| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bryan Strange, Svenja Treu, Juan Barcia, Cristina Torres Diaz, Javier Gonzalez Rosa, Cristina Nombela, Jose Pineda, Daniel Torres, Lukas Kunz, Robin Hellerstedt, Josue Avecillas-Chasin, Monica Lara, Marta Navas, Ana Galarza, Julia Garcia, Antonio Oliviero, Fernando Seijo, Andreas Horn, Ningfei Li, Nikolai Axmacher, Santiago Canals, Blanca Reneses, Anne Bierbraue. Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation. Research square. 2023-12-04. PMID:38045279. |
however, an alternative strategy is to stimulate brain areas providing modulatory inputs to medial temporal memory-related structures, such as the nucleus accumbens (nac), which is implicated in enhancing episodic memory encoding. |
2023-12-04 |
2023-12-10 |
human |
| Bing Huang, Zifei Chen, Fang Huang, Fenfei Gao, Jieling Chen, Peipei Liu, Zhijie Lu, Weiyuan Chen, Jie W. Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory. Progress in neuro-psychopharmacology & biological psychiatry. 2023-11-30. PMID:38036034. |
we found no effect of nicotine withdrawal on the myelination in both of the ventral tegmental area (vta) and nucleus accumbens (nac) regions, but unexpectedly, we observed a demyelination phenomenon in the medial prefrontal cortex (mpfc) after withdrawal from chronic nicotine. |
2023-11-30 |
2023-12-10 |
Not clear |
| Amy M Gancarz, Raveena Parmar, Treefa Shwani, Moriah M Cobb, Michelle N Crawford, Jacob R Watson, Lisa Evans, Michael A Kausch, Craig T Werner, David M Diet. Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017636. |
to determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor smad3 in the nucleus accumbens (nac) when compared with water-exposed controls. |
2023-11-30 |
2023-12-07 |
rat |
| Amy M Gancarz, Raveena Parmar, Treefa Shwani, Moriah M Cobb, Michelle N Crawford, Jacob R Watson, Lisa Evans, Michael A Kausch, Craig T Werner, David M Diet. Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017636. |
to determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor smad3 in the nucleus accumbens (nac) when compared with water-exposed controls. |
2023-11-29 |
2023-12-07 |
rat |
| Neir Eshel, Gavin C Touponse, Allan R Wang, Amber K Osterman, Amei N Shank, Alexandra M Groome, Lara Taniguchi, Daniel F Cardozo Pinto, Jason Tucciarone, Brandon S Bentzley, Robert C Malenk. Striatal dopamine integrates cost, benefit, and motivation. Neuron. 2023-11-28. PMID:38016471. |
here, we measure da release in the nucleus accumbens (nac) and dorsolateral striatum (dls) while independently varying costs and benefits and apply behavioral economic principles to determine a mouse's level of motivation. |
2023-11-28 |
2023-12-07 |
mouse |
| Pratap S Markam, Clément Bourguignon, Lei Zhu, Martin Darvas, Paul V Sabatini, Maia V Kokoeva, Bruno Giros, Kai-Florian Storc. The neurons that drive infradian sleep-wake and mania-like behavioral rhythms. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014299. |
this cycling capacity is abrogated upon genetic disruption of da production in da neurons of the ventral tegmental area (vta) or ablation of nucleus accumbens (nac) projecting, dopamine (da) neurons. |
2023-11-28 |
2023-11-29 |
mouse |
| Sero Toriano Parel, Shannon N Bennett, Cindy J Cheng, Olivia C Timmermans, Laura M Fiori, Gustavo Turecki, Catherine Jensen Peñ. Transcriptional signatures of early-life stress and antidepressant treatment efficacy. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 49. 2023-11-27. PMID:38011563. |
here, we leveraged existing rna sequencing datasets from 1) blood samples from depressed female- and male-identifying patients treated with escitalopram or desvenlafaxine and assessed for treatment response or failure; 2) the nucleus accumbens (nac) of female and male mice exposed to els and/or adult stress; and 3) the nac of mice after adult stress, antidepressant treatment with imipramine or ketamine, and assessed for treatment response or failure. |
2023-11-27 |
2023-11-29 |
mouse |
| Austin Ganaway, Kousuke Tatsuta, Virgil Christian Garcia Castillo, Ryoma Okada, Yoshinori Sunaga, Yasumi Ohta, Jun Ohta, Masahiro Ohsawa, Metin Akay, Yasemin M Aka. Investigating the Influence of Morphine and Cocaine on the Mesolimbic Pathway Using a Novel Microimaging Platform. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003493. |
specifically, the mesolimbic pathway connecting the ventral tegmental area (vta) and the nucleus accumbens (nac) is crucial in regulating memory, emotion, motivation, and behavior due to its responsibility to modulate dopamine. |
2023-11-25 |
2023-11-28 |
mouse |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
brain levels of the endocannabinoid 2-arachidonoylglycerol (2-ag) shape motivated behavior and nucleus accumbens (nac) dopamine release. |
2023-11-24 |
2023-11-28 |
mouse |
| Madalyn Hafenbreidel, Surya Pandey, Sherri B Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D Cameron, Gavin Rumbaugh, Courtney A Mille. Basolateral Amygdala Corticotropin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory in Males. Neurobiology of learning and memory. 2023-11-23. PMID:37995804. |
the effect is highly selective, as nmii inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dphc], nucleus accumbens [nac]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (coc). |
2023-11-23 |
2023-11-29 |
mouse |
| Rifka C Derman, Elizabeth C Bryda, Carrie R Ferrari. Role of Nucleus Accumbens D1-type Medium Spiny Neurons in the Expression and Extinction of Sign-tracking. Behavioural brain research. 2023-11-20. PMID:37984521. |
sign-tracking is dependent upon dopamine activity in the nucleus accumbens (nac). |
2023-11-20 |
2023-11-29 |
rat |
| Erica A Cross, Kim L Huhman, H Elliott Alber. Sex differences in the impact of social status on social reward and associated mesolimbic activation. Physiology & behavior. 2023-11-17. PMID:37977252. |
in a second experiment, we found more activation of the mesolimbic dopamine system (mds) as assessed with cfos immunohistochemistry in the lateral ventral tegmental area (lvta) and the nucleus accumbens (nac) shell of male winners compared to losers. |
2023-11-17 |
2023-11-20 |
Not clear |
| Ingrid Reverte, Claudia Marchetti, Sara Pezza, Soami F Zenoni, Giorgia Scaringi, Laura Ferrucci, Ginevra D'Ottavio, Annabella Pignataro, Diego Andolina, Marcello Raspa, Ferdinando Scavizzi, Marco Venniro, Leslie A Ramsey, Cornelius Gross, Daniele Caprioli, Davide Ragozzin. Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal. Brain, behavior, and immunity. 2023-11-15. PMID:37967660. |
during withdrawal from cocaine, calcium permeable-ampa receptors (cp-ampar) progressively accumulate in nucleus accumbens (nac) synapses, a phenomenon linked to behavioral sensitization and drug-seeking. |
2023-11-15 |
2023-11-20 |
Not clear |
| Abigail M Kelley, Eric J Del Valle, Samin Zaman, Anushree N Karkhani. Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell. Pain. 2023-11-14. PMID:37962155. |
recent studies have shown that the nucleus accumbens (nac) shell is involved in mediating pain sensitivity after peripheral inflammation in rodent models of chronic pain and alcohol use disorder. |
2023-11-14 |
2023-11-20 |
rat |
| Yi He, Yanhua H Huang, Oliver M Schlüter, Yan Don. Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens. eLife. vol 12. 2023-11-14. PMID:37963179. |
here, we show that two genetically distinct bla neuronal types, expressing rspo2 versus ppp1r1b, respectively, project to the nucleus accumbens (nac) and form monosynaptic connections with both dopamine d1 and d2 receptor-expressing neurons. |
2023-11-14 |
2023-11-20 |
mouse |
| Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyan. AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. iScience. vol 26. issue 11. 2023-11-13. PMID:37953959. |
dopamine d1 receptor-expressing medium spiny neurons (d1r-msns) and dopamine d2 receptor-expressing msns (d2r-msns) in nucleus accumbens (nac) have been demonstrated to show different effects on reward and memory of abstinence. |
2023-11-13 |
2023-11-20 |
Not clear |
| Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yu. Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948992. |
we determined dopamine transporter (dat) availability in the medial prefrontal cortex (mpfc), striatum, and nucleus accumbens (nac) after drug treatment. |
2023-11-10 |
2023-11-20 |
mouse |
| Wenting Wang, Meng Yuan, Yaowei Xu, Jingjie Yang, Xiaoling Wang, Yifan Zhou, Zhixiang Yu, Zhongyuan Lu, Yiming Wang, Chenge Hu, Qian Bai, Zhisong L. Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats. Molecular neurobiology. 2023-11-07. PMID:37934398. |
according to previous reports, nucleus accumbens (nac) shell is required for complete expression of neuropathic pain behaviors and mood alternations, we found the elevated mrna and protein level of prokineticin-2 (prok2) in the nac shell after chronic constriction injury (cci). |
2023-11-07 |
2023-11-08 |
rat |
| Michał Sobstyl, Marek Prokopienko, Tadeusz Pietra. The ventral capsule and ventral striatum-Stereotactic targets for the management of treatment-resistant depression. A systematic literature review. Frontiers in psychiatry. vol 14. 2023-11-06. PMID:37928918. |
the main nucleus of the reward circuit is the nucleus accumbens (nac). |
2023-11-06 |
2023-11-08 |
Not clear |
| Harold F Hounchonou, Hui Tang, Raik Paulat, Andrea Kühn, Joachim Spranger, Christoph van Riesen, Lukas Maure. Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet. Scientific reports. vol 13. issue 1. 2023-11-03. PMID:37919311. |
in this study, we tested the hypothesis that high-frequency dbs targeting the nucleus accumbens (nac) shell region reduces food intake and weight gain in mice fed a high-fat diet. |
2023-11-03 |
2023-11-08 |
mouse |