| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K J Jackson, Q Chen, J Chen, S H Aggen, K S Kendler, X Che. Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. The pharmacogenomics journal. vol 11. issue 4. 2011-11-15. PMID:20514075. |
in animal studies, western blot analyses show an increase of hint1 protein level in the mouse nucleus accumbens (nac) after chronic nicotine exposure. |
2011-11-15 |
2023-08-12 |
mouse |
| Bombi Lee, Sunoh Kwon, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-hyun Hah. Wild ginseng attenuates repeated morphine-induced behavioral sensitization in rats. Journal of microbiology and biotechnology. vol 21. issue 7. 2011-11-15. PMID:21791964. |
many studies have suggested that the behavioral and reinforcing effects of morphine are induced by hyperactivation of the mesolimbic dopaminergic system, which results in increases in locomotor activity, c-fos expression in the nucleus accumbens (nac), and tyrosine hydroxylase (th) in the ventral tegmental area (vta). |
2011-11-15 |
2023-08-12 |
rat |
| María Juliana Orejarena, Laurence Lanfumey, Rafael Maldonado, Patricia Robled. Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour. The international journal of neuropsychopharmacology. vol 14. issue 7. 2011-11-10. PMID:20942998. |
basal and mdma-stimulated extracellular levels of da in the nucleus accumbens (nac) and serotonin and noradrenaline in the prefrontal cortex were also assessed. |
2011-11-10 |
2023-08-12 |
mouse |
| Jian Sheng, Zhi gang Lv, Lei Wang, Yuqing Zhou, Bin Hu. Histone H3 phosphoacetylation is critical for heroin-induced place preference. Neuroreport. vol 22. issue 12. 2011-11-10. PMID:21734607. |
we investigated the role of histone h3 phosphoacetylation in the nucleus accumbens (nac) in heroin-conditioned place preference paradigm. |
2011-11-10 |
2023-08-12 |
Not clear |
| Helena J V Rutherford, Sarah K Williams, Sheryl Moy, Linda C Mayes, Josephine M John. Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems. Frontiers in psychiatry. vol 2. 2011-11-10. PMID:21779252. |
therefore, addiction reflects the dysregulation between core reward systems, including the prefrontal cortex (pfc), ventral tegmental area (vta), and nucleus accumbens (nac), as well as the hypothalamic-pituitary-adrenal axis and extended amygdala of the stress system. |
2011-11-10 |
2023-08-12 |
human |
| Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun Su. The Role of BDNF/TrkB Signaling in Acute Amphetamine-Induced Locomotor Activity and Opioid Peptide Gene Expression in the Rat Dorsal Striatum. Frontiers in systems neuroscience. vol 5. 2011-11-10. PMID:21811445. |
injection, the caudate-putamen (cpu), nucleus accumbens (nac), and dorsomedial prefrontal cortex (dmpfc) were extracted and processed for phospho (p)-trkb immunoreactivity. |
2011-11-10 |
2023-08-12 |
rat |
| Nora D Volkow, Gene-Jack Wang, Joanna S Fowler, Dardo Tomasi, Frank Telan. Addiction: beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 37. 2011-11-09. PMID:21402948. |
these studies have corroborated in humans the relevance of drug-induced fast da increases in striatum [including nucleus accumbens (nac)] in their rewarding effects but have unexpectedly shown that in addicted subjects, drug-induced da increases (as well as their subjective reinforcing effects) are markedly blunted compared with controls. |
2011-11-09 |
2023-08-12 |
human |
| Jean-Raymond Teyssier, Sylviane Ragot, Jean-Christophe Chauvet-Gélinier, Benoit Trojak, Bernard Boni. Activation of a ΔFOSB dependent gene expression pattern in the dorsolateral prefrontal cortex of patients with major depressive disorder. Journal of affective disorders. vol 133. issue 1-2. 2011-11-07. PMID:21616539. |
a Δfosb mediated transcriptional response in the nucleus accumbens (nac) is induced by chronic social stress in rodent and a 50% down-regulation of Δfosb has been also reported in the nac of eight depressed subjects. |
2011-11-07 |
2023-08-12 |
human |
| Herbert E Covington, Ian Maze, HaoSheng Sun, Howard M Bomze, Kristine D DeMaio, Emma Y Wu, David M Dietz, Mary Kay Lobo, Subroto Ghose, Ezekiel Mouzon, Rachael L Neve, Carol A Tamminga, Eric J Nestle. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. vol 71. issue 4. 2011-10-25. PMID:21867882. |
here, we identify repressive histone methylation in nucleus accumbens (nac), an important brain reward region, as a key mechanism linking cocaine exposure to increased stress vulnerability. |
2011-10-25 |
2023-08-12 |
mouse |
| John J Byrnes, Erin D Gleason, Matthew K Schoen, Mathew T Schoen, Dennis F Lovelock, Lindsay M Carini, Elizabeth M Byrnes, Robert S Bridge. Accelerated maternal responding following intra-VTA pertussis toxin treatment. Behavioural brain research. vol 223. issue 2. 2011-10-24. PMID:21571006. |
accordingly, the ventral tegmental area (vta) and its dopaminergic projections to the nucleus accumbens (nac) and medial prefrontal cortex (mpfc) have been implicated in both the onset and maintenance of normal maternal behavior. |
2011-10-24 |
2023-08-12 |
rat |
| Candice M Klingerman, Anand Patel, Valerie L Hedges, Robert L Meisel, Jill E Schneide. Food restriction dissociates sexual motivation, sexual performance, and the rewarding consequences of copulation in female Syrian hamsters. Behavioural brain research. vol 223. issue 2. 2011-10-24. PMID:21600244. |
in hamsters, formation of a conditioned place preference (cpp) for copulatory reward is reflected in increased nucleus accumbens (nac) neural activation, measured as immunocytochemical staining for c-fos, the protein product of the immediate-early gene, c-fos. |
2011-10-24 |
2023-08-12 |
Not clear |
| Arif Muhammad, Bryan Kol. Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21515311. |
the spine density was examined in the nucleus accumbens (nac), the medial prefrontal cortex (mpfc), and the orbital frontal cortex (ofc) from golgi-cox stained neurons. |
2011-10-18 |
2023-08-12 |
rat |
| Priscila Fernandes Carrara-Nascimento, William C Griffin, Daniel Mazzeo Pastrello, M Foster Olive, Rosana Camarin. Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice. Alcohol (Fayetteville, N.Y.). vol 45. issue 5. 2011-10-17. PMID:21570797. |
to examine the relationship between age differences in behavioral sensitization to ethanol and the neurochemical adaptations related to glutamate within nucleus accumbens (nac), in vivo microdialysis was conducted in adolescent and adult swiss mice treated with ethanol (1.8 g/kg) or saline for 15 days and subsequently challenged with an acute dose (1.8 g/kg) of ethanol 6 days later. |
2011-10-17 |
2023-08-12 |
mouse |
| I Z Mathews, S M Brudzynski, C M McCormic. Heightened locomotor-activating effects of amphetamine administered into the nucleus accumbens in adolescent rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 5. 2011-10-17. PMID:21616135. |
locomotor activating effects of amphetamine are dependent on drug actions in the core of the nucleus accumbens (nac), but the contribution of this region to age differences in amphetamine sensitivity has not been studied directly. |
2011-10-17 |
2023-08-12 |
rat |
| Gregory P Mark, Shkelzen Shabani, Lauren K Dobbs, Stephen T Hanse. Cholinergic modulation of mesolimbic dopamine function and reward. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21549724. |
the da terminal region of the nucleus accumbens (nac) contains a small but particularly important group of cholinergic interneurons, which have extensive dendritic arbors that make synapses with a vast majority of nac neurons and afferents. |
2011-10-14 |
2023-08-12 |
Not clear |
| Luis Hernández, Daniel Paredes, Pedro Rad. Feeding behavior as seen through the prism of brain microdialysis. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21549733. |
dopamine (da) in the nucleus accumbens (nac) correlates with food reward, stimulus saliency, and goal directed hyperlocomotion but in the ventromedial hypothalamus da correlates with satiety and hypolocomotion. |
2011-10-14 |
2023-08-12 |
Not clear |
| Kathleen M Taylor, Gregory P Mark, Bartley G Hoebe. Conditioned taste aversion from neostigmine or methyl-naloxonium in the nucleus accumbens. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21549734. |
rats were implanted with cannulas aimed above the nucleus accumbens (nac) for injection of the opiate antagonist methyl-naloxonium in morphine-dependent animals or neostigmine to increase ach in drug naïve animals. |
2011-10-14 |
2023-08-12 |
rat |
| Elaine M Hul. Sex, drugs and gluttony: how the brain controls motivated behaviors. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21554895. |
he found that feeding, stimulant drug administration, and electrical stimulation of the lateral hypothalamus (lh) all increased dopamine (da) release in the nucleus accumbens (nac). |
2011-10-14 |
2023-08-12 |
Not clear |
| Marcy J Bubar, Sonja J Stutz, Kathryn A Cunningha. 5-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway. PloS one. vol 6. issue 6. 2011-10-14. PMID:21687728. |
here, we employed double-label fluorescence immunochemistry with the synthetic enzymes for dopamine (tyrosine hydroxylase; th) and gaba (glutamic acid decarboxylase isoform 67; gad-67) and retrograde tract tracing with fluorogold (fg) to uncover whether dopamine and gaba vta neurons that possess 5-ht(2c)r innervate the nucleus accumbens (nac). |
2011-10-14 |
2023-08-12 |
rat |
| Laura H Corbit, Bernard W Ballein. The general and outcome-specific forms of Pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 33. 2011-10-13. PMID:21849539. |
in two experiments, we examined the effects of pretraining lesions (experiment 1) or muscimol-induced inactivation (experiment 2) of either the core or shell regions of the nucleus accumbens (nac) on these forms of pit. |
2011-10-13 |
2023-08-12 |
rat |