| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Obaidullah, Mater H Mahnashi, Osama M Alshehri, Mohammed M Jalal, Khalid J Alzahrani, Ibrahim F Halawan. Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects. Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36234730. |
toxicity induced by 5-fu was manifested by increases in the serum creatinine kinase myocardial band (ck-mb), troponin i (ctni) and lactate dehydrogenase (ldh), lipid profile, and selected liver enzymes, including alp (alkaline phosphatase), alt (alanine transaminase), ast (aspartate aminotransferase), bt (bilirubin total), and bd (direct bilirubin). |
2022-10-14 |
2023-08-14 |
human |
| Johnafaye Mariano, George A MacLare. A Case of Rhabdomyolysis in a Young, Morbidly Obese, Asthmatic Woman With COVID-19. Cureus. vol 14. issue 9. 2022-10-14. PMID:36237756. |
alanine aminotransferase (alt), aspartate aminotransferase (ast), and creatine kinase (ck) levels were noted to be elevated. |
2022-10-14 |
2023-08-14 |
Not clear |
| b' Aleksandar Antonijevi\\xc4\\x87, Emilija Stojanovi\\xc4\\x87, Aleksandar Jevti\\xc4\\x87, Vladimir \\xc5\\xbdivkovi\\xc4\\x87, Sergey Bolevich, Vladimir Jakovljevi\\xc4\\x8. The effect of a 6-month walking program on biochemical parameters in sedentary adults with type 2 diabetes mellitus. Nagoya journal of medical science. vol 84. issue 3. 2022-10-14. PMID:36237879.' |
plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol (ldl), high-density lipoprotein cholesterol (hdl), aspartate aminotransferase (ast), alanine aminotransferase (alt), gamma-glutamyl transferase, urea, creatinine, uric acid, c-reactive protein (crp), and erythrocyte sedimentation rate were measured. |
2022-10-14 |
2023-08-14 |
Not clear |
| Manman Duan, Xuanjun Guo, Xiangguang Chen, Mengyu Guo, Mengna Zhang, Hao Xu, Chengju Wang, Yang Yan. Transcriptome analysis reveals hepatotoxicity in zebrafish induced by cyhalofop‑butyl. Aquatic toxicology (Amsterdam, Netherlands). vol 252. 2022-10-14. PMID:36240591. |
meanwhile, the activities of enzymes related to liver function were significantly increased by 0.2 mg/l cyhalofop‑butyl and higher, such as alanine transaminase (alt) and aspartate transaminase (ast). |
2022-10-14 |
2023-08-14 |
zebrafish |
| Mahsa Rastegar Moghaddam Poorbagher, Ehsan Karimi, Ehsan Oskoueia. Hepatoprotective effect of nanoniosome loaded Myristica fragrans phenolic compounds in mice-induced hepatotoxicity. Journal of cellular and molecular medicine. 2022-10-13. PMID:36226354. |
in addition, the blood levels of triglyceride (tg), cholesterol (chol), liver enzymes (aspartate aminotransferase (ast), alanine transaminase (alt), alkaline phosphatase (alp)) and total bilirubin were significantly (p ≤ 0.05) decreased. |
2022-10-13 |
2023-08-14 |
mouse |
| Reham Hassan, Daniela González, Zaynab Hobloss, Lisa Brackhagen, Maiju Myllys, Adrian Friebel, Abdel-Latif Seddek, Rosemarie Marchan, Benedikt Cramer, Hans-Ulrich Humpf, Stefan Hoehme, Gisela H Degen, Jan G Hengstler, Ahmed Ghalla. Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A. Archives of toxicology. 2022-10-13. PMID:36227364. |
the blood biomarkers of liver damage, alanine transaminase (alt) and aspartate transaminase (ast) both increased > 21- and 30-fold, respectively, when ota was administered to abt pre-treated mice compared to the effect of ota alone. |
2022-10-13 |
2023-08-14 |
mouse |
| Tung Huynh, Stephanie Ma, Ke-Qin H. HCV direct acting antiviral treatment leads to highly durable rates of ALT and AST lower than 30/19 criteria and improved APRI and FIB-4 scores. Hepatology communications. 2022-10-12. PMID:36221305. |
direct acting antiviral treatment (daa) has been the standard of care for hepatitis c virus (hcv) infection, but its long-term benefits in alanine aminotransferase (alt) and aspartate aminotransferase (ast) improvement and hepatic fibrosis assessed by aspartate aminotransferase-to-platelet ratio index (apri) and fibrosis-4 index (fib-4) scores remain unknown. |
2022-10-12 |
2023-08-14 |
Not clear |
| Hongkun Xue, Yu Wang, Hongwei Xiang, Qi Song, Guowei Zhang, Jianguo Wang, Shaoqin G. Exploring the Protective Effects and Mechanism of Huaji Jianpi Decoction against Nonalcoholic Fatty Liver Disease by Network Pharmacology and Experimental Validation. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-06. PMID:36199550. |
compared with the model group, the liver wet weight, liver/body ratio, the levels of total cholesterol (tc), triglyceride (tg), aspartate aminotransferase (ast), alanine aminotransferase (alt), and high-density lipoprotein (hdl) in serum in the hjjpd low-dose (17.52 g/kg·d), medium-dose (35.04 g/kg·d), and high-dose (70.07 g/kg·d) groups significantly decreased ( |
2022-10-06 |
2023-08-14 |
mouse |
| Meiling Zuo, Yue Shang, Ye Guo, Yuxuan Sun, Gaoqi Xu, Jingtao Chen, Liqin Zh. Population Pharmacokinetics of Tacrolimus in Umbilical Cord Blood Transplant Pediatrics. Journal of clinical pharmacology. 2022-10-05. PMID:36196568. |
the impact of demographic features, biological characteristics, and concomitant medications, including sex, age, body weight, postoperative day, white blood cell (wbc), red blood cell (rbc), hemoglobin (hb), platelet (plt), hematocrit (hct), urea nitrogen (bun), creatinine (cr), aspartate transaminase (ast), alanine transaminase (alt), total bilirubin (tbil), albumin (alb), and total protein (tp) were investigated. |
2022-10-05 |
2023-08-14 |
Not clear |
| Anjali Pitamberwale, Tariq Mahmood, Azmat Kamal Ansari, Shabana Andleeb Ansari, Kirti Limgaokar, Lalit Singh, Geeta Kark. Biochemical Parameters as Prognostic Markers in Severely Ill COVID-19 Patients. Cureus. vol 14. issue 8. 2022-10-03. PMID:36185918. |
results of the 178 severely ill covid-19 patients enrolled in the study, 86 were controls and 92 were cases (52% mortality). serum urea (p<0.0001), creatinine (p=0.0019), aspartate transaminase (ast) (p=0.0104), lactate dehydrogenase (ldh) (p=0.0001), procalcitonin (pct) (p=0.0344), and interleukin 6 (il-6) (p=0.0311) levels were significantly higher (p<0.05), while total protein (p=0.0086), albumin (p<0.0001), and indirect bilirubin (p=0.0147) levels were significantly lower (p<0.05) in cases as compared to controls. |
2022-10-03 |
2023-08-14 |
Not clear |
| Yongchao Gao, Chao Sun, Ting Gao, Zhiyong Liu, Zhao Yang, Hui Deng, Peng Fan, Junhong Ga. Taurine ameliorates volatile organic compounds-induced cognitive impairment in young rats Frontiers in veterinary science. vol 9. 2022-10-03. PMID:36187803. |
moreover, taurine decreased malondialdehyde (mda), γ-aminobutyric acid (gaba), aspartate aminotransferase (ast), alanine aminotransferase (alt), urea, creatinine (crea) and injury biomarker level, enhanced superoxide dismutase (sod), reduced glutathione (gsh) and glutamic acid (glu) activities, up-regulated the protein expression of brain derived neurotrophic factor (bdnf) and n-methyl-d-aspartate receptor 1 (nmdar1) in model rats, and in most of cases 1% but not 0.5%, ameliorated the defects induced by vocs. |
2022-10-03 |
2023-08-14 |
rat |
| Bo Zhang, Zeben Wang, Chenxuan Huang, Dehe Wang, Dongmei Chang, Xiaowei Shi, Yifan Chen, Hui Che. Positive effects of Mulberry leaf extract on egg quality, lipid metabolism, serum biochemistry, and antioxidant indices of laying hens. Frontiers in veterinary science. vol 9. 2022-10-03. PMID:36187805. |
hens were fed a basal diet supplemented with 0 (control diet), 0.4, 0.8, or 1.2% mle for 56 d. results showed that the addition of 0.4-1.2% mle to the diet improved aspartate transaminase (ast) activity in the serum of laying hens, reduced low-density lipoprotein (ldl-c) content in the serum, and significantly decreased yolk triglyceride (tg) and total cholesterol (tc) contents ( |
2022-10-03 |
2023-08-14 |
Not clear |
| Xenophon Theodoridis, Georgios Kalopitas, Andreas Vadarlis, Dimitra Rafailia Bakaloudi, Νikolaos Gkiourtzis, Georgios Dionysopoulos, Evangelia Karanika, Eirini Tsekitsidi, Michail Chourdaki. Comparative efficacy of different treatment modalities in the management of pediatric non-alcoholic fatty liver disease: A systematic review and network meta-analysis. Pharmacology & therapeutics. 2022-10-02. PMID:36183848. |
secondary outcomes were changes in aspartate aminotransferase (ast), lipidemic and other biochemical parameters concentrations and body mass index (bmi) values. |
2022-10-02 |
2023-08-14 |
human |
| Changqing Zhang, Chenqinyao Li, Kechun Liu, Yun Zhan. Characterization of zearalenone-induced hepatotoxicity and its mechanisms by transcriptomics in zebrafish model. Chemosphere. 2022-10-01. PMID:36181844. |
first, we found zearalenone exposure can specifically cause liver injury, as evidenced by reduced liver size, decreased liver-specific fluorescence, increased aspartate aminotransferase (ast) activity, delayed yolk sac absorption and lipid accumulation. |
2022-10-01 |
2023-08-14 |
human |
| Yucong Wang, Tao Xu, Hui Zhao, Chunxiao Gu, Zhongzheng L. Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise. Frontiers in physiology. vol 13. 2022-09-30. PMID:36176774. |
we assessed serum creatine kinase (ck), ck isoenzyme, lactate dehydrogenase (ldh), aspartate transaminase (ast), tumor necrosis factor-alpha (tnf-alpha), and interleukin-6 (il-6). |
2022-09-30 |
2023-08-14 |
human |
| Chen Zhu, Xinwei Cheng, Ping Gao, Qianyan Gao, Ximin Wang, Dong Liu, Xiuhua Ren, Chengliang Zhan. Model establishment and microarray analysis of mice with oxaliplatin‑induced hepatic sinusoidal obstruction syndrome. Molecular medicine reports. vol 26. issue 5. 2022-09-30. PMID:36177905. |
the serum levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast) were determined. |
2022-09-30 |
2023-08-14 |
mouse |
| Fei Teng, Xiang-Wei Li, Min Li, Dong-Dong Fan, Jing-Jing Zhu, Hui-Min Gao, Zhi-Min Wan. [Components and lipid-lowering effect of total saponins from underground part of Gynostemma pentaphyllum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164912. |
furthermore, the levels of tc, tg, low-density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), alanine transaminase(alt), aspartate transaminase(ast), bilirubin, and total bile acids in serum, as well as the levels of superoxide dismutase(sod), malondialdehyde(mda), peroxidase proliferator-activated receptor(ppar-γ) in the liver tissue, were determined. |
2022-09-27 |
2023-08-14 |
rat |
| Y Kaçar, Z Mecitoğlu, H Batma. Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning. Australian veterinary journal. 2022-09-27. PMID:36165420. |
blood samples were collected on days 0 and 7, and aspartate aminotransferase (ast), gamma-glutamyltranspeptidase (ggt) and creatinine levels were evaluated. |
2022-09-27 |
2023-08-14 |
Not clear |
| Marawan Abd Elbaset, Maha Nasr, Bassant M M Ibrahim, Omar A H Ahmed-Farid, Rofanda M Bakeer, Nabila S Hassan, Rania F Ahme. Curcumin nanoemulsion counteracts hepatic and cardiac complications associated with high-fat/high-fructose diet in rats. Journal of food biochemistry. 2022-09-27. PMID:36165438. |
results revealed that the high dose level of cur nanoemulsion was superior to conventional cur in ameliorating the hfhf-induced insulin resistance status and hyperlipidemia, with beneficial impact on rats' recorded electrocardiogram (ecg), serum aspartate aminotransferase (alt) and alanine aminotransferase (ast) levels, leptin, adiponectin, creatine phosphokinase, lactate dehydrogenase and cardiac troponin-i. |
2022-09-27 |
2023-08-14 |
rat |
| Huiwen Wang, Jian Zhang, Xiaoxun Zhang, Nan Zhao, Zongtao Zhou, Lijian Tao, Lei Fu, Shifang Peng, Jin Cha. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-26. PMID:36154893. |
we found that akf-pd significantly reduced the levels of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and total bile salts (tba), as well as hepatic bile acids (bas) levels. |
2022-09-26 |
2023-08-14 |
mouse |