| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Qiu, Yuxue Xu, Jun Wang, Ming Liu, Longyu Dou, Ran Deng, Chao Wang, Kent E Williams, Robert B Stewart, Zhongwen Xie, Wei Ren, Zhenwen Zhao, Weinian Shou, Tiebing Liang, Weidong Yon. Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight. Neuroscience. vol 402. 2019-06-21. PMID:30685540. |
additionally, a functional gabaergic alteration was observed in the form of increased mipsc frequency in the ko hippocampus, indicating an increase in presynaptic gaba release. |
2019-06-21 |
2023-08-13 |
mouse |
| Y M Geng, J T Xue, J P Su, H Y L. Molecular mechanism of action of valproate acid alone or in combination with chlorpromazine in the epigenetic regulation of schizophrenia. Journal of biological regulators and homeostatic agents. vol 32. issue 6. 2019-06-14. PMID:30574748. |
the real time pcr assay was used to detect the mrna expression changes of gaba system gene [gabbr1 (gaba b receptor 1)], gad1 (glutamic acid decarboxylase1), gad2 (glutamic acid decarboxylase2), lipase metabolic key enzyme lpl (lipoprotein lipase) gene, glutamate neurotransmitter gene gria2 (ampa subtype glutamate receptors 2), inward rectifier potassium channel members kcnj4 (potassium voltage-gated channel subfamily j member 4) and neuropeptide signal gene tac1 (tachykinin precursor 1,tac1) in four brain regions: the prefrontal cortex (pc), the amygdala (am), the caudate-putamen (cpu) and the hippocampus (hip). |
2019-06-14 |
2023-08-13 |
rat |
| David M Lovinge. Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking. Handbook of experimental pharmacology. vol 248. 2019-06-12. PMID:29204712. |
ethanol-induced release of neuropeptides and small molecule neurotransmitters that act on presynaptic gpcrs also contribute to presynaptic potentiation at synapses in the amygdala and hippocampus and inhibition of gaba release in the striatum. |
2019-06-12 |
2023-08-13 |
Not clear |
| Junhua Li, Minyan Guo, Yafang Liu, Guiyun Wu, Liping Miao, Jing Zhang, Zhiyi Zuo, Yujuan L. Both GSK-3β/CRMP2 and CDK5/CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in neonatal rats. Toxicological sciences : an official journal of the Society of Toxicology. 2019-06-12. PMID:31187143. |
propofol induced apoptosis in the hippocampal neurons and astrocytes, inhibited neuronal proliferation in the dg region, down-regulated the level of γ-aminobutyric acid (gaba) and glutamate in the hippocampus, and impaired long-term cognitive function. |
2019-06-12 |
2023-08-13 |
rat |
| Phani Kumar Kola, Annapurna Akula, Lakshmi Sudeepthi Nissankara Rao, Ravi Chandra Sekhara Reddy Danduga, Abutalaha Mohammad, Srikanth Ineed. Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats. Epilepsy & behavior : E&B. vol 89. 2019-05-27. PMID:30415139. |
it has also been shown to improve neurochemical balance by elevating levels of gamma amino butyric acid (gaba) and dopamine, decreasing levels of glutamate, oxidative biomarker (malondialdehyde (mda)), and increasing levels of antioxidants (glutathione (gsh), superoxide dismutase (sod), catalase (cat), and total thiol and offered neuroprotection in the hippocampus. |
2019-05-27 |
2023-08-13 |
rat |
| Michele Morari, Alberto Brugnoli, Clarissa Anna Pisanò, Salvatore Novello, Carla Caccia, Elsa Melloni, Gloria Padoani, Silvia Vailati, Marco Sardin. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia. The Journal of pharmacology and experimental therapeutics. vol 364. issue 2. 2019-05-21. PMID:29167350. |
safinamide differentially modulates in vivo glutamate and gaba release in the rat hippocampus and basal ganglia. |
2019-05-21 |
2023-08-13 |
rat |
| Michele Morari, Alberto Brugnoli, Clarissa Anna Pisanò, Salvatore Novello, Carla Caccia, Elsa Melloni, Gloria Padoani, Silvia Vailati, Marco Sardin. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia. The Journal of pharmacology and experimental therapeutics. vol 364. issue 2. 2019-05-21. PMID:29167350. |
to this aim, in vivo microdialysis was used to monitor the spontaneous and veratridine-induced glu and gaba release in the hippocampus and basal ganglia of naive, awake rats. |
2019-05-21 |
2023-08-13 |
rat |
| Michele Morari, Alberto Brugnoli, Clarissa Anna Pisanò, Salvatore Novello, Carla Caccia, Elsa Melloni, Gloria Padoani, Silvia Vailati, Marco Sardin. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia. The Journal of pharmacology and experimental therapeutics. vol 364. issue 2. 2019-05-21. PMID:29167350. |
safinamide maximally inhibited the veratridine-induced glu and gaba release in hippocampus at 15 mg/kg, which reached free brain concentrations of 1.89-1.37 |
2019-05-21 |
2023-08-13 |
rat |
| Azam Almasi, Mohammad Zarei, Safoura Raoufi, Abdolrahman Sarihi, Iraj Salehi, Alireza Komaki, Nasrin Hashemi-Firouzi, Siamak Shahid. Influence of hippocampal GABA Metabolic brain disease. vol 33. issue 6. 2019-05-13. PMID:30039187. |
influence of hippocampal gaba the neurotransmitter γ-aminobutyric acid (gaba) is involved in the process of memory. |
2019-05-13 |
2023-08-13 |
Not clear |
| Siyu Chen, Xiangchang Zeng, Wenjing Zong, Xintong Wang, Lulu Chen, Luping Zhou, Chaopeng Li, Qi Huang, Xinyi Huang, Guirong Zeng, Kai Hu, Dong-Sheng Ouyan. Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. Neurochemical research. vol 44. issue 2. 2019-05-07. PMID:30666488. |
furthermore, the contents of γ-aminobutyric acid (gaba) were increased while the levels of glutamate were decreased in the hippocampus with au treatment. |
2019-05-07 |
2023-08-13 |
mouse |
| Yvfeng Liang, Jiahong Li, Tao Jin, Ting Gu, Qingjie Zhu, Yizhong Hu, Yang Yang, Jisui Li, Donghong Wu, Kesheng Jiang, Xiaohong X. Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice. Hormones and behavior. vol 102. 2019-04-25. PMID:29778459. |
western blot analysis further showed that bpa reduced the levels of androgen receptor (ar) and gaba(a)α2 receptor of the hippocampus and the amygdala in sham and inhibited the rescue of tp in these proteins levels of gdx mice. |
2019-04-25 |
2023-08-13 |
mouse |
| Yvfeng Liang, Jiahong Li, Tao Jin, Ting Gu, Qingjie Zhu, Yizhong Hu, Yang Yang, Jisui Li, Donghong Wu, Kesheng Jiang, Xiaohong X. Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice. Hormones and behavior. vol 102. 2019-04-25. PMID:29778459. |
the down-regulated levels of gaba(a)α2 receptor and ar and an inhibited activity of erk1/2 pathway in the hippocampus and the amygdala may be involved in these process. |
2019-04-25 |
2023-08-13 |
mouse |
| Shuai Lian, Bin Xu, Di Wang, Lipeng Wang, Wenjie Li, Ruizhi Yao, Hong Ji, Jianfa Wang, Jingru Guo, Shize Li, Huanmin Yan. Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats. Behavioural brain research. vol 359. 2019-04-19. PMID:30423388. |
to further understand the effects of prenatal cold stress on offspring, we investigated the behavior change; the expression of glucocorticoid receptor (gr), mineralocorticoid receptor (mr), brain-derived neurotrophic factor (bdnf), insulin-like growth factor 1 receptor (igf1r), neuronal nuclei (neun), glial fibrillary acidic protein (gfap), corticotropin-releasing hormone receptor 1 (crhr1), gamma-aminobutyric acid b receptor, 2 (gabab2) proteins in hippocampus; the ratio of cd4/cd8 lymphocyte subsets and the level of norepinephrine (ne), dopamine (da) in the peripheral blood of weaned offspring rats using behavioral tests and biology analysis methods. |
2019-04-19 |
2023-08-13 |
rat |
| Bin Wang, Qiong Wu, Lei Lei, Hailun Sun, Ntim Michael, Xuan Zhang, Ying Wang, Yue Zhang, Biying Ge, Xuefei Wu, Yue Wang, Yi Xin, Jie Zhao, Shao L. Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory. Experimental neurology. vol 311. 2019-04-10. PMID:30219732. |
the results further showed that the l-pwsi significantly decreased the protein expression levels of psd-95, glua1, nr1 and nr2b in the hippocampus, and no significant changes in the extracellular release of glutamate and the protein expression levels of synaptophysin, synapsin i, gap-43, nr2a and gaba |
2019-04-10 |
2023-08-13 |
mouse |
| Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuir. Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2019-03-26. PMID:29440719. |
prefrontal gaba levels, hippocampal resting perfusion and the risk of psychosis. |
2019-03-26 |
2023-08-13 |
human |
| Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuir. Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2019-03-26. PMID:29440719. |
recent neuroimaging studies suggest that resting hippocampal perfusion is increased in subjects at ultra-high risk (uhr) for psychosis, but how this may be related to gaba concentrations is unknown. |
2019-03-26 |
2023-08-13 |
human |
| Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuir. Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2019-03-26. PMID:29440719. |
these findings provide the first human evidence that mpfc gaba+ concentrations are related to resting hippocampal perfusion in the uhr state, and offer some support for a link between gaba levels and hippocampal function in the development of psychosis. |
2019-03-26 |
2023-08-13 |
human |
| R Tao, K N Davis, C Li, J H Shin, Y Gao, A E Jaffe, M C Gondré-Lewis, D R Weinberger, J E Kleinman, T M Hyd. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. Molecular psychiatry. vol 23. issue 6. 2019-03-18. PMID:28485403. |
alternative splicing of gad1 and epigenetic state appear to play roles in the developmental profile of gad1 expression and may contribute to gaba dysfunction in the pfc and hippocampus of patients with schizophrenia. |
2019-03-18 |
2023-08-13 |
human |
| Hiroshi Maejima, Shuta Ninuma, Akane Okuda, Takahiro Inoue, Masataka Hayash. Exercise and low-level GABA Neuroscience letters. vol 685. 2019-03-07. PMID:30037768. |
exercise and low-level gaba aerobic exercise is known to increase expression of brain-derived neurotrophic factor (bdnf) in the hippocampus and to improve cognitive function. |
2019-03-07 |
2023-08-13 |
Not clear |
| Abbi R Hernandez, Caesar M Hernandez, Keila T Campos, Leah M Truckenbrod, Yasemin Sakarya, Joseph A McQuail, Christy S Carter, Jennifer L Bizon, Andrew P Maurer, Sara N Burk. The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 73. issue 4. 2019-03-06. PMID:29040389. |
interestingly, the kd led to significant alterations in protein levels of hippocampal transporters for monocarboxylates, glucose, and vesicular glutamate and gamma-aminobutyric acid. |
2019-03-06 |
2023-08-13 |
rat |