| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Elena Teleuca, Giovanni Sebastiano Alemà, Paola Casolini, Ilaria Barberis, Francesco Ciabattoni, Rosamaria Orlando, Luisa Di Menna, Luisa Iacovelli, Maria Rosaria Scioli, Ferdinando Nicoletti, Anna Rita Zuen. Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330215. |
using an in vivo method for the assessment of polyphosphoinositide (pi) hydrolysis, we examine whether spatial learning and memory extinction cause changes in mglu5 metabotropic glutamate receptor signaling in the hippocampus and prefrontal cortex. |
2022-03-25 |
2023-08-13 |
mouse |
| Margaret L Westwater, Alexander G Murley, Kelly M J Diederen, T Adrian Carpenter, Hisham Ziauddeen, Paul C Fletche. Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior. Translational psychiatry. vol 12. issue 1. 2022-03-16. PMID:35292626. |
we therefore used single-voxel proton magnetic resonance spectroscopy to measure glutamate, myo-inositol, and naa in the right inferior lateral prefrontal cortex and the right occipital cortex of 85 women [n = 22 an (binge-eating/purging subtype; an-bp), n = 33 bn, n = 30 controls]. |
2022-03-16 |
2023-08-13 |
human |
| Ke Jia, Polytimi Frangou, Vasilis M Karlaftis, Joseph J Ziminski, Joseph Giorgio, Reuben Rideaux, Elisa Zamboni, Victoria Hodgson, Uzay Emir, Zoe Kourtz. Neurochemical and functional interactions for improved perceptual decisions through training. Journal of neurophysiology. 2022-03-02. PMID:35235415. |
glutamate, gaba) in sensory (early visual cortex: ev) and decision-related (dorsolateral prefrontal cortex: dlpfc) brain regions. |
2022-03-02 |
2023-08-13 |
Not clear |
| Ke Jia, Polytimi Frangou, Vasilis M Karlaftis, Joseph J Ziminski, Joseph Giorgio, Reuben Rideaux, Elisa Zamboni, Victoria Hodgson, Uzay Emir, Zoe Kourtz. Neurochemical and functional interactions for improved perceptual decisions through training. Journal of neurophysiology. 2022-03-02. PMID:35235415. |
these learning-dependent changes in decision processes relate to lower ev glutamate levels and ev-dlpfc connectivity, suggesting that glutamatergic excitation and functional interactions between visual and dorsolateral prefrontal cortex facilitate perceptual decisions. |
2022-03-02 |
2023-08-13 |
Not clear |
| Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomo. Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects. Schizophrenia bulletin. 2022-01-29. PMID:35092675. |
we found that urb597 prevented mk-801-induced novel object recognition deficits and social interaction abnormalities in adult rats, and reversed glutamate and gaba aberrations in the prelimbic pfc. |
2022-01-29 |
2023-08-13 |
rat |
| Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomo. Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects. Schizophrenia bulletin. 2022-01-29. PMID:35092675. |
together, our findings show that interfering with nmda receptor function in early adolescence has a lasting impact on phenotypes resembling the negative symptoms and cognitive deficits of schizophrenia and on glutamate and gaba marker expression in the pfc. |
2022-01-29 |
2023-08-13 |
rat |
| Jing Gao, Mingyin Lai, Wen Fu, Mengyu Wang, Thi Thanh Tam Mai, Baile Ning, Wenbin F. Electroacupuncture Ameliorates Depressive-Like State and Synaptic Deficits Induced by Hyper-Cholinergic Tone During Chronic Stress in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-20. PMID:34924558. |
consistent with the behavior tests and cholinergic tones, there were increased spine density and expressions of synaptic proteins, including brain-derived neurotrophic factor (bdnf), glutamate receptor 1 (glur1), glutamate receptor 2 (glur2), postsynaptic density protein 95 (psd95), and synapsin i in the pfc. |
2021-12-20 |
2023-08-13 |
rat |
| Pallab Bhattacharyya, Amit Anand, Jian Lin, Murat Altina. Left Dorsolateral Prefrontal Cortex Glx/tCr Predicts Efficacy of High Frequency 4- to 6-Week rTMS Treatment and Is Associated With Symptom Improvement in Adults With Major Depressive Disorder: Findings From a Pilot Study. Frontiers in psychiatry. vol 12. 2021-12-20. PMID:34925079. |
given the significance of excitatory and inhibitory neurotransmitters glutamate (glu) and gamma aminobutyric acid (gaba) in the pathophysiology of mdd, and the involvement of the site of rtms application, left dorsolateral prefrontal cortex (ldlpfc), in mdd, we explored ldlpfc glx (glu + glutamine) and gaba levels, measured by single voxel magnetic resonance spectroscopy (mrs) with total creatine (tcr; sum of creatine and phosphocreatine) as reference, as possible biomarkers of rtms response prediction. |
2021-12-20 |
2023-08-13 |
Not clear |
| Gil D Hoftman, H Holly Bazmi, Andrew J Ciesielski, Liban A Dinka, Kehui Chen, David A Lewi. Postnatal Development of Glutamate and GABA Transcript Expression in Monkey Visual, Parietal, and Prefrontal Cortices. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-12-08. PMID:33279960. |
in layer 3 of adult human neocortex, molecular markers of glutamate neurotransmission were lowest in v1 and highest in pfc, whereas gaba markers had the reverse pattern. |
2021-12-08 |
2023-08-13 |
human |
| Dibyadeep Datta, Shannon N Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P Mecca, Barbara S Slusher, Angus C Nairn, Amy F T Arnste. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867287. |
glutamate carboxypeptidase ii in aging rat prefrontal cortex impairs working memory performance. |
2021-12-07 |
2023-08-13 |
rat |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-ht1a, gaba, glutamate receptor expression in the rat prefrontal cortex. |
2021-11-29 |
2023-08-13 |
rat |
| Venkatesh Gunasekaran, Anitta Augustine, Jinu Avarachan, Abdul Khayum, Arivukkarasu Ramasam. 3-O-Acetyl-11-keto-β-boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats. Clinical and experimental pharmacology & physiology. vol 48. issue 12. 2021-11-18. PMID:34343356. |
plasma corticosterone and brain glutamate level was decreased and gaba level were increased significantly evident with gad activation in akba-treated animals, further confirmed with decreased gr expression improves architecture of prefrontal cortex region. |
2021-11-18 |
2023-08-13 |
rat |
| Max E Joffe, Chiaki I Santiago, Sheryl Anne D Vermudez, Nicole M Fisher, Shalini Dogra, Colleen M Niswender, P Jeffrey Con. Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 12. 2021-11-10. PMID:34035469. |
frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mglu clinical and translational studies suggest that prefrontal cortex (pfc) dysregulation is a hallmark feature of several affective disorders. |
2021-11-10 |
2023-08-13 |
Not clear |
| Alvin S Chiu, Matthew C Kang, Laura L Huerta Sanchez, Anne M Fabella, Kalysta N Holder, Brooke D Barger, Kristina N Elias, Christina B Shin, C Leonardo Jimenez Chavez, Tod E Kippin, Karen K Szumlinsk. Preclinical evidence to support repurposing everolimus for craving reduction during protracted drug withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 12. 2021-11-10. PMID:34188183. |
in a rat model, these addiction-related behavioral pathologies are mediated, respectively, by time-dependent increases in pi3k/akt1 signaling and reduced group 1 metabotropic glutamate receptor (mglu) expression, within the ventromedial prefrontal cortex (vmpfc). |
2021-11-10 |
2023-08-13 |
rat |
| Cora E Smiley, Heyam K Saleh, Katherine E Nimchuk, Constanza Garcia-Keller, Justin T Gas. Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behavioural brain research. vol 415. 2021-11-04. PMID:34389427. |
additionally, exposure to cannabis, alcohol, and stress can induce alterations in glutamate regulation and homeostasis in the prefrontal cortex (pfc) that may lead to impairments in neuronal functioning and cognition. |
2021-11-04 |
2023-08-13 |
Not clear |
| Sara R Westbrook, Megan R Dwyer, Laura R Cortes, Joshua M Gulle. Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats. Behavioural brain research. vol 390. 2021-10-25. PMID:32437887. |
the mechanisms for these age and gender differences remain obscure, but studies in rodents suggest that psychostimulants may disrupt the normal ontogeny of dopamine and glutamate systems in the prefrontal cortex (pfc). |
2021-10-25 |
2023-08-13 |
rat |
| Steven R Laviolett. Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders. Neuropharmacology. vol 184. 2021-10-22. PMID:33245960. |
nicotine can potently regulate the transmission of various neurochemicals, including dopamine (da), γ-amino-butyric acid (gaba) and glutamate, within various mesocorticolimbic structures, such as the ventral tegmental area (vta), nucleus accumbens (nac) and prefrontal cortex (pfc), all of which show pathologies in these disorders. |
2021-10-22 |
2023-08-13 |
Not clear |
| Scott A Bullock, Marc N Potenz. Pathological Gambling: Neuropsychopharmacology and Treatment. Current psychopharmacology. vol 1. issue 1. 2021-10-21. PMID:24349964. |
cortico-limbic circuitry involving the ventral striatum, ventromedial prefrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex are discussed as are the neurotransmitters norepinephrine, serotonin, dopamine, opioids, glutamate, and gamma-aminobutyric acid (gaba). |
2021-10-21 |
2023-08-12 |
Not clear |
| Y Sar. Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA alcohol. vol 1. issue 1. 2021-10-21. PMID:24409344. |
alcohol-seeking behaviour is promoted by increased glutamate transmission in key regions of the mesocorticolimbic reward circuit, including the nucleus accumbens and prefrontal cortex. |
2021-10-21 |
2023-08-12 |
human |
| Lily R Aleksandrova, Anthony G Phillip. Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics. Trends in pharmacological sciences. vol 42. issue 11. 2021-10-19. PMID:34565579. |
through their primary glutamate or serotonin receptor targets, ketamine and psychedelics [psilocybin, lysergic acid diethylamide (lsd), and n,n-dimethyltryptamine (dmt)] induce synaptic, structural, and functional changes, particularly in pyramidal neurons in the prefrontal cortex. |
2021-10-19 |
2023-08-13 |
Not clear |