| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Moore, J Cushman, D Chandra, G E Homanics, R W Olsen, M S Fanselo. Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor. Neurobiology of learning and memory. vol 93. issue 3. 2010-06-23. PMID:20018248. |
the gaba(a)r alpha4 subunit is highly expressed in the dentate gyrus region of the hippocampus at predominantly extra synaptic locations where, along with the gaba(a)r delta subunit, it forms gaba(a) receptors that mediate a tonic inhibitory current. |
2010-06-23 |
2023-08-12 |
mouse |
| Tamar Levav-Rabkin, Osnat Melamed, Gerard Clarke, Malca Farber, John F Cryan, Timothy G Dinan, Yoram Grossman, Hava M Gola. A sensitive period of mice inhibitory system to neonatal GABA enhancement by vigabatrin is brain region dependent. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043003. |
we examined immediate and long-lasting influences of exposure to the gaba-potentiating drug vigabatrin (gvg) on the gabaergic system in the hippocampus and cerebral cortex, before and during the developmental switch in gaba function (postnatal days p1-7 and p4-14). |
2010-06-21 |
2023-08-12 |
mouse |
| Pablo García-Junco-Clemente, Gloria Cantero, Leonardo Gómez-Sánchez, Pedro Linares-Clemente, José A Martínez-López, Rafael Luján, Rafael Fernández-Chacó. Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 21. 2010-06-15. PMID:20505105. |
consistent with this, in hippocampal cultures from these mice, the frequency of miniature ipscs, caused by spontaneous gaba release, progressively declines, whereas the frequency of miniature excitatory ampa receptor-mediated currents (mepscs), caused by spontaneous release of glutamate, is normal. |
2010-06-15 |
2023-08-12 |
mouse |
| Sachin S Talathi, Dong-Uk Hwang, Paul R Carney, William L Ditt. Synchrony with shunting inhibition in a feedforward inhibitory network. Journal of computational neuroscience. vol 28. issue 2. 2010-06-14. PMID:20135213. |
recent experiments have shown that gaba(a) receptor mediated inhibition in adult hippocampus is shunting rather than hyperpolarizing. |
2010-06-14 |
2023-08-12 |
Not clear |
| Lintao Qu, Richard Boyce, L Stan Leun. Seizures in the developing brain result in a long-lasting decrease in GABA(B) inhibitory postsynaptic currents in the rat hippocampus. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20026210. |
seizures in the developing brain result in a long-lasting decrease in gaba(b) inhibitory postsynaptic currents in the rat hippocampus. |
2010-06-08 |
2023-08-12 |
rat |
| Lintao Qu, Richard Boyce, L Stan Leun. Seizures in the developing brain result in a long-lasting decrease in GABA(B) inhibitory postsynaptic currents in the rat hippocampus. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20026210. |
we tested the hypothesis that a model of early-life seizures, induced by systemic injection of a gaba(b) receptor antagonist cgp56999a in immature rats, decreased gaba(b) receptor-mediated inhibitory postsynaptic currents (ipscs) in the hippocampus of adolescent rats. |
2010-06-08 |
2023-08-12 |
rat |
| Francine M Bene. Relationship of GAD(67) regulation to cell cycle and DNA repair in GABA neurons in the adult hippocampus: bipolar disorder versus schizophrenia. Cell cycle (Georgetown, Tex.). vol 9. issue 4. 2010-06-08. PMID:20107308. |
relationship of gad(67) regulation to cell cycle and dna repair in gaba neurons in the adult hippocampus: bipolar disorder versus schizophrenia. |
2010-06-08 |
2023-08-12 |
Not clear |
| Alejandro F Schinder, Nicolás A Morgenster. Preview. Adult neurogenesis is altered by GABAergic imbalance in models of Alzheimer's disease. Cell stem cell. vol 5. issue 6. 2010-06-04. PMID:19951683. |
(2009) propose abnormal gaba signaling as a trigger for impaired network plasticity in the ad hippocampus. |
2010-06-04 |
2023-08-12 |
Not clear |
| Ana M M Oliveira, Joshua D Hawk, Ted Abel, Robbert Haveke. Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learning & memory (Cold Spring Harbor, N.Y.). vol 17. issue 3. 2010-05-24. PMID:20189960. |
to overcome this limitation, we used an intrahippocampal injection of the gaba agonist muscimol to reversibly inactivate the hippocampus immediately after training mice in two versions of an object recognition task. |
2010-05-24 |
2023-08-12 |
mouse |
| Mu Sun, Jonathan C Gewirtz, Lisa Bofenkamp, Robert J Wickham, Hong Ge, Michael B O'Conno. Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 17. 2010-05-24. PMID:20427661. |
however, these mutant mice did show enhancement of paired-pulse facilitation in excitatory synaptic transmission and stronger paired-pulse depression of gaba(a) currents in the hippocampus. |
2010-05-24 |
2023-08-12 |
mouse |
| Mu Sun, Jonathan C Gewirtz, Lisa Bofenkamp, Robert J Wickham, Hong Ge, Michael B O'Conno. Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 17. 2010-05-24. PMID:20427661. |
in summary, we suggest that the canonical tgf-beta signaling pathway is critical for use-dependent modulation of gaba(a) synaptic transmission and dendritic homeostasis; furthermore, a disruption in the balance of the excitatory and inhibitory hippocampal network can result in psychiatric-like behavior. |
2010-05-24 |
2023-08-12 |
mouse |
| Silvia Josefina López-Pérez, Mónica Elisa Ureña-Guerrero, Alberto Morales-Villagrá. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain research. vol 1317. 2010-05-19. PMID:20043888. |
glu levels and hippocampal total content of related amino acids (asp, glu, gln, gly, tau, ala and gaba) were estimated before, immediately and after each injection. |
2010-05-19 |
2023-08-12 |
rat |
| Loren J Martin, Agnieszka A Zurek, John F MacDonald, John C Roder, Michael F Jackson, Beverley A Orse. Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392949. |
we studied the regulation of synaptic plasticity by alpha5 subunit-containing gaba(a)rs (alpha5gaba(a)rs), which generate a tonic inhibitory conductance in ca1 pyramidal neurons using electrophysiological recordings of field and whole-cell potentials in hippocampal slices from both wild-type and null mutant mice for the alpha5 subunit of the gaba(a)r (gabra5(-/-) mice). |
2010-05-14 |
2023-08-12 |
mouse |
| Manuela Mazzuferi, Eleonora Palma, Katiuscia Martinello, Francesca Maiolino, Cristina Roseti, Sergio Fucile, Paolo F Fabene, Federica Schio, Michele Pellitteri, Guenther Sperk, Ricardo Miledi, Fabrizio Eusebi, Michele Simonat. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133704. |
enhancement of gaba(a)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. |
2010-05-10 |
2023-08-12 |
human |
| Manuela Mazzuferi, Eleonora Palma, Katiuscia Martinello, Francesca Maiolino, Cristina Roseti, Sergio Fucile, Paolo F Fabene, Federica Schio, Michele Pellitteri, Guenther Sperk, Ricardo Miledi, Fabrizio Eusebi, Michele Simonat. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133704. |
in particular, the use-dependent decrease (run-down) of the currents (i(gaba)) evoked by the repetitive activation of gaba(a) receptors is markedly enhanced in hippocampal and cortical neurons of tle patients. |
2010-05-10 |
2023-08-12 |
human |
| Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. |
using quantitative receptor autoradiography, ligand binding densities of [(3)h]mk-801, [(3)h]ampa, and [(3)h]muscimol for labeling of nmda, ampa, and gaba(a) receptors were analyzed in sensorimotor cortices par1 and par2, the striatum, and the hippocampus. |
2010-05-06 |
2023-08-12 |
rat |
| Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. |
furthermore, a marked and significant increase of [(3)h]muscimol ligand binding to gaba(a) receptors throughout all hippocampal subfields was seen after 6 hours. |
2010-05-06 |
2023-08-12 |
rat |
| Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. |
this complexity could easily be unraveled when focusing on the balance between excitatory glutamate and inhibitory gaba(a) receptors, in which case only the increase of hippocampal [(3)h]muscimol ligand binding 6 hours after the first application of pravastatin was accompanied by a net shift towards inhibition. |
2010-05-06 |
2023-08-12 |
rat |
| Dimitri De Bundel, Najat Aourz, Foteini Kiagiadaki, Ralph Clinckers, Daniel Hoyer, Andreas Kastellakis, Yvette Michotte, Kyriaki Thermos, Ilse Smolder. Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. Neuroreport. vol 21. issue 4. 2010-05-05. PMID:20134357. |
we showed that intrahippocampal administration of the sst(1) antagonist sra880 (1 microm) induced a robust increase in hippocampal sst-14 levels without affecting gamma-aminobutyric acid levels in conscious rats, indicating that the sst(1) receptor acts as an inhibitory autoreceptor. |
2010-05-05 |
2023-08-12 |
rat |
| Giuseppina Giusi, Rosa Maria Facciolo, Maria Rende, Raffaella Alò, Anna Di Vito, Simona Salerno, Sabrina Morelli, Loredana De Bartolo, Enrico Drioli, Marcello Canonac. Distinct alpha subunits of the GABAA receptor are responsible for early hippocampal silent neuron-related activities. Hippocampus. vol 19. issue 11. 2010-04-27. PMID:19338020. |
in this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major gaba(a) alpha receptor subunits (alpha(2,5)) are capable of early neuronal shaping plus expression differences of some of the main neuronal cytoskeletal factors (gap-43, the neurotrophin--bdnf) and of gluergic subtypes. |
2010-04-27 |
2023-08-12 |
Not clear |