| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Lança, K L Adamson, K M Coen, B L Chow, W A Corrigal. The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727791. |
the objective of this study was to determine whether the pedunculopontine tegmental nucleus plays a role in the maintenance of nicotine self-administration, and whether the ascending cholinergic projection from this nucleus to midbrain dopamine neurons in the ventral tegmental area might be involved. |
2000-05-31 |
2023-08-12 |
rat |
| X Wu, E D Frenc. Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698005. |
effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. |
2000-05-16 |
2023-08-12 |
rat |
| X Wu, E D Frenc. Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698005. |
using single-unit extracellular recordings the activity of midbrain ventral tegmental (vta) and substantia nigra pars compacta (snpc) dopamine neurons was measured in animals that had received twice-daily injections of 5 mg/kg delta9-thc for 14 days. |
2000-05-16 |
2023-08-12 |
rat |
| A R West, A A Grac. Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. Journal of neurophysiology. vol 83. issue 4. 2000-05-15. PMID:10758092. |
striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. |
2000-05-15 |
2023-08-12 |
rat |
| W Schultz, L Tremblay, J R Hollerma. Reward processing in primate orbitofrontal cortex and basal ganglia. Cerebral cortex (New York, N.Y. : 1991). vol 10. issue 3. 2000-04-27. PMID:10731222. |
this article reviews and interprets neuronal activities related to the expectation and delivery of reward in the primate orbitofrontal cortex, in comparison with slowly discharging neurons in the striatum (caudate, putamen and ventral striatum, including nucleus accumbens) and midbrain dopamine neurons. |
2000-04-27 |
2023-08-12 |
Not clear |
| X Zhou, W Zhang, T Ba. [Expression of glial cells line-derived neurotrophic factor in the central nervous system of rat]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 29. issue 3. 2000-04-25. PMID:10684095. |
glial cell line-derived neurotrophic factor (gdnf) iss a distant member of the transforming growth factor-beta, originally isolated by virtue of its ability to induce dopamine uptake and cell survival in cultures of embryonic ventral midbrain dopaminergic neurons, and more recently it has been shown to be a potent neurotrophic factor for motor neurons. |
2000-04-25 |
2023-08-12 |
rat |
| P Grillner, N Berretta, G Bernardi, T H Svensson, N B Mercur. Muscarinic receptors depress GABAergic synaptic transmission in rat midbrain dopamine neurons. Neuroscience. vol 96. issue 2. 2000-04-20. PMID:10683570. |
muscarinic receptors depress gabaergic synaptic transmission in rat midbrain dopamine neurons. |
2000-04-20 |
2023-08-12 |
rat |
| P Grillner, N Berretta, G Bernardi, T H Svensson, N B Mercur. Muscarinic receptors depress GABAergic synaptic transmission in rat midbrain dopamine neurons. Neuroscience. vol 96. issue 2. 2000-04-20. PMID:10683570. |
the effects of muscarine and nicotine on evoked and spontaneous release of gaba were studied using intracellular and whole-cell patch-clamp recordings from rat midbrain dopamine neurons in an in vitro slice preparation. |
2000-04-20 |
2023-08-12 |
rat |
| P Grillner, N Berretta, G Bernardi, T H Svensson, N B Mercur. Muscarinic receptors depress GABAergic synaptic transmission in rat midbrain dopamine neurons. Neuroscience. vol 96. issue 2. 2000-04-20. PMID:10683570. |
our data indicate that a prevalent activation of presynaptic m3 muscarinic receptors inhibits the gaba-mediated synaptic events, while the activation of nicotinic receptors does not affect the release of glutamate and gaba on midbrain dopamine neurons. |
2000-04-20 |
2023-08-12 |
rat |
| E Koga, T Momiyam. Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones. The Journal of physiology. vol 523 Pt 1. 2000-04-18. PMID:10673553. |
the effects of dopamine (da) on non-nmda glutamatergic transmission onto dopaminergic neurones in the ventral tegmental area (vta) were examined in rat midbrain slices using the whole-cell patch-clamp technique. |
2000-04-18 |
2023-08-12 |
rat |
| G H Moll, C Mehnert, M Wicker, N Bock, A Rothenberger, E Rüther, G Huethe. Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675775. |
the binding parameters of highly selective ligands of serotonin (5-ht) transporters ([3h]paroxetine), noradrenaline (ne) transporters ([3h]nisoxetine), and of dopamine (da) transporters ([3h]gbr-12935) were determined on membrane preparations from frontal cortex, striatum, midbrain and brain stem of wistar rats on postnatal days 25, 50, 90 and 240, i.e., from the time of weaning till late adulthood. |
2000-04-11 |
2023-08-12 |
rat |
| S N Haber, J L Fudge, N R McFarlan. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 6. 2000-04-03. PMID:10704511. |
examination of results from multiple tracing experiments simultaneously demonstrates an interface between different striatal regions via the midbrain dopamine cells that forms an ascending spiral between regions. |
2000-04-03 |
2023-08-12 |
Not clear |
| F G Kaddis, E D Clarkson, K P Bell, P K Choi, C R Free. Co-grafts of muscle cells and mesencephalic tissue into hemiparkinsonian rats: behavioral and histochemical effects. Brain research bulletin. vol 51. issue 3. 2000-03-30. PMID:10718512. |
these findings suggest that in vivo, neonatal muscle cells secrete factors that promote survival and/or outgrowth of fetal midbrain dopamine cells and improve the levels of th-ir in grafted striatum. |
2000-03-30 |
2023-08-12 |
rat |
| A C Tomac, A Grinberg, S P Huang, C Nosrat, Y Wang, C Borlongan, S Z Lin, Y H Chiang, L Olson, H Westphal, B J Hoffe. Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682708. |
(1996) nature 382, 80-83], a survival factor for several populations of central and peripheral neurons, including midbrain dopamine neurons [lin l. f. et al. |
2000-03-21 |
2023-08-12 |
mouse |
| C Cosi, M Marie. Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668429. |
the results confirm that mptp reduces striatal atp levels, as previously reported by chan et al., show that mptp causes a regionally-selective (striatal and midbrain) loss of nad+, and indicate that the parp inhibitor benzamide can prevent these losses without interfering with mptp-induced striatal dopamine release. |
2000-03-15 |
2023-08-12 |
mouse |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
the serotoninergic (5-ht) input from the dorsal raphe nucleus (drn) to midbrain dopamine (da) neurons is one of the most prominent. |
2000-03-13 |
2023-08-12 |
rat |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
[factors regulating survival and death of midbrain dopamine neurons]. |
2000-02-16 |
2023-08-12 |
Not clear |
| M A Mena, M J Casarejos, J García de Yébene. The effect of glia-conditioned medium on dopamine neurons in culture. Modulation of apoptosis, tyrosine hydroxylase expression and 1-methyl-4-phenylpyridinium toxicity. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651107. |
in this study we have investigated the effect of gcm on the number of tyrosine hydroxylase (th) immunoreactive neurons, levels of dopamine, number of high affinity dopamine uptake sites, and percentage of apoptotic cells in midbrain neuronal cultures, before and after exposure to 1-methyl-4-phenylpyridinium (mpp+). |
2000-02-15 |
2023-08-12 |
Not clear |
| M A Mena, M J Casarejos, J García de Yébene. The effect of glia-conditioned medium on dopamine neurons in culture. Modulation of apoptosis, tyrosine hydroxylase expression and 1-methyl-4-phenylpyridinium toxicity. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651107. |
therefore, gcm does not only protect against mpp+ but does also induce de novo expression of dopamine phenotype in midbrain cultures. |
2000-02-15 |
2023-08-12 |
Not clear |
| N B Mercuri, M Federici, G Bernard. Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651109. |
in order to study whether the membrane hyperpolarization and firing inhibition caused by dopamine and levodopa on rat midbrain dopamine cells are affected by the inhibition of brain catechol-o-methyl-transferase (comt), intracellular electrophysiological recordings were made from these neurons maintained in vitro. |
2000-02-15 |
2023-08-12 |
rat |