| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Ladefoged, H R Lam, G Ostergaard, E V Hansen, U Hass, S P Lund, L Simonse. Toxicity of the styrene metabolite, phenylglyoxylic acid, in rats after three months' oral dosing. Neurotoxicology. vol 19. issue 4-5. 1998-12-10. PMID:9745934. |
the 5-hydroxytryptamine (5-ht) concentration decreased in cerebellum, cerebral cortex, hippocampus, and medulla oblongata, whereas it increased in thalamus. |
1998-12-10 |
2023-08-12 |
rat |
| D Schmitz, T Gloveli, R M Empson, U Heineman. Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744926. |
the superficial cells of the entorhinal cortex (ec), main input to the hippocampus, receive a serotonergic input from the raphe nuclei and express 5-hydroxytryptamine creatine sulfate complex (5-ht) receptors at high density. |
1998-12-03 |
2023-08-12 |
Not clear |
| Y J Karten, W Hesen, M Joël. Serotonin and carbachol induced suppression of synaptic responses in rat CA1 hippocampal area: effects of corticosteroid receptor activation in vivo. Stress (Amsterdam, Netherlands). vol 2. issue 3. 1998-11-20. PMID:9787266. |
serotonin and carbachol induced suppression of synaptic responses in rat ca1 hippocampal area: effects of corticosteroid receptor activation in vivo. |
1998-11-20 |
2023-08-12 |
rat |
| Y J Karten, W Hesen, M Joël. Serotonin and carbachol induced suppression of synaptic responses in rat CA1 hippocampal area: effects of corticosteroid receptor activation in vivo. Stress (Amsterdam, Netherlands). vol 2. issue 3. 1998-11-20. PMID:9787266. |
previous studies have shown that corticosteroids affect the changes in membrane potential evoked in ca1 hippocampal neurons by serotonin and the metabolically stable cholinergic analogue carbachol: low corticosteroid levels induced by steroid administration to adrenalectomized rats or obtained in adrenally intact rats were associated with small transmitter responses. |
1998-11-20 |
2023-08-12 |
rat |
| G Giannakopoulos, P Galanopoulou, Z Daifotis, C Couvari. Effects of mesulergine treatment on diet selection, brain serotonin (5-HT) and dopamine (DA) turnover in free feeding rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723121. |
5-ht and 5-hiaa in hypothalamus (hy), striatum (st) and hippocampus (hi) as well as da and dopac in (hy) and (st) were assayed at the 8th day of the experiment. |
1998-11-18 |
2023-08-12 |
rat |
| M Durand, A Sarrieau, S Aguerre, P Mormède, F Chaoulof. Differential effects of neonatal handling on anxiety, corticosterone response to stress, and hippocampal glucocorticoid and serotonin (5-HT)2A receptors in Lewis rats. Psychoneuroendocrinology. vol 23. issue 4. 1998-11-12. PMID:9695134. |
differential effects of neonatal handling on anxiety, corticosterone response to stress, and hippocampal glucocorticoid and serotonin (5-ht)2a receptors in lewis rats. |
1998-11-12 |
2023-08-12 |
rat |
| M Durand, A Sarrieau, S Aguerre, P Mormède, F Chaoulof. Differential effects of neonatal handling on anxiety, corticosterone response to stress, and hippocampal glucocorticoid and serotonin (5-HT)2A receptors in Lewis rats. Psychoneuroendocrinology. vol 23. issue 4. 1998-11-12. PMID:9695134. |
neonatal handling (during the first 3 weeks of age) has been reported by others to diminish the hypothalamo-pituitary-adrenal (hpa) responsivity to stress in adult long evans rats, an effect involving a serotonin (5-ht)2a receptor-mediated increase in glucocorticoid receptor (gr) gene expression in the frontal cortex and the hippocampus. |
1998-11-12 |
2023-08-12 |
rat |
| O C Meijer, R Kortekaas, M S Oitzl, E R de Kloe. Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses. European journal of pharmacology. vol 351. issue 1. 1998-11-12. PMID:9698199. |
corticosterone influences 5-ht1a receptor-mediated responses in the rat hippocampus in vitro: activation of the high affinity mineralocorticoid receptor suppresses 5-ht1a receptor-mediated hyperpolarization, while subsequent activation of lower affinity glucocorticoid receptors enhances the effect of 5-ht. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
the mechanisms involved in the enhancement of acetylcholine (ach) release in the rat hippocampus by 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), a serotonin (5-ht)1a receptor agonist, were investigated using in vivo microdialysis. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
), a tryptophan hydroxylase inhibitor, 3 days before the dialysis experiments reduced the hippocampal 5-ht content to 30% of that in saline-treated rats, but did not affect basal ach release in the hippocampus. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
these results suggest that the modification of endogenous 5-ht release via the 5-ht1a autoreceptor is not involved in the 8-oh-dpat-induced increase of hippocampal ach release, and that the increase of ach release induced by locally applied 8-oh-dpat involves mainly hippocampal postsynaptic 5-ht1a receptor stimulation. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
in addition, a possibility that subtypes of 5-ht receptors other than the 5-ht1a receptor, probably 5-ht7 receptor in the septum as well as postsynaptic 5-ht1a receptor in the hippocampus, are involved in the increased hippocampal ach release induced by systemically administered 8-oh-dpat is discussed. |
1998-11-12 |
2023-08-12 |
rat |
| b' S Ruotsalainen, E MacDonald, E Koivisto, R Stefanski, A Haapalinna, P Riekkinen, J Sirvi\\xc3\\xb. 5-HT1A receptor agonist (8-OH-DPAT) and 5-HT2 receptor agonist (DOI) disrupt the non-cognitive performance of rats in a working memory task. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694031.' |
post-mortem neurochemical analysis revealed that serotonin and 5-hydroxyindoleacetic acid levels were reduced in examined brain areas (especially in the hippocampus where there was a 90 percent reduction). |
1998-11-06 |
2023-08-12 |
rat |
| S D Friedman, E Castañeda, G K Hodg. Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity. Pharmacology, biochemistry, and behavior. vol 61. issue 1. 1998-11-05. PMID:9715805. |
initially, 5-ht within medial prefrontal cortex (mpfc), caudate (cdn), and hippocampus (hpc) was reduced to 30% of control levels. |
1998-11-05 |
2023-08-12 |
rat |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in vivo, f 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-ht1a agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-ht) levels and to increase plasma corticosterone levels, respectively). |
1998-11-05 |
2023-08-12 |
human |
| H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
alterations in the activity of the central 5-ht system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-ht1a receptor, 5-ht1b receptor, and 5-ht transporter mrna in the dorsal raphe nucleus and the hippocampus. |
1998-11-04 |
2023-08-12 |
rat |
| H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
the expression of 5-ht transporter, 5-ht1a receptor, and 5-ht1b receptor mrna was examined in the dorsal raphe nucleus and in the ca1 of the hippocampus by means of quantitative in situ hybridisation histochemistry. |
1998-11-04 |
2023-08-12 |
rat |
| M Okada, T Hirano, K Mizuno, Y Kawata, K Wada, T Murakami, H Tasaki, S Kanek. Effects of carbamazepine on hippocampal serotonergic system. Epilepsy research. vol 31. issue 3. 1998-11-02. PMID:9722029. |
to establish the mechanism of action of the antiepileptic and psychotropic effects of carbamazepine (cbz), its effects on serotonin (5-ht) transmission, metabolism and re-uptake activity in the rat hippocampus were studied. |
1998-11-02 |
2023-08-12 |
rat |
| M Okada, T Hirano, K Mizuno, Y Kawata, K Wada, T Murakami, H Tasaki, S Kanek. Effects of carbamazepine on hippocampal serotonergic system. Epilepsy research. vol 31. issue 3. 1998-11-02. PMID:9722029. |
acute administration of the therapeutic dose of cbz resulted in an increase in the hippocampal extracellular and total level of 5-ht, its metabolite, 5-hydroxydoleacetic acid (5-hiaa) and its precursor, 5-hydroxytryptophan (5-htp). |
1998-11-02 |
2023-08-12 |
rat |
| M Okada, T Hirano, K Mizuno, Y Kawata, K Wada, T Murakami, H Tasaki, S Kanek. Effects of carbamazepine on hippocampal serotonergic system. Epilepsy research. vol 31. issue 3. 1998-11-02. PMID:9722029. |
the acute administration of 50 mg/kg cbz resulted in an increase in the hippocampal levels of extracellular 5-ht and 5-hiaa as well as in the total levels of 5-htp, whereas hippocampal levels of extracellular 5-htp, total 5-ht and 5-hiaa remained unaffected. |
1998-11-02 |
2023-08-12 |
rat |