| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Lasley, M E Gilber. Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level. Toxicological sciences : an official journal of the Society of Toxicology. vol 66. issue 1. 2002-06-25. PMID:11861981. |
chronic exposure produced decreases in total k(+)-stimulated hippocampal glu and gaba release at exposure levels of 0.1-0.5% pb. |
2002-06-25 |
2023-08-12 |
rat |
| Stephan Heckers, David Stone, John Walsh, John Shick, Pamposh Koul, Francine M Bene. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Archives of general psychiatry. vol 59. issue 6. 2002-06-24. PMID:12044194. |
expression of messenger rna (mrna) for the gamma-aminobutyric acid (gaba)-synthesizing enzyme, glutamic acid decarboxylase (gad), in the prefrontal cortex and the number of gabaergic neurons in the hippocampus are reduced in schizophrenia and bipolar disorder. |
2002-06-24 |
2023-08-12 |
Not clear |
| Y Ikegaya, M Yamada, T Fukuda, H Kuroyanagi, T Shirasawa, N Nishiyam. Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice. Hippocampus. vol 11. issue 3. 2002-05-30. PMID:11769310. |
the hippocampal mossy fiber-ca3 synapses of pimt-deficient mice showed hyperexcitation that was repressed by a gamma-aminobutyric acid (gaba)a receptor agonist muscimol. |
2002-05-30 |
2023-08-12 |
mouse |
| Brandon M Stell, Istvan Mod. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006605. |
receptors with different affinities mediate phasic and tonic gaba(a) conductances in hippocampal neurons. |
2002-05-29 |
2023-08-12 |
Not clear |
| Brandon M Stell, Istvan Mod. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006605. |
a tonic inhibitory conductance mediated by gaba(a) receptors that supplements the phasic inhibition produced by ipscs has been identified in the hippocampus and cerebellum. |
2002-05-29 |
2023-08-12 |
Not clear |
| Brandon M Stell, Istvan Mod. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006605. |
here we demonstrate that a low concentration (200 nm) of the highly specific competitive gaba(a) antagonist sr95531 (gabazine) reduces phasic inhibition in hippocampal granule cells by 71% but has no effect on tonic inhibition, whereas a high concentration (10 microm) of the antagonist blocked both conductances. |
2002-05-29 |
2023-08-12 |
Not clear |
| Katherine L Perkin. GABA application to hippocampal CA3 or CA1 stratum lacunosum-moleculare excites an interneuron network. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877515. |
whole cell voltage-clamp recording and focal application of the neurotransmitter gamma-aminobutyric acid (gaba) were used to investigate the ability of exogenous gaba applied to different locations within the guinea pig hippocampal slice to trigger a giant gaba-mediated postsynaptic current (gpsc) in pyramidal cells. |
2002-05-20 |
2023-08-12 |
Not clear |
| Siriporn C Chattipakorn, Lori L McMaho. Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877523. |
to examine the potential subunit composition of hippocampal glyrs, we tested the effect of the gaba(a) receptor antagonist, picrotoxin, on i(gly) recorded from both cell types. |
2002-05-20 |
2023-08-12 |
rat |
| Doodipala S Reddy, Michael A Rogawsk. Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978855. |
dhdoc, like thdoc, potentiated gaba-activated cl- currents in cultured hippocampal neurons (< or =1 microm) and directly activated gaba(a) receptor currents (> or =1 microm), compatible with a role for dhdoc in the antiseizure activity of doc. |
2002-05-20 |
2023-08-12 |
mouse |
| Takashi Kanematsu, Il-Sung Jang, Taku Yamaguchi, Hiroyasu Nagahama, Kenji Yoshimura, Kiyoshi Hidaka, Miho Matsuda, Hiroshi Takeuchi, Yoshio Misumi, Keiko Nakayama, Tsuneyuki Yamamoto, Norio Akaike, Masato Hirata, Kei-Ichi Nakayam. Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. The EMBO journal. vol 21. issue 5. 2002-05-14. PMID:11867528. |
electrophysiological analysis revealed that the modulation of gaba-induced cl- current by zn2+ or diazepam, both of which act at gaba(a) receptors containing gamma subunits, is impaired in hippocampal neurons of p130 knockout mice. |
2002-05-14 |
2023-08-12 |
mouse |
| Máriton D Santos, Manickavasagom Alkondon, Edna F R Pereira, Yasco Aracava, Howard M Eisenberg, Alfred Maelicke, Edson X Albuquerqu. The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system. Molecular pharmacology. vol 61. issue 5. 2002-05-13. PMID:11961141. |
in rat hippocampal and human cerebral cortical slices, 1 microm galantamine, acting as a nicotinic apl, increased gamma-aminobutyric acid (gaba) release triggered by 10 microm acetylcholine (ach). |
2002-05-13 |
2023-08-12 |
human |
| I Smolders, C Gousseau, S Marchand, W Couet, G Ebinger, Y Michott. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats. Antimicrobial agents and chemotherapy. vol 46. issue 2. 2002-05-08. PMID:11796360. |
convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats. |
2002-05-08 |
2023-08-12 |
rat |
| I Smolders, C Gousseau, S Marchand, W Couet, G Ebinger, Y Michott. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats. Antimicrobial agents and chemotherapy. vol 46. issue 2. 2002-05-08. PMID:11796360. |
the present study was undertaken to investigate the possible effects of norfloxacin, both in the absence and in the presence of bpaa, on the extracellular hippocampal levels of gaba and glutamate, the main central inhibitory and excitatory amino acid neurotransmitters, respectively. |
2002-05-08 |
2023-08-12 |
rat |
| I Smolders, C Gousseau, S Marchand, W Couet, G Ebinger, Y Michott. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats. Antimicrobial agents and chemotherapy. vol 46. issue 2. 2002-05-08. PMID:11796360. |
these norfloxacin-induced convulsions did not affect extracellular hippocampal gaba levels but were accompanied by enhanced glutamate concentrations. |
2002-05-08 |
2023-08-12 |
rat |
| I Smolders, C Gousseau, S Marchand, W Couet, G Ebinger, Y Michott. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats. Antimicrobial agents and chemotherapy. vol 46. issue 2. 2002-05-08. PMID:11796360. |
in the latter subgroup, again no significant alterations in extracellular gaba levels were observed, but glutamate overflow remained significantly elevated for at least 3 h. in conclusion, norfloxacin exerts convulsant activity in rats, accompanied by elevations of extracellular hippocampal glutamate levels but not gaba levels, even in the presence of bpaa. |
2002-05-08 |
2023-08-12 |
rat |
| Stefan Hefft, Udo Kraushaar, Jörg R P Geiger, Peter Jona. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. The Journal of physiology. vol 539. issue Pt 1. 2002-05-06. PMID:11850513. |
to examine possible interactions between fast depression and modulation of inhibitory synaptic transmission in the hippocampus, we recorded from pairs of synaptically connected basket cells (bcs) and granule cells (gcs) in the dentate gyrus of rat brain slices at 34 degrees c. multiple-pulse depression (mpd) was examined in trains of 5 or 10 inhibitory postsynaptic currents (ipscs) evoked at frequencies of 10-100 hz under several conditions that inhibit transmitter release: block of voltage-dependent ca2+ channels by cd2+ (10 microm), activation of gamma-amino-butyric acid type b receptors (gaba(b)rs) by baclofen (10 microm) and activation of muscarinic acetylcholine receptors (machrs) by carbachol (2 microm). |
2002-05-06 |
2023-08-12 |
rat |
| Y He, A Benz, T Fu, M Wang, D F Covey, C F Zorumski, S Menneric. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804616. |
here we report that in addition to its presynaptic effect, riluzole at higher concentrations also strongly potentiates postsynaptic gaba(a) responses both in cultured hippocampal neurons and in xenopus oocytes expressing recombinant receptors. |
2002-04-29 |
2023-08-12 |
xenopus_laevis |
| Ana I Herrero, Nuria Del Olmo, José R González-Escalada, José M Solí. Two new actions of topiramate: inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804617. |
since the activity of this enzyme is essential for the generation of gaba(a)-mediated depolarizing responses, which appears to participate in epileptogenesis, we investigated whether tpm could inhibit such a response in rat hippocampal slices using intracellular recordings. |
2002-04-29 |
2023-08-12 |
rat |
| L A Dawson, J Galandak, S Djal. Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin. Neurochemistry international. vol 40. issue 3. 2002-04-23. PMID:11741003. |
using sodium azide (nan3)-induced anoxia plus aglycaemia as a model of chemically-induced ischemia in the hippocampal slice, we have evaluated the effects of the novel 5-ht(1a) partial agonist/5-ht(2) receptor antagonist adatanserin and the 5-ht(1a) receptor agonist bayx3702 on the efflux of endogenous glutamate, aspartate and gaba. |
2002-04-23 |
2023-08-12 |
Not clear |
| Yong Li, Tian-Le X. State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport. vol 13. issue 2. 2002-04-22. PMID:11893914. |
the hippocampal neurons lacking gly response (igly) showed no current inhibition with gaba current (igaba), whereas the neurons losing gaba response (igaba) (after complete rundown of igaba) showed no current inhibition with igly. |
2002-04-22 |
2023-08-12 |
rat |