| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S B Miller, P Rotwein, J D Bortz, P J Bechtel, V A Hansen, S A Rogers, M R Hammerma. Renal expression of IGF I in hypersomatotropic states. The American journal of physiology. vol 259. issue 2 Pt 2. 1990-09-14. PMID:1696787. |
stimulation of renal igf i synthesis by gh could be causative of changes in renal function and renal size that occur in states of gh excess such as acromegaly. |
1990-09-14 |
2023-08-11 |
rat |
| H Assadian, A Shimatsu, H Koshiyama, N Hattori, Y Ishikawa, T Tanoh, H Imur. Secretion of alpha and TSH-beta subunits in patients with acromegaly: an in vivo study. Acta endocrinologica. vol 122. issue 6. 1990-08-24. PMID:1695807. |
these findings support the idea that some pituitary adenomas in acromegaly cosecrete gh and either alpha subunit or tsh-beta subunit. |
1990-08-24 |
2023-08-11 |
Not clear |
| P Pagesy, J Y Li, F Rentier-Delrue, O Delalande, Y Le Bouc, M Kujas, D Joubert, J Martial, F Peillo. Growth hormone and somatostatin gene expression in pituitary adenomas with active acromegaly and minimal plasma growth hormone elevation. Acta endocrinologica. vol 122. issue 6. 1990-08-24. PMID:1695808. |
some patients with active acromegaly have elevated plasma igf-i concentrations with only minimal elevation of plasma gh. |
1990-08-24 |
2023-08-11 |
Not clear |
| M Mori, M Murakami, T Satoh, K Miyashita, T Iriuchijima, M Yamada, T Inukai, I Kobayash. A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa. The Journal of clinical endocrinology and metabolism. vol 71. issue 1. 1990-08-23. PMID:2115046. |
the quantitative response of trh-gly-stimulated prl, tsh, and gh was evaluated in nine patients with anorexia nervosa, six age-matched normal women, eight patients with uremia, five patients with acromegaly, and two patients with prolactinoma. |
1990-08-23 |
2023-08-11 |
Not clear |
| b' V Popovi\\xc4\\x87, D Mici\\xc4\\x87, S Damjanovi\\xc4\\x87, M Petakov, D Manojlovi\\xc4\\x87, J Mi\\xc4\\x87i\\xc4\\x8. Discordance between growth hormone responses after growth hormone-releasing hormone (GHRH) and insulin hypoglycemia in ectopic GHRH syndrome. Endocrinologia experimentalis. vol 24. issue 1-2. 1990-08-08. PMID:2113855.' |
it is concluded that: 1. prolonged pituitary exposure to ghrh is associated with chronic gh hypersecretion with or without clinical acromegaly; 2. |
1990-08-08 |
2023-08-11 |
Not clear |
| M D Page, M E Millward, M Hourihan, R Hall, N F Scanlo. Long-term treatment of acromegaly with octreotide (Sandostatin). Hormone research. vol 33 Suppl 1. 1990-07-27. PMID:2192978. |
sixteen patients with acromegaly have been treated with octreotide [100 micrograms twice daily to 200 micrograms 3 times daily according to growth hormone (gh) response] for between 3 and 44 months. |
1990-07-27 |
2023-08-11 |
Not clear |
| R Hirschberg, J D Koppl. Effects of growth hormone and IGF-I on renal function. Kidney international. Supplement. vol 27. 1990-07-03. PMID:2636657. |
chronically elevated gh levels, such as occur in acromegaly, are associated with an increase in renal plasma flow (rpf), glomerular filtration rate (gfr) and kidney size. |
1990-07-03 |
2023-08-11 |
rat |
| M L Hartman, J D Veldhuis, M L Vance, A C Faria, R W Furlanetto, M O Thorne. Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. The Journal of clinical endocrinology and metabolism. vol 70. issue 5. 1990-06-14. PMID:2335577. |
pulsatile gh secretion in acromegaly is characterized by augmented basal gh concentrations, increased gh pulse frequency, and an attenuation of the underlying 24-h rhythm. |
1990-06-14 |
2023-08-11 |
human |
| G L Spadoni, M Tally, K Florell, G Enberg, K Hal. Determination of IGF-II levels in human serum using the erythroleukemia cell line K562. Journal of endocrinological investigation. vol 13. issue 2. 1990-05-25. PMID:2329264. |
the mean level in gh deficient patients was significantly lower (p less than 0.001) compared with healthy subjects whereas no change was found in patients with acromegaly and uremia. |
1990-05-25 |
2023-08-11 |
human |
| R Hampel, H J Rose, G Jahreis, S Krabbe, W Meng, V Hess. [Bone alkaline phosphatase as an activity parameter of acromegaly]. Deutsche medizinische Wochenschrift (1946). vol 115. issue 10. 1990-04-16. PMID:2311510. |
serum levels of growth hormone (gh: arithmetic mean of three measurements eight hours apart), somatomedin c (smc), alkaline phosphatase activity and the bone isoenzyme of alkaline phosphatase (as the liver/bone isoenzyme ratio) were measured in 26 patients with acromegaly (11 men and 15 women; mean age 45.5 [24-66] years), 18 in the active and eight in the nonactive phase of the disease. |
1990-04-16 |
2023-08-11 |
Not clear |
| G Fanghanel, O Larraza, M Villalobos, L Fanghanel, M Velasco, F Velasc. Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 17. issue 1. 1990-04-13. PMID:2107017. |
results suggest that there is more than one type of acromegaly that might be distinguished by the aminergic control on gh secretion. |
1990-04-13 |
2023-08-11 |
Not clear |
| B J Looij, F Roelfsema, M Frölic. The effect of calcitonin on growth hormone secretion in acromegaly. Clinical endocrinology. vol 31. issue 5. 1990-04-13. PMID:2627752. |
to determine whether human calcitonin inhibits gh secretion in acromegaly, as previously described for healthy subjects, the effect of an i.v. |
1990-04-13 |
2023-08-11 |
human |
| B J Looij, F Roelfsema, M Frölic. The effect of calcitonin on growth hormone secretion in acromegaly. Clinical endocrinology. vol 31. issue 5. 1990-04-13. PMID:2627752. |
bolus injection of calcitonin or saline on gh levels in patients with active acromegaly was studied and compared to that of an i.v. |
1990-04-13 |
2023-08-11 |
human |
| B J Looij, F Roelfsema, M Frölic. The effect of calcitonin on growth hormone secretion in acromegaly. Clinical endocrinology. vol 31. issue 5. 1990-04-13. PMID:2627752. |
it is concluded that human calcitonin suppresses gh secretion in acromegaly, but not to normal levels; moreover the effect is less than that found for octreotide. |
1990-04-13 |
2023-08-11 |
human |
| N Hattori, A Shimatsu, Y Kato, H Koshiyama, Y Ishikawa, H Assadian, T Tanoh, M Nagao, H Imur. Growth hormone responses to oral glucose loading measured by highly sensitive enzyme immunoassay in normal subjects and patients with glucose intolerance and acromegaly. The Journal of clinical endocrinology and metabolism. vol 70. issue 3. 1990-04-04. PMID:2106529. |
after surgery, 12 of 16 patients with acromegaly showed low basal gh levels (less than 5.0 micrograms/l). |
1990-04-04 |
2023-08-11 |
human |
| N Hattori, A Shimatsu, Y Kato, H Koshiyama, Y Ishikawa, H Assadian, T Tanoh, M Nagao, H Imur. Growth hormone responses to oral glucose loading measured by highly sensitive enzyme immunoassay in normal subjects and patients with glucose intolerance and acromegaly. The Journal of clinical endocrinology and metabolism. vol 70. issue 3. 1990-04-04. PMID:2106529. |
determination of plasma gh levels after glucose loading by the highly sensitive enzyme immunoassay is useful for evaluating the effect of surgical treatment of acromegaly. |
1990-04-04 |
2023-08-11 |
human |
| b' C Campino, J Szecowka, H Michelsen, M Ser\\xc3\\xb3n-Ferr\\xc3\\xa. Certain large forms of circulating immunoreactive human growth hormone are in fact immunoglobulins. The Journal of clinical endocrinology and metabolism. vol 70. issue 3. 1990-04-04. PMID:2307722.' |
to explain frequent discordances between serum gh levels and clinical manifestation of acromegaly, we investigated the possibility that certain immunoglobulins g (iggs) might be responsible for the displacement of [125i]human (h) gh in the hgh ria. |
1990-04-04 |
2023-08-11 |
human |
| P A van Liessum, G F Pieters, A G Smals, L M Swinkels, T J Benraad, P W Kloppenbor. Does SMS 201-995 normalize growth hormone secretion in acromegaly? GH day profiles and GH concentrations after oral glucose loading. Journal of endocrinological investigation. vol 12. issue 8. 1990-01-25. PMID:2592740. |
gh secretion in acromegaly was studied in 8 patients before and during treatment with sms 201-995, a somatostatin analogue, 100 micrograms twice daily, by evaluating gh day profiles and gh suppressibility after oral glucose tolerance tests (ogtt). |
1990-01-25 |
2023-08-11 |
Not clear |
| J S Bevan, S L Asa, M L Rossi, M M Esiri, C B Adams, C W Burk. Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. Clinical endocrinology. vol 30. issue 3. 1990-01-18. PMID:2512034. |
since this peptide has been demonstrated in normal hypothalamus and pituitary, and provokes gh release when administered intraventricularly, it may have caused ghrh release from the gangliocytoma by a local paracrine action and led to adenoma formation and acromegaly. |
1990-01-18 |
2023-08-11 |
Not clear |
| A J Weissberger, K Y Ho, M C Stuar. Quantification of urinary growth hormone (GH) excretion by centrifugal ultrafiltration and radioimmunoassay: appraisal of the relationship between 24 h urinary GH and mean 24 h serum GH levels in normal and abnormal states of GH secretion. Clinical endocrinology. vol 30. issue 6. 1990-01-17. PMID:2591065. |
forty-four subjects, comprising 13 normal adults, 12 short-statured subjects and 19 subjects with active acromegaly, underwent blood sampling at 20-min intervals and concurrent urine collection for 24 h. mean 24 h serum gh and 24 h ugh were also determined in four post-menopausal women before and during cyclical oestrogen replacement therapy, and 24 h ugh was measured in six normal men prior to and following the subcutaneous administration of biosynthetic gh (0.2 iu/kg). |
1990-01-17 |
2023-08-11 |
human |