| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tal Laviv, Inbal Riven, Iftach Dolev, Irena Vertkin, Bartosz Balana, Paul A Slesinger, Inna Slutsk. Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses. Neuron. vol 67. issue 2. 2010-08-23. PMID:20670833. |
our findings suggest that local variations in basal gaba concentration are a major determinant of gb(1a)/gb(2) conformational variability, which contributes to heterogeneity of neurotransmitter release at hippocampal synapses. |
2010-08-23 |
2023-08-12 |
Not clear |
| L E Hill, S K Droste, D J Nutt, A C E Linthorst, J M H M Reu. Voluntary exercise alters GABA(A) receptor subunit and glutamic acid decarboxylase-67 gene expression in the rat forebrain. Journal of psychopharmacology (Oxford, England). vol 24. issue 5. 2010-08-18. PMID:18801833. |
the alpha5 and delta subunits, in the forebrain specifically associated with extrasynaptic gaba(a) receptors in the hippocampus, showed differential increases in expression levels. |
2010-08-18 |
2023-08-12 |
human |
| L E Hill, S K Droste, D J Nutt, A C E Linthorst, J M H M Reu. Voluntary exercise alters GABA(A) receptor subunit and glutamic acid decarboxylase-67 gene expression in the rat forebrain. Journal of psychopharmacology (Oxford, England). vol 24. issue 5. 2010-08-18. PMID:18801833. |
expression of gad67 mrna was increased in many forebrain regions including all hippocampal cell layers, peri-paraventricular nucleus, bed nucleus stria terminalis, nucleus accumbens core and motor cortex, suggesting that long-term voluntary exercise enhances forebrain gaba synthesis capacity but in a region-specific manner. |
2010-08-18 |
2023-08-12 |
human |
| Theofanis Karayannis, David Elfant, Icnelia Huerta-Ocampo, Sundeep Teki, Ricardo S Scott, Dmitri A Rusakov, Mathew V Jones, Marco Capogn. Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 29. 2010-08-13. PMID:20660272. |
slow gaba transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells. |
2010-08-13 |
2023-08-12 |
Not clear |
| Theofanis Karayannis, David Elfant, Icnelia Huerta-Ocampo, Sundeep Teki, Ricardo S Scott, Dmitri A Rusakov, Mathew V Jones, Marco Capogn. Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 29. 2010-08-13. PMID:20660272. |
here, we provide experimental and modeling data showing that hippocampal ngfcs generate an unusually prolonged (tens of milliseconds) but low-concentration (micromolar range) gaba transient, which is responsible for the slow response kinetics and which leads to a robust desensitization of postsynaptic gaba(a) receptors. |
2010-08-13 |
2023-08-12 |
Not clear |
| Joanna M Wierońska, P Brański, A Siwek, M Dybala, G Nowak, A Pil. GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus. Brain research. vol 1334. 2010-08-12. PMID:20353761. |
the protein levels of gad65 was lowered in mglu7-/- animals only, while gad67 and gaba(b) receptor number were decreased in both mglu7+/- and mglu7-/- mice when measured in the whole hippocampus. |
2010-08-12 |
2023-08-12 |
mouse |
| Tudor Bartoi, Kristoffer T G Rigbolt, Dan Du, Georg Köhr, Blagoy Blagoev, Hans-Christian Korna. GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. The Journal of biological chemistry. vol 285. issue 27. 2010-08-10. PMID:20406808. |
in transfected hippocampal neurons, potassium channel tetramerization domain-containing protein 12 augmented axonal surface targeting of gaba(b2). |
2010-08-10 |
2023-08-12 |
mouse |
| Robert I Westphalen, Jieying Yu, Margarita Krivitski, Ting-Yu Jih, Hugh C Hemming. Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS. Journal of neurochemistry. vol 113. issue 6. 2010-08-06. PMID:20374421. |
na(v) coupling to transmitter release was determined by measuring the sensitivity of 4-aminopyridine (4ap)-evoked [(3)h]glutamate and [(14)c]gaba release to the specific na(v) blocker tetrodotoxin (ttx) for nerve terminals isolated from rat cerebral cortex, hippocampus, striatum and spinal cord. |
2010-08-06 |
2023-08-12 |
rat |
| Martin Mortensen, Bjarke Ebert, Keith Wafford, Trevor G Smar. Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. The Journal of physiology. vol 588. issue Pt 8. 2010-07-29. PMID:20176630. |
here, we study in isolation the activity of three agonists, gaba, muscimol and 4,5,6,7-tetrahydoisoxazolo[5,4-c]pyridin-3(2h)-one (thip), to further understand the activation profiles of alpha 1 beta 3 gamma 2, alpha 4 beta 3 gamma 2 and alpha 4 beta 3 delta receptors that typify synaptic- and extrasynaptic-type receptors expressed in the hippocampus and thalamus. |
2010-07-29 |
2023-08-12 |
Not clear |
| Tero Viitanen, Eva Ruusuvuori, Kai Kaila, Juha Voipi. The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. The Journal of physiology. vol 588. issue Pt 9. 2010-07-29. PMID:20211979. |
gabaergic excitatory [k(+)](o) transients can be readily evoked in the mature rat hippocampus by intense activation of gaba(a) receptors (gaba(a)rs). |
2010-07-29 |
2023-08-12 |
rat |
| Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiter. The GABA B receptor antagonists CGP35348 and CGP52432 inhibit glycine exocytosis: study with GABA B1- and GABA B2-deficient mice. Pharmacological research. vol 61. issue 6. 2010-07-21. PMID:20138995. |
in synaptosomes purified from the spinal cord or the hippocampus of mice lacking either the gaba(b1) (gaba(b1-/-) mice) or the gaba(b2) (gaba(b2-/-) mice) subunit, the evoked exocytosis of [(3)h]glycine was no longer inhibited by (-)-baclofen, whereas the intrinsic activity of cgp35348 and cgp52432 was not decreased. |
2010-07-21 |
2023-08-12 |
mouse |
| M I Naseer, H Y Lee, M O Ki. Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABA(B) receptor and PKA-alpha expression in prenatal rat brain. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20175221. |
our study was designed to investigate the effect of ethanol (100 mm), nicotine (50 microm) (for 30 min and 1 h), vitamin c (vitc, 0.5 mm), ethanol plus vitc, and nicotine plus vitc on expression level of gaba(b1), gaba(b2)r, and protein kinase a-alpha (pka) in prenatal rat cortical and hippocampal neurons at gestational days (gd) 17.5. |
2010-07-19 |
2023-08-12 |
rat |
| M I Naseer, H Y Lee, M O Ki. Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABA(B) receptor and PKA-alpha expression in prenatal rat brain. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20175221. |
the results showed that, upon ethanol and nicotine exposure, gaba(b1) and gaba(b2)r protein expression increased significantly in the cortex and hippocampus for a short (30 min) and long term (1 h), whereas only gaba(b2)r subunit was decreased upon nicotine exposure for a long term in the cortex. |
2010-07-19 |
2023-08-12 |
rat |
| M I Naseer, H Y Lee, M O Ki. Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABA(B) receptor and PKA-alpha expression in prenatal rat brain. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20175221. |
moreover, the cotreatment of vitc with ethanol and nicotine showed significantly decreased expression of gaba(b1), gaba(b2)r, and pka in cortex and hippocampus for a long-term exposure. |
2010-07-19 |
2023-08-12 |
rat |
| Akiko Mizokami, Hiroto Tanaka, Hitoshi Ishibashi, Hisanori Umebayashi, Kiyoko Fukami, Tadaomi Takenawa, Keiichi I Nakayama, Takeshi Yokoyama, Junichi Nabekura, Takashi Kanematsu, Masato Hirat. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20412381. |
we have previously reported that phospholipase c-related inactive protein (prip) is a modulator of gaba(a) receptor trafficking and that knockout (ko) mice exhibit a diazepam-insensitive phenotype in the hippocampus. |
2010-07-19 |
2023-08-12 |
mouse |
| Loreto Cuitino, Juan A Godoy, Ginny G Farías, Andrés Couve, Christian Bonansco, Marco Fuenzalida, Nibaldo C Inestros. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 25. 2010-07-15. PMID:20573888. |
therefore, we postulate that wnt-5a, by activation of camkii, induces the recycling of functional gaba(a)-rs on the mature hippocampal neurons. |
2010-07-15 |
2023-08-12 |
rat |
| Stacey Carmody, Lorraine Brenna. Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. Neurochemistry international. vol 56. issue 2. 2010-07-08. PMID:19913064. |
in the hippocampus of ptz-kindled animals the metabolites changing included lactate, succinate, gaba, naa, choline and taurine. |
2010-07-08 |
2023-08-12 |
rat |
| Zi-li You, Qing Xia, Fan-rong Liang, Yi-jun Tang, Cong-lun Xu, Jian Huang, Ling Zhao, Wen-zheng Zhang, Jia-jia H. Effects on the expression of GABAA receptor subunits by jujuboside A treatment in rat hippocampal neurons. Journal of ethnopharmacology. vol 128. issue 2. 2010-07-01. PMID:20083184. |
to determine the effect of jujuboside a (jua) in modulating the gamma-aminobutyric acid (gaba(a)) receptor subunits gene expression of hippocampal neurons at different terms in vitro. |
2010-07-01 |
2023-08-12 |
rat |
| Suneel Reddy-Alla, Bertram Schmitt, Jörg Birkenfeld, Volker Eulenburg, Sebastien Dutertre, Christian Böhringer, Magdalena Götz, Heinrich Betz, Theofilos Papadopoulo. PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering. The European journal of neuroscience. vol 31. issue 7. 2010-07-01. PMID:20345913. |
furthermore, mice with a forebrain-specific inactivation of the cdc42 gene displayed normal densities of gephyrin and gaba(a) receptor clusters in the hippocampus. |
2010-07-01 |
2023-08-12 |
mouse |
| Mohamed Ouardouz, Pablo Lema, Patricia N Awad, Graziella Di Cristo, Lionel Carman. N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. The European journal of neuroscience. vol 31. issue 7. 2010-07-01. PMID:20345922. |
n-methyl-d-aspartate, hyperpolarization-activated cation current (ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. |
2010-07-01 |
2023-08-12 |
rat |