| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei-Yan Pan, Lin-Jie Su, Dong-Mei Qi. [Study on mitigating effect and mechanism of Cichorium glandulosum n-butanol extraction site on CCl_4-induced chronic liver injury in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812157. |
a chronic liver injury model was constructed by subcutaneous injection of ccl_4 olive oil solution, and after four weeks of cge treatment, serum levels of aspartate aminotransferase(ast), alanine aminotransferase(alt), alkaline phosphatase(akp), hydroxyproline(hyp), interleukin-4(il-4), interleukin-6(il-6), malondialdehyde(mda), superoxide dismutase(sod), and tumor necrosis factor-α(tnf-α) were detected. |
2024-05-30 |
2024-06-17 |
rat |
| Meng-Qiong Shi, Ji-Hong Zhang, Gang Zhou, Wei Guo, Ying Liu, Zhong-Wen Bao, Mao-Hua Chen, Fa-Ming Tan, Hui-Quan Hu, Jun-Zhi Wang, Jian-Xia Ren, Hai-Ming Tan. [Mechanism of total saponins of Panax japonicus against liver injury induced by acetaminophen in mice based on ERK/NF-κB/COX-2 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812159. |
after 24 hours, mouse serum and liver tissue were collected for serum alanine aminotransferase(alt), aspartate aminotransferase(ast), reactive oxygen species(ros), tumor necrosis factor alpha(tnf-α), interleukin-1 beta(il-1β), cyclooxygenase-2(cox-2), il-6, il-4, il-10, as well as lactate dehydrogenase(ldh), glutathione(gsh), superoxide dismutase(sod), catalase(cat), total antioxidant capacity(t-aoc), malondialdehyde(mda), and myeloperoxidase(mpo) liver tissue. |
2024-05-30 |
2024-06-17 |
mouse |
| Ju Huang, Meng-Ling Wang, Zi-Yue Zhou, Ting Yan, Hui Xiong, Zhi-Nan Me. [Mechanism of Biejiajian Pills against non-alcoholic steatohepatitis based on lipidomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812156. |
the results demonstrated that biejiajian pills notably lowered the levels of alanine aminotransferase(alt), aspartate aminotransferase(ast), and alkaline phosphatase(alp) in the serum and the levels of triglyceride(tg) and total cholesterol(tc) in the liver tissue. |
2024-05-30 |
2024-06-17 |
mouse |
| Hua-Guan Lu, Wang-Xia Peng, Li-Hong Jiang, Qiang Yao, Xin Xie, Chang Lei, Dan Huang, Jian-Jun Li. [Mechanism of Fuzheng Huayu Tablets against hepatic fibrosis based on transcriptome and single-cell sequencing]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812160. |
the levels of alanine aminotransferase(alt) and aspartate aminotransferase(ast) were detected by colorimetry. |
2024-05-30 |
2024-06-17 |
mouse |
| Yuqian Yan, Lu Zhang, Xin Xu, Jing Lu, Xinyuan Ge, Maojie Liu, Juan Yang, Chan Tian, Zijun Ge, Chengxiao Yu, Wen Guo, Chunyan Ye, Qun Zhan. Association between exposure to per- and polyfluoroalkyl substance and liver injury in American adults. Journal of biomedical research. 2024-05-29. PMID:38807427. |
liver injury was assessed from two aspects: first, the degree of liver inflammation was determined based on serum alanine aminotransferase (alt), aspartate aminotransferase (ast), glutamyltransferase (ggt), and total bilirubin (tbil) levels; second, the degree of liver fibrosis was determined based on fibrosis-4 (fib-4) index. |
2024-05-29 |
2024-06-03 |
Not clear |
| Hugues Guyot, Damien Legroux, Justine Eppe, Fabrice Bureau, Leah Cannon, Eve Ramer. Hematologic and Serum Biochemical Characteristics of Belgian Blue Cattle. Veterinary sciences. vol 11. issue 5. 2024-05-26. PMID:38787194. |
hematologic parameters, total protein, creatinine, creatine kinase (ck) and aspartate transaminase (ast) activities, albumin, and globulins were measured in 183 clinically healthy adult bb and hf cows. |
2024-05-26 |
2024-05-27 |
cattle |
| Alexis Jose-Abrego, Maria E Trujillo-Trujillo, Saul Laguna-Meraz, Sonia Roman, Arturo Pandur. Epidemiology of Hepatitis C Virus in HIV Patients from West Mexico: Implications for Controlling and Preventing Viral Hepatitis. Pathogens (Basel, Switzerland). vol 13. issue 5. 2024-05-26. PMID:38787212. |
hepatic fibrosis was assessed using three noninvasive methods: transient elastography (te), the aspartate aminotransferase (ast)-to-platelets ratio index score (apri), and the fibrosis-4 score (fib4). |
2024-05-26 |
2024-05-27 |
human |
| Bin Wang, Xiaochan Zhu, Siting Yu, Huan Xue, Lijiao Deng, Yushan Zhang, Yi Zhang, Yunfeng Li. Roflumilast ameliorates GAN diet-induced non-alcoholic fatty liver disease by reducing hepatic steatosis and fibrosis in ob/ob mice. Biochemical and biophysical research communications. vol 722. 2024-05-26. PMID:38797152. |
roflumilast not only reduced liver injury by decreasing serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, but also ameliorated hepatic inflammation by reducing the gene expression of proinflammatory cytokines (tnf-α, il-1β, and il-6). |
2024-05-26 |
2024-05-31 |
mouse |
| Roberta Rinaldi, Sara De Nucci, Rossella Donghia, Rosanna Donvito, Nicole Cerabino, Martina Di Chito, Alice Penza, Francesco Pio Mongelli, Endrit Shahini, Marianna Zappimbulso, Pasqua Letizia Pesole, Sergio Coletta, Vincenzo Triggiani, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergol. Gender Differences in Liver Steatosis and Fibrosis in Overweight and Obese Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease before and after 8 Weeks of Very Low-Calorie Ketogenic Diet. Nutrients. vol 16. issue 10. 2024-05-25. PMID:38794646. |
only in men, liver stiffness, aspartate aminotransferase (ast), creatinine, and c-reactive protein (crp) levels significantly decreased. |
2024-05-25 |
2024-05-27 |
Not clear |
| Juanxia Wang, Xince Sun, Shibo Wei, Xinyue Chen, Haoyu Zhu, Youyou Liantang, Ruikun Bao, Yufeng D. Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B. BMC gastroenterology. vol 24. issue 1. 2024-05-24. PMID:38783185. |
to evaluate the diagnostic accuracy of aspartate aminotransferase(ast)/ alanine transaminase (alt), ast to platelet ratio index (apri), fibrosis-4 score (fib-4) and gamma-glutamyl transpeptidase to platelet count ratio (gpr) for hepatic fibrosis in patients with chronic hepatitis b (chb). |
2024-05-24 |
2024-05-27 |
Not clear |
| Ning Li, Sha Liao, Lu Liu, Xue Wang, Zhenxing Liang, Xiaoyi Liu, Yuefei Song, Shiyan Zhao, Xue Wu, Ye Tian, Xuezeng Xu, Yang Yang, Qiong Li. Pleiotropic Role of Endoplasmic Reticulum Stress in the Protection of Psoralidin against Sepsis-associated encephalopathy. Free radical biology & medicine. 2024-05-24. PMID:38788982. |
we found that pso treatment significantly reduced sepsis scores, aspartate transaminase (ast) and aspartate transaminase (ldh), while increased anal temperature and neurological scores in clp-injured mice. |
2024-05-24 |
2024-05-27 |
mouse |
| Zhi Liu, Qiao Ren, Hongying Mu, Yuping Zeng, Zhenmei An, He H. Preliminary study on the diagnostic value of LEAP-2 and CK18 in biopsy-proven MAFLD. BMC gastroenterology. vol 24. issue 1. 2024-05-22. PMID:38778244. |
correlation studies have found that all three indicators positively correlate with the liver enzymes alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2024-05-22 |
2024-05-27 |
Not clear |
| Angela Liu, Charleen Jacobs-McFarlane, Paola Sebastiani, Jeffrey Glassberg, Sarah McCuskee, Susanna Curti. Plasma free hemoglobin is associated with LDH, AST, total bilirubin, reticulocyte count, and the hemolysis score in patients with sickle cell anemia. Research square. 2024-05-21. PMID:38746469. |
we sought to characterize the relationship between pfh and more clinically available hemolytic markers including lactate dehydrogenase (ldh), aspartate aminotransferase (ast), bilirubin, reticulocyte percentage and to derive a composite hemolysis score derived from principal component analysis (pca) of these biomarkers. |
2024-05-21 |
2024-05-27 |
Not clear |
| Huma Qureshi, Hassan Mahmood, Zubair Nasir, Saad Siddique, Francisco Averhoff, Gavin Clohert. A novel test and treat program for hepatitis C virus infection utilizing HCV core antigen testing, among police and general population, Islamabad, Pakistan, 2022. Journal of viral hepatitis. 2024-05-21. PMID:38771312. |
those who tested positive had venous blood samples tested for hcvcag, platelets and aspartate aminotransferase (ast). |
2024-05-21 |
2024-05-27 |
human |
| Zi-Han Lin, Ling-Yue Zhong, Hui-Bin Jiang, Chuang Zhu, Fen-Fen Wei, Yan Wu, Li-Hua Son. Elucidation of the beneficial role of co-fermented whole grain quinoa and black barley with Lactobacillus on rats fed a western-style diet via a multi-omics approach. Food research international (Ottawa, Ont.). vol 187. 2024-05-19. PMID:38763637. |
additionally, fqb intervention led to decreased levels of serum uric acid (ua), aspartate aminotransferase (ast), and alanine aminotransferase (alt). |
2024-05-19 |
2024-05-27 |
rat |
| Vinay Singh Dagar, Monika Mishra, Aarti Sharma, Manu Sankar, Shubham Goyal, Ranjan Pal, Sarita Kuma. Ascertaining variations in the activity of larval midgut enzymes of Helicoverpa armigera by dietary emamectin benzoate through biochemical and in silico docking study. Chemosphere. vol 359. 2024-05-18. PMID:38750729. |
the impact of dietary emb was examined on four midgut enzymes; alanine aminotransferase (alt), aspartate aminotransferase (ast), acid phosphatase (acp), and alkaline phosphatase (alp). |
2024-05-18 |
2024-05-27 |
Not clear |
| Refaat A Eid, Alsaleem Mohammed Abadi, Mansour A Alghamdi, Attalla F El-Kott, Gamal Mohamed, Mubarak Al-Shraim, Muhammad Alaa Eldeen, Mohamed Samir A Zaki, Fatma Mohsen Shalab. Echinops Asteraceae extract guards against malathion-induced liver damage via minimizing oxidative stress, inflammation, and apoptosis. Toxicon : official journal of the International Society on Toxinology. vol 244. 2024-05-18. PMID:38750940. |
using lipid peroxidation indicators [malondialdehyde (mda), alanine aminotransferase (alt), aspartate aminotransferase (ast)], oxidative stress markers [catalase (cat), superoxide dismutase (sod) and glutathione peroxidase (gpx)], apoptotic markers [bcl-2 & caspase-3] and tumor necrosis factor alpha (tnf-α). |
2024-05-18 |
2024-05-27 |
rat |
| Rubén Tovar, Marialuisa de Ceglia, Miguel Rodríguez-Pozo, Antonio Vargas, Ana Gavito, Juan Suárez, Anna Boronat, Rafael de la Torre, Fernando Rodríguez de Fonseca, Elena Baixeras, Juan Decar. Hydroxytyrosol Linoleoyl Ether Ameliorates Metabolic-Associated Fatty Liver Disease Symptoms in Obese Zucker Rats. ACS pharmacology & translational science. vol 7. issue 5. 2024-05-17. PMID:38751648. |
biochemical analysis demonstrated a favorable safety profile for htle along with decreased concentrations of urea, total cholesterol, and aspartate aminotransferase ast transaminases in plasma. |
2024-05-17 |
2024-05-27 |
rat |
| Rui Liu, Jin Qiao, Lin Zhang, Zhihua Do. Therapeutic effectiveness analysis of tenofovir alafenamide and tenofovir disoproxil fumarate on the treatment for chronic hepatitis B. Medicine. vol 103. issue 20. 2024-05-17. PMID:38758884. |
two groups of patients had no statistically significant difference in the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast) and total bilirubin (tbil) before treatment. |
2024-05-17 |
2024-05-27 |
Not clear |
| Mattia Amoroso, Salvador Augustin, Sven Moosmang, Isabella Gasha. Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review. Journal of molecular medicine (Berlin, Germany). 2024-05-16. PMID:38753041. |
our search strategy identified the following non-invasive biomarkers with prognostic value in studies of nash patients: nafld fibrosis score (nfs), fibrosis-4 (fib-4), aspartate aminotransferase (ast) to platelet ratio index (apri), enhanced liver fibrosis (elf™), bard (bmi, ast/alt (alanine aminotransferase) ratio, diabetes), hepamet fibrosis score (hfs), liver enzymes (ast + alt), alpha-fetoprotein, platelet count, neutrophil to lymphocyte ratio (nlr), lysyl oxidase-like (loxl) 2, mir-122, liver stiffness, mefib (liver stiffness measured with magnetic resonance elastography (mre) + fib-4), and pnpla3 gg genotype. |
2024-05-16 |
2024-05-27 |
Not clear |