| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Stan Leun. Long-lasting changes in hippocampal GABA Brain research bulletin. vol 150. 2020-07-24. PMID:31200097. |
long-lasting changes in hippocampal gaba the hypotheses that hippocampal gaba |
2020-07-24 |
2023-08-13 |
Not clear |
| Cleopatra Rakgantsho, Musa V Mabandl. Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model. Brain research bulletin. vol 149. 2020-07-20. PMID:31051225. |
glutamate decarboxylase (gad)1 and gad 2 expression, as well as gaba concentration in the hippocampus, were assessed. |
2020-07-20 |
2023-08-13 |
rat |
| Cleopatra Rakgantsho, Musa V Mabandl. Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model. Brain research bulletin. vol 149. 2020-07-20. PMID:31051225. |
this suggests that specific nicotinic acetylcholine receptors may be used as therapeutic targets in the maintenance of adequate hippocampal gaba concentration for the prevention of pfs development. |
2020-07-20 |
2023-08-13 |
rat |
| Neela K Codadu, R Ryley Parrish, Andrew J Trevelya. Region-specific differences and areal interactions underlying transitions in epileptiform activity. The Journal of physiology. vol 597. issue 7. 2020-07-17. PMID:30681139. |
hippocampal epileptiform activity is promoted by 4-aminopyridine and inhibited by gaba |
2020-07-17 |
2023-08-13 |
Not clear |
| Ammar L Ujjainwala, Connor D Courtney, Natalia M Wojnowski, Justin S Rhodes, Catherine A Christia. Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice. Journal of neuroscience research. vol 97. issue 6. 2020-07-13. PMID:30680776. |
the hippocampus plays an integral role in these functions, and modulation of synaptic transmission mediated by γ-aminobutyric acid (gaba) type-a receptors (gaba |
2020-07-13 |
2023-08-13 |
mouse |
| Ramsey Najm, Emily A Jones, Yadong Huan. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31186040. |
we focus on γ-aminobutyric acid (gaba)-expressing interneurons in the hippocampus, which are selectively vulnerable to apoe4-mediated neurotoxicity. |
2020-06-23 |
2023-08-13 |
human |
| Wen Yao, Marc D Tambini, Xinran Liu, Luciano D'Adami. Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 35. 2020-06-23. PMID:31235642. |
a peptide encompassing the entire isvaid facilitated glutamate, but not gaba, release acting as dominant negative inhibitor of the functions of this app domain in acute hippocampal slices. |
2020-06-23 |
2023-08-13 |
mouse |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Louise Flood, Sergiy V Korol, Lisa Ekselius, Bryndis Birnir, Zhe Ji. Interferon-γ potentiates GABA Journal of neuroimmunology. vol 337. 2020-06-17. PMID:31505410. |
however, the impact of ifn-γ on the γ-aminobutyric acid (gaba)-mediated currents in the hippocampus, a major brain region involved in the cognitive function, has not been investigated. |
2020-06-17 |
2023-08-13 |
rat |
| Yu-Nu Ma, Ya-Xin Sun, Ting Wang, Han Wang, Yue Zhang, Yun-Ai Su, Ji-Tao Li, Tian-Mei S. Subchronic MK-801 treatment during adolescence induces long-term, not permanent, excitatory-inhibitory imbalance in the rat hippocampus. European journal of pharmacology. vol 867. 2020-06-08. PMID:31751575. |
here, we examined hippocampal e/i biomarkers in adolescent rats treated with mk-801 (0.2 mg/kg, i.p., 14 days) and found increases in the ratio of the expression levels of vesicular glutamate transporter-1 (vglut1) and vesicular gamma-aminobutyric acid (gaba) transporter (vgat) 24 h and 7 days after mk-801 exposure. |
2020-06-08 |
2023-08-13 |
rat |
| Valeria Rytova, Despina E Ganella, David Hawkes, Ross A D Bathgate, Sherie Ma, Andrew L Gundlac. Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30891856. |
chronic activation of the relaxin-3 receptor on gaba neurons in rat ventral hippocampus promotes anxiety and social avoidance. |
2020-05-27 |
2023-08-13 |
rat |
| James E Orfila, Himmat Grewal, Robert M Dietz, Frank Strnad, Takeru Shimizu, Myriam Moreno, Christian Schroeder, Joan Yonchek, Krista M Rodgers, Andra Dingman, Timothy J Bernard, Nidia Quillinan, Wendy B Macklin, Richard J Traystman, Paco S Herso. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 6. 2020-05-19. PMID:29283314. |
in light of recent studies demonstrating delayed gaba antagonists improve motor function, we utilized electrophysiology, biochemistry and neurobehavioral methods to investigate the role of α5 gabaa receptors on hippocampal plasticity and functional recovery following ischemic stroke. |
2020-05-19 |
2023-08-13 |
mouse |
| James E Orfila, Himmat Grewal, Robert M Dietz, Frank Strnad, Takeru Shimizu, Myriam Moreno, Christian Schroeder, Joan Yonchek, Krista M Rodgers, Andra Dingman, Timothy J Bernard, Nidia Quillinan, Wendy B Macklin, Richard J Traystman, Paco S Herso. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 6. 2020-05-19. PMID:29283314. |
western blot analysis of hippocampal tissue reveals proteins responsible for gaba synthesis are upregulated (gad65/67 and maob), increasing gaba in hippocampal interneurons 30 days after stroke. |
2020-05-19 |
2023-08-13 |
mouse |
| Eugene Chun, Argyle V Bumanglag, Sara N Burke, Robert S Slovite. Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Epilepsia. vol 60. issue 5. 2020-04-27. PMID:30963545. |
targeted hippocampal gaba neuron ablation by stable substance p-saporin causes hippocampal sclerosis and chronic epilepsy in rats. |
2020-04-27 |
2023-08-13 |
rat |
| Eugene Chun, Argyle V Bumanglag, Sara N Burke, Robert S Slovite. Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Epilepsia. vol 60. issue 5. 2020-04-27. PMID:30963545. |
in this study, hippocampal gaba neurons were targeted for selective elimination to determine whether a focal hippocampal gabaergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. |
2020-04-27 |
2023-08-13 |
rat |
| Eugene Chun, Argyle V Bumanglag, Sara N Burke, Robert S Slovite. Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Epilepsia. vol 60. issue 5. 2020-04-27. PMID:30963545. |
we used stable substance p-saporin conjugate (ssp-saporin) to target rat hippocampal gaba neurons, which selectively and constitutively express the neurokinin-1 receptors that internalize this neurotoxin. |
2020-04-27 |
2023-08-13 |
rat |
| Rajamani Selvam, Mason L Yeh, Eric S Levin. Endogenous cannabinoids mediate the effect of BDNF at CA1 inhibitory synapses in the hippocampus. Synapse (New York, N.Y.). 2020-04-17. PMID:30334291. |
collectively, these results suggest that in the hippocampus, bdnf-trkb signaling induces the postsynaptic release of the endogenous cannabinoid 2-ag, which acts retrogradely on the presynaptic cb1 receptors to suppress gaba release. |
2020-04-17 |
2023-08-13 |
Not clear |
| Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, Sung Min Nam, Jong Whi Kim, Kyu Ri Hahn, Dae Young Yoo, Yeo Sung Yoon, Soo Young Choi, Dae Won Kim, In Koo Hwan. Role of pyridoxine in GABA synthesis and degradation in the hippocampus. Tissue & cell. vol 61. 2020-04-16. PMID:31759410. |
role of pyridoxine in gaba synthesis and degradation in the hippocampus. |
2020-04-16 |
2023-08-13 |
Not clear |
| Peng Zheng, Benhua Zeng, Meiling Liu, Jianjun Chen, Junxi Pan, Yu Han, Yiyun Liu, Ke Cheng, Chanjuan Zhou, Haiyang Wang, Xinyu Zhou, Siwen Gui, Seth W Perry, Ma-Li Wong, Julio Licinio, Hong Wei, Peng Xi. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Science advances. vol 5. issue 2. 2020-04-10. PMID:30775438. |
compared to hcs, germ-free mice receiving scz microbiome fecal transplants had lower glutamate and higher glutamine and gaba in the hippocampus and displayed scz-relevant behaviors similar to other mouse models of scz involving glutamatergic hypofunction. |
2020-04-10 |
2023-08-13 |
mouse |
| Yuejun Huang, Liu Hu, Hui Li, Yanhong Huang, Yuewa Li, Jianhui Yang, Jiajie Gu, Hongwu X. PKA-mediated phosphorylation of CREB and NMDA receptor 2B in the hippocampus of offspring rats is involved in transmission of mental disorders across a generation. Psychiatry research. vol 280. 2020-03-31. PMID:31419724. |
gad was increased and gaba-t was decreased, which resulted in an increase in gaba levels and decrease of the glutamate/gaba ratio in the hippocampus of cus offspring rats. |
2020-03-31 |
2023-08-13 |
rat |