| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Lindgren, N E Andé. On the use of enzyme inhibitors to study the synthesis and utilization of brain GABA. Acta pharmacologica et toxicologica. vol 55. issue 1. 1984-09-17. PMID:6087618. |
the gaba concentration in the substantia nigra was reduced by 75 per cent 4 days after section of the striato-nigral gaba neurones. |
1984-09-17 |
2023-08-12 |
rat |
| S Lindgren, N E Andé. On the use of enzyme inhibitors to study the synthesis and utilization of brain GABA. Acta pharmacologica et toxicologica. vol 55. issue 1. 1984-09-17. PMID:6087618. |
in the denervated substantia nigra, 4-deoxypyridoxine did not change the concentration of gaba whereas the effect of gamma-acetylenic gaba was reduced by 70 per cent. |
1984-09-17 |
2023-08-12 |
rat |
| M L Kemel, C Gauchy, J Glowinski, M J Besso. In vivo release of [3H]GABA in cat caudate nucleus and substantia nigra. II. Involvement of different thalamic nuclei in the bilateral changes induced by a nigral application of muscimol. Brain research. vol 303. issue 2. 1984-08-30. PMID:6331570. |
in vivo release of [3h]gaba in cat caudate nucleus and substantia nigra. |
1984-08-30 |
2023-08-12 |
cat |
| M L Kemel, C Gauchy, J Glowinski, M J Besso. In vivo release of [3H]GABA in cat caudate nucleus and substantia nigra. II. Involvement of different thalamic nuclei in the bilateral changes induced by a nigral application of muscimol. Brain research. vol 303. issue 2. 1984-08-30. PMID:6331570. |
the contribution of motor and intralaminar thalamic nuclei to the changes of [3h]gaba release evoked in both caudate nuclei (cn) and both substantia nigra (sn) by a unilateral nigral application of muscimol (10(-6) m) was investigated on halothane-anaesthetized cats. |
1984-08-30 |
2023-08-12 |
cat |
| W Löscher, M Vette. Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats. Biochemical pharmacology. vol 33. issue 12. 1984-07-13. PMID:6428417. |
in all the other regions studied (corpus striatum, thalamus, hypothalamus, superior and inferior colliculus, substantia nigra, pons, medulla, cerebellum), increases in gaba were less marked and, at least in part, maximum increases (30-60% over control) were already reached by 1-2 hr. |
1984-07-13 |
2023-08-12 |
rat |
| L M Gunne, J E Häggström, B Sjöquis. Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis. Nature. vol 309. issue 5966. 1984-07-09. PMID:6727989. |
we report here that in three regions of the brains of dyskinetic monkeys (substantia nigra, medial globus pallidus and subthalamic nucleus) glutamate decarboxylase activities and gamma-aminobutyric acid (gaba) levels are reduced relative to control monkeys that had been treated with neuroleptics but which showed none of the symptoms of tardive dyskinesia. |
1984-07-09 |
2023-08-12 |
monkey |
| M R Melis, K Gal. Evidence that nigral substance P controls the activity of the nigrotectal GABAergic pathway. Brain research. vol 295. issue 2. 1984-06-07. PMID:6201231. |
there was no effect of these sp analogs on gaba turnover in the deep layers of superior colliculus when they were microinjected in the ipsilateral median forebrain bundle or in the contralateral substantia nigra. |
1984-06-07 |
2023-08-12 |
Not clear |
| K Koshiya, T Kat. Acute changes in nigral substance P content induced by drugs acting on dopamine, muscarine and GABA receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 3. 1984-02-24. PMID:6197660. |
effects of acutely administered drugs acting on dopamine, muscarine or gaba receptors on the substance p content in rat substantia nigra were examined. |
1984-02-24 |
2023-08-12 |
rat |
| D Pericić, H Mane. Effect of phenoxybenzamine on the GABA system and on convulsive activity. Neuropsychobiology. vol 10. issue 1. 1984-02-24. PMID:6657036. |
whereas 0.1 mg/kg of phenoxybenzamine decreased the levels and the aoaa-induced accumulation of gaba in the substantia nigra and cerebellar cortex, 1.0 mg/kg produced an increased gaba accumulation in the substantia nigra. |
1984-02-24 |
2023-08-12 |
rat |
| G D Frye, T J McCown, G R Brees. Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum. The Journal of pharmacology and experimental therapeutics. vol 227. issue 3. 1984-02-14. PMID:6317842. |
characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (gaba) agonists into the inferior colliculus, substantia nigra or medial septum. |
1984-02-14 |
2023-08-12 |
rat |
| G D Frye, T J McCown, G R Brees. Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum. The Journal of pharmacology and experimental therapeutics. vol 227. issue 3. 1984-02-14. PMID:6317842. |
the relative anticonvulsant potential of the gamma-aminobutyric acid (gaba) agonist, muscimol, was compared after microinjection into either the inferior colliculus, substantia nigra or medial septum of ethanol-dependent rats. |
1984-02-14 |
2023-08-12 |
rat |
| G D Frye, T J McCown, G R Brees. Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum. The Journal of pharmacology and experimental therapeutics. vol 227. issue 3. 1984-02-14. PMID:6317842. |
the relative proconvulsant potential of the gaba antagonist, bicuculline methiodide, also was compared after microinjection into either the inferior colliculus, substantia nigra or medial septum of ethanol naive rats. |
1984-02-14 |
2023-08-12 |
rat |
| C Gauchy, M L Kemel, R Romo, A Chéramy, J Glowinski, M J Besso. Effects of nigral application of muscimol on release of [3H] gamma-aminobutyrate and on multiunit activity in various cat thalamic nuclei. Neuroscience. vol 10. issue 3. 1984-01-27. PMID:6646428. |
the release of [3h] gamma-aminobutyrate (gaba) neosynthesized from [3h]glutamine was estimated in one substantia nigra and in the ipsilateral thalamus of halothane-anesthetized cats by perfusing a [3h]glutamine-enriched physiological medium through a push-pull cannula implanted in the two structures under investigation. |
1984-01-27 |
2023-08-12 |
cat |
| J S Kim, D Claus, H H Kornhube. Cerebral glutamate, neuroleptic drugs and schizophrenia: increase of cerebrospinal fluid glutamate levels and decrease of striate body glutamate levels following sulpiride treatment in rats. European neurology. vol 22. issue 5. 1983-12-20. PMID:6138256. |
sulpiride had no effect on the gaba content of the brain areas investigated (frontal cortex, striatum, hippocampus and substantia nigra). |
1983-12-20 |
2023-08-12 |
rat |
| R D Huffman, M K Tick. The effects of chronic haloperidol administration on GABA receptor binding. Pharmacology, biochemistry, and behavior. vol 19. issue 2. 1983-12-20. PMID:6314387. |
the chronic administration of haloperidol resulted in a marked increase in the number of gaba binding sites within the substantia nigra, but did not affect gaba binding sites in other regions of rat brain or spinal cord. |
1983-12-20 |
2023-08-12 |
rat |
| R D Huffman, M K Tick. The effects of chronic haloperidol administration on GABA receptor binding. Pharmacology, biochemistry, and behavior. vol 19. issue 2. 1983-12-20. PMID:6314387. |
the increase in gaba binding sites in the substantia nigra was evident for at least 4 days following termination of haloperidol treatment; however, 8 days following withdrawal from haloperidol, when dopaminergic supersensitivity had become maximally expressed, the number of gaba binding sites in the substantia nigra had declined and was the same as that observed in the control rats. |
1983-12-20 |
2023-08-12 |
rat |
| R D Huffman, M K Tick. The effects of chronic haloperidol administration on GABA receptor binding. Pharmacology, biochemistry, and behavior. vol 19. issue 2. 1983-12-20. PMID:6314387. |
these observations suggest that blockade of dopamine receptors in the striatum by haloperidol results in a compensatory decrease in the activity of the gabaergic strionigral system that leads to an increase in the number of gaba binding sites within the substantia nigra. |
1983-12-20 |
2023-08-12 |
rat |
| O Hikosaka, R H Wurt. Effects on eye movements of a GABA agonist and antagonist injected into monkey superior colliculus. Brain research. vol 272. issue 2. 1983-11-23. PMID:6311342. |
these results are consistent with a tonic inhibition by the substantia nigra on the superior colliculus mediated by gaba which is reduced at the time of saccade initiation. |
1983-11-23 |
2023-08-12 |
monkey |
| P J de Varebeke, P Niebes, G Pauwels, J Roba, J Kor. Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system. Biochemical pharmacology. vol 32. issue 18. 1983-11-23. PMID:6414480. |
milacemide (cp 1552 s, 2-n-pentylaminoacetamide), a drug with anti-epileptic potency, increases the gamma-aminobutyric acid (gaba) content specifically in the substantia nigra of rat brain. |
1983-11-23 |
2023-08-12 |
rat |
| P J de Varebeke, P Niebes, G Pauwels, J Roba, J Kor. Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system. Biochemical pharmacology. vol 32. issue 18. 1983-11-23. PMID:6414480. |
after 2, 3 and 4 hr the substantia nigra gaba content is significantly increased by 28, 33 and 38%, respectively. |
1983-11-23 |
2023-08-12 |
rat |