| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pan Li, Yuwei Chen, Xiumei Ke, Ruoyu Zhang, Ling Zuo, Meng Wang, Zhiwei Chen, Xianqin Luo, Jianwei Wan. Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL. Archives of biochemistry and biophysics. 2022-04-16. PMID:35429444. |
it was evident that baicalin treatment significantly normalized the serous contents of hepatic triglyceride (tg), alanine aminotransferase (alt), and aspartate aminotransferase (ast), and attenuated the increase of hepatic vacuolization and oil red o staining area caused by alcohol. |
2022-04-16 |
2023-08-13 |
rat |
| Tinsay A Woreta, Mark L Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, Manal F Abdelmalek, Naga Chalasani, Samer Gawrieh, Srinivasan Dasarathy, Raj Vuppalanchi, Mohammad S Siddiqui, Kris V Kowdley, Arthur McCullough, Norah A Terrault, Cynthia Behling, David E Kleiner, Mark Fishbein, Paula Hertel, Laura A Wilson, Emily P Mitchell, Laura A Miriel, Jeanne M Clark, James Tonascia, Arun J Sanya. Validation of the accuracy of the FAST™ score for detecting patients with at-risk nonalcoholic steatohepatitis (NASH) in a North American cohort and comparison to other non-invasive algorithms. PloS one. vol 17. issue 4. 2022-04-15. PMID:35427375. |
the new fast™ score, a combination of fibroscan® parameters liver stiffness measurement (lsm) and controlled attenuation parameter (cap) and aspartate aminotransferase (ast), has shown good diagnostic accuracy for at-risk nash (area-under-the-receiver-operating-characteristic [auroc] = 0.80) in european cohorts. |
2022-04-15 |
2023-08-13 |
Not clear |
| Huiru Xu, Huijing Feng, Weihong Zhang, Feng Wei, Li Zhou, Liang Liu, Yu Zhao, Yingge Lv, Xiuhuan Shi, Junping Zhang, Xiubao Re. Prediction of immune-related adverse events in non-small cell lung cancer patients treated with immune checkpoint inhibitors based on clinical and hematological markers: Real-world evidence. Experimental cell research. 2022-04-15. PMID:35427598. |
a prediction model based on treatment lines, aspartate aminotransferase (ast), lactate dehydrogenase (ldh), absolute lymphocyte count (alc), and systemic immune inflammation index was established. |
2022-04-15 |
2023-08-13 |
Not clear |
| Fabiano Moraes Miguel, Jaqueline Nascimento Picada, Juliana Bondan da Silva, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Renata Minuzzo Hartmann, Cláudio Augusto Marroni, Norma Possa Marron. Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. Inflammation. 2022-04-14. PMID:35419738. |
aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were measured, and hepatic tissue was dissected for histological analysis, evaluation of lipoperoxidation, superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gpx), as well as nuclear factor-erythroid 2 (nrf2), tumor necrosis factor alpha (tnf-α), inducible nitric oxide synthase (inos), and transforming growth factor beta (tgf-β) expression by immunohistochemistry. |
2022-04-14 |
2023-08-13 |
mouse |
| Naghmeh Saadati-Eskandari, Latifeh Navidpour, Parichehreh Yaghmaei, Azadeh Ebrahim-Habib. Phenylalanine and indole effects on the pathogenicity of human lysozyme amorphous aggregates. Enzyme and microbial technology. vol 158. 2022-04-14. PMID:35421678. |
serum levels of liver enzymes (alanine aminotransferase (alt) and aspartate aminotransferase (ast)), specific inflammatory cytokines (tumor necrosis factor alpha (tnf-α) and interleukin 6 (il-6)) as well as glucose, cholesterol, and triglyceride levels were measured. |
2022-04-14 |
2023-08-13 |
human |
| Kiran Kousar Noor, Muhammad Umar Ijaz, Nazia Ehsan, Arfa Tahir, Derya Kertas Yeni, S M Neamul Kabir Zihad, Shaikh Jamal Uddin, Asma Ashraf, Jesus Simal-Gandar. Hepatoprotective role of vitexin against cadmium-induced liver damage in male rats: A biochemical, inflammatory, apoptotic and histopathological investigation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-14. PMID:35421786. |
after 30 days of treatment, it was indicated that cd escalated the level of liver function enzymes namely alanine transaminase (alt), aspartate aminotransferase (ast) and alkaline phosphatase (alp) as well as total bilirubin. |
2022-04-14 |
2023-08-13 |
rat |
| Shira Zelber-Sagi, Vikas N O'Reilly-Shah, Christine Fong, Dana Ivancovsky-Wajcman, May J Reed, Itay Bento. Liver Fibrosis Marker and Postoperative Mortality in Patients Without Overt Liver Disease. Anesthesia and analgesia. 2022-04-13. PMID:35417420. |
the aim of this study was to assess whether fibrosis-4 (fib-4), which consists of age, aspartate aminotransferase (ast), alanine aminotransferase (alt), and platelets, a validated marker of liver fibrosis, is associated with postoperative mortality in the general surgical population. |
2022-04-13 |
2023-08-13 |
Not clear |
| Katy Satué, Laura Miguel-Pastor, Deborah Chicharro, Juan Carlos Gardó. Hepatic Enzyme Profile in Horses. Animals : an open access journal from MDPI. vol 12. issue 7. 2022-04-12. PMID:35405850. |
these two groups of equine liver-specific enzymes include sorbitol dehydrogenase (sdh), glutamate dehydrogenase (gldh), γ-glutamyl transferase (ggt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and alkaline phosphatase (alp). |
2022-04-12 |
2023-08-13 |
Not clear |
| Markus Galler, Julian M M Rogasch, Kai Huang, Henning Jann, Kristina Plehm, Christoph Wetz, Holger Amthaue. Prognostic Value of the Largest Lesion Size for Progression-Free Survival in Patients with NET Undergoing Salvage PRRT with [ Cancers. vol 14. issue 7. 2022-04-12. PMID:35406540. |
the purpose of this study was to evaluate two parameters that have shown prognostic significance in progression-free survival (pfs) in initial prrt treatment, namely the size of the largest lesion (lls) and the de ritis ratio (aspartate aminotransferase (ast)/alanine aminotransferase (alt)), as prognostic factors in the context of salvage prrt. |
2022-04-12 |
2023-08-13 |
Not clear |
| Jingyue Zhang, Shiheng Zhang, Yueming Yang, Ling Li. Transplantation of umbilical cord blood-derived mesenchymal stem cells as therapy for adriamycin induced-cardiomyopathy. Bioengineered. vol 13. issue 4. 2022-04-07. PMID:35387551. |
the serum levels of collagen-i (col-i), brain natriuretic peptide (bnp), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), creatine kinase (ck), ck-mb, interleukin (il)-6, il-10, and tumor necrosis factor alpha (tnf-α) were measured by corresponding kits. |
2022-04-07 |
2023-08-13 |
human |
| Qingfei Xiao, Ying Zhao, Lei Ma, Rongli Pia. Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction. Journal of pharmacological sciences. vol 149. issue 1. 2022-04-04. PMID:35369900. |
our results indicated that ori alleviated apap-induced hepatic pathological changes by reducing mouse mortality, inhibiting the expression of cytochrome p450 2e1 (cyp2e1), maintaining a normal liver structure, and reducing the levels of serum alanine transaminase (alt) and serum aspartate aminotransferase (ast). |
2022-04-04 |
2023-08-13 |
mouse |
| Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G Proud, Jianling Xie, Kaikai She. Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370715. |
anit (80 mg/kg) increased serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), direct bilirubin (dbil), total bilirubin (tbil), and total bile acids (tba) which was attenuated by dcht treatment in a dose-dependent manner. |
2022-04-04 |
2023-08-13 |
Not clear |
| Hong-Shuang Liu, Man-Yu Zhou, Xi Zhang, Ya-Lan Li, Jing-Wei Kong, Xin Gao, Dong-Yu Ge, Jia-Jing Liu, Pei-Guang Ma, Gui-Ying Peng, Yan Lia. Sagittaria sagittifolia polysaccharide protects against six-heavy-metal-induced hepatic injury associated with the activation of Nrf2 pathway to regulate oxidative stress and apoptosis. Journal of inorganic biochemistry. vol 232. 2022-04-03. PMID:35367820. |
ssp can alleviated hepatic injury, as evidenced by significantly decreased the activities of aspartate aminotransferase (ast), alanine aminotransferase (alt), and the malondialdehyde (mda) content, also increased the superoxide dismutase (sod) activity and glutathione (gsh), total sulphydryl (t-sh) contents. |
2022-04-03 |
2023-08-13 |
mouse |
| Shui-Fen Sun, Hui-Jie Zhong, Yun-Li Zhao, Xiu-Ying Ma, Jin-Bo Luo, Ling Zhu, Yu-Ting Zhang, Wen-Xue Wang, Xiao-Dong Luo, Jia-Wei Gen. Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet. Natural products and bioprospecting. vol 12. issue 1. 2022-04-02. PMID:35364708. |
the concentrations of low-density lipoprotein (ldl), triglyceride (tg), aspartate aminotransferase (ast) and alanine aminotransferase (alt) were also decreased significantly in ta-treated mice group, accompanied by an increase in high-density lipoprotein (hdl). |
2022-04-02 |
2023-08-13 |
mouse |
| Carla Diaz-Louzao, Lucia Barrera-Lopez, Maria Lopez-Rodriguez, Clara Casar, Nestor Vazquez-Agra, Hadrian Pernas-Pardavila, Ana Marques-Afonso, Martin Vidal-Vazquez, Jonathan G Montoya, Ariadna H Andrade, Ivan Fernandez-Castro, Pablo Varela, Arturo Gonzalez-Quintela, Esteban Otero, Francisco Gude, Carmen Cadarso-Suarez, Santiago Tom. Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach. Scientific reports. vol 12. issue 1. 2022-04-02. PMID:35365705. |
the patients who died showed a significant elevation in serum aspartate transaminase (ast) and alkaline phosphatase levels over time. |
2022-04-02 |
2023-08-13 |
Not clear |
| Wang Huo, Han Li, Lin Li, Ling Song, Yun-Hang Gao, Jian-Liang Li, Teng-Fei Chen, Hong-Ping Hou, Guang-Ping Zhang, Zu-Guang Y. [Study on regulation of CYP450 enzyme system to reduce liver toxicity through compatibility of Aconiti Kusnezoffii Radix Cocta with Chebulae Fructus and Glycyrrhizae Radix et Rhizoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347961. |
after continuous administration for 8 days, the activities of total bile acid(tba), alkaline phosphatase(alp), amino-transferase(alt) and aspartate aminotransferase(ast)in serum were detected, the pathological changes of liver tissue were observed, and the mrna and protein expression levels of cyp1 a2, cyp2 c11 and cyp3 a1 were observed. |
2022-03-29 |
2023-08-13 |
rat |
| Mohammad Moradzad, Mohammad Abdi, Farshad Sheikh Esmaeili, Dana Ghaderi, Khaled Rahmani, Mohammad Raman Moloudi, Zakaria Vahabzade. Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. Molecular biology reports. 2022-03-29. PMID:35348964. |
methods and results: in 85 confirmed nafld patients and 30 healthy individuals, triglycerides (tg), total cholesterol (chol), low-density lipoprotein (ldl), high-density lipoprotein (hdl), alanine aminotransferase (alt), and aspartate aminotransferase (ast) activities were measured. |
2022-03-29 |
2023-08-13 |
Not clear |
| Okunola Adenrele Alabi, Oluwatoyin Folake Olukunle, Opeyemi Febisara Ojo, Janet Busayo Oke, Taiwo Cosmas Adeb. Comparative study of the reproductive toxicity and modulation of enzyme activities by crude oil-contaminated soil before and after bioremediation. Chemosphere. 2022-03-28. PMID:35341768. |
the levels of total testosterone (tt), follicle stimulating hormone (fsh), and luteinizing hormone (lh); and activities of catalase (cat), alkaline phosphatase (alp), superoxide dismutase (sod), aspartate aminotransferase (ast), and alanine aminotransferase (alt) were determined. |
2022-03-28 |
2023-08-13 |
mouse |
| Sofia Nogueira, Fernanda Garcez, Susana Sá, Luís C Moutinho, Armando Cardoso, Raquel Soares, Bruno M Fonseca, Sandra Lea. Early unhealthy eating habits underlie morpho-functional changes in the liver and adipose tissue in male rats. Histochemistry and cell biology. 2022-03-28. PMID:35344087. |
our results revealed that serum levels of glucose, creatinine, aspartate transaminase (ast), alanine transaminase (alt), and lipid profile were increased in rats red high-sugar and high-energy diets. |
2022-03-28 |
2023-08-13 |
rat |
| Aliah R Alshanwani, Hanan Hagar, Sameerah Shaheen, Ahlam M Alhusaini, Maha M Arafah, Laila M Faddah, Fatima Mb Alharbi, Arun K Sharma, Amira M Bad. A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases. European journal of pharmacology. 2022-03-27. PMID:35339478. |
thioacetamide treatment resulted in hepatic dysfunction manifested by increased serum levels of bilirubin, gamma-glutamyl transferase (ggt), alanine aminotransferase (alt), and aspartate aminotransferase (ast). |
2022-03-27 |
2023-08-13 |
Not clear |