| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Chin, S K Song, J H Cheong, K H Ko, Y Kuroiw. Selective effect of chronic lead ingestion. III: Effect on dopamine beta-hydroxylase activity in brain regions of rats. The Journal of toxicological sciences. vol 18. issue 1. 1993-05-19. PMID:8386259. |
exposure of rats to lead generally decreased na+/k(+)-atpase activity and showed alternative changes of dopamine beta-hydroxylase activity were detected without concomitant changes of na+/k(+)-atpase activity were telencephalon and pons/medulla at 2 weeks of age and telencephalon, diencephalon and pons/medulla at 4 weeks of age and midbrain and pons/medulla at 6 weeks of age and cerebellum at 8 weeks of age in rats exposed to lead at a low dose, and those in rats exposed to lead at a high dose were midbrain at 6 weeks of age and cerebellum at 8 weeks of age. |
1993-05-19 |
2023-08-12 |
rat |
| S B Blunt, P Jenner, C D Marsde. Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 2. 1993-05-18. PMID:8097279. |
this finding suggests a possible suppressive effect in vivo of l-dopa on dopamine cells in the midbrain of adult animals that have been previously exposed to 6-ohda. |
1993-05-18 |
2023-08-12 |
rat |
| S Murase, J M Mathé, J Grenhoff, T H Svensso. Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. Journal of neural transmission. General section. vol 91. issue 1. 1993-04-22. PMID:8452684. |
effects of dizocilpine (mk-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. |
1993-04-22 |
2023-08-12 |
rat |
| S Murase, J M Mathé, J Grenhoff, T H Svensso. Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. Journal of neural transmission. General section. vol 91. issue 1. 1993-04-22. PMID:8452684. |
the effects of the non-competitive n-methyl-d-aspartate (nmda) receptor antagonist dizocilpine ((+)-mk-801) on the firing pattern of midbrain dopamine neurons were studied with single cell recording techniques in male albino rats anaesthetized with chloral hydrate. |
1993-04-22 |
2023-08-12 |
rat |
| S Murase, J M Mathé, J Grenhoff, T H Svensso. Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. Journal of neural transmission. General section. vol 91. issue 1. 1993-04-22. PMID:8452684. |
mk-801 (0.01-1.0 mg/kg iv) induced different effects in different subgroups of midbrain dopamine neurons. |
1993-04-22 |
2023-08-12 |
rat |
| R L Jakab, C Lerant. Presence of somatostatin or neurotensin in lateral septal dopaminergic axon terminals of distinct hypothalamic and midbrain origins: convergence on the somatospiny neurons. Experimental brain research. vol 92. issue 3. 1993-04-21. PMID:7681010. |
in the lateral septal area (lsa), both inhibitory and excitatory dopamine (da) actions, as well as hypothalamic and midbrain da efferents, have been described. |
1993-04-21 |
2023-08-12 |
rat |
| L Iacovitti, M J Evinger, N D Stul. Muscle-derived differentiation factor increases expression of the tyrosine hydroxylase gene and enzyme activity in cultured dopamine neurons from the rat midbrain. Brain research. Molecular brain research. vol 16. issue 3-4. 1993-04-01. PMID:1363326. |
muscle-derived differentiation factor increases expression of the tyrosine hydroxylase gene and enzyme activity in cultured dopamine neurons from the rat midbrain. |
1993-04-01 |
2023-08-11 |
rat |
| L Iacovitti, M J Evinger, N D Stul. Muscle-derived differentiation factor increases expression of the tyrosine hydroxylase gene and enzyme activity in cultured dopamine neurons from the rat midbrain. Brain research. Molecular brain research. vol 16. issue 3-4. 1993-04-01. PMID:1363326. |
incubation of cultured dopamine neurons from the ventral midbrain with mdf elevated the levels of th mrna and th enzyme activity 5- to 40-fold higher than that measured in control cultures. |
1993-04-01 |
2023-08-11 |
rat |
| E Ronken, F L Van Muiswinkel, A H Mulder, A N Schoffelmee. Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus. European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8095023. |
the effects of selective opioid agonists on the evoked release of [3h]dopamine and [3h]noradrenaline were studied in cultured dopaminergic neurons of the ventral mesencephalon (containing the substantia nigra and ventral tegmental area) and in cultured neurons of the noradrenergic locus coeruleus, respectively. |
1993-04-01 |
2023-08-12 |
human |
| G Elliso. Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus. Brain research. vol 598. issue 1-2. 1993-02-25. PMID:1486500. |
this finding supports a rich literature on the involvement of these same pathways in the actions of dopamine agonists, reward mechanisms, and the integration of limbic, extrapyramidal, and midbrain centers. |
1993-02-25 |
2023-08-11 |
rat |
| M Van den Buuse, G A Head, P I Korne. Differential role of brain ascending noradrenergic bundles in the circulatory effects of alpha-methyldopa and clonidine. Journal of cardiovascular pharmacology. vol 21. issue 1. 1993-02-25. PMID:7678665. |
local microinjection of 6-hydroxydopamine (6-ohda) bilaterally into both na fibre bundles in the midbrain produced marked reduction in norepinephrine (ne) after 4 weeks in all forebrain regions examined, but dopamine concentrations generally were not affected. |
1993-02-25 |
2023-08-12 |
Not clear |
| C Orazzo, V A Pieribone, S Ceccatelli, L Terenius, T Hökfel. CGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity. Brain research. vol 600. issue 1. 1993-02-25. PMID:8422589. |
using the indirect immunofluorescence technique and double labelling procedures combined with retrograde tracing it could be demonstrated that the a11 dopamine cell group, located at the border between the diencephalon and mesencephalon of the rat brain and some of which project to the spinal cord, contains calcitonin gene-related peptide (cgrp)-like immunoreactivity. |
1993-02-25 |
2023-08-12 |
rat |
| K Rasmussen, J F Czachura, M E Stockton, J J Howber. Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8423546. |
electrophysiological effects of diphenylpyrazolidinone cholecystokinin-b and cholecystokinin-a antagonists on midbrain dopamine neurons. |
1993-02-23 |
2023-08-12 |
rat |
| D Sulzer, N T Maidment, S Raypor. Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons. Journal of neurochemistry. vol 60. issue 2. 1993-02-09. PMID:8419534. |
amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons. |
1993-02-09 |
2023-08-12 |
Not clear |
| D Sulzer, N T Maidment, S Raypor. Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons. Journal of neurochemistry. vol 60. issue 2. 1993-02-09. PMID:8419534. |
we used weak bases and dopamine uptake blockers in ventral midbrain neuron cultures to separate the effects on blockade of amphetamine uptake from reverse transport of dopamine. |
1993-02-09 |
2023-08-12 |
Not clear |
| J L Cadet, S M Zh. The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat. Brain research. vol 595. issue 2. 1993-01-26. PMID:1467973. |
this approach could also be used to more specifically localize peptidergic receptors on midbrain dopamine cell bodies. |
1993-01-26 |
2023-08-11 |
rat |
| S Fahn, G Cohe. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Annals of neurology. vol 32. issue 6. 1993-01-25. PMID:1471873. |
because the substantia nigra is rich in dopamine, which can undergo both enzymatic oxidation via monoamine oxidase and nonenzymatic autoxidation, hydrogen peroxide and oxyradicals (superoxide anion radical and hydroxyl radical) are generated in this midbrain nucleus. |
1993-01-25 |
2023-08-11 |
Not clear |
| F L Van Muiswinkel, B Drukarch, H W Steinbusch, J C Stoo. Chronic dopamine D2 receptor activation does not affect survival and differentiation of cultured dopaminergic neurons: morphological and neurochemical observations. Journal of neurochemistry. vol 60. issue 1. 1993-01-25. PMID:8093262. |
primary cultures of rat ventral mesencephalon were used to elucidate the role of chronic stimulation of dopamine (da) d2 autoreceptors in the development of fetal dopaminergic neurons in vitro. |
1993-01-25 |
2023-08-12 |
rat |
| A J Stoessl, E Szczutkowski, B Glenn, I Watso. Behavioural effects of selective tachykinin agonists in midbrain dopamine regions. Brain research. vol 565. issue 2. 1993-01-19. PMID:1668812. |
behavioural effects of selective tachykinin agonists in midbrain dopamine regions. |
1993-01-19 |
2023-08-11 |
rat |
| A J Stoessl, E Szczutkowski, B Glenn, I Watso. Behavioural effects of selective tachykinin agonists in midbrain dopamine regions. Brain research. vol 565. issue 2. 1993-01-19. PMID:1668812. |
the effects of selective nk-1, nk-2 and nk-3 tachykinin agonists in midbrain dopamine cell containing regions were investigated in the rat. |
1993-01-19 |
2023-08-11 |
rat |