| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Zhao, F Gao, I D Goldma. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochemical pharmacology. vol 61. issue 7. 2001-04-19. PMID:11274972. |
this resulted in a spectrum of increases in the ic50 values of antifolates upon continuous exposure to drugs [lometrexol (ddathf) (70x) > trimetrexate (tmq) (30x), multitargeted antifolate, ly231514 (alimta) (30x) > raltitrexed, tomudex (zd1694) (10x), 6r-2',5'-thienyl-5,10-dideazatetrahydrofolic acid (ly309887) (10x) > methotrexate (mtx) (6x) > (2s)-2-[o-fluoro-p-[n-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)-n-(prop-2-ynyl)amino]benzamido]-4-(tetrazol-5-yl) butyric acid (zd9331) (3x), n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithine (pt523) (3x)]. |
2001-04-19 |
2023-08-12 |
Not clear |
| S P Tsunoda, R Aggeler, M Yoshida, R A Capald. Rotation of the c subunit oligomer in fully functional F1Fo ATP synthase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 3. 2001-04-12. PMID:11158567. |
previous studies had established that the central gamma and epsilon subunits of the f(1) part rotate relative to a stator of alpha(3)beta(3) and delta subunits during catalysis. |
2001-04-12 |
2023-08-12 |
Not clear |
| T Kajimoto, S Ohmori, Y Shirai, N Sakai, N Sait. Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Molecular and cellular biology. vol 21. issue 5. 2001-04-12. PMID:11238914. |
c(2)-ceramide but not c(2)-dihydroceramide induced translocation of delta pkc-gfp to the golgi complex, while alpha pkc- and zeta pkc-gfp did not respond to ceramide. |
2001-04-12 |
2023-08-12 |
Not clear |
| C Gaiddon, M Lokshin, J Ahn, T Zhang, C Prive. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Molecular and cellular biology. vol 21. issue 5. 2001-04-12. PMID:11238924. |
in this study we have extended these observations to show that in transfected cells a number of mutant p53 proteins could bind and down-regulate several isoforms not only of p73 (p73 alpha, -beta, -gamma, and -delta) but also of p63 (p63 alpha and -gamma; delta np63 alpha and -gamma). |
2001-04-12 |
2023-08-12 |
Not clear |
| H E Moon, A Cavalli, D S Bahia, M Hoffmann, D Massotte, G Milliga. The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha. Journal of neurochemistry. vol 76. issue 6. 2001-04-12. PMID:11259498. |
the human delta opioid receptor activates g(i1)alpha more efficiently than g(o1)alpha. |
2001-04-12 |
2023-08-12 |
human |
| H E Moon, A Cavalli, D S Bahia, M Hoffmann, D Massotte, G Milliga. The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha. Journal of neurochemistry. vol 76. issue 6. 2001-04-12. PMID:11259498. |
an equivalent fusion protein between the human mu opioid receptor-1 and g(i1)alpha produced a similar d-ala(2),d-leu(5) enkephalin-induced gtp turnover number as the delta opioid receptor-g(i1)alpha fusion construct, consistent with agonist occupation of these two opioid receptor subtypes being equally efficiently coupled to activation of g(i1)alpha. |
2001-04-12 |
2023-08-12 |
human |
| K Murata, N Odahara, A Kuniyasu, Y Sato, H Nakayama, K Nagayam. Asymmetric arrangement of auxiliary subunits of skeletal muscle voltage-gated l-type Ca(2+) channel. Biochemical and biophysical research communications. vol 282. issue 1. 2001-04-12. PMID:11264005. |
highly purified l-type ca(2+) channel complexes containing all five subunits (alpha(1), alpha(2), beta, gamma, and delta) and complexes of alpha(1)-beta subunits were obtained from skeletal muscle triad membranes by three-step purification and by 1% triton x-100 treatment, respectively. |
2001-04-12 |
2023-08-12 |
Not clear |
| S Guida, F Trettel, S Pagnutti, E Mantuano, A Tottene, L Veneziano, T Fellin, M Spadaro, K Stauderman, M Williams, S Volsen, R Ophoff, R Frants, C Jodice, M Frontali, D Pietrobo. Complete loss of P/Q calcium channel activity caused by a CACNA1A missense mutation carried by patients with episodic ataxia type 2. American journal of human genetics. vol 68. issue 3. 2001-04-05. PMID:11179022. |
patch-clamp recording in hek 293 cells, coexpressing the mutagenized human alpha(1a-2) subunit, together with human beta(4) and alpha(2)delta subunits, showed that channel activity was completely abolished, although the mutated protein is expressed in the cell. |
2001-04-05 |
2023-08-12 |
human |
| T Husøy, V Cruciani, T Sanner, S O Mikalse. Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase C beta I and mu. Carcinogenesis. vol 22. issue 2. 2001-04-05. PMID:11181442. |
experiments with the general pkc inhibitor gf109203x and the pkc alpha (and beta/gamma) inhibitor gö6976 suggested that both classical (alpha) and novel pkcs (delta and epsilon) might be involved in tpa-induced suppression of intercellular communication, while phosphorylation of cx43 may mainly be mediated by pkc alpha in the present systems. |
2001-04-05 |
2023-08-12 |
rat |
| R S Lee, S C Steffensen, S J Henrikse. Discharge profiles of ventral tegmental area GABA neurons during movement, anesthesia, and the sleep-wake cycle. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 5. 2001-04-05. PMID:11222665. |
vta gaba neuron firing rate decreased 53% during slow-wave sleep (sws) and increased 79% during rem, relative to aw; however, the discharging was not synchronous with electrocortical alpha wave activity during aw, delta wave activity during sws, or gamma wave activity during rem. |
2001-04-05 |
2023-08-12 |
rat |
| P Ikonomi, C T Noguchi, W Miller, H Kassahun, R Hardison, A N Schechte. Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins. Gene. vol 261. issue 2. 2001-03-29. PMID:11167015. |
conserved gata sites were found in each of the hypersensitive sites in both beta-and alpha clusters and in proximal regulatory regions of the zeta-, epsilon- and gamma-globin but not the alpha, delta or beta-globin genes. |
2001-03-29 |
2023-08-12 |
human |
| X A Alvarez, V Pichel, P Pérez, M Laredo, D Corzo, R Zas, L Fernández-Novoa, J M Sempere, J Díaz, R Cacabelo. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Methods and findings in experimental and clinical pharmacology. vol 22. issue 7. 2001-03-29. PMID:11196347. |
patients treated with anapsos (360 mg/day) showed a decrease in relative delta power and an increase in relative theta and alpha brain bioelectrical activity frequencies, indicating an acceleration of the eeg pattern. |
2001-03-29 |
2023-08-12 |
Not clear |
| F Morisson, A Décary, D Petit, G Lavigne, J Malo, J Montplaisi. Daytime sleepiness and EEG spectral analysis in apneic patients before and after treatment with continuous positive airway pressure. Chest. vol 119. issue 1. 2001-03-22. PMID:11157583. |
a previous study showed eeg slowing (ie, a higher ratio of delta + theta frequencies to alpha + beta frequencies on eeg) during rapid eye movement (rem) sleep and wakefulness in untreated osas patients. |
2001-03-22 |
2023-08-12 |
Not clear |
| D Navaneetham, A S Penn, J F Howard, B M Conti-Fin. Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit. Muscle & nerve. vol 24. issue 2. 2001-03-22. PMID:11180203. |
the thymus expresses the achr alpha subunit, but there is controversy regarding the expression in the thymus of the gamma, epsilon and delta subunits. |
2001-03-22 |
2023-08-12 |
human |
| S Marsigliante, A Muscella, S Greco, M G Elia, S Vilella, C Storell. Na+/K+ATPase activity inhibition and isoform-specific translocation of protein kinase C following angiotensin II administration in isolated eel enterocytes. The Journal of endocrinology. vol 168. issue 2. 2001-03-22. PMID:11182772. |
western blot analysis with antibodies to pkc alpha, beta i, beta ii, gamma, delta, epsilon, iota, eta and zeta isoforms showed that eel enterocytes expressed the conventional isoforms (alpha and beta i), the novel isoforms (delta and eta) and the atypical isoforms (zeta and iota). |
2001-03-22 |
2023-08-12 |
Not clear |
| H Lüss, O Klein-Wiele, P Bokník, S Herzig, J Knapp, B Linck, F U Müller, H H Scheld, C Schmid, W Schmitz, J Neuman. Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart. Journal of molecular and cellular cardiology. vol 32. issue 12. 2001-03-15. PMID:11113010. |
expression levels of pp1 alpha, delta, and gamma as well as 2a alpha were higher in right ventricles than in right atria. |
2001-03-15 |
2023-08-12 |
human |
| J Jayawardena-Wolf, A Bendela. CD1 and lipid antigens: intracellular pathways for antigen presentation. Current opinion in immunology. vol 13. issue 1. 2001-03-15. PMID:11154926. |
emerging models suggest that cd1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma delta t cells. |
2001-03-15 |
2023-08-12 |
Not clear |
| b' J Faber, L Srutov\\xc3\\xa1, M Pilarov\\xc3\\xa1, Z Vuckov\\xc3\\xa1, D B\\xc3\\xb6hmov\\xc3\\xa1, L Dobosov\\xc3\\xa. EEG spectrum as information carrier. Sbornik lekarsky. vol 100. issue 3. 2001-03-15. PMID:11221466.' |
the length of reaction time was found dependent on fft changes: the longer the time, the higher are the delta and the lower the alpha activities in the eeg spectrum. |
2001-03-15 |
2023-08-12 |
Not clear |
| b' J Faber, L Srutov\\xc3\\xa1, M Pilarov\\xc3\\xa1, Z Vuckov\\xc3\\xa1, D B\\xc3\\xb6hmov\\xc3\\xa1, L Dobosov\\xc3\\xa. EEG spectrum as information carrier. Sbornik lekarsky. vol 100. issue 3. 2001-03-15. PMID:11221466.' |
however, with alpha increasing during relaxation, the reaction time grew longer regardless of whether delta had increased due to hyperventilation, sleep or subclinical epileptic discharges. |
2001-03-15 |
2023-08-12 |
Not clear |
| b' J Faber, L Srutov\\xc3\\xa1, M Pilarov\\xc3\\xa1, Z Vuckov\\xc3\\xa1, D B\\xc3\\xb6hmov\\xc3\\xa1, L Dobosov\\xc3\\xa. EEG spectrum as information carrier. Sbornik lekarsky. vol 100. issue 3. 2001-03-15. PMID:11221466.' |
during the perception of tones, fft showed changes in the alpha and delta bands different from those during the perception of chords, and different again during relaxation, and that in both normal controls and epileptics. |
2001-03-15 |
2023-08-12 |
Not clear |