| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
one compound, 4-(benzyl-(2-[(2, 5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl)-carbamoyl)-2-decanoylami no butyric acid (sc-alpha alpha delta 9), was previously identified as the most potent reported synthetic inhibitor of cdc25 phosphatases in vitro. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
in the present study, we demonstrate that sc-alpha alpha delta 9 inhibited cdc25-dependent cell cycle progression at both g1 and g2/m phase using tsft210 cells, which express a temperature-sensitive cdc2 mutant. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 blocked both g2/m transition and dephosphorylation of cdc2 in a concentration-dependent manner. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 also enhanced tyrosine phosphorylation of both cdk2 and cdk4, and decreased cdk4 kinase activity. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 did not alter p53, p21 or p16 levels. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
our results support the hypothesis that the disruption in cell cycle transition caused by sc-alpha alpha delta 9 was due to intracellular cdc25 inhibition. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
we propose that the sc-alpha alpha delta 9 pharmacophore could be useful in further clarifying the role of cdc25 phosphatase-dependent pathways in checkpoint control, oncogenesis, and apoptosis. |
2000-01-04 |
2023-08-12 |
Not clear |
| F Nobili, F Copello, P Vitali, T Prastaro, S Carozzo, G Perego, G Rodrigue. Timing of disease progression by quantitative EEG in Alzheimer' s patients. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 16. issue 6. 2000-01-04. PMID:10600024. |
in the whole group, the loss of activities of daily living was predicted by delta power in either side (p = 0.01), incontinence was predicted by alpha power in the right side (p < 0.01), whereas the statistical significance was not reached for death (p < 0.05). |
2000-01-04 |
2023-08-12 |
Not clear |
| F Nobili, F Copello, P Vitali, T Prastaro, S Carozzo, G Perego, G Rodrigue. Timing of disease progression by quantitative EEG in Alzheimer' s patients. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 16. issue 6. 2000-01-04. PMID:10600024. |
in the subgroup of mild demented patients, the loss of activities of daily living was predicted by delta power in the left side (p = 0.01), incontinence by both delta (p < 0.01) and alpha (p < 0.001) power in the right side, and death was not significantly predicted (p = 0.08). |
2000-01-04 |
2023-08-12 |
Not clear |
| T W Spahn, S Issazadah, A J Salvin, H L Weine. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. European journal of immunology. vol 29. issue 12. 2000-01-04. PMID:10602017. |
furthermore, when eae was induced by adoptive transfer of an anti-mog p35 - 55 alpha beta t cell line, there was a striking reduction of disease incidence (0 %) and severity in delta(- / -) as compared to wild-type mice (83 % incidence). |
2000-01-04 |
2023-08-12 |
mouse |
| T W Spahn, S Issazadah, A J Salvin, H L Weine. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. European journal of immunology. vol 29. issue 12. 2000-01-04. PMID:10602017. |
delta(- / -) mice showed no cellular infiltration in the spinal cord whereas wild-type animals had infiltration of macrophages, b cells, alpha beta- and gamma delta t cells. |
2000-01-04 |
2023-08-12 |
mouse |
| H Konishi, H Matsuzaki, H Takaishi, T Yamamoto, M Fukunaga, Y Ono, U Kikkaw. Opposing effects of protein kinase C delta and protein kinase B alpha on H(2)O(2)-induced apoptosis in CHO cells. Biochemical and biophysical research communications. vol 264. issue 3. 1999-12-22. PMID:10544018. |
opposing effects of protein kinase c delta and protein kinase b alpha on h(2)o(2)-induced apoptosis in cho cells. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
we have cloned a novel member of the b type regulatory subunit family, b delta, which is most highly related to b alpha. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
b delta shares with b alpha epitopes previously used to generate subunit-specific antibodies. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
b delta is a cytosolic subunit of pp2a with a subcellular localization different from b alpha and may therefore target a pool of pp2a holoenzymes to specific substrates. |
1999-12-22 |
2023-08-12 |
Not clear |
| R H Winger, K R Liedl, A Pichler, A Hallbrucker, E Maye. Helix morphology changes in B-DNA induced by spontaneous B(I)<==>B(II) substrate interconversion. Journal of biomolecular structure & dynamics. vol 17. issue 2. 1999-12-21. PMID:10563572. |
for alpha and delta inside the interconverting base step, a change is seen in short lived b(ii) conformers. |
1999-12-21 |
2023-08-12 |
Not clear |
| H Taniyama, S Oka, H Yokota, K Hirayama, Y Kagawa, T Kurosawa, H Furuoka, T On. Immunohistochemical detection of the enzyme glutamic acid decarboxylase and hormones of the islets of Langerhans in spontaneous insulin-dependent diabetes mellitus in cattle. Veterinary pathology. vol 36. issue 6. 1999-12-20. PMID:10568450. |
these findings suggest that islet cells in cattle with iddm lose their insulin synthesis function and their ability to regulate hormonal secretion of alpha and delta cells. |
1999-12-20 |
2023-08-12 |
cattle |
| S Crochet, K Saka. Effects of microdialysis application of monoamines on the EEG and behavioural states in the cat mesopontine tegmentum. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564380. |
in the rostral part of the peri-lcalpha and the adjacent x area (nucleus tegmenti pedunculopontinus, pars compacta), which contain many ascending cholinergic neurons, norepinephrine and epinephrine suppressed ps with a significant increase in waking and a decrease in slow-wave sleep, as expressed by a marked decrease in the power of the cortical and hippocampal delta (0.5-2.5 hz) and cortical alpha (8-14 hz) bands, and an increase in the cortical gamma (30-60 hz) band. |
1999-12-08 |
2023-08-12 |
cat |
| R J Hayashi, O Kanagaw. Unique CD4(+) T cells in TCR alpha chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. International immunology. vol 11. issue 9. 1999-12-07. PMID:10464179. |
these cells are negative for tcr delta chain and pre-tcr alpha chain expression, and thus express a unique surface receptor with the tcr beta chain as a component. |
1999-12-07 |
2023-08-12 |
mouse |
| T Kuroki, M Kashiwagi, K Ishino, N Huh, M Ohb. Adenovirus-mediated gene transfer to keratinocytes--a review. The journal of investigative dermatology. Symposium proceedings. vol 4. issue 2. 1999-12-01. PMID:10536991. |
using these vectors, we found that the eta and delta isoforms of pkc, but not the alpha and zeta isoforms, mediate terminal differentiation in normal human keratinocytes. |
1999-12-01 |
2023-08-12 |
mouse |