| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
our results showed that cums caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-ht concentration, tjs protein levels and bdnf expression in the hippocampus. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
however, nab treatment significantly ameliorated behavioral deficits of the cums-induced mice, increased 5-ht concentration, increased bdnf expression, and up-regulated occludin and zonula occludens-1(zo-1) protein levels in the hippocampus, which demonstrated that nab could partially restore cums-induced blood-brain barrier (bbb) impairments. |
2016-08-22 |
2023-08-13 |
mouse |
| Ana Carolina de Moura, Virgínia Meneghini Lazzari, Roberta Oriques Becker, Mirela Severo Gil, Carina Anicet Ruthschilling, Grasiela Agnes, Silvana Almeida, Ana Beatriz Gorini da Veiga, Aldo Bolten Lucion, Márcia Giovenard. Gene expression in the CNS of lactating rats with different patterns of maternal behavior. Neuroscience research. vol 99. 2016-08-19. PMID:26003743. |
this study aimed to analyze the gene expression of the receptors for dopamine (drd1a), prolactin (prlr), serotonin (htr1a, htr1b), estrogen (esr1, esr2), and of bdnf in the olfactory bulb (ob), hippocampus (hp), prefrontal cortex (pfc), and striatum (st) of wistar rats from three groups: ll (n = 8); hl (n = 8); virgin females in diestrus (d; n = 6). |
2016-08-19 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
the release of 5-ht in the hippocampus was measured using a liquid scintillation method and neuronal damage was analyzed by hematoxylin and eosin staining. |
2016-08-15 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
while the anticonvulsant and positive behavioral effects of endurance training were accompanied by an increase of 5-ht release in the hippocampus, it did not exert neuroprotective activity. |
2016-08-15 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
our results indicate that prior exercise is an effective means to attenuate ka-induced seizures and comorbid behavioral changes in a model of hypertension and epilepsy suggesting a potential influence of hippocampal 5-ht on a comorbid depression. |
2016-08-15 |
2023-08-13 |
rat |
| S Liang, T Wang, X Hu, J Luo, W Li, X Wu, Y Duan, F Ji. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. vol 310. 2016-08-15. PMID:26408987. |
l. helveticus ns8 also resulted in lower plasma corticosterone (cort) and adrenocorticotropic hormone (acth) levels, higher plasma interleukin-10 (il-10) levels, restored hippocampal serotonin (5-ht) and norepinephrine (ne) levels, and more hippocampal brain-derived neurotrophic factor (bdnf) mrna expression than in chronic stress rats. |
2016-08-15 |
2023-08-13 |
rat |
| Min Sun, Ke Wang, Yan Yu, Wen-Ting Su, Xin-Xin Jiang, Jian Yang, Jun Jia, Xiao-Min Wan. Electroacupuncture Alleviates Depressive-Like Symptoms and Modulates BDNF Signaling in 6-Hydroxydopamine Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-08-15. PMID:27525025. |
ea treatment did not alter dopamine, norepinephrine, and serotonin levels in the striatum and hippocampus. |
2016-08-15 |
2023-08-13 |
rat |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
in this study, analysis of the 5-ht type 3a receptor subunit-deficient (htr3a(-/-)) mice revealed that lack of the 5-ht type 3 (5-ht3) receptor resulted in loss of exercise-induced hippocampal neurogenesis and antidepressant effects, but not of learning enhancement. |
2016-08-02 |
2023-08-13 |
mouse |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
these findings demonstrate that the 5-ht3 receptor is the critical target of 5-ht action in the brain following exercise, and is indispensable for hippocampal neurogenesis and antidepressant effects induced by exercise. |
2016-08-02 |
2023-08-13 |
mouse |
| Rajeshwari R Solanki, Jamie L Scholl, Michael J Watt, Kenneth J Renner, Gina L Forste. Amphetamine Withdrawal Differentially Increases the Expression of Organic Cation Transporter 3 and Serotonin Transporter in Limbic Brain Regions. Journal of experimental neuroscience. vol 10. 2016-08-01. PMID:27478387. |
amphetamine withdrawal increases anxiety and stress sensitivity related to blunted ventral hippocampus (vhipp) and enhances the central nucleus of the amygdala (cea) serotonin responses. |
2016-08-01 |
2023-08-13 |
rat |
| Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Rajamani Barathidasan, Chidambaram SaravanaBabu, Gilles J Guillemin, Mohammed A S Kha. Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice. PloS one. vol 11. issue 1. 2016-07-26. PMID:26765842. |
injections (once in 3.5 days for 5 weeks) of mptp/p or exposure to cms for 4 weeks, the behavioural (motor and non-motor) impairments, levels and expressions of dopamine (da), serotonin (5-ht), daergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporters-2 (vmat 2) and α-synuclein in nigrostriatal (striatum (st) and substantia nigra (sn)) and extra-nigrostriatal (hippocampus, cortex and cerebellum) tissues were analysed. |
2016-07-26 |
2023-08-13 |
mouse |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
previous work from this laboratory hypothesized that the multimodal antidepressant vortioxetine enhances cognitive function through a complex mechanism, using serotonergic (5-hydroxytryptamine, 5-ht) receptor actions to modulate gamma-butyric acid (gaba) and glutamate neurotransmission in key brain regions like the prefrontal cortex (pfc) and hippocampus. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
effects of serotonin in the hippocampus: how ssris and multimodal antidepressants might regulate pyramidal cell function. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
extensive preclinical research and the notion that modulation of serotonin (5-ht) neurotransmission plays a key role in the therapeutic efficacy of selective serotonin reuptake inhibitors (ssris) support the view that 5-ht is important for hippocampal function in normal and disease-like conditions. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
furthermore, hippocampal cells often co-express multiple 5-ht receptor subtypes that can have either complementary or opposing effects on cell function, adding to the complexity of 5-ht neurotransmission. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
here we review the current knowledge of how 5-ht, through its various receptor subtypes, modulates hippocampal output and the activity of hippocampal pyramidal cells in rodents. |
2016-07-19 |
2023-08-13 |
Not clear |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
in the hippocampus, serotonin (5-ht) is released by ascending serotonergic fibers from the midbrain raphe nuclei, thereby mediating numerous modulatory functions on various neuronal subtypes. |
2016-07-18 |
2023-08-13 |
rat |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
here, we focus on the neuromodulatory effects of 5-ht on gabaergic inhibitory oriens lacunosum-moleculare (o-lm) cells in the hippocampal area ca1 of the rat. |
2016-07-18 |
2023-08-13 |
rat |
| Jing-jing Le, Tao Yi, Li Qi, Ji Li, Lei Shao, Jing-cheng Don. Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression. Neuroscience letters. vol 615. 2016-07-14. PMID:26773866. |
dysfunction of the hippocampal serotonin (5-hydroxytryptamine, 5-ht) system has been shown to be a key factor in depression. |
2016-07-14 |
2023-08-13 |
rat |