| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco de Borja Belloch, María Cortés-Erice, Etienne Herzog, Xiao Min Zhang, Teresa Díaz-Perdigon, Elena Puerta, Rosa M Torder. Fast antidepressant action of ketamine in mouse models requires normal VGLUT1 levels from prefrontal cortex neurons. Progress in neuro-psychopharmacology & biological psychiatry. 2022-10-09. PMID:36209771. |
we analyzed anhedonia and helpless behavior as well as the expression of the proteins linked to glutamate transmission in the pfc of mice treated with ketamine or the reference antidepressant reboxetine. |
2022-10-09 |
2023-08-14 |
mouse |
| Kelsey Barcomb, Samantha S Olah, Matthew J Kennedy, Christopher P For. Properties and modulation of excitatory inputs to the locus coeruleus. The Journal of physiology. 2022-09-26. PMID:36156249. |
excitatory inputs to the locus coeruleus (lc) are important for driving norepinephrine neuron activity and downstream behaviors in response to salient stimuli, but little is known about the functional properties of different glutamate inputs that innervate these neurons we used a viral-mediated optogenetic approach to compare glutamate afferents from the prefrontal cortex (pfc), the lateral hypothalamus (lh) and the periaqueductal grey (pag). |
2022-09-26 |
2023-08-14 |
Not clear |
| Maiko A Schneider, Devon Malhotra, Poli M Spritzer, Taylor Hatchard, Luciano Minuzzi, Benicio N Frey, Sasha A Haefner, Andrew Nicholson, Margaret McKinnon, Sabrina K Syan, Taiane de Azevedo Cardoso, Karine Schwarz, Maurício Anés, Alejandro Santos-Díaz, Maria I R Lobat. Estradiol Replacement as a Potential Enhancer of Working Memory and Neuroplasticity in Hypogonadal Trans Women. Neuroendocrinology. 2022-09-21. PMID:36130584. |
the present study examined the effect of estradiol administration in humans on glutamate concentration in brain regions involved in semantic and working memory (i.e., the dorsolateral prefrontal cortex (dlpfc), the posterior hippocampus, and the pregenual anterior cingulate cortex (acc)) and its relationship with memory. |
2022-09-21 |
2023-08-14 |
Not clear |
| Jelena Martinovic, Marina Zaric Kontic, Milorad Dragic, Ana Todorovic, Ivana Gusevac Stojanovic, Natasa Mitrovic, Ivana Grkovic, Dunja Drakuli. Chronic oral d-galactose intake provokes age-related changes in the rat prefrontal cortex. Behavioural brain research. 2022-08-28. PMID:36030906. |
these changes in the pfc were further accompanied with decreased levels of vesicular glutamate transporter 1, syntaxin-1 and nmda receptor 2b subunit in both treated groups. |
2022-08-28 |
2023-08-14 |
rat |
| Hui Yao, Dalin Zhang, Hao Yu, Hui Shen, Xinze Lan, Hao Liu, Xiaohuan Chen, Xu Wu, Guohua Zhang, Xiaolong Wan. Chronic ethanol exposure induced anxiety-like behaviour by altering gut microbiota and GABA system. Addiction biology. vol 27. issue 5. 2022-08-24. PMID:36001417. |
minocycline also attenuated ethanol-induced apoptosis and decreased expression of glutamate decarboxylases (gads) and gabra1 in the prefrontal cortex. |
2022-08-24 |
2023-08-14 |
mouse |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| Emma Scholey, Matthew A J App. Fatigue: Tough days at work change your prefrontal metabolites. Current biology : CB. vol 32. issue 16. 2022-08-23. PMID:35998595. |
new measurements of the metabolite and neurotransmitter glutamate in prefrontal cortex after a day of hard work indicate that it may be a brain marker of mental fatigue, re-energising searches for the biological roots of fatigue. |
2022-08-23 |
2023-08-14 |
Not clear |
| Antonius Wiehler, Francesca Branzoli, Isaac Adanyeguh, Fanny Mochel, Mathias Pessiglion. A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions. Current biology : CB. 2022-08-12. PMID:35961314. |
at the end of the day, high-demand cognitive work resulted in higher glutamate concentration and glutamate/glutamine diffusion in a cognitive control brain region (lateral prefrontal cortex [lpfc]), relative to low-demand cognitive work and to a reference brain region (primary visual cortex [v1]). |
2022-08-12 |
2023-08-14 |
human |
| Elisa M T Melloni, Beatrice Bravi, Sara Poletti, Sara Dallaspezia, Barbara Barbini, Raffaella Zanardi, Francesco Benedett. Antidepressant chronotherapeutics normalizes prefrontal Progress in neuro-psychopharmacology & biological psychiatry. 2022-07-17. PMID:35843368. |
here we explored the effects of tsd + lt on dorsolateral prefrontal cortex (dlpfc) glutamate and/or glutamine+glutamate (glx) levels. |
2022-07-17 |
2023-08-14 |
Not clear |
| Yvonne S Yang, Richard J Maddock, Huailin Zhang, Junghee Lee, Gerhard Hellemann, Stephen R Marder, Michael F Gree. N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study. Psychiatry research. Neuroimaging. vol 325. 2022-07-15. PMID:35839558. |
we found that nac treatment was associated with increased glutathione (statistically significant) and decreased glutamate (trend-level) compared with placebo in medial prefrontal cortex but not dorsolateral prefrontal cortex. |
2022-07-15 |
2023-08-14 |
Not clear |
| Xiaoyan Ma, Shuo Yang, Zhaoxiang Zhang, Luping Liu, Wenli Shi, Sungchil Yang, Shupeng Li, Xiang Cai, Qiang Zho. Rapid and sustained restoration of astrocytic functions by ketamine in depression model mice. Biochemical and biophysical research communications. vol 616. 2022-06-02. PMID:35653826. |
these behavioral anti-depressant effects are associated with normalized expression of glutamate transporter-1(glt-1), glial fibrillary acidic protein (gfap), brain-derived neurotrophic factor (bdnf) and eukaryotic elongation factor 2 phosphorylation (p-eef2) in the prelimbic prefrontal cortex (prl-pfc). |
2022-06-02 |
2023-08-14 |
mouse |
| Simon Maier, Ansgard Lena Düppers, Kimon Runge, Michael Dacko, Thomas Lange, Thomas Fangmeier, Andreas Riedel, Dieter Ebert, Dominique Endres, Katharina Domschke, Evgeniy Perlov, Kathrin Nickel, Ludger Tebartz van Els. Increased prefrontal GABA concentrations in adults with autism spectrum disorders. Autism research : official journal of the International Society for Autism Research. 2022-05-19. PMID:35587691. |
the aim of this study was to replicate our previous findings of impaired glutamate metabolism in asd in a new sample and to additionally quantify gaba in the acc and dorsolateral prefrontal cortex (dlpfc). |
2022-05-19 |
2023-08-13 |
Not clear |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
while the majority of addiction research has implicated the dopamine system, the long-term neuroplasticity that maintains ma use disorder also involves drug-induced changes in glutamate signaling in reward regions of the brain like the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2022-05-13 |
2023-08-13 |
Not clear |
| Laura L Huerta Sanchez, Mariana Lanz, Hoa Doan, Taylor Li, Karen Szumlinsk. Sucrose reinforcement effects following inhibition of AMPA and NMDA-type glutamate receptors in the ventromedial prefrontal cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560660. |
sucrose reinforcement effects following inhibition of ampa and nmda-type glutamate receptors in the ventromedial prefrontal cortex. |
2022-05-13 |
2023-08-13 |
rat |
| Laura L Huerta Sanchez, Mariana Lanz, Hoa Doan, Taylor Li, Karen Szumlinsk. Sucrose reinforcement effects following inhibition of AMPA and NMDA-type glutamate receptors in the ventromedial prefrontal cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560660. |
sucrose-experienced rats exhibit blunted glutamate release within the ventromedial prefrontal cortex (vmpfc) while cocaine-experienced rats exhibit increased cue-induced glutamate release within the vmpfc. |
2022-05-13 |
2023-08-13 |
rat |
| Carolyn E Jones, Alex Q Chau, Randall J Olson, Cynthia Moore, Peyton T Wickham, Niyati Puranik, Marina Guizzetti, Hung Cao, Charles K Meshul, Miranda M Li. Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles. Current research in neurobiology. vol 2. 2022-05-04. PMID:35505895. |
early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles. |
2022-05-04 |
2023-08-13 |
Not clear |
| Nathalie Sala, Caterina Paoli, Tiziana Bonifacino, Jessica Mingardi, Emanuele Schiavon, Luca La Via, Marco Milanese, Paolo Tornese, Ashok K Datusalia, Jessica Rosa, Roberta Facchinetti, Giulia Frumento, Giulia Carini, Floramarida Salerno Scarzella, Caterina Scuderi, Lia Forti, Alessandro Barbon, Giambattista Bonanno, Maurizio Popoli, Laura Musazz. Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370690. |
recently, we dissected the destabilizing effects of acute stress on the excitatory glutamate system in the prefrontal cortex (pfc). |
2022-04-04 |
2023-08-13 |
rat |
| Nathalie Sala, Caterina Paoli, Tiziana Bonifacino, Jessica Mingardi, Emanuele Schiavon, Luca La Via, Marco Milanese, Paolo Tornese, Ashok K Datusalia, Jessica Rosa, Roberta Facchinetti, Giulia Frumento, Giulia Carini, Floramarida Salerno Scarzella, Caterina Scuderi, Lia Forti, Alessandro Barbon, Giambattista Bonanno, Maurizio Popoli, Laura Musazz. Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370690. |
here, we assessed the effects of single subanesthetic administration of ketamine (10 mg/kg) on glutamate transmission and dendritic arborization in the pfc of footshock (fs)-stressed rats, along with changes in depressive, anxious, and fear extinction behaviors. |
2022-04-04 |
2023-08-13 |
rat |
| Nathalie Sala, Caterina Paoli, Tiziana Bonifacino, Jessica Mingardi, Emanuele Schiavon, Luca La Via, Marco Milanese, Paolo Tornese, Ashok K Datusalia, Jessica Rosa, Roberta Facchinetti, Giulia Frumento, Giulia Carini, Floramarida Salerno Scarzella, Caterina Scuderi, Lia Forti, Alessandro Barbon, Giambattista Bonanno, Maurizio Popoli, Laura Musazz. Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370690. |
we found that ketamine, while inducing a mild increase of glutamate release in the pfc of naïve rats, blocked the acute stress-induced enhancement of glutamate release when administered 24 or 72 h before or 6 h after fs. |
2022-04-04 |
2023-08-13 |
rat |
| Ana Elena Teleuca, Giovanni Sebastiano Alemà, Paola Casolini, Ilaria Barberis, Francesco Ciabattoni, Rosamaria Orlando, Luisa Di Menna, Luisa Iacovelli, Maria Rosaria Scioli, Ferdinando Nicoletti, Anna Rita Zuen. Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330215. |
using an in vivo method for the assessment of polyphosphoinositide (pi) hydrolysis, we examine whether spatial learning and memory extinction cause changes in mglu5 metabotropic glutamate receptor signaling in the hippocampus and prefrontal cortex. |
2022-03-25 |
2023-08-13 |
mouse |