| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy R Powell, Tytus Murphy, Sang H Lee, Jack Price, Sandrine Thuret, Gerome Bree. Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioning. Journal of psychopharmacology (Oxford, England). vol 31. issue 3. 2018-01-04. PMID:28208023. |
we investigated genome-wide transcriptomic changes to human hippocampal progenitor cells treated with therapeutically relevant concentrations of a tricyclic antidepressant (nortriptyline) and a selective serotonin reuptake inhibitor (escitalopram). |
2018-01-04 |
2023-08-13 |
human |
| Alberto Rubio-Casillas, Alonso Fernández-Guast. The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression. Reviews in the neurosciences. vol 27. issue 6. 2018-01-02. PMID:27096778. |
additionally, it has been shown that chronic treatment with antidepressants having divergent mechanisms of action (including tricyclics, selective serotonin reuptake inhibitors, and ketamine) markedly reduced depolarization-evoked glutamate release in the hippocampus. |
2018-01-02 |
2023-08-13 |
Not clear |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
treatment with a pparδ agonist enhanced the expression of pparδ and the serotonin transporter in the hippocampus of rats with stress-induced depression. |
2018-01-01 |
2023-08-13 |
rat |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
additionally, treatment with a pparδ agonist increased the expression of the serotonin transporter in cultured hippocampal (h19-7) cells, and this action was ablated in the absence of pparδ, which was attenuated with shrna. |
2018-01-01 |
2023-08-13 |
rat |
| H Azizi, J Hwang, V Suen, N Z Kang, R Somvanshi, R Tadavarty, U Kumar, B R Sastr. Sleep deprivation induces changes in 5-HT actions and 5-HT Neuroscience letters. vol 655. 2018-01-01. PMID:28668380. |
sleep deprivation induces changes in 5-ht actions and 5-ht a 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-ht) 1a receptors in rat hippocampus that recedes with 48h sleep recovery. |
2018-01-01 |
2023-08-13 |
rat |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
a significantly elevated [(11)c]5-htp accumulation rate, indicative of enhanced decarboxylase activity and thereby serotonin synthesis capacity, was detected in social anxiety disorder patients compared with controls in the hippocampus and basal ganglia nuclei and, at a more lenient (uncorrected) statistical threshold, in the amygdala and anterior cingulate cortex. |
2017-12-28 |
2023-08-13 |
Not clear |
| Meng-Yan Zhan. Establishment of a BALB/c Mouse Model for Assessing the Degree of Inebriation Induced by Luzhou-Flavor Liquors. Journal of AOAC International. vol 100. issue 5. 2017-12-28. PMID:28477404. |
the blood ethanol concentration, blood acetaldehyde concentration, acetylcholinesterase activity in the hippocampus, and concentrations of dopamine and serotonin in the striatum were also determined. |
2017-12-28 |
2023-08-13 |
mouse |
| Meng-Yan Zhan. Establishment of a BALB/c Mouse Model for Assessing the Degree of Inebriation Induced by Luzhou-Flavor Liquors. Journal of AOAC International. vol 100. issue 5. 2017-12-28. PMID:28477404. |
moreover, it had no significant effects on acetylcholinesterase activity in the hippocampus or on the concentrations of dopamine or serotonin in the striatum. |
2017-12-28 |
2023-08-13 |
mouse |
| Andiara E Freitas, Javier Egea, Izaskun Buendia, Vanessa Gómez-Rangel, Esther Parada, Elisa Navarro, Ana Isabel Casas, Aneta Wojnicz, José Avendaño Ortiz, Antonio Cuadrado, Ana Ruiz-Nuño, Ana Lúcia S Rodrigues, Manuela G Lope. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25966970. |
in addition, agmatine treatment in control mice increased noradrenaline, serotonin, and dopamine levels, creb phosphorylation, mature bdnf and synaptotagmin i immunocontents, and reduced pro-bdnf immunocontent in the hippocampus. |
2017-12-25 |
2023-08-13 |
mouse |
| Isabella Caroline da Silva Dias, Bruno Carabelli, Daniela Kaori Ishii, Helen de Morais, Milene Cristina de Carvalho, Luiz E Rizzo de Souza, Silvio M Zanata, Marcus Lira Brandão, Thiago Mattar Cunha, Anete Curte Ferraz, Joice Maria Cunha, Janaina Menezes Zanovel. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26671617. |
to test this hypothesis, diabetic (dbt) and normoglycemic (ngl) groups had the cytokines (tnfα, il-1β, and il-6) and 5-ht and norepinephrine (ne) levels in the hippocampus (hip) evaluated. |
2017-12-22 |
2023-08-13 |
rat |
| Kristian Gaarn Du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfvin. Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine. Synapse (New York, N.Y.). vol 71. issue 1. 2017-12-22. PMID:27589698. |
relative to frl rats, fsl rats displayed enhanced hippocampal transcript levels of 5-ht |
2017-12-22 |
2023-08-13 |
rat |
| Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, María Esther Olvera-Corté. Serotonergic modulation of septo-hippocampal and septo-mammillary theta activity during spatial learning, in the rat. Behavioural brain research. vol 319. 2017-12-21. PMID:27845230. |
we demonstrated that septal serotonin depletion facilitates the acquisition of spatial information in association with a higher functional coupling of the medial septum with the hippocampus and mammillary nuclei. |
2017-12-21 |
2023-08-13 |
rat |
| Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, María Esther Olvera-Corté. Serotonergic modulation of septo-hippocampal and septo-mammillary theta activity during spatial learning, in the rat. Behavioural brain research. vol 319. 2017-12-21. PMID:27845230. |
serotonin, acting in the medial septum, modulates hippocampal theta activity and spatial learning. |
2017-12-21 |
2023-08-13 |
rat |
| T W Robbin. Neurobehavioural sequelae of social deprivation in rodents revisited: Modelling social adversity for developmental neuropsychiatric disorders. Journal of psychopharmacology (Oxford, England). vol 30. issue 11. 2017-12-15. PMID:27678088. |
the specification of the neural and behavioural phenotype of the isolate is brought up-to-date, focusing on changes in motivation and cognitive function, as well as on contrasting changes in the dopamine and serotonin systems, and in cortical (including hippocampal) structure and function. |
2017-12-15 |
2023-08-13 |
rat |
| Connor Thelen, Jonathon Sens, Joseph Mauch, Radhika Pandit, Pothitos M Pitychouti. Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27343934. |
moreover, repeated ketamine treatment induced sustained sex-differentiated neurochemical and molecular effects, as it enhanced hippocampal synapsin protein levels and serotonin turnover in males, but attenuated glutamate and aspartate levels in female mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Weam W Ibrahim, Marwa M Safar, Mahmoud M Khattab, Azza M Agh. 17β-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: Neuroprotective and serotonin reuptake transporter modulatory effects. Psychoneuroendocrinology. vol 74. 2017-12-08. PMID:27685339. |
17β-estradiol augmented the modulatory effects of escitalopram on the hippocampal levels of brain-derived neurotrophic factor and serotonin reuptake transporter as well as tumor necrosis factor-alpha without altering its effects on the gene expressions of serotonin receptor 1a, estrogen receptors alpha and beta, or acetylcholinestearase content. |
2017-12-08 |
2023-08-13 |
human |
| James P Kesby, Athina Markou, Svetlana Semenov. Effects of HIV/TAT protein expression and chronic selegiline treatment on spatial memory, reversal learning and neurotransmitter levels in mice. Behavioural brain research. vol 311. 2017-12-05. PMID:27211061. |
dopamine, serotonin and glutamate tissue levels in the prefrontal/orbitofrontal cortex, hippocampus and caudate putamen were measured using high performance liquid chromatography. |
2017-12-05 |
2023-08-13 |
mouse |
| James P Kesby, Athina Markou, Svetlana Semenov. Effects of HIV/TAT protein expression and chronic selegiline treatment on spatial memory, reversal learning and neurotransmitter levels in mice. Behavioural brain research. vol 311. 2017-12-05. PMID:27211061. |
tat expression decreased dopamine turnover in the caudate putamen, increased serotonin turnover in the hippocampus and tended to increase the conversion of glutamate to glutamine in all regions. |
2017-12-05 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Elnaz Rostam-Nezhad, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection. Behavioural brain research. vol 317. 2017-11-29. PMID:27686024. |
interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection. |
2017-11-29 |
2023-08-13 |
Not clear |
| Mohammad Nasehi, Elnaz Rostam-Nezhad, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection. Behavioural brain research. vol 317. 2017-11-29. PMID:27686024. |
the present study investigated the effect of serotonin 5-ht4 agents into the dorsal hippocampus (the ca1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid cb1 receptors (cb1rs) using arachidonylcyclopropylamide (acpa) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. |
2017-11-29 |
2023-08-13 |
Not clear |