| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liting Sun, Changgeng Peng, Elbert Joosten, Chi Wai Cheung, Fei Tan, Wencheng Jiang, Xiafeng She. Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application. Neural plasticity. vol 2021. 2021-11-24. PMID:34721569. |
evidence from recent research publications indicates that nociceptive processing at peripheral and central sensory systems is thought to be modulated by scs through (i) inhibition of the ascending nociceptive transmission by the release of analgesic neurotransmitters such as gaba and endocannabinoids at the spinal dorsal horn; (ii) facilitation of the descending inhibition by release of noradrenalin, dopamine, and serotonin acting on their receptors in the spinal cord; and (iii) activation of a variety of supraspinal brain areas related to pain perception and emotion. |
2021-11-24 |
2023-08-13 |
Not clear |
| Milton H Werner, C Warren Olano. Parkinson's Disease Modification through Abl Kinase Inhibition: An Opportunity. Movement disorders : official journal of the Movement Disorder Society. 2021-11-24. PMID:34816484. |
historically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, pd pathology is now known to be widespread and to affect serotonin, cholinergic and norepinephrine neurons as well as nerve cells in the olfactory system, cerebral hemisphere, brain stem, spinal cord, and peripheral autonomic nervous system. |
2021-11-24 |
2023-08-13 |
human |
| Ana Carolina P Campos, Miriã B Berzuíno, Gabriela R Barbosa, Helena M R C Freire, Patricia S Lopes, Danielle V Assis, Erich T Fonoff, Rosana L Pagan. Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson's Disease Rat Model. Cells. vol 10. issue 5. 2021-11-15. PMID:34064617. |
the immunoreactivity of dopamine in the substantia nigra and serotonin in the nucleus raphe magnus (nrm) and the neuronal, astrocytic, and microglial activation in the dorsal horn of the spinal cord were evaluated. |
2021-11-15 |
2023-08-13 |
rat |
| Ana Carolina P Campos, Miriã B Berzuíno, Gabriela R Barbosa, Helena M R C Freire, Patricia S Lopes, Danielle V Assis, Erich T Fonoff, Rosana L Pagan. Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson's Disease Rat Model. Cells. vol 10. issue 5. 2021-11-15. PMID:34064617. |
this response was accompanied by an exacerbated increase in serotonin in the nrm and a decrease in neuronal and astrocytic hyperactivation in the spinal cord, without inhibiting epd-induced microglial hypertrophy and hyperplasia. |
2021-11-15 |
2023-08-13 |
rat |
| Julie Fourneau, Florence M Bareyr. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558508. |
following a spinal cord injury, serotonergic projections to the lumbar spinal cord, where the central pattern generators are located, are interrupted resulting in devastating locomotor impairments and changes in the expression and activation of serotonin and its spinal receptors. |
2021-11-10 |
2023-08-13 |
mouse |
| Julie Fourneau, Florence M Bareyr. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558508. |
we show that semaphorin7a controls the wiring of descending serotonin axons in the spinal cord. |
2021-11-10 |
2023-08-13 |
mouse |
| Julie Fourneau, Florence M Bareyr. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558508. |
our results reveal that mistargetting of serotonin fibers in the spinal cord is compensated in healthy uninjured semaphorin7a deficient mice so that their gross locomotion proceeds accurately. |
2021-11-10 |
2023-08-13 |
mouse |
| Julie Fourneau, Florence M Bareyr. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558508. |
we also demonstrate that when the system is challenged with a spinal lesion, the pattern of post-injury serotonin expression is significantly altered in semaphorin7a deficient mice with specific ectopic targeting of serotonin fibers in the lumbar spinal cord. |
2021-11-10 |
2023-08-13 |
mouse |
| Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winsto. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 33. issue 10. 2021-11-09. PMID:33705592. |
estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. |
2021-11-09 |
2023-08-13 |
rat |
| Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winsto. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 33. issue 10. 2021-11-09. PMID:33705592. |
the aims of this study were to examine the roles of estrogen receptor alpha (erα) and an increase in spinal serotonin signaling in promoting this enhanced vhs in female rats and up-regulation of spinal cord bdnf transcription. |
2021-11-09 |
2023-08-13 |
rat |
| Bi-Wei Chen, Shao-Zong Chen, Jian-Qiao Fang, Xiang-Hong Jin. [Research progress and problems of neurobiological mechanisms of acupuncture underlying improvement of irritable bowel syndrome]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 10. 2021-10-27. PMID:34698465. |
the neurobiological mechanisms include two aspects 1) remission of visceral hypersensitivity via peripheral and central pathways (spinal cord and brain), and 2) improvement of intestinal motility via vagus nerve and enteric nervous system (ens)- interstitial cells of cajal (icc)-smooth muscle cells (ens-icc-smc) network, and 5-ht, vasoactive intestinal peptide (vip), neuropeptide y, etc.. at the same time, we also discussed the existing problems in the research of the underlying neurobiological mechanisms of acupuncture and moxibustion for ibs. |
2021-10-27 |
2023-08-13 |
Not clear |
| Shigeharu Tsuda, Mustafa Golam, Jiamei Hou, Rachel Nelson, Phillip Bernavil, Kenneth Richardson, Kevin K W Wang, Floyd Thompson, Prodip Bos. Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats. Brain research. vol 1747. 2021-10-07. PMID:32828734. |
following btbi, physiological/behavioral tests were conducted and tissues in the central motor system (i.e., motor cortex, locus coeruleus, vestibular nuclei, and lumbar spinal cord) were collected for electrochemical detection of norepinephrine, dopamine, and serotonin by high-performance liquid chromatography. |
2021-10-07 |
2023-08-13 |
rat |
| Shigeharu Tsuda, Mustafa Golam, Jiamei Hou, Rachel Nelson, Phillip Bernavil, Kenneth Richardson, Kevin K W Wang, Floyd Thompson, Prodip Bos. Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats. Brain research. vol 1747. 2021-10-07. PMID:32828734. |
on the other hand, serotonin was significantly increased in the motor cortex and the lumbar spinal cord. |
2021-10-07 |
2023-08-13 |
rat |
| Isabelle Vivodtzev, Glen Picard, Kevin O'Connor, J Andrew Taylo. Serotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis. European journal of applied physiology. vol 121. issue 2. 2021-10-04. PMID:33099664. |
serotonin 1a agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis. |
2021-10-04 |
2023-08-13 |
Not clear |
| Aurélie Flaive, Maxime Fougère, Cornelis Immanuel van der Zouwen, Dimitri Ryczk. Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals. Frontiers in neural circuits. vol 14. 2021-10-04. PMID:33224027. |
the locomotor circuitry is directly innervated by 5-ht neurons in the caudal brainstem and spinal cord. |
2021-10-04 |
2023-08-13 |
Not clear |
| Epiphani C Simmons, Natalie E Scholpa, Rick G Schnellman. FDA-approved 5-HT Experimental neurology. vol 341. 2021-10-04. PMID:33848513. |
fda-approved 5-ht vascular and mitochondrial dysfunction are well-established consequences of spinal cord injury (sci). |
2021-10-04 |
2023-08-13 |
Not clear |
| Huy Tran, Varun Sagi, Sarita Jarrett, Elise F Palzer, Rajendra D Badgaiyan, Kalpna Gupt. Diet and companionship modulate pain via a serotonergic mechanism. Scientific reports. vol 11. issue 1. 2021-09-14. PMID:33526805. |
additionally, 5-ht production improved at the rostral ventromedial medulla and 5-ht accumulated at the dorsal horn of the spinal cord of sickle mice, suggesting the involvement of the descending pain pathway in the analgesic response. |
2021-09-14 |
2023-08-13 |
mouse |
| Hillary E Swann-Thomsen, Derek D Viall, Michele R Brumle. Acute intrathecal administration of quipazine elicits air-stepping behavior. Behavioural pharmacology. vol 32. issue 4. 2021-09-06. PMID:33595953. |
serotonin plays a pivotal role in the initiation and modulation of locomotor behavior in the intact animal, as well as following spinal cord injury. |
2021-09-06 |
2023-08-13 |
human |
| Long Ma, Jing-Yuan Tang, Jin-Yong Zhou, Chen Zhu, Xin Zhang, Ping Zhou, Qiu Yu, Yan Wang, Xiao-Jian G. Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury. Neural regeneration research. vol 16. issue 10. 2021-08-21. PMID:33642399. |
fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury. |
2021-08-21 |
2023-08-13 |
mouse |
| Qingyu Yao, Jian Guan, Longbing Ma, Lei Cheng, Feng Duan, Fu Xu, Wang Zhao, Wanru Duan, Hao Wu, Zan Chen, Fengzeng Jia. Wireless Epidural Electrical Stimulation in Combination With Serotonin Agonists Improves Intraspinal Metabolism in Spinal Cord Injury Rats. Neuromodulation : journal of the International Neuromodulation Society. vol 24. issue 3. 2021-08-18. PMID:33377590. |
wireless epidural electrical stimulation in combination with serotonin agonists improves intraspinal metabolism in spinal cord injury rats. |
2021-08-18 |
2023-08-13 |
rat |