| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Field, R J Oles, L Sing. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. British journal of pharmacology. vol 132. issue 1. 2001-05-24. PMID:11156553. |
pregabalin binds with high affinity and selectivity to the alpha(2)delta subunit of voltage dependent calcium channels (vdcc). |
2001-05-24 |
2023-08-12 |
rat |
| M J Field, R J Oles, L Sing. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. British journal of pharmacology. vol 132. issue 1. 2001-05-24. PMID:11156553. |
these data indicate that pregabalin may possess clinical utility as a novel anxiolytic agent and demonstrates the importance of the alpha(2)delta subunit of vdcc in the mediation of anxiety related behaviours. |
2001-05-24 |
2023-08-12 |
rat |
| H Poirier, I Niot, M C Monnot, O Braissant, C Meunier-Durmort, P Costet, T Pineau, W Wahli, T M Willson, P Besnar. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. The Biochemical journal. vol 355. issue Pt 2. 2001-05-24. PMID:11284737. |
differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. |
2001-05-24 |
2023-08-12 |
mouse |
| S Waga, T Masuda, H Takisawa, A Sugin. DNA polymerase epsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11296256. |
although the requirement of other replicative dna polymerases, dna polymerases alpha and delta (pol alpha and delta), for chromosomal dna replication has been well documented by genetic and biochemical studies, the precise role, if any, of pol epsilon in chromosomal dna replication is still obscure. |
2001-05-21 |
2023-08-12 |
xenopus_laevis |
| S Waga, T Masuda, H Takisawa, A Sugin. DNA polymerase epsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11296256. |
these findings strongly suggest that pol epsilon, along with pol alpha and pol delta, is necessary for coordinated chromosomal dna replication in eukaryotic cells. |
2001-05-21 |
2023-08-12 |
xenopus_laevis |
| T Taguchi, M Fukuda, M Ohash. Differences in DNA synthesis in vitro using isolated nuclei from regenerating livers of young and aged rats. Mechanisms of ageing and development. vol 122. issue 2. 2001-05-17. PMID:11166354. |
these results suggest that dna polymerase beta is closely related to abnormal replication when dna polymerases alpha and delta are inhibited and that the effect of cytosol on dna synthesis, as well as the dna synthetic capacity of isolated nuclei, becomes lower in regenerating rat liver during ageing. |
2001-05-17 |
2023-08-12 |
rat |
| M Uhrberg, N M Valiante, N T Young, L L Lanier, J H Phillips, P Parha. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 6. 2001-05-17. PMID:11238637. |
in both donors alpha beta t cells less frequently expressed the inhibitory receptors cd94:nkg2a and kir2dl1 than either gamma delta t cells or nk cells. |
2001-05-17 |
2023-08-12 |
human |
| M Uhrberg, N M Valiante, N T Young, L L Lanier, J H Phillips, P Parha. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 6. 2001-05-17. PMID:11238637. |
overall, alpha beta t cells exhibited a distinct pattern of nkr expression different from that of gamma delta t and nk cells, which expressed highly similar nkr repertoires. |
2001-05-17 |
2023-08-12 |
human |
| C Ribas, A Miralles, X Busquets, J A García-Sevill. Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA. British journal of pharmacology. vol 132. issue 7. 2001-05-17. PMID:11264240. |
after alpha(2)-adrenoceptor alkylation, the analysis of receptor recovery (b(max) for [(3)h]-uk14304) indicated that the increased density of cortical alpha(2)-adrenoceptors in reserpine-treated rats was probably due to a higher appearance rate constant of the receptor ((delta)r=57%) and not to a decreased disappearance rate constant ((delta)k=7%). |
2001-05-17 |
2023-08-12 |
rat |
| T Bashir, J Rommelaere, C Cziepluc. In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies. Journal of virology. vol 75. issue 9. 2001-05-17. PMID:11287588. |
the presence of dna polymerases alpha and delta in these bodies suggests that mvm utilizes partially preformed cellular replication complexes for its replication. |
2001-05-17 |
2023-08-12 |
mouse |
| E Marais, N Klugbauer, F Hofman. Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Molecular pharmacology. vol 59. issue 5. 2001-05-17. PMID:11306709. |
calcium channel alpha(2)delta subunits-structure and gabapentin binding. |
2001-05-17 |
2023-08-12 |
mouse |
| E Marais, N Klugbauer, F Hofman. Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Molecular pharmacology. vol 59. issue 5. 2001-05-17. PMID:11306709. |
high-voltage activated calcium channels are modulated by a series of auxiliary proteins, including those of the alpha(2)delta family. |
2001-05-17 |
2023-08-12 |
mouse |
| E Marais, N Klugbauer, F Hofman. Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Molecular pharmacology. vol 59. issue 5. 2001-05-17. PMID:11306709. |
until recently, only a single alpha(2)delta subunit was known, but two further members, alpha(2)delta-2 and -3, have since been identified. |
2001-05-17 |
2023-08-12 |
mouse |
| E Marais, N Klugbauer, F Hofman. Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Molecular pharmacology. vol 59. issue 5. 2001-05-17. PMID:11306709. |
similar to alpha(2)delta-1, both alpha(2)delta-2 and -3 subunits consist of two proteins-a larger alpha(2) and a smaller delta that can be separated by reduction. |
2001-05-17 |
2023-08-12 |
mouse |
| E Fujii, S H Mello. Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy. Endocrinology. vol 142. issue 5. 2001-05-17. PMID:11316740. |
allopregnanolone caused the greatest increase in muscimol binding to uterine gaba(a) receptors at 19.5 days gestation and the least increase during labor, a time when pi and alpha(1) receptor subunit mrna concentrations were low, and delta and alpha(2) receptor subunit mrna concentrations were high. |
2001-05-17 |
2023-08-12 |
rat |
| T Yuasa, A Maeda, S Higuchi, Y Motohash. Quantitative EEG data and comprehensive ADL (Activities of Daily Living) evaluation of stroke survivors residing in the community. Journal of physiological anthropology and applied human science. vol 20. issue 1. 2001-05-17. PMID:11320778. |
the absolute and relative powers (percent of the total eeg power) of 5 frequency bands (delta, theta, alpha 1, alpha 2 and beta) and the peak frequency were analyzed. |
2001-05-17 |
2023-08-12 |
Not clear |
| T Yuasa, A Maeda, S Higuchi, Y Motohash. Quantitative EEG data and comprehensive ADL (Activities of Daily Living) evaluation of stroke survivors residing in the community. Journal of physiological anthropology and applied human science. vol 20. issue 1. 2001-05-17. PMID:11320778. |
the absolute and relative power of the delta band were lower in normal controls, and the relative power of the alpha (2) band and the peak frequency were higher than those of stroke survivors. |
2001-05-17 |
2023-08-12 |
Not clear |
| V Tretter, B Hauer, Z Nusser, R M Mihalek, H Höger, G E Homanics, P Somogyi, W Sieghar. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. The Journal of biological chemistry. vol 276. issue 13. 2001-05-10. PMID:11136737. |
because 97% of delta subunits are coassembled with alpha(6) subunits in the cerebellum of wild-type mice, these results indicated that, in delta-/- mice, alpha(6)betagamma(2) and alphabeta receptors replaced delta subunit-containing receptors. |
2001-05-10 |
2023-08-12 |
mouse |
| T N Huckerby, R M Lauder, G M Brown, I A Nieduszynski, K Anderson, J Boocock, P L Sandall, S D Week. Characterization of oligosaccharides from the chondroitin sulfates. (1)H-NMR and (13)C-NMR studies of reduced disaccharides and tetrasaccharides. European journal of biochemistry. vol 268. issue 5. 2001-05-10. PMID:11231269. |
these have the structures: delta ua(beta 1--3)galnac4s-ol, delta ua(beta 1--3)galnac6s-ol, delta ua2s(beta 1--3)galnac6s-ol, delta ua(beta 1--3)galnac4s(beta 1--4)l-idoa(alpha 1--3)galnac4s-ol, delta ua(beta 1--3)galnac4s(beta 1--4)glca(beta 1--3)galnac4s-ol, delta ua(beta 1--3)galnac6s(beta 1--4)glca(beta 1--3)galnac4s-ol, delta ua(beta 1--3)galnac6s(beta 1--4)glca(beta 1--3)galnac6s-ol, delta ua2s(beta 1--3)galnac6s(beta 1--4)glca(beta 1--3)galnac4s-ol and delta ua2s(beta 1--3)galnac6s(beta 1--4)glca(beta 1--3)galnac6s-ol, where delta ua represents a 4,5-unsaturated hexuronic acid (4-deoxy-alpha-lthreo-hex-4-enepyranosyluronic acid) and 6s/4s/2s represent o-ester sulfate groups at c6/c4/c2 sites. |
2001-05-10 |
2023-08-12 |
Not clear |
| L Hviid, J A Kurtzhals, V Adabayeri, S Loizon, K Kemp, B Q Goka, A Lim, O Mercereau-Puijalon, B D Akanmori, C Beh. Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria. Infection and immunity. vol 69. issue 5. 2001-05-10. PMID:11292740. |
a very high proportion of the v delta 1(+) t cells produced gamma interferon, while fewer v delta 1(+) cells than the average proportion of all cd3(+) cells produced tumor necrosis factor alpha. |
2001-05-10 |
2023-08-12 |
Not clear |