| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Musazzi, J M Rimland, A Ieraci, G Racagni, E Domenici, M Popol. Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24451568. |
we generated a gene reporter system based on hippocampal and cortical neuronal cultures, in which the transcription of luciferase is regulated by bdnf promoters i, ii, iv or by camp response element (cre), to investigate the activation of selected promoters induced by monoaminergic antidepressants and by serotonin or noradrenaline agonists. |
2014-12-01 |
2023-08-12 |
rat |
| Anshula Samarajeewa, Lolita Goldemann, Maryam S Vasefi, Nawaz Ahmed, Nyasha Gondora, Chandni Khanderia, John G Mielke, Michael A Beazel. 5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation. Frontiers in behavioral neuroscience. vol 8. 2014-11-26. PMID:25426041. |
the serotonin (5-ht) type 7 receptor is expressed throughout the cns including the cortex and hippocampus. |
2014-11-26 |
2023-08-13 |
Not clear |
| Donatella Marazziti, Stefano Baroni, Lionella Palego, Laura Betti, Gino Giannaccini, Maura Castagna, Antonio G Naccarato, Antonio Luccachini, Mario Catena-Dell'Osso, Liliana Dell'Oss. Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem. Journal of psychopharmacology (Oxford, England). vol 28. issue 4. 2014-11-24. PMID:24429224. |
the present work, therefore, aimed at evaluating the effects of clozapine and its major metabolite, norclozapine, on the modulation of adenylyl cyclase (ac) velocity via 5-ht(1a) receptors in human post-mortem brain regions, in particular the prefrontal cortex, hippocampus and raphe nuclei. |
2014-11-24 |
2023-08-12 |
human |
| Donatella Marazziti, Stefano Baroni, Lionella Palego, Laura Betti, Gino Giannaccini, Maura Castagna, Antonio G Naccarato, Antonio Luccachini, Mario Catena-Dell'Osso, Liliana Dell'Oss. Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem. Journal of psychopharmacology (Oxford, England). vol 28. issue 4. 2014-11-24. PMID:24429224. |
the receptor characterisation of the clozapine effect on ac observed in the hippocampus by the use of antagonists showed a mixed profile, involving not only the 5-ht(1a) receptor but also a muscarinic (m) receptor subtype, most likely the m₄ one. |
2014-11-24 |
2023-08-12 |
human |
| Shimako Yoshitake, Eugenia Kuteeva, Tomas Hökfelt, Françoise Mennicken, Elvar Theodorsson, Masatoshi Yamaguchi, Jan Kehr, Takashi Yoshitak. Correlation between the effects of local and intracerebroventricular infusions of galanin on 5-HT release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats. Synapse (New York, N.Y.). vol 68. issue 5. 2014-11-07. PMID:24430888. |
correlation between the effects of local and intracerebroventricular infusions of galanin on 5-ht release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats. |
2014-11-07 |
2023-08-12 |
rat |
| Shimako Yoshitake, Eugenia Kuteeva, Tomas Hökfelt, Françoise Mennicken, Elvar Theodorsson, Masatoshi Yamaguchi, Jan Kehr, Takashi Yoshitak. Correlation between the effects of local and intracerebroventricular infusions of galanin on 5-HT release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats. Synapse (New York, N.Y.). vol 68. issue 5. 2014-11-07. PMID:24430888. |
infusions of galanin on basal extracellular 5-ht levels in medial prefrontal cortex (mpfc), ca1 area of ventral hippocampus (vhpc), central amygdaloid nucleus (cea), ventromedial hypothalamic nucleus ventrolateral part (vmhvl), and ventromedial caudate putamen (cpu). |
2014-11-07 |
2023-08-12 |
rat |
| Samina Bano, Iffat Ara, Kausar Saboohi, Tariq Moattar, Bushra Chaoudhr. St. John's Wort increases brain serotonin synthesis by inhibiting hepatic tryptophan 2, 3 dioxygenase activity and its gene expression in stressed rats. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Spec no. 2014-11-07. PMID:25176236. |
the drug also decreases serotonin turnover in all the brain areas (hypothalamus, hippocampus amygdala) in stressed rats endorsing its monoamine oxidase inhibition property. |
2014-11-07 |
2023-08-13 |
rat |
| Mizuho Takahashi, Ayako Yamanaka, Chihiro Asanuma, Hiroko Asano, Tadaaki Satou, Kazuo Koik. Anxiolytic-like effect of inhalation of essential oil from Lavandula officinalis: investigation of changes in 5-HT turnover and involvement of olfactory stimulation. Natural product communications. vol 9. issue 7. 2014-10-30. PMID:25230519. |
lveo significantly increased the striatal and hippocampal levels of 5-ht and decreased turnover rates in accordance with the anxiolytic behavioral changes. |
2014-10-30 |
2023-08-13 |
mouse |
| N Yu Glazova, S A Merchieva, M A Volodina, E A Sebentsova, D M Manchenko, V S Kudrun, N G Levitskay. Effects of neonatal fluvoxamine administration on the physical development and activity of the serotoninergic system in white rats. Acta naturae. vol 6. issue 3. 2014-10-28. PMID:25349718. |
furthermore, increased noradrenalin level in hypothalamus, serotonin level in hippocampus and serotonin metabolite 5-hiaa level in frontal cortex, hypothalamus, hippocampus, and striatum were observed in drug-treated animals compared to the control group. |
2014-10-28 |
2023-08-13 |
human |
| Eman S H Abd Allah, Asmaa M S Gomaa, Manal M Saye. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta physiologica Hungarica. vol 101. issue 3. 2014-10-24. PMID:25183510. |
serum total antioxidant capacity (tac) and hippocampal serotonin and γ-aminobutyric acid (gaba) levels were decreased in the hypothyroid group as compared to the control group. |
2014-10-24 |
2023-08-13 |
rat |
| C Brad Wilson, Philip J Ebenezer, Leslie D McLaughlin, Joseph Franci. Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551226. |
in this study, we hypothesized the predator exposure/psychosocial stress rodent model of ptsd may alter levels of 5-ht and other neurotransmitters in the rat hippocampus and prefrontal cortex (pfc). |
2014-10-21 |
2023-08-12 |
human |
| C Brad Wilson, Philip J Ebenezer, Leslie D McLaughlin, Joseph Franci. Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551226. |
norepinephrine (ne), 5-hydroxyindoleacetic acid (5-hiaa), homovanillic acid (hva), dopamine (da), and 3,4-dihydroxyphenylacetic acid (dopac), and 5-ht levels in the hippocampus and pfc were measured with high-performance liquid chromatography (hplc). |
2014-10-21 |
2023-08-12 |
human |
| C Brad Wilson, Philip J Ebenezer, Leslie D McLaughlin, Joseph Franci. Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551226. |
in the hippocampus, 5-ht and hva were lower, while ne and dopac were higher, in the ptsd group vs. controls. |
2014-10-21 |
2023-08-12 |
human |
| Ken-Ichi Ohta, Takanori Miki, Katsuhiko Warita, Shingo Suzuki, Takashi Kusaka, Tomiko Yakura, Jun-Qian Liu, Motoki Tamai, Yoshiki Takeuch. Prolonged maternal separation disturbs the serotonergic system during early brain development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 33. 2014-10-10. PMID:24184298. |
hplc revealed imbalance between serotonin and 5-hydroxyindoleacetic acid in midbrain raphe nuclei, the amygdala, the hippocampus, and the medial prefrontal cortex (mpfc) on pds 7 and 14. |
2014-10-10 |
2023-08-12 |
rat |
| Ken-Ichi Ohta, Takanori Miki, Katsuhiko Warita, Shingo Suzuki, Takashi Kusaka, Tomiko Yakura, Jun-Qian Liu, Motoki Tamai, Yoshiki Takeuch. Prolonged maternal separation disturbs the serotonergic system during early brain development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 33. 2014-10-10. PMID:24184298. |
furthermore, real-time rt-pcr showed attenuation of mrna expression of the serotonin 1a receptor in the hippocampus and the mpfc and of the serotonin 2a receptor only in the mpfc on pds 7 and 14. |
2014-10-10 |
2023-08-12 |
rat |
| Benjamin D Sachs, Jason R Ni, Marc G Caro. Sex differences in response to chronic mild stress and congenital serotonin deficiency. Psychoneuroendocrinology. vol 40. 2014-10-09. PMID:24485484. |
although cms did not reduce cell proliferation in the hippocampus, low levels of brain 5-ht were associated with increased hippocampal cell proliferation, an effect that was predominantly observed in females. |
2014-10-09 |
2023-08-12 |
mouse |
| Karita Raudkivi, Tanel Mällo, Jaanus Harr. Effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5-HT in rats with persistent differences in positive affectivity. Acta neuropsychiatrica. vol 24. issue 4. 2014-10-08. PMID:25286813. |
effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5-ht in rats with persistent differences in positive affectivity. |
2014-10-08 |
2023-08-13 |
rat |
| Yun-Fang Jia, Ning-Ning Song, Rong-Rong Mao, Jin-Nan Li, Qiong Zhang, Ying Huang, Lei Zhang, Hui-Li Han, Yu-Qiang Ding, Lin X. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in behavioral neuroscience. vol 8. 2014-10-08. PMID:25294992. |
these results suggest that the deficiency of central 5-ht may not be sufficient to induce anxiety/depression-like behaviors in mice, and the enhanced hippocampal neurogenesis may contribute to the altered depression-like behaviors in the 5-ht-deficient mice with diabetes. |
2014-10-08 |
2023-08-13 |
mouse |
| Mai A Abd-El-Fattah, Noha F Abdelakader, Hala F Zak. Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats. European journal of pharmacology. vol 723. 2014-10-07. PMID:24315930. |
rats were then sacrificed and homogenates of cortical and hippocampal tissues were used for the estimation of noradrenaline, dopamine, serotonin and heat shock protein 70 contents along with acetylcholinesterase activity. |
2014-10-07 |
2023-08-12 |
rat |
| Li-Ping Guan, Li-Ming Tang, Cheng-Yan Pan, Shui-Lian Zhao, Si-Hong Wan. Evaluation of potential antidepressant-like activity of chalcone-1203 in various murine experimental depressant models. Neurochemical research. vol 39. issue 2. 2014-10-07. PMID:24343532. |
it was found that chalcone-1203 significantly increased the concentrations of the main neurotransmitters 5-ht and ne in the hippocampus, hypothalamus and cortex. |
2014-10-07 |
2023-08-12 |
mouse |