| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harvey Wong, Randy C Dockens, Lori Pajor, Suresh Yeola, James E Grace, Arlene D Stark, Rebecca A Taub, Frank D Yocca, Robert C Zaczek, Yu-Wen L. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 8. 2007-11-02. PMID:17494642. |
both compounds appeared to be approximately 4-fold more potent in occupying presynaptic 5-ht(1a) receptors in the dorsal raphe than the postsynaptic receptors in the hippocampus. |
2007-11-02 |
2023-08-12 |
rat |
| Guillaume Lucas, Vladimir V Rymar, Jenny Du, Ouissame Mnie-Filali, Christina Bisgaard, Stella Manta, Laura Lambas-Senas, Ove Wiborg, Nasser Haddjeri, Graciela Piñeyro, Abbas F Sadikot, Guy Debonne. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron. vol 55. issue 5. 2007-11-01. PMID:17785179. |
moreover, a 3 day regimen with such compounds modifies rat brain parameters considered to be key markers of antidepressant action, but that are observed only after 2-3 week treatments with classical molecules: desensitization of 5-ht(1a) autoreceptors, increased tonus on hippocampal postsynaptic 5-ht(1a) receptors, and enhanced phosphorylation of the creb protein and neurogenesis in the hippocampus. |
2007-11-01 |
2023-08-12 |
rat |
| Akira Tanabe, Soichiro Nomur. [Pathophysiology of depression]. Nihon rinsho. Japanese journal of clinical medicine. vol 65. issue 9. 2007-10-31. PMID:17876979. |
morphological changes of hippocampus, polymorphism of serotonin transporter gene, and down regulation of neurotrophin are also discussed in this review. |
2007-10-31 |
2023-08-12 |
Not clear |
| Yoshiaki Maruyama, Mitsuhiko Yamad. [TREK-1: a potential target for novel antidepressants]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 27. issue 4. 2007-10-30. PMID:17879592. |
moreover, trek-1-deficient mice showed a reduced elevation of corticosterone level under stress, an increased efficacy of 5-ht neurotransmission and an increased fluoxetine-induced neurogenesis in the hippocampus. |
2007-10-30 |
2023-08-12 |
mouse |
| Wen-Huang Peng, Kuan-Lin Lo, Yi-Hsuen Lee, Tai-Huang Hung, Ying-Chih Li. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life sciences. vol 81. issue 11. 2007-10-26. PMID:17804020. |
then we further measured the levels of monoamines [na, dopamine (da) and 5-ht) in mice striatum, hippocampus and frontal cortex. |
2007-10-26 |
2023-08-12 |
mouse |
| Wen-Huang Peng, Kuan-Lin Lo, Yi-Hsuen Lee, Tai-Huang Hung, Ying-Chih Li. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life sciences. vol 81. issue 11. 2007-10-26. PMID:17804020. |
increased na and 5-ht levels in the hippocampus and frontal cortex. |
2007-10-26 |
2023-08-12 |
mouse |
| Wen-Huang Peng, Kuan-Lin Lo, Yi-Hsuen Lee, Tai-Huang Hung, Ying-Chih Li. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life sciences. vol 81. issue 11. 2007-10-26. PMID:17804020. |
the antidepressant-like mechanism of ber may be related to the increase in na and 5-ht levels in the hippocampus and frontal cortex. |
2007-10-26 |
2023-08-12 |
mouse |
| J R Homberg, J D A Olivier, B M G Smits, J D Mul, J Mudde, M Verheul, O F M Nieuwenhuizen, A R Cools, E Ronken, T Cremers, A N M Schoffelmeer, B A Ellenbroek, E Cuppe. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467186. |
as a result, 5-ht homeostasis was found to be severely affected in sert-/- rats: 5-ht tissue levels and depolarization-induced 5-ht release were significantly reduced, and basal extracellular 5-ht levels in the hippocampus were ninefold increased. |
2007-10-25 |
2023-08-12 |
rat |
| Fraser Murray, Peter H Hutso. Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. European journal of pharmacology. vol 569. issue 1-2. 2007-10-25. PMID:17582397. |
hippocampal bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-ht(1a) or 5-ht(2c/2b) receptor antagonists. |
2007-10-25 |
2023-08-12 |
mouse |
| Fraser Murray, Peter H Hutso. Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. European journal of pharmacology. vol 569. issue 1-2. 2007-10-25. PMID:17582397. |
similarly, fourteen day but not acute treatment with the 5-ht(1a) and 5-ht(2c/2b) receptor antagonists way100635 (0.3 mg/kg) and sb221284 (1 mg/kg) also markedly and significantly increased hippocampal bcl-2 expression (95 and 52% respectively). |
2007-10-25 |
2023-08-12 |
mouse |
| Fraser Murray, Peter H Hutso. Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. European journal of pharmacology. vol 569. issue 1-2. 2007-10-25. PMID:17582397. |
these data present the first substantive evidence that clinically used antidepressants increase the expression of hippocampal bcl-2 as did chronic blockade of 5-ht(1a) and 5-ht(2c/2b) receptors, which may be involved in the mechanism of action of antidepressants. |
2007-10-25 |
2023-08-12 |
mouse |
| Manabu Amano, Katsuya Suemaru, Ranji Cui, Yuichi Umeda, Bingjin Li, Yutaka Gomita, Hiromu Kawasaki, Hiroaki Arak. Effects of physical and psychological stress on 5-HT2A receptor-mediated wet-dog shake responses in streptozotocin-induced diabetic rats. Acta medica Okayama. vol 61. issue 4. 2007-10-23. PMID:17726509. |
in the present studies, we examined the behavioral changes in streptozotocin-induced diabetic rats, and investigated the effects of physical and psychological stress on the hippocampal bdnf levels and on the serotonin 2a (5-ht(2a)) receptor-mediated wet-dog shake responses. |
2007-10-23 |
2023-08-12 |
rat |
| G de Foubert, M J O'Neill, T S C Zetterströ. Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560041. |
the present study investigated the effects of 5-ht(6)-receptor activation on hippocampal and cortical levels of mrna expression of bdnf and arc in the rat. |
2007-10-19 |
2023-08-12 |
rat |
| Ying Xu, Baoshan Ku, Li Cui, Xuejun Li, Philip A Barish, Thomas C Foster, William O Ogl. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain research. vol 1162. 2007-10-19. PMID:17617388. |
in addition, curcumin significantly prevented the stress-induced decrease in 5-ht(1a) mrna and bdnf protein levels in the hippocampal subfields, two molecules involved in hippocampal neurogenesis. |
2007-10-19 |
2023-08-12 |
rat |
| Ying Xu, Baoshan Ku, Li Cui, Xuejun Li, Philip A Barish, Thomas C Foster, William O Ogl. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain research. vol 1162. 2007-10-19. PMID:17617388. |
moreover, curcumin treatment, via up-regulation of 5-ht(1a) receptors and bdnf, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin. |
2007-10-19 |
2023-08-12 |
rat |
| Duk-Soo Kim, Ji-Eun Kim, Sung-Eun Kwak, Dae-Won Kim, Soo-Young Choi, Oh-Shin Kwon, Tae-Chon Kan. Seizure activity selectively reduces 5-HT1A receptor immunoreactivity in CA1 interneurons in the hippocampus of seizure-prone gerbils. Brain research. vol 1154. 2007-10-12. PMID:17493597. |
since the correlation between the serotonin (5-hydroxytryptamine, 5-ht) system and seizure activity remains to be clarified, we investigated the 5-ht system in the hippocampus of seizure-resistant (sr) and seizure-sensitive (ss) gerbils. |
2007-10-12 |
2023-08-12 |
Not clear |
| K Tekes, L Tóthfalusi, M Hantos, G Csab. Effect of neonatal benzpyrene imprinting on the brain serotonin content and nocistatin level in adult male rats. Acta physiologica Hungarica. vol 94. issue 3. 2007-10-04. PMID:17853770. |
single neonatal treatment (imprinting) with 20 microg benzpyrene results in significant increase of the brain serotonin level in the striatum, while in the other four regions (cortex, brainstem, hippocampus, hypothalamus) when measured in adults can be detected. |
2007-10-04 |
2023-08-12 |
rat |
| Sâmia Regiane Lourenço Joca, Frederico Rogério Ferreira, Francisco Silveira Guimarãe. Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems. Stress (Amsterdam, Netherlands). vol 10. issue 3. 2007-10-02. PMID:17613938. |
serotonin (5-ht) seems to exert a protective role in the hippocampus and attenuates the behavioural consequences of stress by activating 5-ht1a receptors in this structure. |
2007-10-02 |
2023-08-12 |
Not clear |
| L Truchot, S N Costes, L Zimmer, B Laurent, D Le Bars, C Thomas-Antérion, B Croisile, B Mercier, M Hermier, A Vighetto, P Krolak-Salmo. Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Neurology. vol 69. issue 10. 2007-09-28. PMID:17785670. |
up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. |
2007-09-28 |
2023-08-12 |
Not clear |
| L Truchot, S N Costes, L Zimmer, B Laurent, D Le Bars, C Thomas-Antérion, B Croisile, B Mercier, M Hermier, A Vighetto, P Krolak-Salmo. Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Neurology. vol 69. issue 10. 2007-09-28. PMID:17785670. |
this study aims at exploring hippocampus 5-ht(1a) receptor density in patients at the amnesic mild cognitive impairment (amci) and mild ad dementia stages. |
2007-09-28 |
2023-08-12 |
Not clear |