| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
enzyme inhibition studies in vitro revealed that sc-alpha alpha delta 9 was a potent inhibitor of phospholipase c (plc; ic50 = 25 microm) but did not inhibit phospholipase d activity at concentrations up to 100 microm. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
in h-ras (q61l)-transformed rat-1 fibroblasts with constitutively elevated levels of phosphorylated extracellular signal-regulated kinase (erk), sc-alpha alpha delta 9 inhibited both proliferation and oncogenic erk activation at concentrations that inhibited plc in vitro. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
a sc-alpha alpha delta 9 congener that lacked antiproliferative activity also did not inhibit plc in vitro. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
in the plc-dependent scratch wound healing model, sc-alpha alpha delta 9 was 10-fold more potent than the phosphatidylcholine-specific plc inhibitor d-609. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
we propose that the structural resemblance of sc-alpha alpha delta 9 to phospholipids allows it to inhibit cellular plc, thereby providing a possible molecular mechanism for sc-alpha alpha delta 9's effects on oncogenic erk activation. |
2003-04-15 |
2023-08-12 |
Not clear |
| Jeffrey E Christensen, Jeffery R Broadbent, James L Steel. Hydrolysis of casein-derived peptides alpha(S1)-casein(f1-9) and beta-casein(f193-209) by Lactobacillus helveticus peptidase deletion mutants indicates the presence of a previously undetected endopeptidase. Applied and environmental microbiology. vol 69. issue 2. 2003-04-15. PMID:12571058. |
peptides derived from hydrolysis of alpha(s1)-casein(f1-9) [alpha(s1)-cn(f1-9)] and beta-cn(f193-209) with cell extracts of lactobacillus helveticus cnrz32 and single-peptidase mutants (delta pepc, delta pepe, delta pepn, delta pepo, and delta pepx) were isolated by using reverse-phase high-performance liquid chromatography and were characterized by mass spectrometry. |
2003-04-15 |
2023-08-12 |
Not clear |
| Zheng W Che. Comparative biology of gamma delta T cells. Science progress. vol 85. issue Pt 4. 2003-04-10. PMID:12661423. |
in contrast, a unique subset of circulating gamma delta t cells in primates, like alpha beta t cells, can mount adaptive immune responses in infections. |
2003-04-10 |
2023-08-12 |
Not clear |
| H Thomas Lee, Charles W Emal. Characterization of adenosine receptors in human kidney proximal tubule (HK-2) cells. Experimental nephrology. vol 10. issue 5-6. 2003-04-09. PMID:12381923. |
immunoblotting with ar subtype specific antibodies detected all 4 subtypes of ars (a(1), a(2a), a(2b) and a(3)), several isoforms of protein kinase c (alpha, delta, and epsilon and several heterotrimeric g-protein isoforms (g(i)alpha, g(s)alpha and g(q)alpha). |
2003-04-09 |
2023-08-12 |
human |
| Adam R Clarke, Robert J Barry, Rory McCarthy, Mark Selikowit. Children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder: an EEG analysis. Psychiatry research. vol 111. issue 2-3. 2003-04-07. PMID:12374635. |
the eegs were fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. |
2003-04-07 |
2023-08-12 |
human |
| Adam R Clarke, Robert J Barry, Rory McCarthy, Mark Selikowit. Children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder: an EEG analysis. Psychiatry research. vol 111. issue 2-3. 2003-04-07. PMID:12374635. |
regionally, the adhd groups had less relative alpha and more relative delta in posterior regions, and less relative beta in the frontal regions, than the control group. |
2003-04-07 |
2023-08-12 |
human |
| Matthew D Westfall, Deborah J Mays, Joseph C Sniezek, Jennifer A Pietenpo. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640112. |
the delta np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by hay-wells syndrome-derived mutations. |
2003-04-04 |
2023-08-12 |
mouse |
| Matthew D Westfall, Deborah J Mays, Joseph C Sniezek, Jennifer A Pietenpo. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640112. |
during hek differentiation, delta np63 alpha and p53 levels decreased, while expression of p53 target genes p21 and 14-3-3 sigma increased. |
2003-04-04 |
2023-08-12 |
mouse |
| Matthew D Westfall, Deborah J Mays, Joseph C Sniezek, Jennifer A Pietenpo. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640112. |
delta np63 alpha had transcriptional repressor activity in vitro, and this activity was reduced in delta np63 alpha proteins containing point mutations, corresponding to those found in patients with hay-wells syndrome. |
2003-04-04 |
2023-08-12 |
mouse |
| Matthew D Westfall, Deborah J Mays, Joseph C Sniezek, Jennifer A Pietenpo. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640112. |
further, we show that delta np63 alpha and p53 can bind the p21 and 14-3-3 sigma promoters in vitro and in vivo, with decreased binding of p63 to these promoters during hek differentiation. |
2003-04-04 |
2023-08-12 |
mouse |
| Matthew D Westfall, Deborah J Mays, Joseph C Sniezek, Jennifer A Pietenpo. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640112. |
these data suggest that delta np63 alpha acts as a transcriptional repressor at select growth regulatory gene promoters in heks, and this repression likely plays an important role in the proliferative capacity of basal keratinocytes. |
2003-04-04 |
2023-08-12 |
mouse |
| Marie-Agnès Doucey, Laurence Goffin, Dieter Naeher, Olivier Michielin, Petra Baumgärtner, Philippe Guillaume, Ed Palmer, Immanuel F Luesche. CD3 delta establishes a functional link between the T cell receptor and CD8. The Journal of biological chemistry. vol 278. issue 5. 2003-04-03. PMID:12215456. |
t cells expressing t cell receptor (tcr) complexes that lack cd3 delta, either due to deletion of the cd3 delta gene, or by replacement of the connecting peptide of the tcr alpha chain, exhibit severely impaired positive selection and tcr-mediated activation of cd8 single-positive t cells. |
2003-04-03 |
2023-08-12 |
mouse |
| Marie-Agnès Doucey, Laurence Goffin, Dieter Naeher, Olivier Michielin, Petra Baumgärtner, Philippe Guillaume, Ed Palmer, Immanuel F Luesche. CD3 delta establishes a functional link between the T cell receptor and CD8. The Journal of biological chemistry. vol 278. issue 5. 2003-04-03. PMID:12215456. |
this association was not observed on t1 hybridomas expressing only cd8 alpha alpha or a cd3 delta(-) variant of the t1 tcr. |
2003-04-03 |
2023-08-12 |
mouse |
| Annette Nicke, Marion L Loughnan, Emma L Millard, Paul F Alewood, David J Adams, Norelle L Daly, David J Craik, Richard J Lewi. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of biological chemistry. vol 278. issue 5. 2003-04-03. PMID:12419800. |
gid inhibits alpha 7 and alpha 3 beta 2 nachrs with ic(50) values of 5 and 3 nm, respectively and is at least 1000-fold less potent at the alpha 1 beta 1 gamma delta, alpha 3 beta 4, and alpha 4 beta 4 combinations. |
2003-04-03 |
2023-08-12 |
Not clear |
| Annette Nicke, Marion L Loughnan, Emma L Millard, Paul F Alewood, David J Adams, Norelle L Daly, David J Craik, Richard J Lewi. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of biological chemistry. vol 278. issue 5. 2003-04-03. PMID:12419800. |
deletion of the n-terminal sequence (gid delta 1-4) significantly decreased activity at the alpha 4 beta 2 nachr but hardly affected potency at alpha 3 beta 2 and alpha 7 nachrs, despite enhancing the off-rates at these receptors. |
2003-04-03 |
2023-08-12 |
Not clear |
| E Miyamoto, K Fukunaga, Y Takeuchi, H Yamamoto, J Kasahara, Jie Li. [Calcium signaling and brain functions]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 1. 2003-04-01. PMID:12491766. |
the isoforms of camk subunits such as alpha b, gamma a, gamma a.b, delta 3 and delta 7 contain nts in the sequences of the structures. |
2003-04-01 |
2023-08-12 |
Not clear |