| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruiqiang Li, Wenqiang Zhan, Jingyi Ren, Xian Gao, Xin Huang, Yuxia M. Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12-19 years: A mixture analysis. Environmental pollution (Barking, Essex : 1987). 2022-09-26. PMID:36155224. |
liver function tests (lfts) include aspartate aminotransferase (ast), albumin (alb), alanine aminotransferase (alt), alkaline phosphatase (alp), gamma-glutamyl transferase (ggt), total bilirubin (tbil), total protein (tp), and ast/alt. |
2022-09-26 |
2023-08-14 |
human |
| Dong Sub Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Youngsang Park, Bonglee Kim, Bumsang Shim, Sung-Hoon Ki. The underlying hepatoprotective mechanism of PKC#963 in alcohol or carbon tetrachloride induced liver injury via inhibition of iNOS, COX-2, and p-STAT3 and enhancement of SOD and catalase. Phytotherapy research : PTR. 2022-09-24. PMID:36151597. |
here, pkc#963 significantly suppressed aspartate aminotransferase (ast), alanine aminotransferase (alt), phosphorylated signal transducer and activator of transcription 3 (p-stat3), inducible nitric oxide synthase (inos), and cyclooxygenase (cox-2) in ccl4-treated hepg2 cells. |
2022-09-24 |
2023-08-14 |
rat |
| Jiaji Hu, Yigang Zheng, Hanglu Ying, Huabin Ma, Long Li, Yufen Zha. Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation. Nutrients. vol 14. issue 18. 2022-09-23. PMID:36145172. |
the results showed that ala-gln treatment significantly attenuated mcd-induced hepatic pathological changes, lowered nafld activity score, and reduced plasma alanine transaminase (alt), aspartate transaminase (ast) and lactate dehydrogenase (ldh) levels. |
2022-09-23 |
2023-08-14 |
mouse |
| Jin-Yu Gong, Huan Ren, Hui-Qing Chen, Kai Xing, Chen-Lin Xiao, Jian-Quan Lu. Magnesium Isoglycyrrhizinate Attenuates Anti-Tuberculosis Drug-Induced Liver Injury by Enhancing Intestinal Barrier Function and Inhibiting the LPS/TLRs/NF-κB Signaling Pathway in Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145350. |
the results demonstrated that intraperitoneal injection of mgig (40 mg/kg) significantly ameliorated hrze-induced liver injury by reducing alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (akp), and malondialdehyde (mda) levels and improved liver pathological changes. |
2022-09-23 |
2023-08-14 |
mouse |
| Chirayu Padhiar, Muthuraman Muthuchamy, Vignesh Ganesan, Swathi Desireddy, Mayur Abhaya, Ramanujam Siva, Kalaivani Periyathamb. Dehydrated Human Amnion/Chorion Membrane Allografts as an Adjunct Wound Healing Therapy in Diabetic Rats. The international journal of lower extremity wounds. 2022-09-22. PMID:36131388. |
also, in the animals of g5 and g6 of the diabetic group, there was no statistically significant difference (p > 0.05) in the levels of glucose, urea, creatinine, aspartate aminotransferase (ast), alanine aminotransferase (alt), and alkaline phosphate (alp), when compared to g4 animals during the experiment. |
2022-09-22 |
2023-08-14 |
human |
| Young-Jun Seo, Young Suk Shim, Hae Sang Lee, Jin Soon Hwan. Updated reference ranges for aminotransferase levels of Korean children and young adolescents based on the risk factors for metabolic syndrome. Scientific reports. vol 12. issue 1. 2022-09-21. PMID:36131081. |
overall, aspartate aminotransferase (ast), alanine aminotransferase (alt), and the ast/alt ratio varied with sex and age. |
2022-09-21 |
2023-08-14 |
human |
| Qianqian Luo, Yuanyi Ling, Yufei Li, Xiaoqin Qu, Qiaoqing Shi, Shuangyan Zheng, Yanhong Li, Yonghong Huang, Xiaoyan Zho. Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120358. |
we demonstrated that pebp4 cko aggravated ccl4-triggered liver fibrosis, as evidenced by altered histopathology, an increase in the activities of alanine aminotransferase (alt), aspartate aminotransferase (ast) and hydroxyproline (hyp) levels, and more collagen deposition, as well as by enhanced expression of fibrotic markers including α-smooth muscle actin (α-sma), collagen i and collagen iii. |
2022-09-19 |
2023-08-14 |
mouse |
| Xiyu Song, Yang Zha, Jing Liu, Peng He, Lijie H. Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2022-09-17. PMID:36114736. |
in this review, by integrating the latest research, we summarized the association of some common and novel liver function parameters (alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), gamma-glutamyl transpeptidase (ggt), serum bilirubin, pre-albumin, albumin, albumin-globulin ratio (agr), serum ferritin, and hyaluronic acid) with clinical outcomes in pd patients. |
2022-09-17 |
2023-08-14 |
Not clear |
| Yong-Ming He, Xing-Ling Shen, Yan-Na Guo, Shao-Shan Liang, Kang-Ning Ding, Meng-Han Lu, Lu-Ping Tan. Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling. Ecotoxicology and environmental safety. vol 244. 2022-09-17. PMID:36115150. |
apap exposure significantly increased serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels to 35 and 6 multiples than their original levels. |
2022-09-17 |
2023-08-14 |
mouse |
| Dyah A Perwitasari, Didik Setiawan, Thang Nguyen, Arum Pratiwi, Laila Rahma Fauziah, Erin Saebrinah, Triantoro Safaria, Nunuk Aries Nurulita, Idha Arfianti Wiraagn. Investigating the Relationship between Knowledge and Hepatotoxic Effects with Medication Adherence of TB Patients in Banyumas Regency, Indonesia. International journal of clinical practice. vol 2022. 2022-09-16. PMID:36110263. |
the respondents were 91 tb patients with hepatotoxicity characterized by an increased aspartate transaminase (ast) and alanine aminotransferase (alt). |
2022-09-16 |
2023-08-14 |
Not clear |
| Haiying Zhang, Yanan Gao, Bin Liu, Haobin Jin, Li Fan, Xirui Yang, Qiang Gao, Yi Yu, Yueping Guo, Yan Li. The activation of M muscarinic receptor reverses liver injuryvia the Sp1/lncRNA Gm2199/miR-212 axis. Acta biochimica et biophysica Sinica. 2022-09-16. PMID:36111745. |
we evaluate liver injury and detect the changes in related indexes, including alanine aminotransferase (alt), aspartate aminotransferase (ast), hydroxyproline (hyp), and transforming growth factor-β1 (tgf-β1), after administration of an mr agonist. |
2022-09-16 |
2023-08-14 |
Not clear |
| Subhasis Roy, Monali Chakrabarti, Hemantika Dasgupta, Ashutosh Mahale, Shraddha Tripathi, Vivek Sharma, Manish Banerjee, Onkar Prakash Kulkarn. Inhibition of Autotaxin Ameliorates LPA-Mediated Neuroinflammation and Alleviates Neurological Dysfunction in Acute Hepatic Encephalopathy. ACS chemical neuroscience. 2022-09-16. PMID:36112416. |
treatment with the autotaxin inhibitor (atxi) did not affect liver injury, as we observed no change in liver function markers including aspartate aminotransferase (ast), alanine aminotransferase (alt), and total bilirubin (tbil) and no change in ammonia levels in the brain and plasma. |
2022-09-16 |
2023-08-14 |
mouse |
| Yingjie Wang, Shanqiu Jian, Wen Li, Ling Zhao, Gang Ye, Fei Shi, Lixia Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Yinglun Li, Huaqiao Tan. Epigallocatechin-3-gallate ameliorates liver injury secondary to Pseudomonas aeruginosa pneumonia. International immunopharmacology. vol 112. 2022-09-16. PMID:36113316. |
egcg significantly decreased the serum levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2022-09-16 |
2023-08-14 |
mouse |
| Raminderpal Singh Sibia, Ankita Sood, Arshula Subedi, Anushya Sharma, Anirudh Mittal, Gaaminepreet Singh, Thakur Gurjeet Singh, Ravinder Singh Jaura, Sanjay Goya. Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity. Journal of medical virology. 2022-09-15. PMID:36109338. |
the platelet count (plt) and hematocrit (hct) were analyzed using an automated hematology analyzer and liver function enzymes aspartate transaminase (ast), alanine transaminase (alt), and alkaline phosphate (alp), bilirubin were checked by auto-analyzer using diagnostic kits. |
2022-09-15 |
2023-08-14 |
human |
| Lei Zhao, Yunjiao Shen, Yunlong Wang, Lei Wang, Lin Zhang, Zijian Zhao, Shengyu L. Lactobacillus plantarum S9 alleviates lipid profile, insulin resistance, and inflammation in high-fat diet-induced metabolic syndrome rats. Scientific reports. vol 12. issue 1. 2022-09-15. PMID:36109620. |
l. plantarum s9 also decreased the levels of alanine aminotransferase (alt) and aspartate transaminase (ast) in liver. |
2022-09-15 |
2023-08-14 |
rat |
| Reyhaneh Oliaei, Zahra Keshtmand, Ronak Shaban. The effect of Lactobacillus casei and Bacillus coagulans probiotics on liver damage induced by silver nanoparticles and expression of Bax, Bcl2 and Caspase 3 genes in male rats. European journal of translational myology. 2022-09-14. PMID:36101996. |
based on the biochemical results of this study, exposure of rats to different concentrations of silver nanoparticles compared with the control group caused a significant increase in the serum levels of alanine transaminase (alt) and aspartate transaminase (ast), alkaline phosphatase (alp), especially at high concentrations. |
2022-09-14 |
2023-08-14 |
rat |
| Jamie L Ryan, Ashley K Sherman, Daniel E Heble, Craig A Friesen, James F Daniel, Ryan T Fischer, Voytek Slowi. The effect of neuropsychiatric medication on pediatric nonalcoholic fatty liver disease. Clinical and translational science. vol 15. issue 9. 2022-09-13. PMID:35769031. |
outcome measures included body mass index (bmi) percentile, bmi z-score, aspartate aminotransferase (ast), alanine aminotransferase (alt), total bilirubin, and gamma glutamyltransferase, and were collected at diagnosis, 6-18 month follow-up, and 18-36 months. |
2022-09-13 |
2023-08-16 |
human |
| Fang Liu, Yan Liu, Qifeng Peng, Guodong Wang, Qing Tan, Zhongyue Ou, Qishan Xu, Chixiang Liu, Daming Zuo, Jianbo Zha. Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway. Frontiers in pharmacology. vol 13. 2022-09-12. PMID:36091804. |
herein, clinical data on patients with drug-induced liver injury revealed that the creatinine concentration between 82-442 μmol/l for female and 98-442 μmol/l for male is positively correlated with alanine aminotransferase (alt), aspartate aminotransferase (ast). |
2022-09-12 |
2023-08-14 |
mouse |
| Ömer Gökhan Eyisoy, Ümit Taşdemir, Mucize Eriç Özdemir, Seden Eyisoy, Özge Kahramanoğlu, Aydın Öçal, Oya Demirc. Aspartate aminotransferase to platelet ratio index (APRI) score: is it useful in patients with intrahepatic cholestasis of pregnancy? The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2022-09-12. PMID:36093839. |
it is aimed to evaluate the efficacy of using aspartate aminotransferase (ast)/platelet count ratio [ast to platelet ratio index (apri) score] in icp patients. |
2022-09-12 |
2023-08-14 |
Not clear |
| Ferdane Pirincci Sapmaz, Galip Büyükturan, Yusuf Serdar Sakin, İsmail Hakki Kalkan, Pinar Ataso. How effective are APRI, FIB-4, FIB-5 scores in predicting liver fibrosis in chronic hepatitis B patients? Medicine. vol 101. issue 36. 2022-09-10. PMID:36086763. |
aspartate aminotransferase (ast)-to-platelet ratio index (apri), fibrosis index based on 4 factors (fib-4), and fibrosis index based on 5 factors (fib-5) scores are noninvasive fibrosis markers, and previous comparative studies have shown that they are as effective as liver biopsy in detecting liver fibrosis in different liver diseases. |
2022-09-10 |
2023-08-14 |
Not clear |