| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Seutin, S W Johnson, R A Nort. Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons. Brain research. vol 630. issue 1-2. 1994-04-05. PMID:8118703. |
intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nm) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in n-methyl-d-aspartate. |
1994-04-05 |
2023-08-12 |
rat |
| S Schinelli, M Paolillo, M Quartieri, G Santagostin. Dopamine synthesis, uptake and metabolism in embryonic rat mesencephalic cultures. Pharmacological research. vol 28. issue 3. 1994-03-24. PMID:8108317. |
we have developed an hplc method using electrochemical detection (ed) to study the synthesis, uptake and metabolism of dopamine (da) in primary cell cultures dissociated from rat embryonic mesencephalon. |
1994-03-24 |
2023-08-12 |
rat |
| T Wang, E D Frenc. L-glutamate excitation of A10 dopamine neurons is preferentially mediated by activation of NMDA receptors: extra- and intracellular electrophysiological studies in brain slices. Brain research. vol 627. issue 2. 1994-03-09. PMID:7905352. |
the aim of the present study was to assess the effects of l-glutamate (l-glu) on the neurophysiology of ventral tegmental a10 dopamine neurons in rat midbrain slices using extracellular and intracellular recording methods. |
1994-03-09 |
2023-08-12 |
rat |
| T Wang, E D Frenc. L-glutamate excitation of A10 dopamine neurons is preferentially mediated by activation of NMDA receptors: extra- and intracellular electrophysiological studies in brain slices. Brain research. vol 627. issue 2. 1994-03-09. PMID:7905352. |
these results suggest that in physiological-like conditions that low extracellular levels of glutamate excite midbrain dopamine neurons via a preferential activation of nmda receptors, and that only at higher concentrations of l-glu are non-nmda receptors brought into play. |
1994-03-09 |
2023-08-12 |
rat |
| C Solà, G Mengod, W C Low, J Norton, B Ghetti, J M Palacios, L C Triarho. Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts. The European journal of neuroscience. vol 5. issue 11. 1994-02-22. PMID:8287193. |
these results suggest that the transplanted mesencephalic cells mature very similarly to those in the normal substantia nigra, expressing different mrnas that are normally present in the ventral midbrain and which are reduced in the weaver mutant as a consequence of dopamine neuron loss. |
1994-02-22 |
2023-08-12 |
mouse |
| I Strömberg, L Björklund, M Johansson, A Tomac, F Collins, L Olson, B Hoffer, C Humpe. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Experimental neurology. vol 124. issue 2. 1994-02-18. PMID:7904571. |
the potential role of glial cell line-derived neurotrophic factor (gdnf) as a trophic molecule for midbrain dopamine neurons was examined using two different approaches: in situ hybridization and intraocular transplantation. |
1994-02-18 |
2023-08-12 |
rat |
| A M Gardier, E Lepoul, J H Trouvin, E Chanut, M C Dessalles, C Jacquo. Changes in dopamine metabolism in rat forebrain regions after cessation of long-term fluoxetine treatment: relationship with brain concentrations of fluoxetine and norfluoxetine. Life sciences. vol 54. issue 4. 1994-02-18. PMID:8289580. |
we also measured dopamine (da) levels in 2 midbrain regions (the striatum, st and nucleus accumbens, nac) in rats killed 1-14 days after the last dose. |
1994-02-18 |
2023-08-12 |
rat |
| S R Sesack, C Aoki, V M Picke. Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 1. 1994-02-16. PMID:7904306. |
ultrastructural localization of d2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. |
1994-02-16 |
2023-08-12 |
rat |
| S R Sesack, C Aoki, V M Picke. Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 1. 1994-02-16. PMID:7904306. |
these ultrastructural results are consistent with the localization of a dopamine d2 receptor-like protein that is strategically positioned to subserve (1) autoreceptor functions at the level of dendrites in the midbrain and presynaptic axon terminals in the striatum, as well as (2) postsynaptic actions on striatal spiny dendrites and other nondopamine terminals. |
1994-02-16 |
2023-08-12 |
rat |
| B Meister, R Eld. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology. vol 58. issue 4. 1994-02-16. PMID:8284024. |
the results suggest that hypothalamic dopamine neurons have an active uptake mechanism for dopamine, however, that dat mrna levels may be considerably lower than those encountered in the ventral midbrain. |
1994-02-16 |
2023-08-12 |
rat |
| G Engberg, T Kling-Petersen, H Nissbrand. GABAB-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra. Synapse (New York, N.Y.). vol 15. issue 3. 1994-02-09. PMID:8278899. |
previous electrophysiological experiments have emphasized the importance of the firing pattern for the functioning of midbrain dopamine (da) neurons. |
1994-02-09 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
tonic activation of nmda receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. |
1994-01-27 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
midbrain dopamine neurons in vivo discharge in a single-spike firing pattern or in a burst-firing pattern. |
1994-01-27 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
we have recently shown that burst activity in vivo of midbrain dopamine neurons is due to the local activation of excitatory amino acid receptors, as microapplication of the broad-spectrum antagonist of excitatory amino acids, kynurenic acid, strongly regularized the spontaneous firing pattern of these dopamine neurons. |
1994-01-27 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
in the present study, we investigated which subtypes of excitatory amino acid receptors are involved in the burst-firing of midbrain dopamine neurons in chloral hydrate-anaesthetized rats, iontophoretic or pressure microejections of 6-cyano, 7-nitroquinoxaline-2,3-dione (cnqx), a non-n-methyl-d-aspartate (nmda) receptor antagonist, did not alter the spontaneous burst firing of dopamine neurons (n = 36). |
1994-01-27 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
these data suggest that burst-firing of midbrain dopamine neurons in vivo results from the tonic activation of nmda receptors by endogenous excitatory amino acids. |
1994-01-27 |
2023-08-12 |
rat |
| K Chergui, P J Charléty, H Akaoka, C F Saunier, J L Brunet, M Buda, T H Svensson, G Chouve. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. The European journal of neuroscience. vol 5. issue 2. 1994-01-27. PMID:8261095. |
in view of the critical dependency of catecholamine release on the discharge pattern of source neurons, excitatory amino acid inputs to midbrain dopamine neurons may constitute a major physiological substrate in the control of the dopamine level in target areas. |
1994-01-27 |
2023-08-12 |
rat |
| N H Chen, M E Reit. Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263807. |
the effects of dopamine (da) and 5-hydroxytryptamine (5-ht) autoreceptor agents on electrically induced [3h]da and [3h]5-ht release from superfused slices of striatum, nucleus accumbens and ventral mesencephalon (vm) containing a9 and a10 neurons were investigated in rats made tolerant to the stimulatory effect of cocaine on locomotor behavior by a 14-day continuous infusion of cocaine (29 mg/kg/day) by s.c. implanted osmotic minipumps followed by a 7-day drug-free period. |
1994-01-27 |
2023-08-12 |
rat |
| D L Cardoz. Midbrain dopaminergic neurons from postnatal rat in long-term primary culture. Neuroscience. vol 56. issue 2. 1994-01-05. PMID:8247269. |
midbrain dopamine neurons project extensively throughout the vertebrate forebrain and influence a wide variety of brain functions. |
1994-01-05 |
2023-08-12 |
rat |
| D L Cardoz. Midbrain dopaminergic neurons from postnatal rat in long-term primary culture. Neuroscience. vol 56. issue 2. 1994-01-05. PMID:8247269. |
dopamine neurons were dissociated from slices of ventral midbrain from neonatal rat pups and maintained in cell culture for several months. |
1994-01-05 |
2023-08-12 |
rat |