| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Karatayev, Jessica R Barson, Guo-Qing Chang, Sarah F Leibowit. Hypothalamic injection of non-opioid peptides increases gene expression of the opioid enkephalin in hypothalamic and mesolimbic nuclei: Possible mechanism underlying their behavioral effects. Peptides. vol 30. issue 12. 2010-02-17. PMID:19782113. |
they were sacrificed 1h later for analysis of enk mrna levels in the pvn, ventral tegmental area (vta), central nucleus of the amygdala (cea), and nucleus accumbens (nac). |
2010-02-17 |
2023-08-12 |
rat |
| M J Hunt, P Matulewicz, C Gottesmann, S Kasick. State-dependent changes in high-frequency oscillations recorded in the rat nucleus accumbens. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19716859. |
among the local field potentials recorded in the rat nucleus accumbens (nac) spontaneous high frequency oscillations (hfo) are typically represented by a small peak in the power spectra in the range of 140-180 hz. |
2010-02-12 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Xia Li, Xiao-Qing Peng, Jie Li, Lauren Chun, Eliot L Gardner, Ajit G Thomas, Barbara S Slusher, Charles R Ashb. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895667. |
microinjections of 2-pmpa (3-5 microg/side) or naag (3-5 microg/side) into the nucleus accumbens (nac), but not into the dorsal striatum, also inhibited cocaine-induced reinstatement, an effect that was blocked by intra-nac injection of ly341495, a selective mglur2/3 antagonist. |
2010-02-05 |
2023-08-12 |
rat |
| Vasileios Boulougouris, Trevor W Robbin. Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 3. 2010-02-05. PMID:20089901. |
the roles of 5-ht(2c) and 5-ht(2a) receptors were examined within some of the brain regions implicated in cognitive flexibility, namely the orbitofrontal cortex (ofc), medial prefrontal cortex (mpfc), and nucleus accumbens (nac), by means of targeted infusions of selective 5-ht(2c) and 5-ht(2a) receptor antagonists (sb 242084 and m100907, respectively). |
2010-02-05 |
2023-08-12 |
Not clear |
| Karine Guillem, Laura L People. Progressive and lasting amplification of accumbal nicotine-seeking neural signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 1. 2010-02-04. PMID:20053909. |
although neuroadaptations in the nucleus accumbens (nac) are thought to contribute to nicotine addiction, little is known about the chronic effects of nicotine on nac neuronal activity. |
2010-02-04 |
2023-08-12 |
rat |
| Yun-Hai Qiu, Xin-Yin Wu, Hao Xu, David Sacket. Neuroimaging study of placebo analgesia in humans. Neuroscience bulletin. vol 25. issue 5. 2010-01-25. PMID:19784082. |
the mu-opioid receptor-selective radiotracer-labeled pet studies show that the placebo effects are accompanied by reduction in activation of opioid neural transmission in pain-sensitive brain regions, including racc, prefrontal cortex, insula, thalamus, amygdala, nucleus accumbens (nac) and pag. |
2010-01-25 |
2023-08-12 |
human |
| Mary Kay Lob. Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future. International review of neurobiology. vol 89. 2010-01-25. PMID:19900613. |
the two msn populations are morphologically identical except in their projections through the direct verses indirect bg pathways and they are heterogeneously dispersed throughout the dorsal striatum (dstr) and nucleus accumbens (nac). |
2010-01-25 |
2023-08-12 |
mouse |
| Yao-Ying Ma, Carlos Cepeda, Cai-Lian Cu. The role of striatal NMDA receptors in drug addiction. International review of neurobiology. vol 89. 2010-01-25. PMID:19900618. |
furthermore, selective blockade of nr2b-containing nmda receptors in the striatum, especially in the nucleus accumbens (nac) can inhibit drug craving and reinstatement. |
2010-01-25 |
2023-08-12 |
Not clear |
| Kathleen S Alexander, Julie M Brooks, Martin Sarter, John P Brun. Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 13. 2010-01-19. PMID:19693002. |
stimulation of nmda receptors in nucleus accumbens (nac) increases acetylcholine (ach) release in prefrontal cortex (pfc), an activation thought to contribute to attentional processing. |
2010-01-19 |
2023-08-12 |
rat |
| Ryan K Bachtell, David W Sel. Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats. Psychopharmacology. vol 206. issue 3. 2010-01-14. PMID:19641899. |
dopamine (da) receptor stimulation in the nucleus accumbens (nac) plays an important role in regulating cocaine-seeking behavior. |
2010-01-14 |
2023-08-12 |
rat |
| Arati S Kreibich, Lisa Briand, Jessica N Cleck, Laurel Ecke, Kenner C Rice, Julie A Blend. Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 12. 2010-01-12. PMID:19675537. |
furthermore, fs-induced increase in phosphorylated creb (pcreb), specifically in the lateral septum (ls) and nucleus accumbens (nac) is also blocked by antalarmin. |
2010-01-12 |
2023-08-12 |
mouse |
| Kelle M Franklin, Eric A Engleman, Cynthia M Ingraham, Joseph A McClaren, Carrie M Keith, William J McBride, James M Murph. A single, moderate ethanol exposure alters extracellular dopamine levels and dopamine d receptor function in the nucleus accumbens of wistar rats. Alcoholism, clinical and experimental research. vol 33. issue 10. 2010-01-11. PMID:19572982. |
the nucleus accumbens (nac) has been implicated in the neurochemical effects of ethanol (etoh). |
2010-01-11 |
2023-08-12 |
rat |
| Marco Bortolato, Roberto Frau, A Paola Piras, William Luesu, Valentina Bini, Giacomo Diaz, Gianluigi Gessa, M Grazia Ennas, M Paola Castell. Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity. Neurotoxicity research. vol 15. issue 3. 2010-01-08. PMID:19384596. |
at both 1 and 3 weeks after treatment, meth-injected rats exhibited a significant decline in the number of exploratory approaches to unfamiliar objects, which was significantly correlated with a parallel reduction in dat immunoreactivity (ir) in the nucleus accumbens (nac) core. |
2010-01-08 |
2023-08-12 |
rat |
| Chun-Mei Xu, Jun Wang, Ping Wu, Wei-Li Zhu, Qian-Qian Li, Yan-Xue Xue, Hai-Fen Zhai, Jie Shi, Lin L. Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization. Journal of neurochemistry. vol 111. issue 6. 2010-01-08. PMID:19799712. |
the present study investigated the effects of chronic cocaine exposure on gsk-3beta activity in the nucleus accumbens (nac) and determined whether changes in gsk-3beta activity in the nac are associated with cocaine-induced locomotor sensitization. |
2010-01-08 |
2023-08-12 |
rat |
| J Kuhn, R Bauer, S Pohl, D Lenartz, W Huff, E H Kim, J Klosterkoetter, V Stur. Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens. European addiction research. vol 15. issue 4. 2010-01-07. PMID:19622886. |
we explore whether clinical research on deep brain stimulation (dbs) of the nucleus accumbens (nac) to treat addiction is justified besides theoretical speculation. |
2010-01-07 |
2023-08-12 |
Not clear |
| Benjamin B Land, Michael R Bruchas, Selena Schattauer, William J Giardino, Megumi Aita, Daniel Messinger, Thomas S Hnasko, Richard D Palmiter, Charles Chavki. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 45. 2010-01-06. PMID:19864633. |
drn serotonergic neurons project broadly throughout the brain, but the inactivation of kor in the nucleus accumbens (nac) coupled with viral re-expression in the drn of kor ko mice demonstrated that aversion was encoded by a drn to nac projection. |
2010-01-06 |
2023-08-12 |
mouse |
| S J Wanchoo, A C Swann, N Dafn. Descending glutamatergic pathways of PFC are involved in acute and chronic action of methylphenidate. Brain research. vol 1301. 2010-01-05. PMID:19747456. |
since pfc sends glutamatergic afferents to both ventral tegmental area (vta) and nucleus accumbens (nac), sites that are involved in induction and expression of behavioral sensitization respectively and glutamate from pfc is known to modulate dopamine cell activity in vta and nac, this study investigated the role of descending glutamate from pfc in mpd elicited behavioral sensitization. |
2010-01-05 |
2023-08-12 |
Not clear |
| Susan M Ferguson, Nolan A Sandygren, John F Neumaie. Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19817843. |
in order to examine how these factors interact to influence the development of behaviors associated with addiction, we used viral-mediated gene transfer to transiently increase expression of 5-ht(1b) receptors in the nucleus accumbens (nac) shell along with exposure to repeated mild stress (novelty + saline injection) in rats. |
2010-01-05 |
2023-08-12 |
rat |
| Amy C Janes, Kathleen M Kantak, James A Cherr. The involvement of type IV phosphodiesterases in cocaine-induced sensitization and subsequent pERK expression in the mouse nucleus accumbens. Psychopharmacology. vol 206. issue 2. 2009-12-22. PMID:19588125. |
cocaine exposure produces sensitization that is partly mediated by cyclic adenosine monophosphate (camp) pathways within the nucleus accumbens (nac). |
2009-12-22 |
2023-08-12 |
mouse |
| Anna M Nelson, Gaynor A Larson, Nancy R Zahnise. Low or high cocaine responding rats differ in striatal extracellular dopamine levels and dopamine transporter number. The Journal of pharmacology and experimental therapeutics. vol 331. issue 3. 2009-12-22. PMID:19729579. |
paralleling their locomotor profiles, lcrs and hcrs had similar basal extracellular da levels in dorsal striatum (dstr) and nucleus accumbens (nac); after acute cocaine injection (10 mg/kg i.p. |
2009-12-22 |
2023-08-12 |
rat |