| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. |
thus, the increase of midbrain dopamine d2 receptor density in the nnr line can only be accounted for in part by an increase in the number of dopamine neurons. |
1993-08-19 |
2023-08-12 |
mouse |
| B J Hoffer, K L Leenders, D Young, G Gerhardt, G O Zerbe, M Bygdeman, A Seiger, L Olson, I Strömberg, R Freedma. Eighteen-month course of two patients with grafts of fetal dopamine neurons for severe Parkinson's disease. Experimental neurology. vol 118. issue 3. 1993-08-06. PMID:1306484. |
the patients each received stereotaxic implantation of ventral mesencephalic tissue containing midbrain dopamine neurons from aborted human fetuses of 8 to 10 weeks gestational age into the caudate and putamen of one hemisphere. |
1993-08-06 |
2023-08-11 |
human |
| D Afonso, C Santana, M Rodrigue. Neonatal lateralization of behavior and brain dopaminergic asymmetry. Brain research bulletin. vol 32. issue 1. 1993-08-03. PMID:8319098. |
in 2-day-old rats (10 litters with one male and one female per litter), the right brain side had a higher content in dopamine (mesencephalon) and dopac (proencephalon) than the left brain side. |
1993-08-03 |
2023-08-12 |
rat |
| J R Prohaska, W R Baile. Persistent regional changes in brain copper, cuproenzymes and catecholamines following perinatal copper deficiency in mice. The Journal of nutrition. vol 123. issue 7. 1993-08-03. PMID:8391562. |
compared with values in +cu mice, regional brain dopamine in -cu mice was markedly elevated in cerebellum and medulla, unchanged in cerebrum and striatum, and elevated variably in hypothalamus and midbrain. |
1993-08-03 |
2023-08-12 |
mouse |
| Veeranna, P L Reddy, H N Bhargav. Effect of chronic administration of U-50,488H, a kappa-opioid receptor agonist, on central dopamine D2 receptors of the rat. European journal of pharmacology. vol 235. issue 1. 1993-07-29. PMID:8390939. |
the binding characteristics (bmax and kd values) of [3h]spiroperidol to dopamine d2 receptors were determined in discrete brain regions (hypothalamus, hippocampus, cortex, pons and medulla, midbrain, corpus striatum and amygdala) and spinal cord of u-50,488h-tolerant and -abstinent rats. |
1993-07-29 |
2023-08-12 |
rat |
| T Wang, E D Frenc. Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: an extracellular in vitro study. Life sciences. vol 53. issue 1. 1993-07-22. PMID:7685848. |
extracellular single-unit recordings in rat midbrain slices were used to assess the effects of phencyclidine (pcp) on the spontaneous and excitatory amino acid-induced firing of ventral tegmental (vta) dopamine neurons. |
1993-07-22 |
2023-08-12 |
rat |
| D C German, C L Lian. Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D28k. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513124. |
calbindin-d28k may play a role in the co-release of neuroactive peptides with dopamine from the midbrain da neurons. |
1993-07-22 |
2023-08-12 |
rat |
| M Takashima, M Takita, A Umino, T Nishikawa, H Mitsushio, K Takahash. Modulation of cerebral acetylcholine metabolism by the dorsal diencephalic conduction system in the rat. Neurochemistry international. vol 20. issue 4. 1993-07-15. PMID:1304873. |
we investigated the effects of interruption of the impulse flow in the habenulopeduncular pathways by local infusion of tetrodotoxin on the acetylcholine and choline content in selected dopamine rich regions in the forebrain and midbrain in rats. |
1993-07-15 |
2023-08-11 |
rat |
| C Solà, G Mengod, B Ghetti, J M Palacios, L C Triarho. Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry. Brain research. Molecular brain research. vol 17. issue 3-4. 1993-07-15. PMID:8510506. |
the cellular localization of amyloid beta-protein precursor (beta app) rna transcripts was studied by in situ hybridization histochemistry in normal, heterozygous and homozygous weaver (wv) mutant mice, which lose midbrain dopamine (da) neurons, cerebellar granule cells, and purkinje cells. |
1993-07-15 |
2023-08-12 |
mouse |
| L Arborelius, K Chergui, S Murase, G G Nomikos, B B Höök, G Chouvet, U Hacksell, T H Svensso. The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 4. 1993-07-15. PMID:8510763. |
the 5-ht1a receptor selective ligands, (r)-8-oh-dpat and (s)-uh-301, differentially affect the activity of midbrain dopamine neurons. |
1993-07-15 |
2023-08-12 |
rat |
| M A Mena, B Pardo, C L Paino, J G De Yebene. Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid. Neuroreport. vol 4. issue 4. 1993-07-01. PMID:8499605. |
levodopa, a dopamine (da) precursor administered to patients with parkinson's disease (pd), produces at 25-200 x 10(-6) m concentrations a dose-dependent reduction of 3h-da uptake in foetal rat midbrain cultures. |
1993-07-01 |
2023-08-12 |
rat |
| T Wang, E D Frenc. Electrophysiological evidence for the existence of NMDA and non-NMDA receptors on rat ventral tegmental dopamine neurons. Synapse (New York, N.Y.). vol 13. issue 3. 1993-06-22. PMID:7684531. |
in vitro extracellular single-unit recordings from rat midbrain slices were used to assess the effects of excitatory amino acid agonists on the activity of a10 dopamine neurons. |
1993-06-22 |
2023-08-12 |
rat |
| M D Kelland, A S Freeman, J Rubin, L A Chiod. Ascending afferent regulation of rat midbrain dopamine neurons. Brain research bulletin. vol 31. issue 5. 1993-06-22. PMID:8495379. |
ascending afferent regulation of rat midbrain dopamine neurons. |
1993-06-22 |
2023-08-12 |
rat |
| M D Kelland, A S Freeman, J Rubin, L A Chiod. Ascending afferent regulation of rat midbrain dopamine neurons. Brain research bulletin. vol 31. issue 5. 1993-06-22. PMID:8495379. |
standard, extracellular single-unit recording techniques were used to examine the electrophysiological and pharmacological responsiveness of midbrain dopamine (da) neurons to selected, ascending afferent inputs. |
1993-06-22 |
2023-08-12 |
rat |
| L F Lin, D H Doherty, J D Lile, S Bektesh, F Collin. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (New York, N.Y.). vol 260. issue 5111. 1993-06-16. PMID:8493557. |
in embryonic midbrain cultures, recombinant human gdnf promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. |
1993-06-16 |
2023-08-12 |
human |
| M I Colado, M J Ormazabal, M J Alfaro, M I Marti. Effect of Bay K 8644 on the synthesis and metabolism of dopamine and 5-hydroxytryptamine in various brain areas of the rat. The Journal of pharmacy and pharmacology. vol 45. issue 3. 1993-06-03. PMID:7683338. |
caused an increase in the synthesis of both dopamine in the striatum and 5-ht in the midbrain and striatum, measured as the accumulation of 3,4-dihydroxyphenylalanine (dopa) and 5-hydroxytryptophan, respectively. |
1993-06-03 |
2023-08-12 |
rat |
| M I Colado, M J Ormazabal, M J Alfaro, M I Marti. Effect of Bay K 8644 on the synthesis and metabolism of dopamine and 5-hydroxytryptamine in various brain areas of the rat. The Journal of pharmacy and pharmacology. vol 45. issue 3. 1993-06-03. PMID:7683338. |
moreover, bay k 8644 at the dose of 4 mg kg-1 increased the turnover of dopamine in the striatum and of 5-ht in midbrain and striatum. |
1993-06-03 |
2023-08-12 |
rat |
| C Cerruti, D M Walther, M J Kuhar, G R Uh. Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain. Brain research. Molecular brain research. vol 18. issue 1-2. 1993-05-21. PMID:8479287. |
dopamine transporter mrna expression is intense in rat midbrain neurons and modest outside midbrain. |
1993-05-21 |
2023-08-12 |
rat |
| J Grenhoff, T H Svensso. Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8097162. |
previous studies have indicated a noradrenergic modulation of midbrain dopamine cell activity. |
1993-05-19 |
2023-08-12 |
rat |
| J Grenhoff, T H Svensso. Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8097162. |
the effects of systemic administration of the alpha 1-adrenoceptor antagonist prazosin and the alpha 2-antagonist idazoxan on midbrain dopamine cell firing were now studied with extracellular recording from single dopamine neurons in the ventral tegmental area of chloral hydrate-anaesthetized male rats. |
1993-05-19 |
2023-08-12 |
rat |