| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G N Woodruff, K J Watling, C D Andrews, J A Poat, J D McDerme. Dopamine receptors in rat striatum and nucleus accumbens; conformational studies using rigid analogues of dopamine. The Journal of pharmacy and pharmacology. vol 29. issue 7. 1977-10-14. PMID:19581. |
the most active compounds on adenylate cyclase from both striatum and nucleus accumbens were dopamine and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene(6,7-diohatn). |
1977-10-14 |
2023-08-11 |
rat |
| M Miyamoto, Y Nagaw. Mesolimbic involvement in the locomotor stimulant action of thyrotropin-releasing hormone (TRH) in rats. European journal of pharmacology. vol 44. issue 2. 1977-09-29. PMID:407089. |
the locomotor stimulation was also produced by bilateral injection of trh and dopamine (da) into the nucleus accumbens but not by bilateral injection of these substances into the caudate nucleus. |
1977-09-29 |
2023-08-11 |
rat |
| B Costall, R J Naylor, J G Cannon, T Le. Differentiation of the dopamine mechanisms mediating stereotyped behaviour and hyperactivity in the nucleus accumbens and caudate-putamen. The Journal of pharmacy and pharmacology. vol 29. issue 6. 1977-09-22. PMID:18569. |
differentiation of the dopamine mechanisms mediating stereotyped behaviour and hyperactivity in the nucleus accumbens and caudate-putamen. |
1977-09-22 |
2023-08-11 |
Not clear |
| N E Andé. Functional effects of local injections of dopamine and analogs into the neostriatum and nucleus accumbens. Advances in biochemical psychopharmacology. vol 16. 1977-09-17. PMID:196491. |
functional effects of local injections of dopamine and analogs into the neostriatum and nucleus accumbens. |
1977-09-17 |
2023-08-11 |
Not clear |
| T J Crow, J F Deakin, A Longde. The nucleus accumbens--possible site of antipsychotic action of neuroleptic drugs? Psychological medicine. vol 7. issue 2. 1977-08-12. PMID:560024. |
the hypothesis that neuroleptic drugs exert their therapeutic effects by blocking dopaminergic transmission has been investigated by examining the effects of 3 neuroleptic drugs on dopamine turnover in 2 dopaminergically innervated regions of brain--the neostriatum and nucleus accumbens. |
1977-08-12 |
2023-08-11 |
rat |
| T J Crow, J F Deakin, A Longde. The nucleus accumbens--possible site of antipsychotic action of neuroleptic drugs? Psychological medicine. vol 7. issue 2. 1977-08-12. PMID:560024. |
while the concentrations of dopamine metabolites in the frontal cortex were too low to assess the possibility that neuroleptic drugs have actions at this level, our results are consistent with the hypothesis that these drugs exert their therapeutic effects by dopamine receptor blockade in the nucleus accumbens. |
1977-08-12 |
2023-08-11 |
rat |
| P S McCarthy, R J Walker, G N Woodruf. On the depressant action of dopamine in rat caudate nucleus and nucleus accumbens [proceedings]. British journal of pharmacology. vol 59. issue 3. 1977-05-20. PMID:843711. |
on the depressant action of dopamine in rat caudate nucleus and nucleus accumbens [proceedings]. |
1977-05-20 |
2023-08-11 |
rat |
| B Costall, R J Naylor, J G Cannon, T Le. Differential activation by some 2-aminotetralin derivatives of the receptor mechanisms in the nucleus accumbens of rats which mediate hyperactivity and stereotyped biting. European journal of pharmacology. vol 41. issue 3. 1977-04-15. PMID:556988. |
a series of 2-aminotetralin derivatives were injected into the nucleus accumbens of rat to assess the nature of the dopamine mechanisms in this nucleus which modulate hyperactivity and stereotyped behaviour. |
1977-04-15 |
2023-08-11 |
rat |
| B Costall, R J Naylor, J G Cannon, T Le. Differential activation by some 2-aminotetralin derivatives of the receptor mechanisms in the nucleus accumbens of rats which mediate hyperactivity and stereotyped biting. European journal of pharmacology. vol 41. issue 3. 1977-04-15. PMID:556988. |
it is concluded that the dopamine mechanisms in the nucleus accumbens which mediate/regulate hyperactivity and stereotyped behaviour are different. |
1977-04-15 |
2023-08-11 |
rat |
| K Fuxe, P Eneroth, J A Gustafsson, A Löfström, P Sket. Dopamine in the nucleus accumbens: preferential increase of DA turnover by rat prolactin. Brain research. vol 122. issue 1. 1977-04-15. PMID:837221. |
dopamine in the nucleus accumbens: preferential increase of da turnover by rat prolactin. |
1977-04-15 |
2023-08-11 |
rat |
| B Costall, R J Naylo. Aporphines, 21. (1,2) Dopaminergic activity of aporphine and benzylisoquinoline derivatives. Synthesis of 8-hydroxyaporphines and 1-(hydroxybenzyl)-2-n-propyl-1,2,3,4-tetrahydroisoquinolines. Journal of medicinal chemistry. vol 20. issue 2. 1977-04-01. PMID:556776. |
2,3b, 4 and 5 neither enhanced locomotor activity on direct injection into the nucleus accumbens nor antagonized the hyperactivity response to intraacumbens dopamine when administered peripherally. |
1977-04-01 |
2023-08-11 |
Not clear |
| P Protais, J Costentin, J C Schwart. Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology. vol 50. issue 1. 1977-03-31. PMID:827755. |
this peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxy-dopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. |
1977-03-31 |
2023-08-11 |
mouse |
| J Engel, S Liljequis. The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology. vol 49. issue 3. 1977-02-16. PMID:826942. |
the effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. |
1977-02-16 |
2023-08-11 |
rat |
| J Engel, S Liljequis. The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology. vol 49. issue 3. 1977-02-16. PMID:826942. |
the effect of local application of dopamine into the nucleus accumbens on locomotor activity was studied in rats during and after withdrawal of long-term ethanol treatment. |
1977-02-16 |
2023-08-11 |
rat |
| J Engel, S Liljequis. The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology. vol 49. issue 3. 1977-02-16. PMID:826942. |
the bilateral application of dopamine into the nucleus accumbens of both the ethanol and withdrawal rats produced a pronounced increase in coordinated locomotor activity, which was 8-10 times higher than that of untreated water control rats. |
1977-02-16 |
2023-08-11 |
rat |
| J Engel, S Liljequis. The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology. vol 49. issue 3. 1977-02-16. PMID:826942. |
it is concluded that prolonged ethanol administration may produce an increased sensitivity of the dopamine receptors in the nucleus accumbens and further support the contention that central catecholamine mechanisms are involved in the mediation of the withdrawal syndrome observed after long-term treatment with ethanol. |
1977-02-16 |
2023-08-11 |
rat |
| B Costall, R J Naylo. A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems. European journal of pharmacology. vol 40. issue 1. 1977-01-28. PMID:791660. |
dopamine injected directly into the caudate--putamen, nucleus accumbens or tuberculum olfactorium of rat brain, following a nialamide pretreatment, caused dose-dependent hyperactivity. |
1977-01-28 |
2023-08-11 |
rat |
| B Costall, R J Naylo. A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems. European journal of pharmacology. vol 40. issue 1. 1977-01-28. PMID:791660. |
sulpiride, clozapine and thioridazine also caused dose-dependent reductions in the hyperactivity induced by dopamine injections into the caudata--putamen, nucleus accumbens and tuberculum olfactorium, although the doses required to effect this inhibition were notably larger than for the typical neuroleptics. |
1977-01-28 |
2023-08-11 |
rat |
| B Costall, R J Naylo. A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems. European journal of pharmacology. vol 40. issue 1. 1977-01-28. PMID:791660. |
metoclopramide differed from all other agents tested in failing to antagonise the hyperactivity induced by dopamine injections into the nucleus accumbens. |
1977-01-28 |
2023-08-11 |
rat |
| B Costall, R J Naylo. A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems. European journal of pharmacology. vol 40. issue 1. 1977-01-28. PMID:791660. |
the alpha- and beta-adrenergic blocking agents, aceperone and propranolol, failed to reduce the hyperactivity induced by dopamine injections into the caudate-putamen, nucleus accumbens or tuberculum olfactorium. |
1977-01-28 |
2023-08-11 |
rat |