| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hornia, Z Lu, T Sukezane, M Zhong, T Joseph, P Frankel, D A Foste. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Molecular and cellular biology. vol 19. issue 11. 1999-11-24. PMID:10523655. |
antagonistic effects of protein kinase c alpha and delta on both transformation and phospholipase d activity mediated by the epidermal growth factor receptor. |
1999-11-24 |
2023-08-12 |
human |
| A Hornia, Z Lu, T Sukezane, M Zhong, T Joseph, P Frankel, D A Foste. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Molecular and cellular biology. vol 19. issue 11. 1999-11-24. PMID:10523655. |
since tpa downregulates all phorbol ester-responsive pkc isoforms, we examined the effects of pkc delta- and pkc alpha-specific inhibitors and the expression of dominant negative mutants for both pkc delta and alpha. |
1999-11-24 |
2023-08-12 |
human |
| A Hornia, Z Lu, T Sukezane, M Zhong, T Joseph, P Frankel, D A Foste. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Molecular and cellular biology. vol 19. issue 11. 1999-11-24. PMID:10523655. |
in contrast, the pkc alpha-specific inhibitor go6976 and expression of a dominant negative pkc alpha mutant blocked the transformed phenotype induced by both egf and pkc delta inhibition. |
1999-11-24 |
2023-08-12 |
human |
| A Hornia, Z Lu, T Sukezane, M Zhong, T Joseph, P Frankel, D A Foste. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Molecular and cellular biology. vol 19. issue 11. 1999-11-24. PMID:10523655. |
the elevation of pld activity in response to inhibiting pkc delta, like transformation, was dependent upon pkc alpha and restricted to the egfr cells. |
1999-11-24 |
2023-08-12 |
human |
| A Hornia, Z Lu, T Sukezane, M Zhong, T Joseph, P Frankel, D A Foste. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Molecular and cellular biology. vol 19. issue 11. 1999-11-24. PMID:10523655. |
these data demonstrate that pkc isoforms alpha and delta have antagonistic effects on both transformation and pld activity and further support a tumor suppressor role for pkc delta that may be mediated by suppression of tyrosine kinase-dependent increases in pld activity. |
1999-11-24 |
2023-08-12 |
human |
| S Srinivasan, D W Sapp, A J Tobin, R W Olse. Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates. Neurochemical research. vol 24. issue 11. 1999-11-24. PMID:10555776. |
using recombinant gaba(a) receptors, expressed in insect cell line sf9 using baculovirus, enhancement by steroids of [35s]tbps binding was sensitive to the presence of the gamma2 subunit and the nature of the alpha subunit (alpha1 beta2 gamma2s > alpha1 beta2, alpha6 beta2, alpha6 beta2 gamma2s, and alpha6 beta2 delta). |
1999-11-24 |
2023-08-12 |
rat |
| K Häsler, O Pänke, W Jung. On the stator of rotary ATP synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. Biochemistry. vol 38. issue 41. 1999-11-17. PMID:10521283. |
on the stator of rotary atp synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. |
1999-11-17 |
2023-08-12 |
Not clear |
| K Häsler, O Pänke, W Jung. On the stator of rotary ATP synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. Biochemistry. vol 38. issue 41. 1999-11-17. PMID:10521283. |
proton flow drives the rotor (namely, subunits c12 epsilon gamma) relative to the stator (namely, subunits ab2 delta(alpha beta)3) and extrudes spontaneously formed atp from three symmetrically arranged binding sites on (alpha beta)3 into the solution. |
1999-11-17 |
2023-08-12 |
Not clear |
| K Häsler, O Pänke, W Jung. On the stator of rotary ATP synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. Biochemistry. vol 38. issue 41. 1999-11-17. PMID:10521283. |
we asked whether the binding of subunit delta to (alpha beta)3 is of sufficient strength to hold against the elastic strain, which is generated during the operation of this enzyme. |
1999-11-17 |
2023-08-12 |
Not clear |
| K Häsler, O Pänke, W Jung. On the stator of rotary ATP synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. Biochemistry. vol 38. issue 41. 1999-11-17. PMID:10521283. |
taking the upper limit of this figure into account, the dissociation constant between monomeric delta and (alpha beta)3 gamma was 0.8 nm if not smaller. |
1999-11-17 |
2023-08-12 |
Not clear |
| K Häsler, O Pänke, W Jung. On the stator of rotary ATP synthase: the binding strength of subunit delta to (alpha beta)3 as determined by fluorescence correlation spectroscopy. Biochemistry. vol 38. issue 41. 1999-11-17. PMID:10521283. |
our data were compatible with a single binding site for delta on the hexagon of (alpha beta)3. |
1999-11-17 |
2023-08-12 |
Not clear |
| T S Grabow, R W Hurley, P N Banfor, D L Hammon. Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain. vol 83. issue 1. 1999-11-16. PMID:10506671. |
supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. |
1999-11-16 |
2023-08-12 |
rat |
| T S Grabow, R W Hurley, P N Banfor, D L Hammon. Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain. vol 83. issue 1. 1999-11-16. PMID:10506671. |
the norepinephrine, acting at alpha(2)-adrenoceptors, interacts in a synergistic manner with intrathecally administered delt, acting at spinal delta(2) opioid receptors, to produce antinociception. |
1999-11-16 |
2023-08-12 |
rat |
| F Jouen-Beades, F Halary, L Drouot, M A Peyrat, E Paris, P Joly, D Gilbert, M Bonneville, F Tro. Expansion of circulating V gamma 9/V delta 1 T cells in a patient with a syndrome of recurrent fever: evidence for an unusual antigen-driven process leading to selection of recurrent motifs within TCR junctional loops of diverse lengths. European journal of immunology. vol 29. issue 10. 1999-11-16. PMID:10540346. |
these results constitute the first strong evidence for a nominal antigen-driven selection of vdelta1 t cells in vivo and also suggest that the hierarchy of the constraints imposed by antigens respectively on the length and amino acid composition of tcr cdr3 loops differs between alpha beta and gamma delta t cells. |
1999-11-16 |
2023-08-12 |
human |
| A I Golovk. [GABA-A receptor subunits and their reactions to neuropharmacological substances]. Eksperimental'naia i klinicheskaia farmakologiia. vol 62. issue 4. 1999-11-05. PMID:10513343. |
the existence of 5 classes of subunits (alpha, beta, gamma, delta, rho) was proved, each of them possessing isoforms (alpha 1-6, beta 1-4, gamma 1-4, delta, rho 1-2). |
1999-11-05 |
2023-08-12 |
Not clear |
| M Wang, J Offord, D L Oxender, T Z S. Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding. The Biochemical journal. vol 342 ( Pt 2). 1999-11-01. PMID:10455017. |
gabapentin [neurontin, 1-(aminomethyl)cyclohexaneacetic acid] is a novel anticonvulsant drug with a high binding affinity for the ca(2+)-channel subunit alpha(2)delta. |
1999-11-01 |
2023-08-12 |
Not clear |
| M Wang, J Offord, D L Oxender, T Z S. Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding. The Biochemical journal. vol 342 ( Pt 2). 1999-11-01. PMID:10455017. |
in this study, the gabapentin-binding properties of wild-type and mutated porcine brain alpha(2)delta proteins were investigated. |
1999-11-01 |
2023-08-12 |
Not clear |
| M Wang, J Offord, D L Oxender, T Z S. Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding. The Biochemical journal. vol 342 ( Pt 2). 1999-11-01. PMID:10455017. |
removal of the disulphide bonds between the alpha(2) and the delta subunits did not result in a significant loss of gabapentin binding, suggesting that the disulphide linkage between the two subunits is not required for binding. |
1999-11-01 |
2023-08-12 |
Not clear |
| M Wang, J Offord, D L Oxender, T Z S. Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding. The Biochemical journal. vol 342 ( Pt 2). 1999-11-01. PMID:10455017. |
however, alpha(2) alone was unable to bind gabapentin, unless the cells were concurrently transfected with the expression vector for delta, suggesting that both alpha(2) and delta are required for gabapentin binding. |
1999-11-01 |
2023-08-12 |
Not clear |
| M Hama. Preferential repopulation of the small intestine by gut-derived T cell precursors in the murine system. Cytobios. vol 97. issue 384. 1999-10-28. PMID:10510846. |
flow cytometry (fcm) analyses of thy-1.1+ iel showed that thy-1.1 was co-expressed with cd3, cd4, cd5, cd8, tcr alpha beta and tcr gamma delta t cell markers. |
1999-10-28 |
2023-08-12 |
mouse |