| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
previous work from this laboratory hypothesized that the multimodal antidepressant vortioxetine enhances cognitive function through a complex mechanism, using serotonergic (5-hydroxytryptamine, 5-ht) receptor actions to modulate gamma-butyric acid (gaba) and glutamate neurotransmission in key brain regions like the prefrontal cortex (pfc) and hippocampus. |
2016-07-19 |
2023-08-13 |
Not clear |
| J-T Li, Y-Y Zhao, H-L Wang, X-D Wang, Y-A Su, T-M S. Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. Neuroscience. vol 308. 2016-07-19. PMID:26349007. |
the parvalbumin-positive (pv+) γ-aminobutyric acid (gaba)-ergic interneurons and presynaptic markers for excitatory and inhibitory neurons, vesicular glutamate transporter-1 (vglut1) and vesicular gaba transporter (vgat) were examined in the hippocampus to reflect the e/i balance. |
2016-07-19 |
2023-08-13 |
rat |
| Sampurna Chakrabarti, Mingxing Qian, Kathiresan Krishnan, Douglas F Covey, Steven Mennerick, Gustav Ak. Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors. Molecular pharmacology. vol 89. issue 4. 2016-07-01. PMID:26769414. |
comparison of steroid modulation of spontaneous inhibitory postsynaptic currents in cultured hippocampal neurons and steady-state single-channel currents from heterologously expressed α1β2γ2l gaba(a) receptors. |
2016-07-01 |
2023-08-13 |
rat |
| Liang Tian, Jin-hai Wang, Run-jie Sun, Xing-hua Zhang, Bo Yuan, Xiao-zheng D. [Development of Researches on Scalp Acupuncture for Ischemic Stroke]. Zhen ci yan jiu = Acupuncture research. vol 41. issue 1. 2016-07-01. PMID:27141629. |
results indicate that scalp acupuncture intervention can 1) improve cerebral blood circulation to promote regional energy metabolism, 2) up-regulate expression of glial cell-line derived neurotrophic factor (gdnf), etc., possibly promoting proliferation and differentiation of neural stem cells in the focal cerebral cortex and hippocampus, 3) reduce contents of excitatory amino acid and increase level of gamma-aminobutyric acid (gaba) to lower neurogenic toxicity, and relieve cerebral injury, 4) ease cerebral vascular immunoinflammatory reactions, 5) regulate blood lipid metabolism to resist cerebral free radical damage, and 6) inhibit cerebral cortical apoptosis. |
2016-07-01 |
2023-08-13 |
Not clear |
| Olaf Schijns, Ümit Karaca, Pablo Andrade, Laurence de Nijs, Benno Küsters, Andrea Peeters, Jim Dings, Heinz Pannek, Alois Ebner, Kim Rijkers, Govert Hooglan. Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis. Journal of chemical neuroanatomy. vol 68. 2016-06-29. PMID:26212582. |
hippocampal gaba transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis. |
2016-06-29 |
2023-08-13 |
Not clear |
| Patricia Salazar, Ricardo Tapi. Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats. Epilepsy research. vol 116. 2016-06-07. PMID:26354164. |
we conclude that in adult awake rats, drugs acting on plp availability have only a weak effect on gaba neurotransmission, whereas direct gad inhibition produced by mpa induces hyperexcitation leading to epilepsy and hippocampal neurodegeneration. |
2016-06-07 |
2023-08-13 |
mouse |
| Lejun Lin, Bofeng Cao, Zhiying Xu, Yanbin Sui, Jiao Chen, Qiang Luan, Ruifang Yang, Shanchun Li, Ke Feng L. In vivo HMRS and lipidomic profiling reveals comprehensive changes of hippocampal metabolism during aging in mice. Biochemical and biophysical research communications. vol 470. issue 1. 2016-06-07. PMID:26707637. |
we found n-acetylaspartic acid (naa), gama-aminobutyric acid (gaba), glutamate/glutamine, taurine, choline, sphingolipids (sms), phosphatidylethanolamines (pes), phosphatidylinositols (pis), phosphatidylglycerols (pgs) and phosphatidylserines (pss), all of them decreasing with the aging process in mice hippocampus. |
2016-06-07 |
2023-08-13 |
mouse |
| Ayako Inoue, Jotaro Akiyoshi, Masaaki Muronaga, Koji Masuda, Saeko Aizawa, Hirofumi Hirakawa, Yoshinobu Ishitobi, Haruka Higuma, Yoshihiro Maruyama, Taiga Ninomiya, Yoshihiro Tanaka, Hiroaki Hanada, Yoshihisa Kawan. Association of TMEM132D, COMT, and GABRA6 genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic and major depressive disorder. International journal of psychiatry in clinical practice. vol 19. issue 3. 2016-05-26. PMID:25974322. |
the aim of the study was to evaluate the association of transmembrane protein 132d (tmem132d), catechol-o-methyltransferase (comt), and gamma-aminobutyric acid (gaba) receptor alpha 6 subunit (gabra6) genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic disorder (pd) and major depressive disorder (mdd). |
2016-05-26 |
2023-08-13 |
Not clear |
| M Mesgari, N Ghaffarian, M Khaleghi Ghadiri, H Sadeghian, E-J Speckmann, W Stummer, A Gorj. Altered inhibition in the hippocampal neural networks after spreading depression. Neuroscience. vol 304. 2016-05-24. PMID:26210578. |
intra- and extracellular recordings of bioelectrical activities were performed in the rodent hippocampus to investigate the role of γ-aminobutyric acid (gaba)-mediated inhibition in the late hyperexcitable state of sd. |
2016-05-24 |
2023-08-13 |
Not clear |
| Chia Ying Chang, Tzu Yu Lin, Cheng Wei Lu, Chia Chuan Wang, Ying Chou Wang, Shang Shing Peter Chou, Su Jane Wan. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European journal of pharmacology. vol 762. 2016-05-20. PMID:26007643. |
furthermore, we determined that gamma-aminobutyric acid type a (gabaa) receptors are present in the hippocampal nerve terminals because they are colocalized with the presynaptic marker synaptophysin. |
2016-05-20 |
2023-08-13 |
rat |
| André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A Valente, David Blum, Ana Maria Sebastião, Maria José Diógene. Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24860020. |
in the present study, we found that (1) aβ selectively increases mrna levels for the truncated trkb isoforms without affecting trkb-fl mrna levels, (2) aβ induces a calpain-mediated cleavage on trkb-fl receptors, downstream of shc-binding site, originating a new truncated trkb receptor (trkb-t') and an intracellular fragment (trkb-icd), which is also detected in postmortem human brain samples, (3) aβ impairs bdnf function in a calpain-dependent way, as assessed by the inability of bdnf to modulate neurotransmitter (gaba and glutamate) release from hippocampal nerve terminals, and long-term potentiation in hippocampal slices. |
2016-05-10 |
2023-08-13 |
human |
| Chadi G Abdallah, Andrea Jackowski, João R Sato, Xiangling Mao, Guoxin Kang, Raminder Cheema, Jeremy D Coplan, Sanjay J Mathew, Dikoma C Shung. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25983019. |
prefrontal cortical gaba abnormalities are associated with reduced hippocampal volume in major depressive disorder. |
2016-05-06 |
2023-08-13 |
human |
| Chadi G Abdallah, Andrea Jackowski, João R Sato, Xiangling Mao, Guoxin Kang, Raminder Cheema, Jeremy D Coplan, Sanjay J Mathew, Dikoma C Shung. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25983019. |
to better understand the role of amino acid neurotransmission in hippocampal volume deficits, and subsequent resistance to treatment, this study investigated the relationship between hippocampal volumes and gaba levels in the anterior cingulate cortex (acc), previously associated with trd. |
2016-05-06 |
2023-08-13 |
human |
| Chadi G Abdallah, Andrea Jackowski, João R Sato, Xiangling Mao, Guoxin Kang, Raminder Cheema, Jeremy D Coplan, Sanjay J Mathew, Dikoma C Shung. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25983019. |
participants underwent high-resolution magnetic resonance imaging (mri) to estimate hippocampal volume and proton mr spectroscopy ((1)h mrs) to measure acc gaba levels. |
2016-05-06 |
2023-08-13 |
human |
| Chadi G Abdallah, Andrea Jackowski, João R Sato, Xiangling Mao, Guoxin Kang, Raminder Cheema, Jeremy D Coplan, Sanjay J Mathew, Dikoma C Shung. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25983019. |
we found a significant reduction in hippocampal volume in the mdd low gaba group compared to mdd high gaba (p<0.001) and hc (p=0.01). |
2016-05-06 |
2023-08-13 |
human |
| Chadi G Abdallah, Andrea Jackowski, João R Sato, Xiangling Mao, Guoxin Kang, Raminder Cheema, Jeremy D Coplan, Sanjay J Mathew, Dikoma C Shung. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25983019. |
the relationship between hippocampal volume and cortical gaba was population (i.e. |
2016-05-06 |
2023-08-13 |
human |
| Chiara Chiapponi, Federica Piras, Fabrizio Piras, Carlo Caltagirone, Gianfranco Spallett. GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies. Frontiers in psychiatry. vol 7. 2016-05-05. PMID:27148090. |
conversely, multimodal results showed reduced level of glutamate, but not of gaba, in patients mirrored by in vitro biochemical findings revealing hippocampal reduction in glutamate signaling in sz, and no deficits in gaba synthesis. |
2016-05-05 |
2023-08-13 |
mouse |
| Javier Del Pino, María Teresa Frejo, María José Anadon Baselga, Paula Moyano, María Jesús Día. Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells. Neurotoxicology and teratology. vol 50. 2016-04-25. PMID:26141220. |
to confirm if amitraz disrupts glutamatergic/gabaergic transmission by these mechanisms, we evaluated, in primary hippocampal neurons, the effect of amitraz (0.01 μm to 100 μm) with or without the α2 adrenergic antagonist idazoxan (1 μm) and/or the h1 receptor agonist n-methylhistaprodifen (30 μm) co-treatment on 4-aminobutyrate aminotransferase, glutamate decarboxylase 65 (gad 65), succinate-semialdehyde dehydrogenase and glutaminase gene expression and on glutamate and gaba levels after 24h treatment. |
2016-04-25 |
2023-08-13 |
Not clear |
| Stephen B McHugh, Anna Francis, J Devin McAuley, Amanda L Stewart, Mark G Baxter, David M Bannerma. Hippocampal acetylcholine depletion has no effect on anxiety, spatial novelty preference, or differential reward for low rates of responding (DRL) performance in rats. Behavioral neuroscience. vol 129. issue 4. 2016-04-14. PMID:26214215. |
rats were then tested on several behavioral tests previously shown to be sensitive to either (a) hippocampal lesions or (b) nonselective ms/vdb lesions which target both cholinergic and γ-aminobutyric acid (gaba)-ergic projections, or both. |
2016-04-14 |
2023-08-13 |
rat |
| Awanish Mishra, Rajesh Kumar Goe. Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy. Metabolic brain disease. vol 30. issue 4. 2016-04-08. PMID:25613529. |
on day 20, after behavioral evaluations, animals were sacrificed to analyze glutamate, gaba, norepinephrine, dopamine, serotonin, total nitrite level and acetylcholinesterase level in cortex and hippocampus. |
2016-04-08 |
2023-08-13 |
Not clear |