| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yao-Ying Ma, Sandy M Henley, Jeff Toll, James D Jentsch, Christopher J Evans, Michael S Levine, Carlos Ceped. Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens. ASN neuro. vol 5. issue 4. 2014-06-15. PMID:24000958. |
to examine the mechanisms of drug relapse, we first established a model for cocaine ivsa (intravenous self-administration) in mice, and subsequently examined electrophysiological alterations of msns (medium-sized spiny neurons) in the nac (nucleus accumbens) before and after acute application of cocaine in slices. |
2014-06-15 |
2023-08-12 |
mouse |
| S J Tye, A D Miller, C D Blah. Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders. Neuroscience. vol 252. 2014-06-11. PMID:23962648. |
activation of glutamate receptors within the ventral tegmental area (vta) stimulates extrasynaptic (basal) dopamine release in terminal regions, including the nucleus accumbens (nac). |
2014-06-11 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
in the present study, we characterized age-dependent differences in bdnf signaling and trkb expression within the nucleus accumbens (nac), caudate putamen (cp) and pfc in rats and determined the effects of administration of the dopamine agonist, skf 83959, which activates the gq-coupled dopamine receptors, the dopamine d5 receptor and the d1-d2 receptor heteromer. |
2014-06-09 |
2023-08-12 |
rat |
| Jason B Cook, David F Werner, Antoniette M Maldonado-Devincci, Maggie N Leonard, Kristen R Fisher, Todd K O'Buckley, Patrizia Porcu, Thomas J McCown, Joyce Besheer, Clyde W Hodge, A Leslie Morro. Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760842. |
the p450scc-expressing vector (raav2-p450scc) or control gfp-expressing vector (raav2-gfp) were injected bilaterally into the ventral tegmental area (vta) or nucleus accumbens (nac) of alcohol preferring (p) rats trained to self-administer ethanol. |
2014-06-09 |
2023-08-13 |
rat |
| Yahav Dikshtein, Royi Barnea, Noam Kronfeld, Elad Lax, Ilana Roth-Deri, Alexander Friedman, Iris Gispan, Einat Elharrar, Sarit Levy, Moshe Ben-Tzion, Gal Yadi. β-endorphin via the delta opioid receptor is a major factor in the incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23800967. |
rats exposed to the drug-associated cue on day 1 of forced abstinence demonstrated minimal cue-induced cocaine-seeking behavior concurrently with a significant increase in β-endorphin release in the nucleus accumbens (nac). |
2014-06-03 |
2023-08-12 |
rat |
| Yuexiang Wang, Jang-Won Lee, Gyeon Oh, Sharon R Grady, J Michael McIntosh, Darlene H Brunzell, Jason R Cannon, Ryan M Drena. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs. Journal of neurochemistry. vol 129. issue 2. 2014-05-27. PMID:24266758. |
α6β2* nicotinic acetylcholine receptors (nachrs)s in the ventral tegmental area to nucleus accumbens (nac) pathway are implicated in the response to nicotine, and recent work suggests these receptors play a role in the rewarding action of ethanol. |
2014-05-27 |
2023-08-12 |
mouse |
| Kevin D Lominac, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh Rajasekar, Dan Maliniak, Andrew B Thompson, Lawrence E Urman, Tamara J Phillips, Karen K Szumlinsk. Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation. Frontiers in systems neuroscience. vol 8. 2014-05-21. PMID:24847220. |
as stimulant-elicited neuroplasticity within dopamine neurons innervating the nucleus accumbens (nac) and prefrontal cortex (pfc) is theorized as central for addiction-related behavioral anomalies, we used a multi-disciplinary research approach in mice to examine the interactions between sub-toxic ma dosing, motivation for ma and mesocorticolimbic monoamines. |
2014-05-21 |
2023-08-13 |
mouse |
| Giuseppe Gangarossa, Julie Espallergues, Alban de Kerchove d'Exaerde, Salah El Mestikawy, Charles R Gerfen, Denis Hervé, Jean-Antoine Girault, Emmanuel Valjen. Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens. Frontiers in neural circuits. vol 7. 2014-05-19. PMID:23423476. |
the nucleus accumbens (nac) is a critical brain region involved in many reward-related behaviors. |
2014-05-19 |
2023-08-12 |
mouse |
| Gemma L Dalton, Anthony G Phillips, Stan B Floresc. Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24672007. |
different subregions of nucleus accumbens (nac) have been implicated in reward seeking, promoting flexible approach responses, suppressing nonrewarded actions, and facilitating shifts between different discrimination strategies. |
2014-05-19 |
2023-08-12 |
rat |
| Sara Karimi, Maryam Radahmadi, Mohammad Fazilati, Hamid Azizi-Malekabadi, Hojjatallah Alae. Roles of the nucleus accumbens (shell) in the acquisition and expression of morphine-induced conditioned behavior in freely moving rats. International journal of preventive medicine. vol 5. issue 3. 2014-05-15. PMID:24829709. |
the nucleus accumbens (nac) is a part of the rewarding cortico-mesolimbic dopamine (da) pathway. |
2014-05-15 |
2023-08-13 |
rat |
| Junran Cao, Jennifer B Dwyer, Nicole M Gautier, Frances M Leslie, Ming D L. Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally. Neuroscience letters. vol 553. 2014-05-08. PMID:23962570. |
three limbic brain regions, the prefrontal cortex (pfc), caudate putamen (cpu), and nucleus accumbens (nac), were dissected. |
2014-05-08 |
2023-08-12 |
rat |
| Daniel C Castro, Kent C Berridg. Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting". The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 12. 2014-05-08. PMID:24647944. |
a specialized cubic-millimeter hotspot in the rostrodorsal quadrant of medial shell in nucleus accumbens (nac) of rats may mediate opioid enhancement of gustatory hedonic impact or "liking". |
2014-05-08 |
2023-08-12 |
rat |
| Jennifer M Mitchell, James P O'Neil, William J Jagust, Howard L Field. Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry. Clinical and translational science. vol 6. issue 5. 2014-05-07. PMID:24127930. |
furthermore, alcohol consumption leads to endogenous opioid release in the cortex and nucleus accumbens (nac), and this opioid release is correlated with greater positive hedonic effect. |
2014-05-07 |
2023-08-12 |
Not clear |
| Junshi Wang, Sanya Fanous, Ernest F Terwilliger, Caroline E Bass, Ronald P Hammer, Ella M Nikulin. BDNF overexpression in the ventral tegmental area prolongs social defeat stress-induced cross-sensitization to amphetamine and increases ΔFosB expression in mesocorticolimbic regions of rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23689674. |
additionally, overexpression of bdnf in the vta alone increased Δfosb in the nucleus accumbens (nac) and prefrontal cortex. |
2014-05-05 |
2023-08-12 |
rat |
| C Dejean, T Boraud, C Le Moin. Opiate dependence induces network state shifts in the limbic system. Neurobiology of disease. vol 59. 2014-05-05. PMID:23911767. |
in opiate addiction, evidence show that the dopamine system principal targets, prefrontal cortex (pfc), nucleus accumbens (nac) and basolateral amygdala complex (bla) also adapt to repeated drug stimulation. |
2014-05-05 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. Journal of neurochemistry. vol 128. issue 5. 2014-04-29. PMID:24111505. |
using high-speed amperometry with enzyme-based biosensors in freely moving rats, we show that initial intravenous cocaine induces rapid, transient glutamate (glu) release in the nac (nucleus accumbens), rapidly becoming a stronger, two-component increase with subsequent injections. |
2014-04-29 |
2023-08-12 |
rat |
| Hai-Feng Lu, Peng-Fei Wu, Yuan-Jian Yang, Wen Xiao, Jun Fan, Jing Liu, Yuan-Long Li, Yi Luo, Zhuang-Li Hu, You Jin, Fang Wang, Jian-Guo Che. Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 10. 2014-04-29. PMID:24599450. |
many studies have reported a withdrawal-dependent increase in synaptic ampa receptor (ampar) levels in the nucleus accumbens (nac) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered ampar surface expression in the nac has not yet been investigated. |
2014-04-29 |
2023-08-12 |
rat |
| R M Villalba, Y Smit. Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? Neuroscience. vol 251. 2014-04-23. PMID:23867772. |
in pd, nigrostriatal dopamine degeneration results in a significant loss of dendritic spines in the dorsal striatum, while rodents chronically exposed to cocaine and other psychostimulants, display an increase in the density of "thin and immature" spines in the nucleus accumbens (nac). |
2014-04-23 |
2023-08-12 |
Not clear |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
synaptic transmission between ventral tegmental area and nucleus accumbens (nac) is critically involved in reward-motivated behaviors and thought to be altered in addiction. |
2014-04-22 |
2023-08-12 |
mouse |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
extracellular 5-ht, ne and da levels were evaluated in the ventral hippocampus (vhc), medial prefrontal cortex (mpfc) and nucleus accumbens (nac) after acute and subchronic treatment with lu aa21004 or escitalopram. |
2014-04-21 |
2023-08-12 |
rat |