| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Bannon, C J Whitt. Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology. vol 48. issue 4. 1997-05-15. PMID:9109886. |
we assessed the abundance of dopamine transporter messenger rna (dat mrna) in various human midbrain dopamine cell groups using in situ hybridization. |
1997-05-15 |
2023-08-12 |
human |
| P A Lapchak, S Jiao, F Collins, P J Mille. Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection. Brain research. vol 747. issue 1. 1997-05-14. PMID:9042532. |
this study shows that intraventricularly injected gdnf can access basal ganglia structures, most notably the midbrain dopamine cell body region, and remains present in this area for at least 7 days following a single administration. |
1997-05-14 |
2023-08-12 |
rat |
| C V Borlongan, C E Stahl, D F Cameron, S Saporta, T B Freeman, D W Cahill, P R Sanber. CNS immunological modulation of neural graft rejection and survival. Neurological research. vol 18. issue 4. 1997-05-13. PMID:8875445. |
most animal studies concerned with neural transplantation for the treatment of pd have utilized dopamine (da) neurons from tissues of the embryonic ventral mesencephalon. |
1997-05-13 |
2023-08-12 |
human |
| F J Whit. Synaptic regulation of mesocorticolimbic dopamine neurons. Annual review of neuroscience. vol 19. 1997-05-12. PMID:8833449. |
many intrinsic membrane properties and synaptic regulators have been identified and characterized in the midbrain ventral tegmental dopamine neurons that give rise to this system. |
1997-05-12 |
2023-08-12 |
human |
| F J Whit. Synaptic regulation of mesocorticolimbic dopamine neurons. Annual review of neuroscience. vol 19. 1997-05-12. PMID:8833449. |
this work is placed within the context of the behavioral responsiveness of midbrain dopamine neurons and the alterations produced in these neurons by repeated treatment with and withdrawal from antipsychotic drugs and drugs of abuse. |
1997-05-12 |
2023-08-12 |
human |
| R H Zetterström, L Solomin, L Jansson, B J Hoffer, L Olson, T Perlman. Dopamine neuron agenesis in Nurr1-deficient mice. Science (New York, N.Y.). vol 276. issue 5310. 1997-04-28. PMID:9092472. |
these results suggest that putative nurr1 ligands may be useful for treatment of parkinson's disease and other disorders of midbrain dopamine circuitry. |
1997-04-28 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
seven days later, dopamine concentrations were measured in the striatum using high performance liquid chromatography, and midbrain dopaminergic neurons were identified using an antibody against tyrosine hydroxylase. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
although the highest dose (300 mg/kg) caused an 86% reduction in striatal dopamine concentrations, there was only a moderate and non-significant loss of midbrain dopaminergic neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
in the c57bl/6 strain, however, a high dose of mptp (240 mg/kg) caused a significant reduction in both striatal dopamine concentrations (95%), and midbrain dopaminergic cells; 69% loss of nucleus a8 cells, 75% loss of nucleus a9 cells, and in nucleus a10 subnuclei there was 42% loss of ventral tegmental area cells, 55% loss of interfascicular nucleus cells, and no loss of cells in the central linear nucleus. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
these data (1) provide further evidence for differential susceptibility to mptp toxicity among different mouse strains, (2) indicate that a significant depletion of striatal dopamine is not necessarily due to degeneration of midbrain dopaminergic neurons, (3) provide the precise locations of midbrain dopaminergic cells that are vulnerable to mptp, which will aid future studies that seek to determine the mechanism/s by which-mptp selectively destroys only certain midbrain dopaminergic neurons, and (4) indicate that mptp produces midbrain dopaminergic neuronal degeneration in the same nuclei in the c57bl16 mouse that degenerate in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| Y Chen, M Herrera-Marschitz, B Bjelke, M Blum, J Gross, K Andersso. Perinatal asphyxia-induced changes in rat brain tyrosine hydroxylase-immunoreactive cell body number: effects of nicotine treatment. Neuroscience letters. vol 221. issue 2-3. 1997-04-18. PMID:9121704. |
in contrast, perinatal asphyxia (15-20 min) resulted in an increased number of th-ir nerve cell bodies in the a9 (zona compacta of the substantia nigra) and the a10 (ventral tegmental area) regions of the mesencephalon, probably reflecting an increased survival of dopamine nerve cell bodies. |
1997-04-18 |
2023-08-12 |
rat |
| b' R Alonso, M Fournier, P Carayon, G Petitpretre, G Le Fur, P Soubri\\xc3\\xa. Evidence for modulation of dopamine-neuronal function by tachykinin NK3 receptor stimulation in gerbil mesencephalic cell cultures. The European journal of neuroscience. vol 8. issue 4. 1997-04-03. PMID:9081631.' |
primary cultures of gerbil mesencephalon were used for studying the modulation exerted by tachykinin nk(3) receptor activation on the activity of dopamine (da) neurons. |
1997-04-03 |
2023-08-12 |
Not clear |
| B J Everitt, T W Robbin. Central cholinergic systems and cognition. Annual review of psychology. vol 48. 1997-03-31. PMID:9046571. |
we also suggest that nucleus basalis-amygdala cholinergic projections have a role in the retention of affective conditioning while brainstem cholinergic projections to the thalamus and midbrain dopamine neurons affect basic arousal processes (e.g. |
1997-03-31 |
2023-08-12 |
Not clear |
| J Kamei, A Saito. Involvement of dopamine D2 receptor-mediated functions in the modulation of morphine-induced antinociception in diabetic mouse. Neuropharmacology. vol 35. issue 3. 1997-03-26. PMID:8783201. |
the dopamine turnover ratio in the limbic forebrain and midbrain in diabetic mice were significantly greater than those in non-diabetic mice. |
1997-03-26 |
2023-08-12 |
mouse |
| J Kamei, A Saito. Involvement of dopamine D2 receptor-mediated functions in the modulation of morphine-induced antinociception in diabetic mouse. Neuropharmacology. vol 35. issue 3. 1997-03-26. PMID:8783201. |
when mice were pretreated with quinpirole (100 and 300 nmol, i.c.v), this enhanced dopamine turnover ratio was not observed in either the limbic forebrain or the midbrain of diabetic mice. |
1997-03-26 |
2023-08-12 |
mouse |
| B J Bowery, Z Razzaque, F Emms, S Patel, S Freedman, L Bristow, J Kulagowski, G R Seabroo. Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. British journal of pharmacology. vol 119. issue 7. 1997-03-26. PMID:8968560. |
antagonism of the effects of (+)-pd 128907 on midbrain dopamine neurones in rat brain slices by a selective d2 receptor antagonist l-741,626. |
1997-03-26 |
2023-08-12 |
rat |
| B J Bowery, Z Razzaque, F Emms, S Patel, S Freedman, L Bristow, J Kulagowski, G R Seabroo. Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. British journal of pharmacology. vol 119. issue 7. 1997-03-26. PMID:8968560. |
the affinity of l-741,626 for these nerve terminal autoreceptors (pkb = 7.71 +/- 0.06; = 20 nm) was identical to that observed on midbrain dopamine neurones. |
1997-03-26 |
2023-08-12 |
rat |
| B J Bowery, Z Razzaque, F Emms, S Patel, S Freedman, L Bristow, J Kulagowski, G R Seabroo. Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. British journal of pharmacology. vol 119. issue 7. 1997-03-26. PMID:8968560. |
these data demonstrate that the d3 receptor ligand (+)-pd 128907 is a potent agonist on rat midbrain dopamine neurones. |
1997-03-26 |
2023-08-12 |
rat |
| S S Shim, B S Bunney, W X Sh. Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914116. |
effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. |
1997-03-14 |
2023-08-12 |
rat |
| S S Shim, B S Bunney, W X Sh. Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914116. |
to determine whether lesions in the prefrontal cortex (pfc) alter the activity of midbrain dopamine (da) neurons, single unit recordings were made from da neurons in control and lesioned rats. |
1997-03-14 |
2023-08-12 |
rat |