| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Mitchell, S Fleetwood-Walke. Substance P, but not TRH, modulates the 5-HT autoreceptor in ventral lumbar spinal cord. European journal of pharmacology. vol 76. issue 1. 1982-03-13. PMID:6172281. |
substance p, but not trh, modulates the 5-ht autoreceptor in ventral lumbar spinal cord. |
1982-03-13 |
2023-08-12 |
Not clear |
| H E Connor, L Finc. Postsynaptic spinal alpha-adrenoceptors mediate effects of intrathecal clonidine. European journal of pharmacology. vol 76. issue 1. 1982-03-13. PMID:6274674. |
the cardiovascular effects of intrathecal administration of clonidine were examined after depletion of spinal cord noradrenaline or 5-hydroxytryptamine by pretreatment with 6-hydroxydopamine or 5,6-dihydroxytryptamine. |
1982-03-13 |
2023-08-12 |
Not clear |
| S Bööj, A G Dahllöf, P A Larsson, A Dahlströ. Influence of descending bulbospinal monoamine neurons on axonal transport of acetylcholine and cholinergic enzymes. Journal of neural transmission. vol 52. issue 3. 1982-02-12. PMID:6171616. |
the injection of 6-hydroxydopamine (6-oh-da) and 5,6-dihydroxytryptamine (5,6-dioh-ta) (50 micrograms x 2) caused a degeneration of catecholamine (ca) and 5-hydroxytryptamine (5-ht) nerve terminals, respectively, and a combination of the two neurotoxins caused a loss of virtually all ma terminals in the lumbar spinal cord. |
1982-02-12 |
2023-08-12 |
rat |
| G Jancsó, T Hökfelt, J M Lundberg, E Kiraly, N Halász, G Nilsson, L Terenius, J Rehfeld, H Steinbusch, A Verhofstad, R Elde, S Said, M Brow. Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine. Journal of neurocytology. vol 10. issue 6. 1982-02-12. PMID:6171625. |
after neonatal treatment of rats with capsaicin, the spinal cord, the spinal trigeminal nucleus and spinal and trigeminal ganglia were analysed with immunohistochemistry using antisera to several peptides and 5-hydroxytryptamine. |
1982-02-12 |
2023-08-12 |
rat |
| G Jancsó, T Hökfelt, J M Lundberg, E Kiraly, N Halász, G Nilsson, L Terenius, J Rehfeld, H Steinbusch, A Verhofstad, R Elde, S Said, M Brow. Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine. Journal of neurocytology. vol 10. issue 6. 1982-02-12. PMID:6171625. |
no definite depleting effect of capsaicin could be established on 5-hydroxytryptamine and peptides, such as enkephalin and neurotensin, present in centrally originating fibres in the dorsal horn of the spinal cord. |
1982-02-12 |
2023-08-12 |
rat |
| O Johansson, T Hökfelt, B Pernow, S L Jeffcoate, N White, H W Steinbusch, A A Verhofstad, P C Emson, E Spinde. Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. Neuroscience. vol 6. issue 10. 1982-01-28. PMID:6170907. |
immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. |
1982-01-28 |
2023-08-12 |
Not clear |
| F Godefroy, J Weil-Fugazza, M Bineau-Thurotte, J M Besso. The relationship between morphine analgesia and the activity of bulbo-spinal serotonergic system as studied by tolerance phenomenon. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:6271344. |
the effect of various doses of acute morphine on both analgesia and 5-hydroxytryptamine (5-ht) synthesis in the brain and the spinal cord has been studied in rats rendered tolerant by chronic administration of the analgesic. |
1982-01-20 |
2023-08-12 |
rat |
| F Godefroy, J Weil-Fugazza, M Bineau-Thurotte, J M Besso. The relationship between morphine analgesia and the activity of bulbo-spinal serotonergic system as studied by tolerance phenomenon. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:6271344. |
in morphine-tolerant rats, the incorporation of tritiated-l-tryptophan (trp) in the brain and the spinal cord was higher than in non-tolerant rats, but there was no significant difference in the synthesis rate of the newly formed 5-ht between the two groups. |
1982-01-20 |
2023-08-12 |
rat |
| F Godefroy, J Weil-Fugazza, M Bineau-Thurotte, J M Besso. The relationship between morphine analgesia and the activity of bulbo-spinal serotonergic system as studied by tolerance phenomenon. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:6271344. |
higher acute doses of morphine which restored analgesia in tolerant rats, induced a discrete increase in [3h]trp incorporation and a marked increase in 5-ht synthesis in the spinal cord of these animals. |
1982-01-20 |
2023-08-12 |
rat |
| F Godefroy, J Weil-Fugazza, M Bineau-Thurotte, J M Besso. The relationship between morphine analgesia and the activity of bulbo-spinal serotonergic system as studied by tolerance phenomenon. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:6271344. |
these results show that tolerance to morphine is associated with a decrease in the effects of the drug on 5-ht synthesis in the spinal cord and the brain and tend further support to the hypothesis that an enhancement of 5-ht synthesis in the spinal cord, induced independently of modifications of the availability of trp, is associated with the analgesic effect of morphine. |
1982-01-20 |
2023-08-12 |
rat |
| R M Bowker, K N Westlund, J D Coulte. Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:7028211. |
large numbers of stained neurons (greater than 70%) in the medullary raphe nuclear complex were found to contain both hrp retrogradely transported from the spinal cord and positive 5-ht staining. |
1982-01-20 |
2023-08-12 |
rat |
| R M Bowker, K N Westlund, J D Coulte. Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:7028211. |
more rostrally in the midbrain reticular formation, many 5-ht neurons were found to have projections exclusively to the cervical spinal cord. |
1982-01-20 |
2023-08-12 |
rat |
| R M Bowker, K N Westlund, J D Coulte. Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:7028211. |
these findings indicate that the descending serotonin inputs to the spinal cord originate not only from the serotonergic neurons located in the medullary raphe complex, but also from other new sources located in the central gray and reticular formation of the midbrain. |
1982-01-20 |
2023-08-12 |
rat |
| J W Commission. Spinal monoaminergic systems: an aspect of somatic motor function. Federation proceedings. vol 40. issue 13. 1982-01-09. PMID:6117486. |
the activation of gamma-mns in the spinal cord partly depleted of 5-hydroxytryptamine (5-ht) is a striking example of that selectivity. |
1982-01-09 |
2023-08-12 |
Not clear |
| T L Yaksh, G M Tyc. Release of norepinephrine and serotonin in cat spinal cord: direct in vivo evidence for the activation of descending monoamine pathways by somatic stimulation. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:7288659. |
release of norepinephrine and serotonin in cat spinal cord: direct in vivo evidence for the activation of descending monoamine pathways by somatic stimulation. |
1981-12-22 |
2023-08-12 |
cat |
| S P Markey, R W Colburn, J N Johannesse. Efficient extraction and mass spectrometric assay of serotonin in biological fluids. Biomedical mass spectrometry. vol 8. issue 7. 1981-12-21. PMID:6793109. |
examples of applications for the assay of serotonin in human platelets, rat spinal cord, and monkey cerebrospinal fluid are presented. |
1981-12-21 |
2023-08-12 |
human |
| R A Browning, D G Bramlet, J H Myers, M C Bundman, M L Smit. Failure to produce blood pressure changes following pharmacological or surgical depletion of brain serotonin in the spontaneously hypertensive rat. Clinical and experimental hypertension. vol 3. issue 5. 1981-12-15. PMID:6456876. |
moreover, treatment of 10 day-old hypertensive rat pups with intracisternal injections of 5,7-dht (10 microgram) failed to alter the development of hypertension despite a 75-80% decrease in spinal cord 5-ht. |
1981-12-15 |
2023-08-12 |
rat |
| E Carstens, D Klumpp, M Randić, M Zimmerman. Effect of iontophoretically applied 5-hydroxytryptamine on the excitability of single primary afferent C- and A-fibers in the cat spinal cord. Brain research. vol 220. issue 1. 1981-11-18. PMID:7272748. |
effect of iontophoretically applied 5-hydroxytryptamine on the excitability of single primary afferent c- and a-fibers in the cat spinal cord. |
1981-11-18 |
2023-08-12 |
cat |
| R S Cheng, B Pomeran. Monoaminergic mechanism of electroacupuncture analgesia. Brain research. vol 215. issue 1-2. 1981-10-14. PMID:6114781. |
since previous studies show that raphe or dlf (dorsolateral fasciculus) lesions abolish eaa, we postulate that descending axons from raphe release serotonin to inhibit trigeminal or spinal cord nociception during eaa. |
1981-10-14 |
2023-08-12 |
mouse |
| A R Green, J E Hall, A R Ree. A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6166345. |
in contrast, cypropheptadine, cinanserin and mianserin had no effects on the behaviour.3 similar findings were obtained when the behaviours were elicited by administration of tranylcypromine (10 mg/kg) followed by the putative 5-ht receptor agonist, 5-methoxy-n,n-dimethyltryptamine (5-meodmt) (2 mg/kg).4 when the behaviours were elicited by the putative 5-ht receptor agonist, quipazine (50 mg/kg), all the drugs effectively inhibited head weaving and forepaw treading.5 when the dose of cypropheptadine was doubled to 20 mg/kg an inhibition of the tranylcypromine/l-tryptophan induced behaviours was seen.6 methiothepin produced a marked inhibition of apomorphine-induced locomotor activity whilst all the others enhanced this response, suggesting that only methiothepin inhibits the 5-ht behaviours by dopamine antagonism and that the increased reactivity seen following tranylcypromine/l-tryptophan after pretreatment with methysergide or methergoline might be due to enhanced dopamine function.7 pretreatment with p-chlorophenylalanine resulted in enhanced behavioural responses to both 5-meodmt and quipazine.8 both methergoline and methiothepin decreased the rate of 5-ht synthesis in whole brain but not spinal cord and methergoline decreased spinal cord 5-hiaa concentration. |
1981-09-25 |
2023-08-12 |
rat |