| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia S Rozas, John B Redell, Juan D Pita-Almenar, James Mckenna, Anthony N Moore, Michael J Gambello, Pramod K Das. Intrahippocampal glutamine administration inhibits mTORC1 signaling and impairs long-term memory. Learning & memory (Cold Spring Harbor, N.Y.). vol 22. issue 5. 2016-01-12. PMID:25878136. |
intracellular recordings in hippocampal slices showed that glutamine did not alter either excitatory or inhibitory synaptic activity, suggesting that the observed memory impairments may not result from conversion of glutamine to either glutamate or gaba. |
2016-01-12 |
2023-08-13 |
rat |
| Andrew Karls, Michelle Mynlief. GABA(B) receptors couple to Gαq to mediate increases in voltage-dependent calcium current during development. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26212383. |
previously, we have shown that gaba(b) receptors couple to a non-gi/o g-protein to enhance calcium influx through l-type calcium channels by activating protein kinase c in neonatal rat hippocampal neurons. |
2016-01-08 |
2023-08-13 |
rat |
| Andrew Karls, Michelle Mynlief. GABA(B) receptors couple to Gαq to mediate increases in voltage-dependent calcium current during development. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26212383. |
activation of gaba(b) receptors in the neonatal rat hippocampus enhances voltage-dependent calcium currents independently of gi/o . |
2016-01-08 |
2023-08-13 |
rat |
| Ilgam Khalilov, Marat Minlebaev, Marat Mukhtarov, Roustem Khazipo. Dynamic Changes from Depolarizing to Hyperpolarizing GABAergic Actions during Giant Depolarizing Potentials in the Neonatal Rat Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377455. |
during development, gaba exerts depolarizing action on immature neurons and, acting in synergy with glutamate, drives giant depolarizing potentials (gdps) in the hippocampal network. |
2016-01-04 |
2023-08-13 |
rat |
| Ilgam Khalilov, Marat Minlebaev, Marat Mukhtarov, Roustem Khazipo. Dynamic Changes from Depolarizing to Hyperpolarizing GABAergic Actions during Giant Depolarizing Potentials in the Neonatal Rat Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377455. |
yet, blockade of the gaba(a) receptors transforms gdps to epileptiform discharges suggesting dual, both excitatory and inhibitory, actions of gaba in the immature hippocampal network. |
2016-01-04 |
2023-08-13 |
rat |
| Elham Goudarzi, Mahmoud Elahdadi Salmani, Taghi Lashkarbolouki, Iran Goudarz. Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. Pharmacology, biochemistry, and behavior. vol 130. 2015-12-23. PMID:25600753. |
therefore, in this study, the effect of hippocampal orexin 1 and 2 receptors on seizure and glutamate and gaba (gamma-aminobutyric acid) contents was explored. |
2015-12-23 |
2023-08-13 |
rat |
| Naruyoshi Fujiwara, Jun Shimizu, Kenji Takai, Nagisa Arimitsu, Yuji Ueda, Sueshige Wakisaka, Tomoko Suzuki, Noboru Suzuk. Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells. Experimental neurology. vol 271. 2015-12-22. PMID:26196079. |
in addition, human and mouse vesicular gaba transporter (vgat)-positive neurons were located mainly in the hippocampus and, though the number was small, human vgat-positive neurons were observed in the cortex. |
2015-12-22 |
2023-08-13 |
mouse |
| Xiaohong Xu, Fangni Dong, Yanling Yang, Yu Wang, Ran Wang, Xiuying She. Sex-specific effects of long-term exposure to bisphenol-A on anxiety- and depression-like behaviors in adult mice. Chemosphere. vol 120. 2015-12-18. PMID:25112706. |
western blot analysis further indicated that bpa at 0.4, 4, or 40 mg kg(-1)d(-1) significantly down-regulated the protein level of estrogen receptor β (erβ) in the hippocampus of the adult males but not females, and inhibited the protein level of gaba(a)α2 receptor in hippocampus of males but promoted that of females. |
2015-12-18 |
2023-08-13 |
mouse |
| Xiaohong Xu, Fangni Dong, Yanling Yang, Yu Wang, Ran Wang, Xiuying She. Sex-specific effects of long-term exposure to bisphenol-A on anxiety- and depression-like behaviors in adult mice. Chemosphere. vol 120. 2015-12-18. PMID:25112706. |
changes in the levels of gaba(a)α2 receptor and erβ proteins of hippocampus might be associated with bpa-induced changes in these emotional behaviors. |
2015-12-18 |
2023-08-13 |
mouse |
| Bingjin Li, Liang Wang, Zhihui Sun, Yang Zhou, Dongyuan Shao, Jing Zhao, Yunong Song, Jiayin Lv, Xue Dong, Changhong Liu, Pu Wang, Xingyi Zhang, Ranji Cu. The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice. PloS one. vol 9. issue 4. 2015-12-15. PMID:24690630. |
an elisa study showed that sr 57227 attenuated the ptz-induced inhibitory effects of gaba levels in hippocampus and cortex, and the attenuated effects of sr 57227 were antagonized by ondansetron in hippocampus but not cortex. |
2015-12-15 |
2023-08-13 |
mouse |
| Bingjin Li, Liang Wang, Zhihui Sun, Yang Zhou, Dongyuan Shao, Jing Zhao, Yunong Song, Jiayin Lv, Xue Dong, Changhong Liu, Pu Wang, Xingyi Zhang, Ranji Cu. The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice. PloS one. vol 9. issue 4. 2015-12-15. PMID:24690630. |
our findings suggest that activation of 5-ht3 receptor by sr 57227, which plays an important role on the control of seizure induced by ptz, may be related to gaba activity in hippocampus. |
2015-12-15 |
2023-08-13 |
mouse |
| S Q Cui, Q Wang, Y Zheng, B Xiao, H W Sun, X L Gu, Y C Zhang, C H Fu, P X Dong, X M Wan. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 48. issue 6. 2015-12-15. PMID:25831201. |
glutamic acid (glu) and gamma amino butyric acid (gaba) in the cortex and hippocampus were assayed by high-performance liquid chromatography (hplc), and tumor necrosis factor (tnf)-α and interleukin (il)-1β were determined by elisa. |
2015-12-15 |
2023-08-13 |
mouse |
| A D Stan, S Ghose, C Zhao, K Hulsey, P Mihalakos, M Yanagi, S U Morris, J J Bartko, C Choi, C A Tamming. Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia. Molecular psychiatry. vol 20. issue 4. 2015-12-09. PMID:24912493. |
gamma-aminobutyric acid (gaba) concentrations and gad67 protein were not significantly different in hippocampus in schizophrenia. |
2015-12-09 |
2023-08-13 |
mouse |
| Ikram Ullah, Haroon Badshah, Muhammad Imran Naseer, Hae Young Lee, Myeong Ok Ki. Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. Neuromolecular medicine. vol 17. issue 1. 2015-12-09. PMID:25429759. |
epileptic seizures caused a decline in expression of gamma-aminobutyric acid b1 receptor (gabab1r) (p > 0.05), unchanged expression of protein kinase a (pka), decreased calcium/calmodulin-dependent protein kinase ii (camkii) (p > 0.05) and inhibit the phosphorylation of camp response element-binding protein (creb) (p > 0.05) in cortex and hippocampus, respectively, compared with control. |
2015-12-09 |
2023-08-13 |
rat |
| María Guadalupe Valle-Dorado, César Emmanuel Santana-Gómez, Sandra Adela Orozco-Suárez, Luisa Roch. The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. Neuropharmacology. vol 92. 2015-12-01. PMID:25578265. |
in contrast to ss-se group, rats from the cg-se group showed increased latency to the establishment of the status epilepticus (p = 0.048), absence of wet-dog shakes, reduced histamine (but not gaba and glutamate) release, lower number of mast cells (p = 0.008) and reduced neuronal damage in hippocampus. |
2015-12-01 |
2023-08-13 |
rat |
| Paolo Follesa, Gabriele Floris, Gino P Asuni, Antonio Ibba, Maria G Tocco, Luca Zicca, Beniamina Mercante, Franca Deriu, Giorgio Gorin. Chronic Intermittent Ethanol Regulates Hippocampal GABA(A) Receptor Delta Subunit Gene Expression. Frontiers in cellular neuroscience. vol 9. 2015-11-30. PMID:26617492. |
chronic intermittent ethanol regulates hippocampal gaba(a) receptor delta subunit gene expression. |
2015-11-30 |
2023-08-13 |
mouse |
| Paolo Follesa, Gabriele Floris, Gino P Asuni, Antonio Ibba, Maria G Tocco, Luca Zicca, Beniamina Mercante, Franca Deriu, Giorgio Gorin. Chronic Intermittent Ethanol Regulates Hippocampal GABA(A) Receptor Delta Subunit Gene Expression. Frontiers in cellular neuroscience. vol 9. 2015-11-30. PMID:26617492. |
chronic ethanol consumption causes structural and functional reorganization in the hippocampus and induces alterations in the gene expression of gamma-aminobutyric acid type a receptors (gabaars). |
2015-11-30 |
2023-08-13 |
mouse |
| Olga Ostrovskaya, Keqiang Xie, Ikuo Masuho, Ana Fajardo-Serrano, Rafael Lujan, Kevin Wickman, Kirill A Martemyano. RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. eLife. vol 3. 2015-11-17. PMID:24755289. |
in the hippocampus, the inhibitory neurotransmitter gaba shapes the activity of the output pyramidal neurons and plays important role in cognition. |
2015-11-17 |
2023-08-13 |
mouse |
| Niamh Cawley, Bhavana S Solanky, Nils Muhlert, Carmen Tur, Richard A E Edden, Claudia A M Wheeler-Kingshott, David H Miller, Alan J Thompson, Olga Ciccarell. Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26304151. |
thirty patients with secondary progressive multiple sclerosis and 17 healthy control subjects underwent single-voxel mega-press (mescher-garwood point resolved spectroscopy) magnetic resonance spectroscopy at 3 t, to quantify gamma-aminobutyric acid levels in the prefrontal cortex, right hippocampus and left sensorimotor cortex. |
2015-11-16 |
2023-08-13 |
human |
| Niamh Cawley, Bhavana S Solanky, Nils Muhlert, Carmen Tur, Richard A E Edden, Claudia A M Wheeler-Kingshott, David H Miller, Alan J Thompson, Olga Ciccarell. Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26304151. |
patients had significantly lower gamma-aminobutyric acid levels in the hippocampus (adjusted difference = -0.403 mm, 95% confidence intervals -0.792, -0.014, p = 0.043) and sensorimotor cortex (adjusted difference = -0.385 mm, 95% confidence intervals -0.667, -0.104, p = 0.009) compared with controls. |
2015-11-16 |
2023-08-13 |
human |