| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saritha Krishna, Zhoumeng Lin, Claire B de La Serre, John J Wagner, Donald H Harn, Lacey M Pepples, Dylan M Djani, Matthew T Weber, Leena Srivastava, Nikolay M Filipo. Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake. Physiology & behavior. vol 157. 2016-12-13. PMID:26852949. |
behaviorally, prolonged intake of hfd caused mice to be hypoactive and bury fewer marbles in a marble burying task; the latter was associated with significantly impaired hippocampal serotonin homeostasis. |
2016-12-13 |
2023-08-13 |
mouse |
| b' Jan Vevera, Karel Vale\\xc5\\xa1, Zden\\xc4\\x9bk Fi\\xc5\\xa1ar, Jana Hroudov\\xc3\\xa1, Namrata Singh, Ale\\xc5\\xa1 Stuchl\\xc3\\xadk, Petr Ka\\xc4\\x8der, Tereza Nekov\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model. Physiology & behavior. vol 158. 2016-12-13. PMID:26917054.' |
we have studied selected biologic traits potentially affected by statin treatment - serotonin (5-ht) uptake in platelets, membrane microviscosity in erythrocytes, cholesterol level in the brain (amygdala; hippocampus and prefrontal cortex), as well as behavioral changes in an elevated plus maze and open field test in male long-evans rats, which were treated by simvastatin (30mg/kg per day) for 2 or 4weeks. |
2016-12-13 |
2023-08-13 |
rat |
| Yimin Qiu, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen, Shitong L. 5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity. IUBMB life. vol 68. issue 4. 2016-12-13. PMID:26946964. |
it was found that 5-hydroxy-3-indoleacetic acid (5-hiaa), 3,4-dihydroxyphenylacetic acid, and homovanillic acid concentrations in the csf of scopolamine-induced delirium rats were significantly increased, among which 5-hiaa was also increased in hippocampus and basolateral amygdala (bla), and 5-ht(1a) receptor was significantly higher in the hippocampuses and bla than other brain regions. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
this serotonergic reactivity paralleled results from clinical positron emission tomography studies with [(18)f]mppf revealing an overexpression of 5-ht(1a)r in the hippocampus of patients with mild cognitive impairment. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
because aβ40 and aβ42 isoforms are found in amyloid plaques, we tested in this study the hypothesis of a peptide- and region-specific 5-ht(1a)r reactivity by injecting them, separately, into the hippocampus or striatum of rats. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
[(18)f]mppf in vitro autoradiography revealed that aβ40 fibrils, but not aβ42, were triggering an overexpression of 5-ht(1a)r in the hippocampus and striatum of rat brains after 7 days. |
2016-12-13 |
2023-08-13 |
rat |
| A Ferrés-Coy, M Galofré, F Pilar-Cuéllar, R Vidal, V Paz, E Ruiz-Bronchal, L Campa, Á Pazos, J R Caso, J C Leza, G Alvarado, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. Molecular psychiatry. vol 21. issue 3. 2016-11-14. PMID:26100539. |
hence, c-sert-sirna (i) downregulated 5-ht1a-autoreceptors and facilitated forebrain serotonin neurotransmission, (ii) accelerated the proliferation of neuronal precursors and (iii) increased hippocampal complexity and plasticity. |
2016-11-14 |
2023-08-13 |
mouse |
| Chengjian Li, Haiou Tong, Qiongxian Yan, Shaoxun Tang, Xuefeng Han, Wenjun Xiao, Zhiliang Ta. L-Theanine Improves Immunity by Altering TH2/TH1 Cytokine Balance, Brain Neurotransmitters, and Expression of Phospholipase C in Rat Hearts. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2016-11-07. PMID:26922362. |
high-dose l-theanine administration increased the levels of dopamine and 5-hydroxytryptamine in the pituitary and hippocampus, resulting in decrease in corticosterone level in the serum. |
2016-11-07 |
2023-08-13 |
rat |
| Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska, Władysława A Danie. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain. Drug metabolism and disposition: the biological fate of chemicals. vol 44. issue 3. 2016-10-24. PMID:26884482. |
we measured serotonin tissue content in some brain regions (the cortex, hippocampus, nucleus accumbens, striatum, thalamus, hypothalamus, brain stem, medulla oblongata, and cerebellum) (model a), as well as its extracellular concentration in the striatum using an in vivo microdialysis (model b) after melatonin injection (100 mg/kg i.p.) |
2016-10-24 |
2023-08-13 |
rat |
| Karen E Murray, Kerry J Ressler, Michael J Owen. In vivo investigation of escitalopram's allosteric site on the serotonin transporter. Pharmacology, biochemistry, and behavior. vol 141. 2016-10-19. PMID:26621784. |
microdialysis studies in the ventral hippocampus found no measurable decrease in extracellular serotonin response after local escitalopram challenge in mice without the allosteric site compared to mice with the site (p=0.297). |
2016-10-19 |
2023-08-13 |
mouse |
| Aude Muzerelle, Sophie Scotto-Lomassese, Jean François Bernard, Mariano Soiza-Reilly, Patricia Gaspa. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem. Brain structure & function. vol 221. issue 1. 2016-10-17. PMID:25403254. |
we illustrate the distinctive and largely non-overlapping projection areas of these cell groups: for instance, dr (b7) projects to basal parts of the forebrain, such as the amygdala, whereas mr (b8) is the main 5-ht source to the hippocampus, septum, and mesopontine tegmental nuclei. |
2016-10-17 |
2023-08-13 |
mouse |
| Suzan Gonçalves Rosa, Caroline Brandão Quines, Eluza Curte Stangherlin, Cristina Wayne Nogueir. Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters. Physiology & behavior. vol 155. 2016-10-17. PMID:26657020. |
diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal bdnf-akt pathway and uptake of gaba and serotonin neurotransmitters. |
2016-10-17 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Alexander O Tarakanov, Kjell Fux. FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression. Trends in neurosciences. vol 39. issue 1. 2016-10-07. PMID:26687454. |
they were first described in the hippocampus and later in midbrain 5-ht neurons, where these heterocomplexes are enriched in 5-ht1a autoreceptors. |
2016-10-07 |
2023-08-13 |
Not clear |
| Anu Aonurm-Helm, Kaili Anier, Tamara Zharkovsky, Eero Castrén, Tomi Rantamäki, Vladimir Stepanov, Jaak Järv, Alexander Zharkovsk. NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26499173. |
serotonergic nerve fiber density and sert (serotonin transporter) protein levels were robustly reduced in the hippocampus, prefrontal cortex and basolateral amygdala of adult ncam(-)(/-) mice. |
2016-10-05 |
2023-08-13 |
mouse |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
sirna-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. |
2016-10-05 |
2023-08-13 |
rat |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
we found that sps treatment did not alter anxiety-related behaviors but prolonged the extinction of contextual fear memory, and such a behavioral phenomenon was correlated with increased hippocampal autophagy, decreased 5-ht level, and increased expression of beclin-1 and lc3-ii/lc3-i ratio in the hippocampus. |
2016-10-05 |
2023-08-13 |
rat |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
furthermore, intra-drn infusion of slc6a4 sirnas promoted the extinction of contextual fear memory, prevented hippocampal autophagy, increased 5-ht level, and decreased expression of beclin-1 and lc3-ii/lc3-i ratio. |
2016-10-05 |
2023-08-13 |
rat |
| Darakhshan J Haleem, Zeba Haque, Qurrat-ul-Aen Inam, Huma Ikram, Muhammad Abdul Halee. Behavioral, hormonal and central serotonin modulating effects of injected leptin. Peptides. vol 74. 2016-09-27. PMID:26456504. |
serotonin metabolism in the hypothalamus and hippocampus decreased only at higher dose of leptin. |
2016-09-27 |
2023-08-13 |
rat |
| Rizwan ul Haq, Marlene L Anderson, Jan-Oliver Hollnagel, Franziska Worschech, Muhammad Azahr Sherkheli, Christoph J Behrens, Uwe Heineman. Serotonin dependent masking of hippocampal sharp wave ripples. Neuropharmacology. vol 101. 2016-09-22. PMID:26409781. |
serotonin dependent masking of hippocampal sharp wave ripples. |
2016-09-22 |
2023-08-13 |
mouse |
| Rizwan ul Haq, Marlene L Anderson, Jan-Oliver Hollnagel, Franziska Worschech, Muhammad Azahr Sherkheli, Christoph J Behrens, Uwe Heineman. Serotonin dependent masking of hippocampal sharp wave ripples. Neuropharmacology. vol 101. 2016-09-22. PMID:26409781. |
spontaneous spw-rs in mice hippocampal slices were also masked by 5-ht and fenfluramine. |
2016-09-22 |
2023-08-13 |
mouse |