08-11 |
human |
| G S Zubenko, J Moossy, I Hanin, A J Martinez, G R Rao, U Kop. Bilateral symmetry of cholinergic deficits in Alzheimer's disease. Archives of neurology. vol 45. issue 3. 1988-03-17. PMID:3341949. |
the specific activities of the cholinergic enzymes, choline acetyltransferase and acetylcholinesterase, as well as the density of muscarinic binding sites, were determined in five corresponding left and right regions of 16 brains obtained at autopsy from patients with histologically confirmed alzheimer's disease. |
1988-03-17 |
2023-08-11 |
Not clear |
| M E Appleyard, A D Smith, P Berman, G K Wilcock, M M Esiri, D Neary, D M Bowe. Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Brain : a journal of neurology. vol 110 ( Pt 5). 1988-01-12. PMID:3676702. |
acetylcholinesterase (ache) and nonspecific cholinesterase (nsche) activities of lumbar ceresbrospinal fluid (csf) from patients with a clinical or histological diagnosis of alzheimer's disease have been compared with those of normal age-matched control patients and patients with dementia of non-alzheimer aetiology. |
1988-01-12 |
2023-08-11 |
Not clear |
| V M Vostriko. Electron-cytochemical study of acetylcholinesterase in the cerebral cortex in Alzheimer's disease. Neuroscience and behavioral physiology. vol 17. issue 4. 1987-12-22. PMID:3683828. |
electron-cytochemical study of acetylcholinesterase in the cerebral cortex in alzheimer's disease. |
1987-12-22 |
2023-08-11 |
Not clear |
| B Drukarch, K S Kits, E G Van der Meer, J C Lodder, J C Stoo. 9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current. European journal of pharmacology. vol 141. issue 1. 1987-12-14. PMID:2444444. |
9-amino-1,2,3,4-tetrahydroacridine (tha), an alleged drug for the treatment of alzheimer's disease, inhibits acetylcholinesterase activity and slow outward k+ current. |
1987-12-14 |
2023-08-11 |
rat |