| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuan Sun, Xing Wang, Hou-Cheng Zhou, Jian Zheng, Yun-Xiao Su, Fei Lu. β3-adrenoceptor activation exhibits a dual effect on behaviors and glutamate receptor function in the prefrontal cortex. Behavioural brain research. vol 412. 2021-10-18. PMID:34157371. |
β3-adrenoceptor activation exhibits a dual effect on behaviors and glutamate receptor function in the prefrontal cortex. |
2021-10-18 |
2023-08-13 |
rat |
| Joseph A McQuail, B Sofia Beas, Kyle B Kelly, Caesar M Hernandez, Jennifer L Bizon, Charles J Frazie. Attenuated NMDAR signaling on fast-spiking interneurons in prefrontal cortex contributes to age-related decline of cognitive flexibility. Neuropharmacology. vol 197. 2021-10-14. PMID:34273386. |
ionotropic glutamate receptors of the nmda and ampa subtypes transduce excitatory signaling on neurons in the prefrontal cortex (pfc) in support of cognitive flexibility. |
2021-10-14 |
2023-08-13 |
rat |
| Joseph A McQuail, B Sofia Beas, Kyle B Kelly, Caesar M Hernandez, Jennifer L Bizon, Charles J Frazie. Attenuated NMDAR signaling on fast-spiking interneurons in prefrontal cortex contributes to age-related decline of cognitive flexibility. Neuropharmacology. vol 197. 2021-10-14. PMID:34273386. |
cognitive flexibility is reliably observed to decline at advanced ages, coinciding with changes in pfc glutamate receptor expression and neuronal physiology. |
2021-10-14 |
2023-08-13 |
rat |
| Robert S Talay, Yaling Liu, Matthew Michael, Anna Li, Isabel D Friesner, Fei Zeng, Guanghao Sun, Zhe Sage Chen, Qiaosheng Zhang, Jing Wan. Pharmacological restoration of anti-nociceptive functions in the prefrontal cortex relieves chronic pain. Progress in neurobiology. vol 201. 2021-10-07. PMID:33545233. |
here, we studied the nociceptive response of neurons in the prelimbic region of the prefrontal cortex (pl-pfc) in freely behaving rats using a spared nerve injury (sni) model of chronic pain, and the impact of ampakines, a class of drugs that increase central glutamate signaling, on such response. |
2021-10-07 |
2023-08-13 |
rat |
| Robert A McCutcheon, Kate Merritt, Oliver D Howe. Dopamine and glutamate in individuals at high risk for psychosis: a meta-analysis of in vivo imaging findings and their variability compared to controls. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 3. 2021-09-23. PMID:34505389. |
there were no significant differences between high-risk individuals and controls in striatal presynaptic dopaminergic function, striatal d2/d3 receptor availability, prefrontal cortex glutamate or glx, hippocampal glutamate or glx, or basal ganglia glx. |
2021-09-23 |
2023-08-13 |
Not clear |
| Matsuhiko Oka, Koki Ito, Minori Koga, Ichiro Kusum. Changes in subunit composition of NMDA receptors in animal models of schizophrenia by repeated administration of methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32473191. |
repeated administration of meth significantly decreased the gene expression levels of glutamate ionotropic receptor nmda type subunit (grin) subtypes grin1 and grin2c in the prefrontal cortex (pfc), grin1 and grin2a in the hippocampus (hpc), and grin1, grin2b, and grin2d in the striatum (st).we observed a significant difference in grin1 expression between the pfc and st. |
2021-08-27 |
2023-08-13 |
mouse |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xiao-Qin Zhang, He-Jia Jiang, Le Xu, Si-Yu Yang, Gao-Zhe Wang, Hong-De Jiang, Teng Wu, Han Du, Zhi-Peng Yu, Qi-Qi Zhao, Yu Ling, Zhong-Yu Zhang, Hao-Wei She. The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation. Neuropharmacology. vol 177. 2021-08-12. PMID:32693006. |
given the critical role of metabotropic glutamate receptors (mglurs) in synaptic homeostasis of the prefrontal cortex (pfc), pharmacological intervention on mglurs has been attempted in order to improve cognitive dysfunction in animal models of neurodevelopmental disorder, as well as in clinical trials. |
2021-08-12 |
2023-08-13 |
mouse |
| Katie H Atmore, Dan J Stein, Brian H Harvey, Vivienne A Russell, Fleur M Howell. Differential effects of social isolation rearing on glutamate- and GABA-stimulated noradrenaline release in the rat prefrontal cortex and hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32553548. |
then at p90-94, ne release was measured in the pfc and hc after stimulating the tissue in vitro with either glutamate or gaba. |
2021-08-10 |
2023-08-13 |
rat |
| Katie H Atmore, Dan J Stein, Brian H Harvey, Vivienne A Russell, Fleur M Howell. Differential effects of social isolation rearing on glutamate- and GABA-stimulated noradrenaline release in the rat prefrontal cortex and hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32553548. |
sir pfc ne release was decreased when glutamate stimulation followed gaba stimulation and tended to increase when gaba stimulation followed glutamate stimulation, differences were predominantly due to male isolates. |
2021-08-10 |
2023-08-13 |
rat |
| M Giménez, M Cano, I Martínez-Zalacaín, E Real, P Alonso, C Segalàs, J Munuera, L S Kegeles, J J Weinstein, X Xu, J M Menchón, N Cardoner, C Soriano-Mas, M A Fullan. Is glutamate associated with fear extinction and cognitive behavior therapy outcome in OCD? A pilot study. European archives of psychiatry and clinical neuroscience. vol 270. issue 8. 2021-08-05. PMID:31432262. |
fear extinction is linked to structural and functional variability in the ventromedial prefrontal cortex (vmpfc) and has been consistently associated with glutamate neurotransmission. |
2021-08-05 |
2023-08-13 |
Not clear |
| Zi-Jun Wang, Ben Rein, Ping Zhong, Jamal Williams, Qing Cao, Fengwei Yang, Freddy Zhang, Kaijie Ma, Zhen Ya. Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 9. 2021-08-04. PMID:34007043. |
kmt5b deficiency also produces deficits in pfc glutamatergic synaptic transmission, which is accompanied by the reduced synaptic expression of glutamate receptor subunits and associated proteins. |
2021-08-04 |
2023-08-13 |
mouse |
| Tiago Marcon Dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, André Quincozes-Santos, Angela T S Wys. Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect? Cellular and molecular neurobiology. 2021-07-29. PMID:34324129. |
in the present study, we evaluated the emotional behavior and neurochemical pathways (atpases, glutamate homeostasis, and cell viability) in amygdala and prefrontal cortex rats subjected to mild hyperhomocysteinemia (in vivo studies). |
2021-07-29 |
2023-08-13 |
rat |
| Sharon Sima Lander, Sergiy Chornyy, Hazem Safory, Amit Gross, Herman Wolosker, Inna Gaisler-Salomo. Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory. Genes, brain, and behavior. vol 19. issue 6. 2021-07-16. PMID:31898404. |
glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory. |
2021-07-16 |
2023-08-13 |
mouse |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |
| Beata R Godlewska, Amedeo Minichino, Uzay Emir, Ilinca Angelescu, Belinda Lennox, Masa Micunovic, Oliver Howes, Philip J Cowe. Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case-control study at 7 T. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34226485. |
this study aimed to use high-field (7 t) mrs to measure concentrations of glutamate and glutamine in three brain regions, anterior cingulate cortex (acc), dorsolateral prefrontal cortex (dlpfc) and putamen (put), in young men with early psychosis. |
2021-07-14 |
2023-08-13 |
human |
| Hyeonwi Son, Ji Hyeong Baek, Jae Soon Kang, Soonwoong Jung, Hye Jin Chung, Hyun Joon Ki. Acutely increased β-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response. Biochemical and biophysical research communications. vol 554. 2021-07-12. PMID:33774275. |
moreover, increased levels of acetyl-coa, pyruvate carboxylase, and glutamate dehydrogenase 1 were found in the pfc, implicating the metabolism of increased bhb in the brain. |
2021-07-12 |
2023-08-13 |
Not clear |
| Hyeonwi Son, Ji Hyeong Baek, Jae Soon Kang, Soonwoong Jung, Hye Jin Chung, Hyun Joon Ki. Acutely increased β-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response. Biochemical and biophysical research communications. vol 554. 2021-07-12. PMID:33774275. |
thus, we checked the levels of glutamate, glutamine, and gaba and found increased levels of glutamate and glutamine in the stressed group compared with that in the control group in the pfc. |
2021-07-12 |
2023-08-13 |
Not clear |
| Marcelo C Batistuzzo, Bruna A Sottili, Roseli G Shavitt, Antonio C Lopes, Carolina Cappi, Maria Alice de Mathis, Bruno Pastorello, Juliana B Diniz, Renata M F Silva, Euripedes C Miguel, Marcelo Q Hoexter, Maria C Otadu. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive-Compulsive Disorder. Frontiers in psychiatry. vol 12. 2021-06-26. PMID:34168581. |
lower ventromedial prefrontal cortex glutamate levels in patients with obsessive-compulsive disorder. |
2021-06-26 |
2023-08-13 |
Not clear |
| Jimmy Olusakin, Imane Moutkine, Sylvie Dumas, Evgeni Ponimaskin, Eleni Paizanis, Mariano Soiza-Reilly, Patricia Gaspa. Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 13. 2021-06-23. PMID:32688364. |
sert is transiently expressed in the glutamate neurons of the mouse pfc, that project to the drn. |
2021-06-23 |
2023-08-13 |
mouse |