| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordanna E Bermack, Guy Debonne. Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors. Journal of psychopharmacology (Oxford, England). vol 21. issue 1. 2007-03-16. PMID:16533864. |
opc applied by microiontophoresis, produced a significant decrease in the firing activity of 5-ht neurons of the drn and of quisqualate-activated ca3 pyramidal neurons of the dorsal hippocampus. |
2007-03-16 |
2023-08-12 |
rat |
| C D'Addario, M Di Benedetto, S Izenwasser, S Candeletti, P Romuald. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS. Neuroscience. vol 144. issue 1. 2007-03-15. PMID:17055175. |
these findings suggest that serotonin is necessary to maintain normal levels of dynorphin mrna in all of the investigated brain areas and that the regulation of prodynorphin mrna expression by chronic treatment with a kappa-opioid receptor agonist or cocaine requires serotonin in the hippocampus, but not in the hypothalamus or caudate putamen. |
2007-03-15 |
2023-08-12 |
rat |
| M M W Straiko, L M Coolen, F P Zemlan, G A Gudelsk. The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain. Neuroscience. vol 144. issue 1. 2007-03-15. PMID:17084036. |
a dopamine (da)-depleting regimen of amph produced an increase in c-tau immunoreactivity in the striatum, while a da- and serotonin (5-ht)-depleting regimen of meth produced an increase in the number of c-tau immunoreactive cells in the striatum and ca2/ca3 and dentate gyrus regions of the hippocampus. |
2007-03-15 |
2023-08-12 |
rat |
| M M W Straiko, L M Coolen, F P Zemlan, G A Gudelsk. The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain. Neuroscience. vol 144. issue 1. 2007-03-15. PMID:17084036. |
mdma and pma, two psychostimulant drugs that produce selective 5-ht depletion in the striatum, had no effect on c-tau immunoreactivity in the striatum or hippocampus. |
2007-03-15 |
2023-08-12 |
rat |
| Li Ma, Mark H Shalinsky, Angel Alonso, Clayton T Dickso. Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons. Hippocampus. vol 17. issue 2. 2007-03-14. PMID:17146777. |
serotonin is thus likely to influence, in a composite fashion, the information processing of layer ii neurons in the mec and thus, the passage of neocortical information via the perforant pathway to the hippocampus. |
2007-03-14 |
2023-08-12 |
rat |
| Grégory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Côté, Guy Debonnel, Annie Daszuta, Aline Dumuis, André Nieoullon, René Hen, Joël Bockaert, Valérie Compa. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930432. |
with the exception of increased 5-ht turnover index in the hypothalamus and nucleus accumbens and a decreased density of 5-ht(1a)r sites in the dorsal hippocampus (ca1) and septum, no major changes were detected in 5-ht territories of projection, suggesting region-specific adaptive changes. |
2007-03-06 |
2023-08-12 |
mouse |
| Mario M Dorostkar, Stefan Boeh. Opposite effects of presynaptic 5-HT3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses. Journal of neurochemistry. vol 100. issue 2. 2007-03-06. PMID:17064350. |
we used rat hippocampal neurons in single-neuron microcultures to identify the roles of presynaptic 5-ht(3) receptors at central synapses. |
2007-03-06 |
2023-08-12 |
rat |
| Christoffer Bundgaard, Frank Larsen, Martin Jørgensen, Johan Gabrielsso. Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: application to escitalopram-induced effects on brain serotonin levels. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 29. issue 5. 2007-03-05. PMID:17014998. |
the extracellular 5-ht output in the hippocampus was continuously monitored by intracerebral microdialysis in conjunction with serial arterial blood sampling for evaluation of escitalopram pharmacokinetics. |
2007-03-05 |
2023-08-12 |
rat |
| Xiu-Lan Sun, Jian-Hua Ding, Yi Fan, Jing Zhang, Lin Gao, Gang H. Aquaporin 4 regulates the effects of ovarian hormones on monoamine neurotransmission. Biochemical and biophysical research communications. vol 353. issue 2. 2007-03-05. PMID:17196551. |
further study showed that exogenous estrogen decreased da and 5-ht in cortex, reduced da and 5-ht in striatum, but increased 5-ht in hippocampus in aqp4+/+ male mice. |
2007-03-05 |
2023-08-12 |
mouse |
| B Topic, I Willuhn, N Palomero-Gallagher, K Zilles, J P Huston, R U Hasenöhr. Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus. Hippocampus. vol 17. issue 1. 2007-03-02. PMID:17111411. |
no significant differences between inferior and superior learners were evident with regard to ampa, kainate, gaba(a), muscarinergic m(1), dopamine d(1), and 5-ht(2) binding densities in any hippocampal region analyzed. |
2007-03-02 |
2023-08-12 |
rat |
| B Topic, I Willuhn, N Palomero-Gallagher, K Zilles, J P Huston, R U Hasenöhr. Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus. Hippocampus. vol 17. issue 1. 2007-03-02. PMID:17111411. |
these results show that increased nmda, 5-ht(1a), and alpha-adrenoceptor binding in the hippocampus is associated with a decline in spatial memory. |
2007-03-02 |
2023-08-12 |
rat |
| Li-Xiang Ren, Yi-Fan Luo, Xia Li, Dai-Ying Zuo, Ying-Liang W. Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae). Biological & pharmaceutical bulletin. vol 29. issue 11. 2007-02-26. PMID:17077534. |
in addition, the neurochemical assays showed that sarsasapogenin produced a marked increase of noradrenaline and serotonin levels at 50 mg/kg in both the hypothalamus and the hippocampus. |
2007-02-26 |
2023-08-12 |
mouse |
| Andrew C McCreary, Jeffrey C Glennon, Charles R Ashby, Herbert Y Meltzer, Zhu Li, Jan-Hendrik Reinders, Mayke B Hesselink, Stephen K Long, Arnoud H Herremans, Herman van Stuivenberg, Rolf W Feenstra, Chris G Krus. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 1. 2007-02-09. PMID:16710314. |
acetylcholine and dopamine were elevated in the hippocampus and mpfcx, the latter antagonized by way100635, suggesting possible 5-ht(1a)-dependent efficacy for the treatment of cognitive and attentional processes. |
2007-02-09 |
2023-08-12 |
human |
| Kevin Chen, Olivier Cases, Igor Rebrin, Weihua Wu, Timothy K Gallaher, Isabelle Seif, Jean Chen Shi. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17090537. |
significant mao a catalytic activity, autoradiographic labeling of 5-ht, and immunocytochemistry of mao a were found in the frontal cortex, striatum, and hippocampus but not in the cerebellum of the forebrain transgenic mice. |
2007-02-08 |
2023-08-12 |
mouse |
| C Vakalopoulo. Neurocognitive deficits in major depression and a new theory of ADHD: a model of impaired antagonism of cholinergic-mediated prepotent behaviours in monoamine depleted individuals. Medical hypotheses. vol 68. issue 1. 2007-01-30. PMID:16997497. |
the model also predicts memory impairment in major depression by proposing that low serotonin levels in the neocortex is linked to focal hippocampal dysfunction. |
2007-01-30 |
2023-08-12 |
Not clear |
| Rebeca Martínez-Turrillas, Sonia Moyano, Joaquín Del Río, Diana Frechill. Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on BDNF mRNA expression in rat frontal cortex and hippocampus. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16644117. |
we previously found that 5-ht depletion induced by acute mdma treatment was transient in the frontal cortex, but not in the hippocampus, and recovery of cortical 5-ht levels correlated with an induction of cre-binding activity and increased expression of tryptophan-hydroxylase (tph), the rate-limiting enzyme in 5-ht biosynthesis. |
2007-01-16 |
2023-08-12 |
rat |
| Rebeca Martínez-Turrillas, Sonia Moyano, Joaquín Del Río, Diana Frechill. Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on BDNF mRNA expression in rat frontal cortex and hippocampus. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16644117. |
the differential regulation of bdnf mrna expression in the two brain regions examined appears to account for the enhanced tph expression and the recovery of 5-ht levels in the frontal cortex, but not in the hippocampus, after neurotoxin treatment. |
2007-01-16 |
2023-08-12 |
rat |
| Lin Zhang, Yukihiko Shirayama, Eiji Shimizu, Masaomi Iyo, Kenji Hashimot. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16859675. |
the repeated administration of mdma (10 mg/kg x 3, 3-h intervals, s.c.) significantly decreased the contents of 5-ht and its major metabolite 5-hydroxyindole acetic acid (5-hiaa) in the frontal cortex and hippocampus, and the density of the 5-ht transporter (5-htt) in the frontal cortex, hippocampus and striatum. |
2007-01-12 |
2023-08-12 |
mouse |
| Brian H Harvey, Renché Retief, Ané Korff, Gregers Wegene. Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors. Metabolic brain disease. vol 21. issue 2-3. 2007-01-10. PMID:16865538. |
increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5ht 2a/c-receptors. |
2007-01-10 |
2023-08-12 |
rat |
| Brian H Harvey, Renché Retief, Ané Korff, Gregers Wegene. Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors. Metabolic brain disease. vol 21. issue 2-3. 2007-01-10. PMID:16865538. |
antidepressant discontinuation therefore increases stress responsiveness together with disinhibition of hippocampal nos through a mechanism involving 5ht(2a/c) receptor activation. |
2007-01-10 |
2023-08-12 |
rat |