| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mo Xian Chen, Shu Cheng, Lei Lei, Xiao Fan Zhang, Qiang Liu, Aijin Lin, Chloe U Wallis, Michael James Lukowicz, Pak C Sham, Qi Li, Li Juan A. The effects of maternal SSRI exposure on the serotonin system, prefrontal protein expression and behavioral development in male and female offspring rats. Neurochemistry international. vol 146. 2021-06-18. PMID:33836218. |
moreover, down-regulation of 5-ht and sert expression were identified in the pfc. |
2021-06-18 |
2023-08-13 |
rat |
| Angela Patricia França, Marissa Giovanna Schamne, Bruna Soares de Souza, Débora da Luz Scheffer, Angelica Karina Bernardelli, Thiago Corrêa, Geison de Souza Izídio, Alexandra Latini, José Eduardo da Silva-Santos, Paula M Canas, Rodrigo A Cunha, Rui Daniel Predige. Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32621279. |
the association of caffeine consumption plus physical exercise during adolescence increased the levels of snap-25, syntaxin, and serotonin in the hippocampus and prefrontal cortex, and striatal dopamine levels in shrs. |
2021-06-03 |
2023-08-13 |
rat |
| Jin Zhou, Yanlin Tao, Han Zhu, Hui Wu, Hailian Shi, Fei Huang, Xiaojun W. Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system. Neuroreport. vol 31. issue 7. 2021-05-28. PMID:32282584. |
after that, a series of behavioral tests were used to detect the anxiety-like behavioral changes of the anit-induced cholestatic mice, and then the level of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in serum and prefrontal cortex were detected. |
2021-05-28 |
2023-08-13 |
mouse |
| Jin Zhou, Yanlin Tao, Han Zhu, Hui Wu, Hailian Shi, Fei Huang, Xiaojun W. Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system. Neuroreport. vol 31. issue 7. 2021-05-28. PMID:32282584. |
in addition, the expression of 5-hydroxytryptamine 1a, 5-hydroxytryptamine 2c, 5-hydroxytryptamine 3a, and 5-hydroxytryptamine 7 receptors increased in the prefrontal cortex of the model mice compared to their controls. |
2021-05-28 |
2023-08-13 |
mouse |
| Andrea Forero, Hsing-Ping Ku, Ana Belén Malpartida, Sina Wäldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H J Norton, Andrew M J Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesc. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. vol 168. 2021-05-27. PMID:32113967. |
our results show that exclusive inactivation of cdh13 in 5-ht neurons selectively increases 5-ht neuron density in the embryonic dorsal raphe, with persistence into adulthood, and serotonergic innervation of the developing prefrontal cortex. |
2021-05-27 |
2023-08-13 |
mouse |
| Aline Guimarães Pereira, Anicleto Poli, Filipe Carvalho Matheus, Lucila de Bortoli da Silva, Guilherme Pasetto Fadanni, Geison Souza Izídio, Alexandra Latini, Rui Daniel Predige. Temporal development of neurochemical and cognitive impairments following reserpine administration in rats. Behavioural brain research. vol 383. 2021-05-25. PMID:32006562. |
here, we investigated the temporal-dependent effects of res (1 mg/kg, s.c.) on short-term memory and locomotion, as well as, the levels of dopamine, serotonin and its metabolites in the striatum, hippocampus and prefrontal cortex at 3, 24 or 72 h after res administration. |
2021-05-25 |
2023-08-13 |
rat |
| Yane Costa Chaves, Karina Genaro, Cristina Aparecida Stern, Gisele de Oliveira Guaita, José Alexandre de Souza Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes. Neuroscience letters. vol 729. 2021-05-14. PMID:32360935. |
besides, the levels of serotonin (5-ht), noradrenaline (na) and dopamine (da) in two emotion-related brain regions, the prefrontal cortex (pfc) and hippocampus (hip) were evaluated using high-pressure liquid chromatography. |
2021-05-14 |
2023-08-13 |
rat |
| Yane Costa Chaves, Karina Genaro, Cristina Aparecida Stern, Gisele de Oliveira Guaita, José Alexandre de Souza Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes. Neuroscience letters. vol 729. 2021-05-14. PMID:32360935. |
our results showed that cbd treatment (only at the higher dose of 30 mg/kg) reduced the exaggerated depressive- and anxiogenic-like behaviors of diabetic (dbt) rats, which may be associated with altered 5-ht, na and/or da levels observed in the pfc and hip. |
2021-05-14 |
2023-08-13 |
rat |
| Colm M P O'Tuathaigh, Lieve Desbonnet, Christina Payne, Emilie Petit, Rachel Cox, Samim Loftus, Gerard Clarke, John F Cryan, Orna Tighe, Steve Wilson, Brian P Kirby, Timothy G Dinan, John L Waddingto. Ethologically based behavioural and neurochemical characterisation of mice with isoform-specific loss of dysbindin-1A in the context of schizophrenia. Neuroscience letters. vol 736. 2021-05-13. PMID:32615248. |
dys-1a ko demonstrated lower levels of 5-ht in ratio to its metabolite 5-hiaa in the prefrontal cortex. |
2021-05-13 |
2023-08-13 |
mouse |
| Hiroki Chiba, Takeya Kitta, Yu Ohmura, Madoka Higuchi, Masafumi Kon, Michiko Nakamura, Mitsuhiro Yoshioka, Nobuo Shinohar. Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors. International journal of urology : official journal of the Japanese Urological Association. vol 27. issue 8. 2021-04-27. PMID:32533581. |
serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2a and 5-hydroxytryptamine 7 receptors. |
2021-04-27 |
2023-08-13 |
rat |
| Hiroki Chiba, Takeya Kitta, Yu Ohmura, Madoka Higuchi, Masafumi Kon, Michiko Nakamura, Mitsuhiro Yoshioka, Nobuo Shinohar. Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors. International journal of urology : official journal of the Japanese Urological Association. vol 27. issue 8. 2021-04-27. PMID:32533581. |
to identify the types of serotonin (5-hydroxytryptamine) receptors of the prefrontal cortex related to the micturition reflex. |
2021-04-27 |
2023-08-13 |
rat |
| Jodi L Pawluski, Rafaella Paravatou, Alan Even, Gael Cobraiville, Marianne Fillet, Nikolaos Kokras, Christina Dalla, Thierry D Charlie. Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31935392. |
results show that pregnant females have significantly higher serum levels of sertraline compared to non-pregnant females but that rates of serotonin turnover in the hippocampus and pfc are similar between pregnant and non-pregnant females. |
2021-04-02 |
2023-08-13 |
rat |
| Tin-Tin Win-Shwe, Chaw Kyi-Tha-Thu, Yuji Fujitani, Shinji Tsukahara, Seishiro Hiran. Perinatal Exposure to Diesel Exhaust-Origin Secondary Organic Aerosol Induces Autism-Like Behavior in Rats. International journal of molecular sciences. vol 22. issue 2. 2021-03-30. PMID:33430368. |
serotonin receptor (5-ht(5b)) and brain-derived neurotrophic factor (bdnf) mrnas were downregulated whereas interleukin 1 β (il-β) and heme oxygenase 1 (ho-1) mrnas were upregulated in the prefrontal cortex of male and female rats exposed to de-soa. |
2021-03-30 |
2023-08-13 |
rat |
| Lucia Caffino, Francesca Mottarlini, Boyd Van Reijmersdal, Francesca Telese, Michel M M Verheij, Fabio Fumagalli, Judith R Homber. The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration. Addiction biology. vol 26. issue 2. 2021-03-26. PMID:32187792. |
the role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration. |
2021-03-26 |
2023-08-13 |
Not clear |
| Feng Zhu, Ruijin Guo, Wei Wang, Yanmei Ju, Qi Wang, Qingyan Ma, Qiang Sun, Yajuan Fan, Yuying Xie, Zai Yang, Zhuye Jie, Binbin Zhao, Liang Xiao, Lin Yang, Tao Zhang, Bing Liu, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao, Xun Xu, Huanming Yang, Jian Wang, Yonghui Dang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Huijue Jia, Xiancang M. Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:31391545. |
these mice also showed elevation of the kynurenine-kynurenic acid pathway of tryptophan degradation in both periphery and brain, as well as increased basal extracellular dopamine in prefrontal cortex and 5-hydroxytryptamine in hippocampus, compared with their counterparts receiving feces from healthy controls. |
2021-03-15 |
2023-08-13 |
mouse |
| Karl-Jürgen Bär, Stefanie Köhler, Feliberto de la Cruz, Andy Schumann, Florian D Zepf, Gerd Wagne. Functional consequences of acute tryptophan depletion on raphe nuclei connectivity and network organization in healthy women. NeuroImage. vol 207. 2021-03-03. PMID:31743788. |
the aim was to perturb 5-ht synthesis and to detect its impact on brain functional connectivity (fc) of the upper serotonergic raphe nuclei, the amygdala and the ventromedial prefrontal cortex as well as on network organization using resting state fmri. |
2021-03-03 |
2023-08-13 |
human |
| Charlène Faye, René Hen, Bruno P Guiard, Christine A Denny, Alain M Gardier, Indira Mendez-David, Denis J Davi. Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus. Biological psychiatry. vol 87. issue 6. 2021-01-06. PMID:31623825. |
rapid anxiolytic effects of rs67333, a serotonin type 4 receptor agonist, and diazepam, a benzodiazepine, are mediated by projections from the prefrontal cortex to the dorsal raphe nucleus. |
2021-01-06 |
2023-08-13 |
Not clear |
| Katie L Burkhouse, Jagan Jimmy, Nicholas Defelice, Heide Klumpp, Olusola Ajilore, Bobby Hosseini, Kate D Fitzgerald, Christopher S Monk, K Luan Pha. Nucleus accumbens volume as a predictor of anxiety symptom improvement following CBT and SSRI treatment in two independent samples. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31756730. |
we examined whether gray matter volume of three neural regions supporting fear and avoidance responses [bilateral amygdala, nucleus accumbens (nacc), and ventromedial prefrontal cortex (pfc)] predicted cognitive-behavioral therapy (cbt) and selective serotonin reuptake inhibitor (ssri) treatment outcome in two independent samples of patients with anxiety disorders. |
2020-12-28 |
2023-08-13 |
Not clear |
| Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V Schally, Luigi Brunetti, Sheila Leon. Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice. Scientific reports. vol 10. issue 1. 2020-11-25. PMID:31959947. |
in vivo, both mia-690 and mr-409 induced anxiolytic and antidepressant-like effects, increased norepinephrine and serotonin levels and decreased nuclear factor-kb, tumor necrosis factor-α and interleukin-6 gene expression in prefrontal cortex. |
2020-11-25 |
2023-08-13 |
mouse |
| Ernest Dallé, William M U Daniels, Musa V Mabandl. Long-Term Treatment with Fluvoxamine Decreases Nonmotor Symptoms and Dopamine Depletion in a Postnatal Stress Rat Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2020. 2020-11-17. PMID:32273939. |
a 6-ohda lesion effect was evidenced by impairment in the limb-use asymmetry test as well as decreased dopamine (da) and serotonin levels in the striatum, prefrontal cortex, and hippocampus. |
2020-11-17 |
2023-08-13 |
rat |