| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
finally, we report that 6-ohda also increased kv currents in cultured midbrain dopamine neurons and this toxicity was blocked with kv channel antagonists. |
2007-01-26 |
2023-08-12 |
rat |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
following uptake, 6-ohda triggers the oxidant-associated kv channel-dependent cell death pathway that is conserved in non-dopaminergic cortical neurons and midbrain dopamine neurons. |
2007-01-26 |
2023-08-12 |
rat |
| Yotam Sagi, Silvia Mandel, Tamar Amit, Moussa B H Youdi. Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Neurobiology of disease. vol 25. issue 1. 2007-01-23. PMID:17055733. |
employing conventional neurochemical techniques, transcriptomics and proteomic screening tools combined with a biology-based clustering method, we show that rasagiline, given chronically post-mptp (n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), exerts neurorescue/neurotrophic activity in mice midbrain dopamine neurons. |
2007-01-23 |
2023-08-12 |
mouse |
| Alfonso Abizaid, Zhong-Wu Liu, Zane B Andrews, Marya Shanabrough, Erzsebet Borok, John D Elsworth, Robert H Roth, Mark W Sleeman, Marina R Picciotto, Matthias H Tschöp, Xiao-Bing Gao, Tamas L Horvat. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17060947. |
ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. |
2007-01-22 |
2023-08-12 |
mouse |
| Chunjuan Huang, Han Cheng, Shufeng Hao, Hui Zhou, Xujia Zhang, Jianen Gao, Qi-Hong Sun, Hongyu Hu, Chih-Chen Wan. Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates. Journal of molecular biology. vol 364. issue 3. 2007-01-16. PMID:17010992. |
alpha-synuclein (as) is a main component of lewy bodies in midbrain dopamine neurons pathologically characteristic of parkinson's disease. |
2007-01-16 |
2023-08-12 |
Not clear |
| Raffaella Geracitano, Mauro Federici, Giorgio Bernardi, Nicola B Mercur. On the effects of psychostimulants, antidepressants, and the antiparkinsonian drug levodopa on dopamine neurons. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105928. |
the effects caused by these compounds are partly associated with an increased dopamine (da) levels within the terminal areas of da neurons and in the ventral midbrain. |
2007-01-10 |
2023-08-12 |
Not clear |
| Asa Abeliovich, M Flint Bea. Parkinsonism genes: culprits and clues. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:16836655. |
pathological studies have linked this presentation to the loss of midbrain dopamine neurons (gelb et al. |
2007-01-09 |
2023-08-12 |
Not clear |
| H A Boger, L D Middaugh, P Huang, V Zaman, A C Smith, B J Hoffer, A C Tomac, A-Ch Granhol. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16889771. |
glial cell line-derived neurotrophic factor (gdnf) is a trophic factor for peripheral organs, spinal cord, and midbrain dopamine (da) neurons. |
2007-01-03 |
2023-08-12 |
mouse |
| S Totterdel. The anatomy of co-morbid neuropsychiatric disorders based on cortico-limbic synaptic interactions. Neurotoxicity research. vol 10. issue 2. 2007-01-03. PMID:17062369. |
we have also examined local and extrinsic connections in the prefrontal cortex and the basis for regulation of both cortical neurons and midbrain dopamine neurons by serotonin from the raph é nucleus. |
2007-01-03 |
2023-08-12 |
Not clear |
| Chang-Hwan Park, Jin Sun Kang, Yeon Ho Shin, Mi-Yoon Chang, Seungsoo Chung, Hyun-Chul Koh, Mei Hong Zhu, Seog Bae Oh, Yong-Sung Lee, Georgia Panagiotakos, Vivian Tabar, Lorenz Studer, Sang-Hun Le. Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 14. 2007-01-01. PMID:17077287. |
however, little progress has been made in directing naive neural precursors toward specific neuronal fates such as midbrain dopamine (da) neurons. |
2007-01-01 |
2023-08-12 |
rat |
| Yukari Date, Takuya Shimbara, Shuichi Koda, Koji Toshinai, Takanori Ida, Noboru Murakami, Mikiya Miyazato, Koichi Kokame, Yuta Ishizuka, Yasushi Ishida, Haruaki Kageyama, Seiji Shioda, Kenji Kangawa, Masamitsu Nakazat. Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell metabolism. vol 4. issue 4. 2006-12-21. PMID:17011505. |
in addition, bilateral midbrain transections rostral to the nts, or toxin-induced loss of neurons in the hindbrain that express dopamine beta hydroxylase (an na synthetic enzyme), abolished ghrelin-induced feeding. |
2006-12-21 |
2023-08-12 |
Not clear |
| Paola Sacchetti, Rodolphe Carpentier, Pascaline Ségard, Cécile Olivé-Cren, Philippe Lefebvr. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1. Nucleic acids research. vol 34. issue 19. 2006-12-20. PMID:17020917. |
the orphan nuclear receptor nurr1 (nr4a2) is an essential transcription factor for the acquisition and maintenance of the phenotype of dopamine (da)-synthesizing neurons in the mesencephalon. |
2006-12-20 |
2023-08-12 |
Not clear |
| Yu Mi Choi, Shin Hye Kim, Sungkwon Chung, Dae Yong Uhm, Myoung Kyu Par. Regional interaction of endoplasmic reticulum Ca2+ signals between soma and dendrites through rapid luminal Ca2+ diffusion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 47. 2006-12-15. PMID:17122037. |
here, we show that continuous or repetitive applications of caffeine produced robust ca2+ release from the er ca2+ store in dendritic areas without severe store depletion, but that similar stimuli applied to soma caused rapid store depletion in acutely isolated midbrain dopamine neurons. |
2006-12-15 |
2023-08-12 |
Not clear |
| Mathew E Brevard, Jerrold S Meyer, Josie A Harder, Craig F Ferri. Imaging brain activity in conscious monkeys following oral MDMA ("ecstasy"). Magnetic resonance imaging. vol 24. issue 6. 2006-12-07. PMID:16824965. |
following mdma administration, the midbrain raphe nuclei and substantia nigra, major sources of serotonin and dopamine, were activated as were the hippocampus, hypothalamus and amygdala. |
2006-12-07 |
2023-08-12 |
monkey |
| Sanjay Jain, Judith P Golden, David Wozniak, Elizabeth Pehek, Eugene M Johnson, Jeffrey Milbrand. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 43. 2006-11-24. PMID:17065462. |
a detailed morphometric and biochemical analysis including dopaminergic neuron number and size in snc and vta, and fiber density in the striatum and nucleus accumbens, and dopamine levels indicate that ret is not required for providing global trophic support to midbrain dopaminergic neurons in adult mice. |
2006-11-24 |
2023-08-12 |
mouse |
| Jonathan D Hommel, Richard Trinko, Robert M Sears, Dan Georgescu, Zong-Wu Liu, Xiao-Bing Gao, Jeremy J Thurmon, Michela Marinelli, Ralph J DiLeon. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron. vol 51. issue 6. 2006-11-07. PMID:16982424. |
leptin receptor signaling in midbrain dopamine neurons regulates feeding. |
2006-11-07 |
2023-08-12 |
Not clear |
| Jesse R Schank, Rossella Ventura, Stefano Puglisi-Allegra, Antonio Alcaro, Charlene D Cole, L Cameron Liles, Philip Seeman, David Weinshenke. Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16395294. |
multiple lines of evidence demonstrate that the noradrenergic system provides both direct and indirect excitatory drive onto midbrain dopamine (da) neurons. |
2006-11-01 |
2023-08-12 |
mouse |
| Matthew Maingay, Marina Romero-Ramos, Manolo Carta, Deniz Kiri. Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. Neurobiology of disease. vol 23. issue 3. 2006-11-01. PMID:16806952. |
while most profound neurodegeneration is seen in the dopamine (da) synthesizing neurons located in the ventral midbrain, it is unclear why some da cell groups are more susceptible than others. |
2006-11-01 |
2023-08-12 |
human |
| K Strecker, J P Schneider, H Barthel, W Hermann, F Wegner, A Wagner, J Schwarz, O Sabri, C Zimme. Profound midbrain atrophy in patients with Wilson's disease and neurological symptoms? Journal of neurology. vol 253. issue 8. 2006-10-26. PMID:16607473. |
there was a strong and significant correlation between midbrain atrophy and the severity of neurological symptoms (r= -0.68, p < 0.001) while midbrain atrophy and dopamine transporter binding correlated significantly but was less pronounced (r=0.46, p < 0.001). |
2006-10-26 |
2023-08-12 |
Not clear |
| Paul D Shepard, Henry H Holcomb, James M Gol. Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes. Schizophrenia bulletin. vol 32. issue 3. 2006-10-18. PMID:16717257. |
we present preliminary evidence that habenula projections to the midbrain are capable of producing a transient, but nearly complete, inhibition of dopamine neurons at a population level similar to that observed in behaving primates following an unexpected negative outcome. |
2006-10-18 |
2023-08-12 |
human |