| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramamoorthy Rajkumar, Sana Suri, Hong Min Deng, Gavin Stewart Daw. Nicotine and clozapine cross-prime the locus coeruleus noradrenergic system to induce long-lasting potentiation in the rat hippocampus. Hippocampus. vol 23. issue 7. 2014-01-23. PMID:23520012. |
a priming-challenge schedule of nicotine treatment causes long-lasting potentiation (llp), a form of synaptic plasticity closely associated with the norepinephrine (ne) neurotransmitter system, at the medial perforant path (mpp)-dentate gyrus (dg) synapse in the rat hippocampus. |
2014-01-23 |
2023-08-12 |
rat |
| Yanling Wang, Johanna M Fälting, Charlotte L Mattsson, Therése E Holmström, Jan Nedergaar. In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation. Experimental cell research. vol 319. issue 17. 2013-12-04. PMID:23948306. |
brown adipose tissue is unusual in that the neurotransmitter norepinephrine influences cell destiny in ways generally associated with effects of classical growth factors: regulation of cell proliferation, of apoptosis, and progression of differentiation. |
2013-12-04 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
novel drugs in development include those that combine multiple simultaneous pharmacologic mechanisms in addition to sert inhibition within the same molecule, such as vilazodone (combining 5ht1a partial agonism with sert inhibition), triple reuptake inhibitors (combining norepinephrine and dopamine reuptake inhibition with sert inhibition), and vortioxetine, a multimodal antidepressant combining actions at the g protein receptor mode (5ht1a and 5ht1b partial agonism and 5ht7 antagonism), at the ion channel mode (5ht3 antagonism) as well as the neurotransmitter transporter mode (sert inhibition). |
2013-10-29 |
2023-08-12 |
Not clear |
| Hong-Mei Wang, Li-Wei Wang, Xin-Min Liu, Chang-Lu Li, Shu-Ping Xu, Ahsana-Dar Faroo. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23290932. |
forsythiaside (60, 120 and 240mg/kg) was orally administered to aged (8months old) samp8 mice for 45days followed by evaluating cognitive impairment (morris water maze and step-through passive avoidance), inflammation (interleukin-1β (il-1β) and interleukin-6 (il-6) levels), oxidative stress (glutathione peroxidase (gsh-px) and total superoxide dismutase (t-sod) activities; malondialdehyde (mda) and nitric oxide (no) contents) and neurotransmitter such as norepinephrine (ne), dopamine (da), 5-hydroxytryptamine (5-ht), glutamate (glu) gamma-aminobutyric acid (gaba) and acetyl choline (ach). |
2013-10-23 |
2023-08-12 |
mouse |
| Amy J Eshleman, Katherine M Wolfrum, Meagan G Hatfield, Robert A Johnson, Kevin V Murphy, Aaron Janowsk. Substituted methcathinones differ in transporter and receptor interactions. Biochemical pharmacology. vol 85. issue 12. 2013-08-09. PMID:23583454. |
3,4-methylenedioxypyrovalerone and naphyrone had high affinity for radioligand binding sites on recombinant human dopamine (hdat), serotonin (hsert) and norepinephrine (hnet) transporters, potently inhibited [³h]neurotransmitter uptake, and, like cocaine, did not induce transporter-mediated release. |
2013-08-09 |
2023-08-12 |
human |
| Sruthi Pandipati, Nathan E Schopp. Age-dependent adrenergic actions in the main olfactory bulb that could underlie an olfactory-sensitive period. Journal of neurophysiology. vol 108. issue 7. 2013-06-14. PMID:22815401. |
we focused on the neurotransmitter norepinephrine (ne), shown to be important in different forms of olfactory learning, examining whether two specific cellular effects of ne previously observed in rats less than p14 extended to older animals. |
2013-06-14 |
2023-08-12 |
rat |
| Sarah M Rothman, Mark P Mattso. Sleep disturbances in Alzheimer's and Parkinson's diseases. Neuromolecular medicine. vol 14. issue 3. 2013-06-03. PMID:22552887. |
perturbations in neurotransmitter and hormone signaling (e.g., serotonin, norepinephrine and melatonin) and the neurotrophic factor bdnf likely contribute to the disease process. |
2013-06-03 |
2023-08-12 |
Not clear |
| Omer Ates, Feryal Cam Celikel, Serap Erdogan Taycan, Saime Sezer, Nevin Karaku. Association between 1603C>T polymorphism of DBH gene and bipolar disorder in a Turkish population. Gene. vol 519. issue 2. 2013-05-20. PMID:23384717. |
dopamine-β-hydroxylase (dbh) is the enzyme responsible for the conversion of dopamine (da) to norepinephrine (ne, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. |
2013-05-20 |
2023-08-12 |
Not clear |
| Md Khalilur Rahman, Farhana Rahman, Tania Rahman, Takeshi Kat. Dopamine-β-Hydroxylase (DBH), Its Cofactors and Other Biochemical Parameters in the Serum of Neurological Patients in Bangladesh. International journal of biomedical science : IJBS. vol 5. issue 4. 2013-05-16. PMID:23675164. |
dopamine-β-hydroxylase (dbh) is a neurotransmitter synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. |
2013-05-16 |
2023-08-12 |
Not clear |
| Eugene Lipov, Briana Kelzenberg, Courtney Rothfeld, Salahadin Abd. Modulation of NGF by cortisol and the Stellate Ganglion Block - is this the missing link between memory consolidation and PTSD? Medical hypotheses. vol 79. issue 6. 2013-04-18. PMID:22998954. |
ans has significant effect on enhancing encoding of emotional memories, sensitization, and fear conditioning with the main neurotransmitter being norepinephrine (ne). |
2013-04-18 |
2023-08-12 |
Not clear |
| Carl D Smith, M Allie Holschbach, Joshua Olsewicz, Joseph S Lonstei. Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female rats. Psychopharmacology. vol 224. issue 2. 2013-04-04. PMID:22644129. |
neurotransmitter systems in the bstv and mpoa influencing maternal behaviors are not well understood, although norepinephrine is an excellent candidate because the bstv contains the densest noradrenergic fiber plexus in the forebrain and norepinephrine in the mpoa is known to influence other female reproductive functions. |
2013-04-04 |
2023-08-12 |
rat |
| Lena Sørensen, Jacob Andersen, Mette Thomsen, Stinna M R Hansen, Xiaobei Zhao, Albin Sandelin, Kristian Strømgaard, Anders S Kristense. Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. The Journal of biological chemistry. vol 287. issue 52. 2013-02-26. PMID:23086945. |
the serotonin transporter (sert) and the norepinephrine transporter (net) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. |
2013-02-26 |
2023-08-12 |
human |
| Bartłomiej Wilkowski, Marcelo Fiszman, Christopher M Miller, Dimitar Hristovski, Sivaram Arabandi, Graciela Rosemblat, Thomas C Rindflesc. Graph-based methods for discovery browsing with semantic predications. AMIA ... Annual Symposium proceedings. AMIA Symposium. vol 2011. 2013-02-25. PMID:22195216. |
the methodology is illustrated with depressive disorder and focuses on the interaction of inflammation, circadian phenomena, and the neurotransmitter norepinephrine. |
2013-02-25 |
2023-08-12 |
Not clear |
| Joanne Ryan, Marie-Laure Anceli. Polymorphisms of estrogen receptors and risk of depression: therapeutic implications. Drugs. vol 72. issue 13. 2013-01-14. PMID:22901010. |
estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. |
2013-01-14 |
2023-08-12 |
Not clear |
| Gregory A Ordway, Attila Szebeni, Michelle J Chandley, Craig A Stockmeier, Lianbin Xiang, Samuel S Newton, Gustavo Turecki, Michelle M Duffourc, Meng-Yang Zhu, Hobart Zhu, Katalin Szeben. Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression. The international journal of neuropsychopharmacology. vol 15. issue 7. 2012-12-11. PMID:21896235. |
the noradrenergic locus coeruleus (lc) is the principal source of brain norepinephrine, a neurotransmitter thought to play a major role in the pathology of major depressive disorder (mdd) and in the therapeutic action of many antidepressant drugs. |
2012-12-11 |
2023-08-12 |
human |
| Camila Guindalini, Ronaldo Laranjeira, David Collier, Guilherme Messas, Homero Vallada, Gerome Bree. Dopamine-beta hydroxylase polymorphism and cocaine addiction. Behavioral and brain functions : BBF. vol 4. 2012-10-02. PMID:18173840. |
dopamine-beta hydroxylase (dbh) catalyzes the conversion of dopamine to norepinephrine and could, therefore, have an influence on both cocaine action and the basal sensitivity of neurotransmitter systems to cocaine. |
2012-10-02 |
2023-08-12 |
Not clear |
| Paul J Fitzgeral. Neurodrinking: is alcohol a substrate in a novel, endogenous synthetic pathway for norepinephrine? Medical hypotheses. vol 78. issue 6. 2012-08-22. PMID:22425177. |
a number of preclinical and clinical studies indicate multiple types of interaction between ethanol intake and the mood-related neurotransmitter, norepinephrine (ne). |
2012-08-22 |
2023-08-12 |
mouse |
| Philip J Medeiros, Baraa K Al-Khazraji, Nicole M Novielli, Lynne M Postovit, Ann F Chambers, Dwayne N Jackso. Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line. International journal of cancer. vol 131. issue 2. 2012-07-30. PMID:21823118. |
chronic stress is associated with elevated levels of sympathetic neurotransmitter (norepinephrine and neuropeptide y: npy) release and immunosuppression. |
2012-07-30 |
2023-08-12 |
mouse |
| Stefano Comai, Michael Tau, Zoran Pavlovic, Gabriella Gobb. The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium. Journal of clinical psychopharmacology. vol 32. issue 2. 2012-06-18. PMID:22367663. |
in the past 10 years, the psychopharmacological treatment of aggression has changed dramatically owing to the introduction of atypical antipsychotics on the market and the increased use of anticonvulsants and lithium in the treatment of aggressive patients.this review (second of 2 parts) uses a translational medicine approach to examine the neurobiology of aggression, discussing the major neurotransmitter systems implicated in its pathogenesis (serotonin, glutamate, norepinephrine, dopamine, and γ-aminobutyric acid) and the neuropharmacological rationale for using atypical antipsychotics, anticonvulsants, and lithium in the therapeutics of aggressive behavior. |
2012-06-18 |
2023-08-12 |
human |
| Stefano Comai, Michael Tau, Gabriella Gobb. The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology. Journal of clinical psychopharmacology. vol 32. issue 1. 2012-05-23. PMID:22198449. |
in the last 19 years, the psychopharmacological treatment of aggression has changed dramatically because of the introduction of atypical antipsychotics into the market and the increased use of anticonvulsants and lithium in the treatment of aggressive patients.using a translational medicine approach, this review (part 1 of 2) examines the neurobiology of aggression, discussing the major neurotransmitter systems implicated in its pathogenesis, namely, serotonin, glutamate, norepinephrine, dopamine, and γ-aminobutyric acid, and also their respective receptors. |
2012-05-23 |
2023-08-12 |
Not clear |