| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kohei Ohta, Tamotsu Nomura, Takeshi Kanno, Kaoru Nagai, Satoshi Yamamoto, Yukio Yajima, Takeshi Kondoh, Eiji Kohmura, Naoaki Saito, Tomoyuki Nishizak. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150959. |
the glutamate transporter inhibitor, l-trans-pyrrolidine-2,4-dicarboxylic acid (pdc) reversibly enhanced hippocampal neuronal activity in the rat and mouse dentate gyrus. |
2002-08-29 |
2023-08-12 |
mouse |
| Kohei Ohta, Tamotsu Nomura, Takeshi Kanno, Kaoru Nagai, Satoshi Yamamoto, Yukio Yajima, Takeshi Kondoh, Eiji Kohmura, Naoaki Saito, Tomoyuki Nishizak. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150959. |
pdc did not influence the rate of spontaneous miniature excitatory postsynaptic currents and spontaneous inhibitory postsynaptic currents, ionotropic glutamate receptor currents, or gaba-evoked currents in cultured rat hippocampal neurons. |
2002-08-29 |
2023-08-12 |
mouse |
| Kohei Ohta, Tamotsu Nomura, Takeshi Kanno, Kaoru Nagai, Satoshi Yamamoto, Yukio Yajima, Takeshi Kondoh, Eiji Kohmura, Naoaki Saito, Tomoyuki Nishizak. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150959. |
pdc increased glutamate released from cultured hippocampal astrocytes from normal rats, normal mice, and glt-1 knock-out mice, that is not inhibited by deleting extracellular na(+), while the drug had no effect on the release from cultured rat hippocampal neurons. |
2002-08-29 |
2023-08-12 |
mouse |
| Kohei Ohta, Tamotsu Nomura, Takeshi Kanno, Kaoru Nagai, Satoshi Yamamoto, Yukio Yajima, Takeshi Kondoh, Eiji Kohmura, Naoaki Saito, Tomoyuki Nishizak. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150959. |
the results of the present study thus suggest that pdc stimulates glial glutamate release by a mechanism independent of inhibiting glutamate transporters, which perhaps causes an increase in synaptic glutamate concentrations, in part responsible for the enhancement in hippocampal neuronal activity. |
2002-08-29 |
2023-08-12 |
mouse |
| Yi Sun, Pia März, Uwe Otten, Jiguang Ge, Stefan Rose-Joh. The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150983. |
primary hippocampal neurons from newborn rats treated with glutamate showed clear excitotoxicity. |
2002-08-29 |
2023-08-12 |
rat |
| George F Koob, Barbara J Mason, Philippe De Witte, John Littleton, George R Siggin. Potential neuroprotective effects of acamprosate. Alcoholism, clinical and experimental research. vol 26. issue 4. 2002-08-16. PMID:11981137. |
the presentations were (1) acamprosate inhibits alcohol withdrawal-induced neurotoxicity in organotypic hippocampal cultures, by john littleton; (2) acamprosate alteration of nmda receptor-dependent synaptic transmission and synaptic plasticity, by george r. siggins; (3) acamprosate and glutamate during ethanol withdrawal, by philippe de witte; (4) clinical evidence of protective cns effects of acamprosate in alcohol-dependent individuals, by barbara j. mason. |
2002-08-16 |
2023-08-12 |
Not clear |
| N Brustovetsky, T Brustovetsky, J M Dubinsk. On the mechanisms of neuroprotection by creatine and phosphocreatine. Journal of neurochemistry. vol 76. issue 2. 2002-08-15. PMID:11208905. |
creatine and phosphocreatine were evaluated for their ability to prevent death of cultured striatal and hippocampal neurons exposed to either glutamate or 3-nitropropionic acid (3np) and to inhibit the mitochondrial permeability transition in cns mitochondria. |
2002-08-15 |
2023-08-12 |
rat |
| Rosa Cossart, Jérôme Epsztein, Roman Tyzio, Hélène Becq, June Hirsch, Yehezkel Ben-Ari, Valérie Crépe. Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons. Neuron. vol 35. issue 1. 2002-08-13. PMID:12123615. |
quantal release of glutamate generates pure kainate and mixed ampa/kainate epscs in hippocampal neurons. |
2002-08-13 |
2023-08-12 |
Not clear |
| Rosa Cossart, Jérôme Epsztein, Roman Tyzio, Hélène Becq, June Hirsch, Yehezkel Ben-Ari, Valérie Crépe. Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons. Neuron. vol 35. issue 1. 2002-08-13. PMID:12123615. |
in both hippocampal neurons, the quantal release of glutamate generates kainate receptor-mediated epscs that provide as much as half of the total glutamatergic current. |
2002-08-13 |
2023-08-12 |
Not clear |
| Jingyi Ma, L Stan Leun. Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity. Behavioural brain research. vol 133. issue 1. 2002-08-12. PMID:12048173. |
metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity. |
2002-08-12 |
2023-08-12 |
rat |
| Jingyi Ma, L Stan Leun. Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity. Behavioural brain research. vol 133. issue 1. 2002-08-12. PMID:12048173. |
the involvement of metabotropic glutamate receptor (mglur) subtypes in the generation of hippocampal eeg (30-100 hz) and behaviors induced by a hippocampal afterdischarge (ad) was examined in freely behaving rats. |
2002-08-12 |
2023-08-12 |
rat |
| Luigia Trabace, Tommaso Cassano, Antonia Loverre, Luca Steardo, Vincenzo Cuom. CHF2819: pharmacological profile of a novel acetylcholinesterase inhibitor. CNS drug reviews. vol 8. issue 1. 2002-08-09. PMID:12070526. |
by oral administration to young adult rats chf2819 did not affect extracellular hippocampal levels of glutamate (glu), aspartate (asp), gamma-aminobutyric acid (gaba), taurine (tau), arginine (arg) or citrulline (cit). |
2002-08-09 |
2023-08-12 |
rat |
| Beatrice Pöschel, Andreas Draguhn, Uwe Heineman. Glutamate-induced gamma oscillations in the dentate gyrus of rat hippocampal slices. Brain research. vol 938. issue 1-2. 2002-08-08. PMID:12031531. |
in this paper we show that gamma oscillations can be elicited by brief (< or = 200 ms) local applications of glutamate in the dentate gyrus of rat hippocampal slices. |
2002-08-08 |
2023-08-12 |
rat |
| O Godukhin, A Savin, S Kalemenev, S Levi. Neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and L-type Ca(2+) channels. Neuropharmacology. vol 42. issue 4. 2002-08-07. PMID:11955517. |
neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and l-type ca(2+) channels. |
2002-08-07 |
2023-08-12 |
rat |
| O Godukhin, A Savin, S Kalemenev, S Levi. Neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and L-type Ca(2+) channels. Neuropharmacology. vol 42. issue 4. 2002-08-07. PMID:11955517. |
the purpose of this study was: (i) to determine whether ionotropic glutamate receptors and l-type ca(2+) channels are involved in the development of epileptiform activity induced by repeated exposures of hippocampal slices to hypoxia; and (ii) to compare the properties of hypoxia- and high k(+)(o)-induced hyperexcitability. |
2002-08-07 |
2023-08-12 |
rat |
| Marie E Rose, Michele B Huerbin, John Melick, Donald W Marion, Alan M Palmer, Joanne K Schiding, Patrick M Kochanek, Steven H Graha. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain research. vol 935. issue 1-2. 2002-08-07. PMID:12062471. |
did not significantly decrease dialysate glutamate compared to vehicle controls in hippocampus (10.4+/-2.4 vs. 11.9+/-1.6 microm), but there was significant decrease in dialysate glutamate in cortex after 619c89 treatment (19.3+/-3 vs. 12.6+/-1.1 microm p<0.05). |
2002-08-07 |
2023-08-12 |
rat |
| Marie E Rose, Michele B Huerbin, John Melick, Donald W Marion, Alan M Palmer, Joanne K Schiding, Patrick M Kochanek, Steven H Graha. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain research. vol 935. issue 1-2. 2002-08-07. PMID:12062471. |
addition of 30 mm glucose to the dialysate, a treatment that decreases eaa(i) after ischemia, had no significant effect upon dialysate glutamate after tbi in cortex (20.0+/-4.9 vs. 11.7+/-3.4 microm) or in hippocampus (10.9+/-2.0 vs. 8.9+/-2.4 microm). |
2002-08-07 |
2023-08-12 |
rat |
| Shinjiro Fukami, Kaori Watanabe, Nobuhisa Iwata, Jo Haraoka, Bao Lu, Norma P Gerard, Craig Gerard, Paul Fraser, David Westaway, Peter St George-Hyslop, Takaomi C Said. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neuroscience research. vol 43. issue 1. 2002-08-07. PMID:12074840. |
among various cell types, gabaergic and metabotropic glutamate 2/3 receptor-positive neurons but not catecholaminergic or cholinergic neurons, expressed neprilysin in hippocampus and neocortex, implying the presence of a cell type-specific mechanism that regulates neprilysin gene expression. |
2002-08-07 |
2023-08-12 |
mouse |
| Alessandra Nejar Bruno, Carla Denise Bonan, Susana Tchernin Wofchuk, João José Freitas Sarkis, Ana Maria Oliveira Battastin. ATP diphosphohydrolase (NTPDase 1) in rat hippocampal slices and effect of glutamate on the enzyme activity in different phases of development. Life sciences. vol 71. issue 2. 2002-07-30. PMID:12031690. |
atp diphosphohydrolase (ntpdase 1) in rat hippocampal slices and effect of glutamate on the enzyme activity in different phases of development. |
2002-07-30 |
2023-08-12 |
rat |
| Alessandra Nejar Bruno, Carla Denise Bonan, Susana Tchernin Wofchuk, João José Freitas Sarkis, Ana Maria Oliveira Battastin. ATP diphosphohydrolase (NTPDase 1) in rat hippocampal slices and effect of glutamate on the enzyme activity in different phases of development. Life sciences. vol 71. issue 2. 2002-07-30. PMID:12031690. |
the effect of glutamate on the atpase and adpase activities in rat hippocampal slices of different ages was also studied since adenosine, the final product of an enzymatic chain that includes ntpdase 1 and 5'-nucleotidase, can act upon a1 receptors in turn decreasing the release of glutamate. |
2002-07-30 |
2023-08-12 |
rat |