| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nan Wang, Guang-Fen Zhang, Xiao-Yu Liu, He-Liang Sun, Xing-Ming Wang, Li-Li Qiu, Chun Yang, Jian-Jun Yan. Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the rat brain may contribute to the antidepressant properties of ketamine. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24633675. |
the results showed that ketamine reduced the immobility time and latency to feed of rats receiving the fst, downregulated the levels of nrg1, phosphorylated erbb4 (p-erbb4), parvalbumin, 67-kda isoform of glutamic acid decarboxylase (gad67), gamma-aminobutyric acid (gaba), and upregulated the levels of glutamate in the rat prefrontal cortex and hippocampus. |
2015-05-28 |
2023-08-12 |
rat |
| Li Wan, Xu Liu, Zheng Wu, Wanting Ren, Shuzhen Kong, Raya Abou Dargham, Longzhen Cheng, Yun Wan. Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons. Neuroscience bulletin. vol 30. issue 5. 2015-05-27. PMID:25260800. |
in this study, we used cyclothiazide (ctz)-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic gaba(a)rs by 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridine-3-ol (thip) on the ctz-induced epileptiform activity in hippocampal neurons. |
2015-05-27 |
2023-08-13 |
Not clear |
| Jing Ding, Chen Huang, Zhong Peng, Yuxuan Xie, Shining Deng, Yan-Zhen Nie, Tian-Le Xu, Wei-Hong Ge, Wei-Guang Li, Fei L. Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:24980777. |
at lower concentrations (∼30 μm), me significantly sensitized gaba-induced, but not glutamate- or glycine-induced, currents in cultured hippocampal neurons, indicative of a preferentially modulatory role of this compound for a type gaba receptors (gabaars). |
2015-05-26 |
2023-08-13 |
human |
| Ana Paula dos S C L da Silva, Joselma S L Lopes, Priscila de S Vieira, Emanuelly E A Pinheiro, Mirna L de G da Silva, José Carlos C L Silva Filho, Joaquim S da Costa, Jorge M David, Rivelilson M de Freita. Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24911645. |
the present study aimed to evaluate the gfc effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (γ-aminobutyric acid (gaba), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (ache) activity in mice hippocampus after seizures. |
2015-05-19 |
2023-08-13 |
mouse |
| Ana Paula dos S C L da Silva, Joselma S L Lopes, Priscila de S Vieira, Emanuelly E A Pinheiro, Mirna L de G da Silva, José Carlos C L Silva Filho, Joaquim S da Costa, Jorge M David, Rivelilson M de Freita. Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24911645. |
in addition, gaba content of mice hippocampus treated with gfc75 plus p400 showed an increase of 46.90% when compared with seized mice. |
2015-05-19 |
2023-08-13 |
mouse |
| Ana Paula dos S C L da Silva, Joselma S L Lopes, Priscila de S Vieira, Emanuelly E A Pinheiro, Mirna L de G da Silva, José Carlos C L Silva Filho, Joaquim S da Costa, Jorge M David, Rivelilson M de Freita. Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24911645. |
in conclusion, our data suggest that gfc may influence in epileptogenesis and promote anticonvulsant actions in pilocarpine model by modulating the gaba and glutamate contents and of ache activity in seized mice hippocampus. |
2015-05-19 |
2023-08-13 |
mouse |
| Mathieu D Santin, Romain Valabrègue, Isabelle Rivals, Romain Pénager, Raphaël Paquin, Luce Dauphinot, Christelle Albac, Benoit Delatour, Marie-Claude Potie. In vivo 1H MRS study in microlitre voxels in the hippocampus of a mouse model of Down syndrome at 11.7 T. NMR in biomedicine. vol 27. issue 10. 2015-05-18. PMID:25088227. |
thus, the excitation-inhibition imbalance described in ds does not appear to be related to a radical change in the levels of either gaba or glutamate in the hippocampus. |
2015-05-18 |
2023-08-13 |
mouse |
| b' P F\\xc3\\xa1bera, P Mare\\xc5\\xa. Effect of GABA(B) receptor agonist SKF97541 on cortical and hippocampal epileptic afterdischarges. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702499.' |
effect of gaba(b) receptor agonist skf97541 on cortical and hippocampal epileptic afterdischarges. |
2015-05-15 |
2023-08-13 |
rat |
| b' P F\\xc3\\xa1bera, P Mare\\xc5\\xa. Effect of GABA(B) receptor agonist SKF97541 on cortical and hippocampal epileptic afterdischarges. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702499.' |
the present study examined possible effects of gaba(b) receptor agonist skf97541 on cortical and hippocampal epileptic afterdischarges (ads). |
2015-05-15 |
2023-08-13 |
rat |
| b' P F\\xc3\\xa1bera, P Mare\\xc5\\xa. Effect of GABA(B) receptor agonist SKF97541 on cortical and hippocampal epileptic afterdischarges. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702499.' |
our present data demonstrated that neither cortical nor hippocampal ads in adult rats were suppressed by gaba(b) receptor agonist skf97541. |
2015-05-15 |
2023-08-13 |
rat |
| Stephanie M Perez, Daniel J Lodg. New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways. Drug design, development and therapy. vol 8. 2015-05-11. PMID:25061280. |
here we review the dopamine, gamma-aminobutyric acid (gaba), and glutamate hypotheses of schizophrenia and describe a pathway whereby a loss of inhibitory signaling in ventral regions of the hippocampus actually drives a dopamine hyperfunction. |
2015-05-11 |
2023-08-13 |
rat |
| Fei Huang, Tingting Wang, Yunyi Lan, Li Yang, Weihong Pan, Yonghui Zhu, Boyang Lv, Yuting Wei, Hailian Shi, Hui Wu, Beibei Zhang, Jie Wang, Xiaofeng Duan, Zhibi Hu, Xiaojun W. Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior. Frontiers in behavioral neuroscience. vol 9. 2015-04-14. PMID:25870546. |
fxr deletion decreased the amount of the gaba synthesis enzyme gad65 in hippocampus but increased gaba transporter gat1 in cerebral cortex. |
2015-04-14 |
2023-08-13 |
mouse |
| Yuqing Duan, Zhigao Wang, Haihui Zhang, Yuanqing He, Rong Fan, Yanxiang Cheng, Guibo Sun, Xiaobo Su. Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod. Food & function. vol 5. issue 9. 2015-04-13. PMID:25066354. |
the results showed that elf-emf exposure induced the increased contents of glutamate, gaba, excessively activated nmda receptors, increasing the number of nmda receptor 2b (nr2b) and intracellular ca(2+) concentration [ca(2+)]i in hippocampus. |
2015-04-13 |
2023-08-13 |
mouse |
| Fazheng Shen, Lei Hui, Xiang Zhou, Zhongwei Wang, Xinli Zhao, Wenke Zhou, Xinzhong Zhang, Guangming Yang, Feng Wang, Tao Su. [Effects of hippocampal stimulus on α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats]. Zhonghua yi xue za zhi. vol 94. issue 23. 2015-04-08. PMID:25154851. |
[effects of hippocampal stimulus on α₅ subunit of extrasynaptic gaba(a) receptor in kainic acid-induced epileptic rats]. |
2015-04-08 |
2023-08-13 |
rat |
| Fazheng Shen, Lei Hui, Xiang Zhou, Zhongwei Wang, Xinli Zhao, Wenke Zhou, Xinzhong Zhang, Guangming Yang, Feng Wang, Tao Su. [Effects of hippocampal stimulus on α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats]. Zhonghua yi xue za zhi. vol 94. issue 23. 2015-04-08. PMID:25154851. |
to observe the effects of electrical hippocampal stimulation of α₅ subunit of extrasynaptic gaba(a) receptor in kainic acid-induced epileptic rats, explore the optimal therapeutic parameters and elucidate the possible mechanism of electrical stimulation for hippocampal epilepsy. |
2015-04-08 |
2023-08-13 |
rat |
| Claudius E Degro, Akos Kulik, Sam A Booker, Imre Vid. Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells. Frontiers in synaptic neuroscience. vol 7. 2015-04-08. PMID:25852540. |
pharmacologically isolated slow inhibitory postsynaptic currents were elicited in the three major hippocampal principal cell types by endogenous gaba released by electrical stimulation, photolysis of caged-gaba, as well as the canonical agonist baclofen, with the highest amplitudes observed in the ca3. |
2015-04-08 |
2023-08-13 |
rat |
| Claudius E Degro, Akos Kulik, Sam A Booker, Imre Vid. Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells. Frontiers in synaptic neuroscience. vol 7. 2015-04-08. PMID:25852540. |
spatially restricted currents were assessed along the axis of principal cells by uncaging gaba in the different hippocampal layers. |
2015-04-08 |
2023-08-13 |
rat |
| Marilia S Albuquerque, Ian Mahar, Maria Antonietta Davoli, Jean-Guy Chabot, Naguib Mechawar, Rémi Quirion, Slavica Kranti. Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease. Frontiers in aging neuroscience. vol 7. 2015-04-08. PMID:25852545. |
hippocampal network activity is predominantly coordinated by γ-amino-butyric acid (gaba)ergic neurons. |
2015-04-08 |
2023-08-13 |
mouse |
| Li Yue, Huo Xiao-lin, Song Ta. The effects of chronic repetitive transcranial magnetic stimulation on glutamate and gamma-aminobutyric acid in rat brain. Brain research. vol 1260. 2015-03-30. PMID:19401169. |
results showed that the content of glutamate and gamma-aminobutyric acid increased significantly in hippocampus and striatum after chronic rtms, but reduced significantly in the hypothalamus. |
2015-03-30 |
2023-08-12 |
human |
| Sandra Giovanoli, Liz Weber, Urs Meye. Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation. Brain, behavior, and immunity. vol 40. 2015-03-30. PMID:24859043. |
the present study explored the consequences of combined prenatal immune challenge and peripubertal stress on discrete cellular abnormalities in the γ-aminobutyric acid (gaba) system of the hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |