| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Craig H Bassing, Robert E Tillman, Barbara B Woodman, David Canty, Robert J Monroe, Barry P Sleckman, Frederick W Al. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604775. |
we used gene-targeted mutation to evaluate whether the identity of e alpha and the position of e delta are critical for the developmental stage-specific assembly of tcr delta and alpha variable region genes. |
2003-05-13 |
2023-08-12 |
Not clear |
| Craig H Bassing, Robert E Tillman, Barbara B Woodman, David Canty, Robert J Monroe, Barry P Sleckman, Frederick W Al. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604775. |
specific replacement of e alpha with e delta, the core e alpha element (e alpha c), or the ig heavy chain intronic enhancer (ie mu), all of which promote accessibility in the context of transgenic v(d)j recombination substrates, did not promote a significant level of tcr alpha rearrangement beyond that observed in the absence of e alpha. |
2003-05-13 |
2023-08-12 |
Not clear |
| Craig H Bassing, Robert E Tillman, Barbara B Woodman, David Canty, Robert J Monroe, Barry P Sleckman, Frederick W Al. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604775. |
in the absence of the endogenous e delta element, specific replacement of e alpha with e delta also did not promote tcr delta rearrangement. |
2003-05-13 |
2023-08-12 |
Not clear |
| Craig H Bassing, Robert E Tillman, Barbara B Woodman, David Canty, Robert J Monroe, Barry P Sleckman, Frederick W Al. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604775. |
therefore, unlike e alpha, e delta lacks ability to function over the large intervening tcr alpha locus and or e delta function requires proximity to additional upstream element(s) to promote tcr delta accessibility. |
2003-05-13 |
2023-08-12 |
Not clear |
| Ouliana Ziouzenkova, Stephane Perrey, Liana Asatryan, Juliana Hwang, Karen L MacNaul, David E Moller, Daniel J Rader, Alex Sevanian, Rudolf Zechner, Gerald Hoefler, Jorge Plutzk. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12606719. |
further studies reveal specificity for ppar activation through lipolysis in regards to lipoprotein substrate (vldl >> ldl > hdl), ppar isoform (ppar alpha >> ppar delta > ppar gamma), and among fatty acid-releasing lipases. |
2003-05-13 |
2023-08-12 |
mouse |
| Y Mizuno, H Takada, A Nomura, C-H Jin, H Hattori, K Ihara, T Aoki, K Eguchi, T Har. Th1 and Th1-inducing cytokines in Salmonella infection. Clinical and experimental immunology. vol 131. issue 1. 2003-05-12. PMID:12519393. |
the results suggest that th1-inducing cytokines appear to be involved in the in vivo response against salmonella infection, promoting ifn-gamma production by alpha beta and gamma delta t cells which plays a protective role against salmonella. |
2003-05-12 |
2023-08-12 |
human |
| Xing-Zhi Song, Iraida E Andreeva, Steen E Pederse. Site-selective agonist binding to the nicotinic acetylcholine receptor from Torpedo californica. Biochemistry. vol 42. issue 14. 2003-05-12. PMID:12680774. |
fluorescent energy transfer measurements of dansyl-c6-choline binding to the nicotinic acetylcholine receptor (achr) from torpedo californica were used to determine binding characteristics of the alpha gamma and alpha delta binding sites. |
2003-05-12 |
2023-08-12 |
Not clear |
| Xing-Zhi Song, Iraida E Andreeva, Steen E Pederse. Site-selective agonist binding to the nicotinic acetylcholine receptor from Torpedo californica. Biochemistry. vol 42. issue 14. 2003-05-12. PMID:12680774. |
equilibrium binding measurements show that the alpha gamma site has a lower fluorescence than the alpha delta site; the emission difference is due to differences in the intrinsic fluorescence of the bound fluorophores rather than differences in energy transfer at the two sites. |
2003-05-12 |
2023-08-12 |
Not clear |
| Xing-Zhi Song, Iraida E Andreeva, Steen E Pederse. Site-selective agonist binding to the nicotinic acetylcholine receptor from Torpedo californica. Biochemistry. vol 42. issue 14. 2003-05-12. PMID:12680774. |
stopped-flow fluorescence kinetics showed that dissociation of dansyl-c6-choline from the achr in the desensitized conformation occurs 5-10-fold faster from the alpha gamma site than from the alpha delta site. |
2003-05-12 |
2023-08-12 |
Not clear |
| Xing-Zhi Song, Iraida E Andreeva, Steen E Pederse. Site-selective agonist binding to the nicotinic acetylcholine receptor from Torpedo californica. Biochemistry. vol 42. issue 14. 2003-05-12. PMID:12680774. |
equilibrium fluorescent binding measurements show that dansyl-c6-choline binds with higher affinity to the alpha delta site (k = 3 nm) than to the alpha gamma site (k = 9 nm) when the achr is desensitized. |
2003-05-12 |
2023-08-12 |
Not clear |
| Joel E Wright, Andre Rosowsk. Synthesis and enzymatic activation of N-[N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithiny]-L-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (ADEPT). Bioorganic & medicinal chemistry. vol 10. issue 3. 2003-05-01. PMID:11814834. |
synthesis and enzymatic activation of n-[n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithiny]-l-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (adept). |
2003-05-01 |
2023-08-12 |
human |
| Joel E Wright, Andre Rosowsk. Synthesis and enzymatic activation of N-[N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithiny]-L-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (ADEPT). Bioorganic & medicinal chemistry. vol 10. issue 3. 2003-05-01. PMID:11814834. |
n-[n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithinyl]-l-phenylalanine (1), a carboxypeptidase a (cpa) cleavable prodrug was synthesized for use in an antibody directed strategy to improve the therapeutic selectivity of n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithine (2), an extremely potent nonpoly-glutamatable dhfr inhibitor which is also highly cytotoxic. |
2003-05-01 |
2023-08-12 |
human |
| Carles Gil, Abderrahim Najib, José Aguiler. Serotonin transport is modulated differently by tetanus toxin and growth factors. Neurochemistry international. vol 42. issue 7. 2003-05-01. PMID:12590935. |
pkc gamma, delta, and epsilon isoforms are equally activated by both compounds, whereas the beta isoform is activated in a sustained manner only by tetx, and the alpha isoform is only down-regulated by ngf. |
2003-05-01 |
2023-08-12 |
Not clear |
| Kazuichi Sakamoto, Yousuke Ishii, Tomomi Onodera, Tomoko Sugan. Cloning and characterization of the novel isoforms for PGF2 alpha receptor in the bovine corpus luteum. DNA sequence : the journal of DNA sequencing and mapping. vol 13. issue 5. 2003-04-30. PMID:12592712. |
the sequence analysis revealed that each fp isoform, respectively, encodes 325 (alpha), 326 (beta), 339 (gamma), 293 (delta), and 298 (epsilon) amino acid proteins, carrying the specific carboxyl tails (c-tails) caused by alternative mrna splicing. |
2003-04-30 |
2023-08-12 |
cattle |
| Nicholas J Brandon, Jasmina N Jovanovic, Marcie Colledge, Josef T Kittler, Julia M Brandon, John D Scott, Stephen J Mos. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Molecular and cellular neurosciences. vol 22. issue 1. 2003-04-21. PMID:12595241. |
gaba(a) receptors, the key mediators of fast synaptic inhibition in the brain, are predominantly constructed from alpha(1-6), beta(1-3), gamma(1-3), and delta subunit classes. |
2003-04-21 |
2023-08-12 |
Not clear |
| B Saletu, P Anderer, L Linzmayer, H V Semlitsch, E Lindeck-Pozza, A Assandri, C di Padova, G M Saletu-Zyhlar. Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine (SAMe) infusions in elderly subjects, utilizing EEG mapping and psychometry. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 12. 2003-04-18. PMID:12486491. |
acute same-induced changes were characterized by a decrease in total power, an increase in absolute delta and a decrease in absolute alpha power, further by an increase in relative delta and a decrease in relative alpha power, a slowing of the delta/theta centroid as well as a slowing of the centroid of the total power spectrum. |
2003-04-18 |
2023-08-12 |
human |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
the antisignaling agent sc-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase c inhibitory activity. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
here we investigated the actions of a previously described antitumor agent, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid (sc-alpha alpha delta 9), which has antisignaling properties, on phospholipases. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
although sc-alpha alpha delta 9 had been shown to be a potent and selective inhibitor of the cdc25 family of dual-specificity phosphatases, many of its cellular effects are not readily reconciled with phosphatase inhibition. |
2003-04-15 |
2023-08-12 |
Not clear |
| Andreas Vogt, Katharine E Pestell, Billy W Day, John S Lazo, Peter Wip. The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481409. |
molecular modeling studies suggested that sc-alpha alpha delta 9 shared several structural features with membrane phospholipids. |
2003-04-15 |
2023-08-12 |
Not clear |