| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N B Mercuri, M Federici, G Bernard. Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651109. |
here we report that a treatment of the cerebral tissue with tolcapone, a central and peripheral inhibitor of comt, does not change the membrane responses of midbrain dopamine neurons to dopamine and levodopa. |
2000-02-15 |
2023-08-12 |
rat |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| S R Sinclair, J W Fawcett, S B Dunnet. Dopamine cells in nigral grafts differentiate prior to implantation. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594660. |
precursor cells that would differentiate into dopaminergic neurons beyond e14 if left in situ in the intact ventral mesencephalon do not readily differentiate into mature dopamine neurons following transplantation. |
2000-02-10 |
2023-08-12 |
rat |
| K R Shieh, J T Pa. Stimulatory role of prolactin on the development of tuberoinfundibular dopaminergic neurones in prepubertal female rats: studies with cysteamine and somatostatin. Journal of neuroendocrinology. vol 11. issue 12. 2000-01-18. PMID:10583725. |
these results indicate that serum prolactin is important for the maturation and maintenance of dopamine systems in the median eminence, nucleus accumbens and striatum, while somatostatin exhibits inhibitory and stimulatory effects on hypothalamic and midbrain dopamine systems, respectively. |
2000-01-18 |
2023-08-12 |
rat |
| B Gronier, K Rasmusse. Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. Neuropharmacology. vol 38. issue 12. 2000-01-18. PMID:10608285. |
extracellular single-unit recordings and iontophoresis were used to compare the effect of a single administration of pertussis toxin (ptx, 1 microg), into midbrain dopamine (da) nuclei (a9 and a10 regions), on the muscarinic, nmda and da receptor responses of midbrain da cells in the anesthetized rat. |
2000-01-18 |
2023-08-12 |
rat |
| D S Castro, M Arvidsson, M Bondesson Bolin, T Perlman. Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2. The Journal of biological chemistry. vol 274. issue 52. 2000-01-13. PMID:10601324. |
nurr1, a member of the nuclear hormone receptor superfamily, was recently demonstrated to be of critical importance in the developing central nervous system, where it is required for the generation of midbrain dopamine cells. |
2000-01-13 |
2023-08-12 |
human |
| B C Jones, L M Tarantino, L A Rodriguez, C L Reed, G E McClearn, R Plomin, V G Erwi. Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry. Pharmacogenetics. vol 9. issue 5. 2000-01-06. PMID:10591541. |
in separate groups of animals, densities of dopamine d1, and d2 receptors and dopamine uptake transporters were measured in the medial prefrontal cortex, caudate-putamen, nucleus accumbens and ventral midbrain. |
2000-01-06 |
2023-08-12 |
mouse |
| R Y Shen, J H Hannigan, G Kapato. Prenatal ethanol reduces the activity of adult midbrain dopamine neurons. Alcoholism, clinical and experimental research. vol 23. issue 11. 1999-12-30. PMID:10591597. |
prenatal ethanol reduces the activity of adult midbrain dopamine neurons. |
1999-12-30 |
2023-08-12 |
Not clear |
| R Y Shen, J H Hannigan, G Kapato. Prenatal ethanol reduces the activity of adult midbrain dopamine neurons. Alcoholism, clinical and experimental research. vol 23. issue 11. 1999-12-30. PMID:10591597. |
prenatal ethanol exposure has been demonstrated to reduce dopamine (da) neurotransmission in the forebrain area, which could be contributed by altered electrical activity in midbrain da neurons. |
1999-12-30 |
2023-08-12 |
Not clear |
| B Amini, J W Clark, C C Canavie. Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study. Journal of neurophysiology. vol 82. issue 5. 1999-12-17. PMID:10561403. |
a mathematical model of midbrain dopamine neurons has been developed to understand the mechanisms underlying two types of calcium-dependent firing patterns that these cells exhibit in vitro. |
1999-12-17 |
2023-08-12 |
Not clear |
| H Washio, K Takigachi-Hayashi, S Konish. Early postnatal development of substantia nigra neurons in rat midbrain slices: hyperpolarization-activated inward current and dopamine-activated current. Neuroscience research. vol 34. issue 2. 1999-12-15. PMID:10498335. |
whole-cell voltage-clamp recordings in rat midbrain slices were used to determine the characteristics and postnatal development of a hyperpolarization-activated inward current (ih) and a dopamine receptor-activated current of neurons in the substantia nigra pars compacta (snc). |
1999-12-15 |
2023-08-12 |
rat |
| P Szot, S S White, R C Veith, D D Rasmusse. Reduced gene expression for dopamine biosynthesis and transport in midbrain neurons of adult male rats exposed prenatally to ethanol. Alcoholism, clinical and experimental research. vol 23. issue 10. 1999-11-30. PMID:10549997. |
reduced gene expression for dopamine biosynthesis and transport in midbrain neurons of adult male rats exposed prenatally to ethanol. |
1999-11-30 |
2023-08-12 |
rat |
| P Rojas, C D Klaasse. Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neuroscience letters. vol 273. issue 2. 1999-11-22. PMID:10505629. |
seven days after the last dose, brains were removed and dopamine (da) and homovanillic acid (hva) contents were analyzed in striatum and midbrain by high pressure liquid chromatography (hplc). |
1999-11-22 |
2023-08-12 |
mouse |
| W Le, O M Conneely, L Zou, Y He, O Saucedo-Cardenas, J Jankovic, D R Mosier, S H Appe. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506516. |
nurr1, a member of the nuclear receptor superfamily of transcription factors, has been found to be essential for the development of ventral midbrain dopamine (da)ergic neurons. |
1999-11-19 |
2023-08-12 |
mouse |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
cocaine is a highly addictive drug that binds to the dopamine transporter (dat), inhibits the reuptake of dopamine, and initiates multiple actions within midbrain dopaminergic systems. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
furthermore, we observed that dat mrna was differentially expressed within fetal midbrain dopamine neurons with the highest levels detected in the ventral tier of the substantia nigra pars compacta, and the lowest levels in the ventral tegmental area and the linear/interfascicular nuclei. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
in utero cocaine exposure between days 22 and 70 significantly increased dat mrna expression, and the density of [125i]rti-121 binding sites within midbrain dopamine neurons in the 70-d-old fetus. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
this increased dat expression is accompanied by other presynaptic and postsynaptic neuronal changes, which collectively suggest that midbrain dopamine neurons are hypoactive after prolonged cocaine exposure, a state that may be a contributing factor in the development of attention deficit disorders observed in subjects exposed prenatally to cocaine. |
1999-10-28 |
2023-08-12 |
human |
| A M Kang, M A Palmatier, K K Kid. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418689. |
the dopamine transporter (dat) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and mptp. |
1999-10-25 |
2023-08-12 |
Not clear |