| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Kukit. Solvent effects on squid sodium channels are attributable to movements of a flexible protein structure in gating currents and to hydration in a pore. The Journal of physiology. vol 522 Pt 3. 2000-03-30. PMID:10713962. |
for sodium currents, alpha was equal to that of gating currents but delta was 2-3 times greater, suggesting that the final channel opening was primarily sensitive to osmolarity (delta delta was 5 water molecules). |
2000-03-30 |
2023-08-12 |
squid |
| Z Yin, D H Zhang, T Welte, G Bahtiyar, S Jung, L Liu, X Y Fu, A Ray, J Craf. Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 6. 2000-03-28. PMID:10706694. |
splenic gamma delta t cells could be polarized into ifn-gamma- or il-4-secreting cells in vitro; however, in contrast to cd4+ alpha beta t cells, gamma delta t cells predominantly produced ifn-gamma, even in the presence of il-4, a finding independent of genetic background. |
2000-03-28 |
2023-08-12 |
Not clear |
| L F Li, V C Fiedler, R Kuma. Induction of hair growth by skin irritants and its relation to skin protein kinase C isoforms. The British journal of dermatology. vol 140. issue 4. 2000-03-27. PMID:10233310. |
considering the stimulatory effect of pkc alpha and inhibitory effect of pkc delta on cell growth, we postulate that pkc alpha may be responsible for enhancement of hair growth while pkc delta may inhibit hair growth to keep the hair growth in balance. |
2000-03-27 |
2023-08-12 |
mouse |
| b' D Visnji\\xc4\\x87, D Batini\\xc4\\x87, H Banfi\\xc4\\x8. Different roles of protein kinase C alpha and delta isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells. The Biochemical journal. vol 344 Pt 3. 2000-03-17. PMID:10585882.' |
different roles of protein kinase c alpha and delta isoforms in the regulation of neutral sphingomyelinase activity in hl-60 cells. |
2000-03-17 |
2023-08-12 |
Not clear |
| b' D Visnji\\xc4\\x87, D Batini\\xc4\\x87, H Banfi\\xc4\\x8. Different roles of protein kinase C alpha and delta isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells. The Biochemical journal. vol 344 Pt 3. 2000-03-17. PMID:10585882.' |
furthermore, pkc delta had an inhibitory effect on sphingomyelinase, suggesting that the difference between the 1,25(oh)(2)d(3)- and pma-mediated effects on sphingomyelin turnover depends on the specific regulation of the pkc alpha and pkc delta isoforms. |
2000-03-17 |
2023-08-12 |
Not clear |
| A J Rajan, V C Asensio, I L Campbell, C F Brosna. Experimental autoimmune encephalomyelitis on the SJL mouse: effect of gamma delta T cell depletion on chemokine and chemokine receptor expression in the central nervous system. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 4. 2000-03-09. PMID:10657666. |
elisa data confirmed reduced expression of mip-1 alpha and monocyte chemoattractant protein-1 at disease onset in gamma delta t cell-depleted mice, and total t cell numbers were also reduced. |
2000-03-09 |
2023-08-12 |
mouse |
| D J Dooley, C A Mieske, S A Borosk. Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin. Neuroscience letters. vol 280. issue 2. 2000-03-09. PMID:10686389. |
since l-glutamic acid (glu) is involved in various cns (central nervous system) disorders, gabapentin may attenuate the release of this neurotransmitter possibly by interacting with the auxiliary alpha(2)delta subunit of voltage-sensitive calcium channels (vscc). |
2000-03-09 |
2023-08-12 |
rat |
| K A Kim, T Chakraborti, G W Goldstein, J P Bressle. Immediate early gene expression in PC12 cells exposed to lead: requirement for protein kinase C. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693946. |
it is interesting that lead activated protein kinase c isoforms delta and epsilon, but not isoforms alpha and beta. |
2000-03-09 |
2023-08-12 |
Not clear |
| G Maga, M Stucki, S Spadari, U Hübsche. DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of molecular biology. vol 295. issue 4. 2000-03-07. PMID:10656791. |
an important not yet fully understood event in dna replication is the dna polymerase (pol) switch from pol alpha to pol delta. |
2000-03-07 |
2023-08-12 |
Not clear |
| G Maga, M Stucki, S Spadari, U Hübsche. DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of molecular biology. vol 295. issue 4. 2000-03-07. PMID:10656791. |
by using purified pol alpha/primase, pol delta, rf-c, pcna and rp-a we show that: (i) rf-c can inhibit pol alpha in the presence of atp prior to pcna loading, (ii) rf-c decreases the affinity of pol alpha for the 3'oh primer ends, (iii) the inhibition of pol alpha by rf-c is released upon pcna loading, (iv) atp hydrolysis is required for pcna loading and subsequent release of inhibition of pol alpha, (v) under these conditions a switching from pol alpha/primase to pol delta is evident. |
2000-03-07 |
2023-08-12 |
Not clear |
| G Maga, M Stucki, S Spadari, U Hübsche. DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of molecular biology. vol 295. issue 4. 2000-03-07. PMID:10656791. |
thus, rf-c appears to be critical for the pol alpha to pol delta switching. |
2000-03-07 |
2023-08-12 |
Not clear |
| S C O'Connor, K L Brain, M R Bennet. Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens. British journal of pharmacology. vol 128. issue 8. 2000-03-02. PMID:10588930. |
the alpha(2) adrenoceptor agonist clonidine (1 microm) decreased delta[ca(2+)](v) by over 40% during short trains (five impulses at 5 hz) in most varicosities, although some were unaffected. |
2000-03-02 |
2023-08-12 |
mouse |
| S C O'Connor, K L Brain, M R Bennet. Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens. British journal of pharmacology. vol 128. issue 8. 2000-03-02. PMID:10588930. |
the alpha(2) adrenoceptor antagonist idazoxan (2 microm) increased the delta[ca(2+)](v) plateau following long trains in most varicosities. |
2000-03-02 |
2023-08-12 |
mouse |
| X A Alvarez, R Mouzo, V Pichel, P Pérez, M Laredo, L Fernández-Novoa, L Corzo, R Zas, M Alcaraz, J J Secades, R Lozano, R Cacabelo. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669911. |
patients treated with citicoline showed an increase in the percentage of brain bioelectrical activity of alpha (occipital electrodes) and theta type (left side electrodes), accompanied by a decrease in relative delta activity particularly marked in the left temporal lobe. |
2000-02-28 |
2023-08-12 |
Not clear |
| S K Wei, H M Colecraft, C D DeMaria, B Z Peterson, R Zhang, T A Kohout, T B Rogers, D T Yu. Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells. Circulation research. vol 86. issue 2. 2000-02-24. PMID:10666413. |
(3) despite the heteromultimeric composition of l-type channels (composed of alpha(1c), beta, and alpha(2)delta), expression of recombinant beta subunits alone enhanced ca(2+) channel current density up to 3- to 4-fold, which argues that beta subunits are "rate limiting" for expression of current in heart. |
2000-02-24 |
2023-08-12 |
rat |
| M H Wilson, L E Limbir. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. vol 39. issue 4. 2000-02-23. PMID:10651634. |
the delta 3i alpha(2a)ar (lacking the third intracellular loop), d79n alpha(2a)ar (impaired g protein coupling), and cam alpha(2a)ar (enhanced g protein coupling) all exhibited a cell surface alpha(2a)ar turnover in chinese hamster ovary cells that was faster than that of the wild type (wt). |
2000-02-23 |
2023-08-12 |
Not clear |
| M H Wilson, L E Limbir. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. vol 39. issue 4. 2000-02-23. PMID:10651634. |
cell surface receptor turnover could be slowed with ligand occupancy of d79n alpha(2a)ar (agonist or antagonist) and cam alpha(2a)ar (antagonist only) but not the delta 3i- or wt alpha(2a)ar. |
2000-02-23 |
2023-08-12 |
Not clear |
| M H Wilson, L E Limbir. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. vol 39. issue 4. 2000-02-23. PMID:10651634. |
in contrast, the shorter surface t(1/2) of the delta 3i alpha(2a)ar, whose cell surface t(1/2) and steady state density were not altered by ligand occupancy, occurred in the context of a structurally stable receptor in detergent solution. |
2000-02-23 |
2023-08-12 |
Not clear |
| S Wilkens, J Zhou, R Nakayama, S D Dunn, R A Capald. Localization of the delta subunit in the Escherichia coli F(1)F(0)-ATPsynthase by immuno electron microscopy: the delta subunit binds on top of the F(1). Journal of molecular biology. vol 295. issue 3. 2000-02-18. PMID:10623533. |
the images show that the antibody is bound at the very top of the f(1) domain indicating that at least part of delta is bound in the dimple formed by the n termini of the alpha and beta subunits. |
2000-02-18 |
2023-08-12 |
Not clear |
| T Hisayama, M Inomoto, Y Hioki, H Fuku. [Identification of PKC isozymes and effect of knockdown of PKC alpha by antisense oligodeoxynucleotide on iNOS expression via interleukin-1 receptor in vascular smooth muscle cells]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629861. |
western blot analysis revealed the presence of cpkc (alpha), npkcs (delta and epsilon) and apkcs (tau and lambda). |
2000-02-16 |
2023-08-12 |
rat |